Colchicine 독성에 따른 골격근의 형태학적 변화에 관한 연구 : 막성소체 출현에 관한 전자현미경적 검색 Electron Microscopic Study

이화동,김경수,장희경,허만하 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.11

To investigate the morphological changes in skeletal muscle produced by colchicine toxicity, 42 rats were given a single intraperitoneal dose(0.4mg/kg) of colchicine, and the animals were killed at daily intervals up to 7 days. The results of light microscopic and electron microscopic observations are summarized as follows : 1) At the light microscopic level, colchicine treated rats show non-inflammatory, nonspecific scattered degeneration or necrosis of myofibers irrrspective of location of the skeletal muscle. No significant pathologic changes in peripheral nerve fibers distributed in affected muscles are seen.2) The general ultrastructural changes are dilation of sarcoplasmic reticulum, swelling and pleomorphism of mitochondria, and appearance of membraneous bodies characterized by a single or multiple concentric layers of membranes in subsarcolemmal zones and intermyosbrillar zones, and focal necrosis or loss of myofibrils. The incidence and severity of these changes show gradual increase and reach maximal peak 3 days after colchicine administration, and then they show gradual decrease. Nerve fibers and motor-end plates show no difference compared with the control. 3) The observations are consistent with the opinion that the muscle weakness or paresis produced by toxic dose of colchicine is not of neuropathic, but of myopathic alterations. 4) The membraneous bodies are classified into the following 3 types : Type Ⅰ is those bodies outlined by a few concentric membranes with osmiophilic granules, small vesicles, free ribosomes, and mitochondria in central zone. Type Ⅱ is those outlined by several concentric layers of membranes with osmiophilic gradules, small vesicles, free ribosomes, and mitochondria in center. Type Ⅲ is those outlined by multilayered or thick concentric membranes with osmiophilic granules, small vesicles, free ribosomes, and mitochondria in central zone, frequently with complicated lamellar structures. 5) The skeletal muscle lesions produred by colchicine toxicity may be categorized into those degenerative changes characterized by the appearance of membraneous bodies. And, morphologically, it is presumed that the membraneous bodies are heterogenous in origin, alterations of subcellular structures such as sarcoplasmic reticulum, mitochondria, and lysosome.

통합 차량 네트워크 시스템을 위한 노드 기반 FlexRay-CAN 게이트웨이 설계

김만호(Man Ho Kim),이석(Suk Lee),이경창(Kyung Chang Lee),하경남(Kyong Nam Ha) 한국자동차공학회 2011 한국자동차공학회 부문종합 학술대회 Vol.2011 No.5

As vehicles become more intelligent, in-vehicle networking (IVN) systems such as controller area network (CAN) or FlexRay are essential for the convenience and safety of drivers. To expand the applicability of IVN systems, attention is currently being focused on the communication between heterogeneous networks such as body networking systems or chassis networking systems. Message mapping based gateway was developed to communicate between FlexRay and CAN network to improve exchanging information of vehicle. However, there are obstacles for the wide acceptance of the FlexRay-CAN gateway of vehicle. First, when message ID was changed of network, gateway must be reloaded changed message mapping table. Second, if the exchanging message is increased in the network, software complexity of gateway is increased rapidly. In order to overcome these obstacles, this paper presents a node mapping -based FlexRay-CAN gateway for IVN systems. In addition, this paper presents a node mapping based FlexRay-CAN gateway operation algorithm along with the experimental evaluation for ID change.

DRG 지불제도 도입에 따른 의료보험청구 행태 변화

강길원,박형근,김창엽,김용익,하범만,Kang, Gil-Won,Park, Hyoung-Keun,Kim, Chang-Yup,Kim, Yong-Ik,Ha, Beom-Man 대한예방의학회 2000 예방의학회지 Vol.33 No.4

