폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

정수처리용 응집제 주입율 및 경제성에 관한 연구

박성천,문병석,김강석 東新大學校 工業技術硏究所 1997 工業技術硏究 Vol.3 No.-

The purpose of this study was to compare the characteristics of coagulant LAS (Liquid Aluminum Sulfate) with PAC (Poly Aluminum Chloride) and to determine their injection rate for the water treatment. LAS have been used as a coagulant for the water treatment in the city of Kwangju. PAC is considered as an alternation of LAS. The injection rate of the coagulant in water treatment is one of main factors affecting the whole water treatment process. The injection rate have been adjusted based on the jar test results obtained daily. There are a number of factors affecting the flocculation such as turbidity, pH, temperature, alkalinity. If we relate somehow these factors as well as jar test results, more scientific and theoretical approach for adjusting the injection rate of coagulant is possible. Therefore, two flocculants, LAS and PAC, were examined in this study in water drawn from the Ju-am dam. The comparison between LAS and PAC was accomplished with the Jar-Test results and other factors involved in coagulation and settling such as pH, turbidity, water temperature, and alkalinity. The data were gathered and subjected to multivariate regression analysis. Analysis of the subordinate and independent correlation variables were conducted to determine which factor in the model supported the best correlation. As a results of analysis, it was found that PAC is more suitable than LAS and that the statistical formula for the injection rate was found to be suitable for practical application in real water purification plants

다층 페셉트론을 이용한 단기 급수량 예측

朴成天,文炳錫 東新大學校 1999 論文集 Vol.11 No.-

This study investigates the prediction of daily supply, which is a necessary for the efficient management of water distribution system. The purpose of this study is to establish a method of estimating the daily urban water demand using Back propagation algorithm is part of ANN(Artificial Neural Network). The datum used were the daily urban water demand, the population and weather conditions such as temperature, precipitation, relative humidity, etc. Kwangju city was selected for the case study area. We normalized the non-stationary time series data [-1, +1] to fast converge, and choose the input patterns by statistical methods. We separated the training and checking patterns from input data patterns. We discussed the representation ability the model building process and the applicability of ANN approach for the daily water demand. ANN provided the reasonable results for time series forecasting.

大都市의 上水道管網 解析에 관한 硏究

朴成天,文炳錫,吳昌柱 동신대학교 환경연구소 1995 환경연구 Vol.1 No.1

급배수시설은 생산된 상수를 안정적으로 공급하는 시설로서 국민생활과 경제활동에 기본이 되는 중요한 사회 간접시설 중의 하나이다. 그러나 우리나라의 대도시들은 급속한 도시성장과 산업발달 등의 수요증대 요인으로 인하여 시설확장을 계속해 왔음에도 불구하고 급배수시설에 대한 과학적인 분석이나 개선방향에 대한 연구는 미흡한 실정이다. 그러므로 본 논문에서는 대상지역으로 선정된 광주광역시의 주요 송 배수관망에 대한 관망해석을 실시하여 관로의 수리상태를 파악하고 문제점을 제시하여 안정급수를 도모하는데 그 목적을 두었다. 광주광역시의 급배수지와 300mm이상의 주요 송배수관을 대상으로 주간 최대급수량과 야간 최소급수량으로 구분하여 관망해석을 실시한 결과 급수불량지역으로 판명된 지점은 급수관에서 분기되는 급수소관에서 발생하는 것으로 판명되었다. 현재 광주광역시의 누수율은 약 16%에 이르고 있는 것으로 추정되는데, 관망해석 결과에 의하면 현재광주광역시에서 운용하고 있는 급배수 관망에서 야간시에 대체적으로 허용치 이상의 높은 수압이 발생하고 있는 실정이며, 몇몇 지역의 수압은 누수방지를 위한 최대수압을 초과하고 있으므로 이 지역에 상당량의 누수가 있을 것으로 판단된다. Water supply system in modern society is one of the most important urban infrastructures as a life line suppling necessary amount of treated water to meet living standard and proper operations of city organizations and urban facilities according to social development and economic growth. The purpose of this study is to analyze the water supply and distribution systems in large cities in Korea and to suggest the enhanced maintenance and the management methods of those facilities. The data used for this study were obtained from the city of Kwangju in Korea. The population