Objectives : To evaluate the impacts of the DRG payment system on the behavior of medical insurance claimants. Specifically, we evaluated the case-mix index, the numbers of diagnosis and procedure codes utilized, and the corresponding rate of diagnosis codes before, during and after implementation of the DRG payment system. Methods : In order to evaluate the case-mix index, the number of diagnosis and procedure codes utilized, we used medical insurance claim data from all medical facilities that participated in the DRG-based Prospective Payment Demonstration Program. This medical insurance claim data consisted of both pre-demonstration program data (fee-for-service, from November, 1998 to January, 1999) and post-demonstration program data (DRG-based Prospective Payment, from February, 1999 to April, 1999). And in order to evaluate the corresponding rate of diagnosis codes utilized, we reviewed 820 medical records from 20 medical institutes that were selected by random sampling methods. Results : The case-mix index rate decreased after the DRG-based Prospective Payment Demonstration Program was introduced. The average numbers of different claim diagnosis codes used decreased (new DRGs from 2.22 to 1.24, and previous DRGs from 1.69 to 1.21), as did the average number of claim procedure codes used (new DRGs from 3.02 to 2.16, and previous DRGs from 2.97 to 2.43). With respect to the time of participation in the program, the change in number of claim procedure codes was significant, but the change in number of claim diagnosis codes was not. The corresponding rate of claim diagnosis codes increased (from 57.5% to 82.6%), as did the exclusion rate of claim diagnosis codes (from 16.5% to 25.1%). Conclusions : After the implementation of the DRG payment system, the corresponding rate of insurance claim codes and the corresponding exclusion rate of claim diagnosis codes both increased, because the inducement system for entering the codes for claim review was changed.

15년 전의 신의 투명 세포암에 속발하여 발생한 갑상선의 투명 세포암에 대한 조직화학 및 면역병리학적 검색 : A Case report Histochemical and Immunohistochemical Studies

장희경,김혜숙,허방,허만하 고신대학교 의학부 1988 高神大學校 醫學部 論文集 Vol.4 No.1

A case of metastatic clear cell carcinoma of the thyroid in a 60 year old Korean male, ensuing clear cell carcinoma of the kidney after 15 years, is reported, associated with a literature review, in view of its rarity and the method of surgicopathological access we adopted toward the final anatomic diagnosis. An emphasis is placed on the way of differential diagnosis of metastatic carcinoma from primary clear cell carcinoma of the thyroid and secondary malignancy from primary parathyroid carcinoma. Not only gross and ordinary microscopic observations including special stains, an immunoperoxidase method is performed to confirm that the thyroid lesion is not of the thyroid cell origin, which reconfirms the immunopathological method is a useful tool in surgical pathology.

병기 ⅠB-ⅡB 자궁경부암에서의 CD44v4/5, CD44v6, α-Smooth Muscle Actin과 nm23의 발현

장희경,허만하,김동휘,박은동 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.6

大邱地域 中小企業의 效率的인 技術開發 方案에 관한 硏究

全瑨文,張晩植,尹在坤,金圭昌,李栽燁,朴筍植,黃建夏 효성여자대학교 산업경영연구소 1988 경영경제 Vol.5 No.-

For modern business firms, the most important factor in determining comprtitiveness of a firm is technology, rather than capital. Technogical innovation is a driving force to develop an economy and is essential in growth and/or survival of a business firm. Following studies concerned with this subject, small business firms seem to be more efficient in technological innovation and developing new technology in several respects. Espercially in the new technology based industries, the small business firms have several advantages in technological innovation. In this study, we tried to show how to plan a technology development strategy in relation to management strategy when small business of theoretical and empirical study, we aimed to show the way to efficient management and procedure of technological innovation. For the research methodology, we firstly reviewed and analyzed current and previous studies about technological innovation strategy, efficient management, and selection of R&D projects. Secondly, the results of this theoretical study was examined empirically. The empirical study contains 153 questionaires and 30 interviews for business firms of this area. In addition, for the evaluation criteria for the selection of R&D projects, we sent questionaires to 60 professors who teaches R&D OR in university or college level. The result of these questionaires was analyzed and compared with that of the business firms of this area. The result of this empirical study shows that top management of small business firms should notice the importance of technological innovation and try to stimulate R&D activity. For the evaluation criteria for R&D projection, the criteria which could reduce the possibility of future uncertainty, maximize profit, and he suited for the situation of the business firm, should be established.

Efficiency of Flushing through a Sluice-Gated Weir

Son, Kwang Ik,Hwang, Man Ha,Son, Gyo Chang Trans Tech Publications, Ltd. 2013 Advanced materials research Vol.726 No.-

<P>The four major rivers restoration project (4MRRP) was carried out in Korea between Oct., 2009 and Sep., 2012. The major purposes and effects of the 4MRRP were flood control, safe water security and water quality improvement. For flood control, 450 million m<SUP>3</SUP> of sediments were dredged with the reinforcement of 620 km-long old levees. Sixteen weirs were constructed and 93 reservoir banks were elevated for safe water security. Deformation of the main channels appeared to be inevitable because the longitudinal slope and cross section of the river had changed. In particular the construction of weirs could take the role of sediment detention ponds because the weirs will slow down the velocity and reduce the capability of sediment transportation. Therefore, it is crucial to determine how the siltation phenomena upstream of a weir can be fixed. This study examined the sluicing efficiency of the gate operation for the Gumi weir using 2-dimensional numerical simulations.</P>

남성 유방암 3증례에 관한 병리학적 및 임상적 고찰

李忠漢,李承道,徐在寬,朴瑛勳,장희경,허방,허만하 고신대학교 의학부 1988 高神大學校 醫學部 論文集 Vol.4 No.1

We have experienced three cases of male breast cancer in our series, 586 cases of all surgically treated breast cancer from 1970 to 1987. Pathological diagnosis covered infiltrating ductal carcinoma, intraductal carcinoma, and papillary carcinoma. One case was treated on partial mastectomy and two cases on simple mastectomy with axillary dissection. In view of academic and clinical interacts, we report three cases of male breast carcinoma along with literature review.

개 대뇌겉질에서 Platelet-Derived Growth Factor α-Receptor의 출생 후 발달에 관한 면역조직화학적 연구

윤영,안병수,김인정,양경철,박선홍,김기훈,박도영,김장만,문정석,장인엽,조하영 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background and Objectives : The localization of platelet-derived growth factor-α receptor (PDGF-α R) was commonly restricted to oligodendrocyte progenitors during late embryonic and postnatal development. However, several studies recently demonstrated that mature neurons could also synthesize PDGF-α, Materials and Methods : In the present study, to analyze the distributional pattern of PDGF-αR during postnatal development of the canine cerebral cortex, we used immunohistochemistry on sections of canine brain tissue. Results : We found that neurons of various regions of cerebral cortex exhibited the immunoreactivity to PDGF-αR as early as postnatal day 0, and slightly decreased after postnatal day 14. Whereas neuronal PDGF-αR were maintained at all ages, the oligodendroglia-like expression of PDGF-αR could not be confirmed. Conclusion : The localization of PDGF-αR in immature and mature neurons supports the several roles of PDGF during development, protection and survival of neurons.

Neural Tissue-Specific Epidermal Growth Factor (EGF)-like Domain Containing Protein, NELL2, Plays on Important Role in the Control Regulation of Puberty Onset in the Female Rat Hypothalamus

Ha, Chang-Man,Kang, Hae-Mook,Lee, Byung-Ju The Korean Society for Integrative Biology 2000 Korean journal of biological sciences Vol.4 No.4

In the present study we determined if NELL2, a neural tissue-specific protein containing 6 epidermal growth factor (EGF)-like repeat domains, plays an important role in the regulation of puberty initiation in the rat hypothalamus. We origin811y found that NELL2 is a new estrogen-responsive gene in hypothalami derived from estrogen-sterilized and control rats using a PCR differential display. In the 40-day-old female rat hypothalamus, NELL2 was up-regulated by neonatal estrogen treatment. In situ hybridization histochemistry showed that NELL2 is very abundant in the ventromedial hypothalamic nucleus that is responsible for the control of sex behavior. NELL2 mRNA level in the medial basal hypothalamus showed a dramatic increase before female puberty onset, which suggests that NELL2 may be involved in the process regulating female puberty onset. We attemped to block NELL2 synthesis with intracerebroventricular injection of an antisense oligodeoxynucleotide (ODN) to the NELL2 mRNA, and examined its effect on the puberty onset of the female rat. The antisense ODN significantly delayed puberty initiation determined by vaginal opening. In summary, NELL2 may play an important role in the regulation of female puberty onset.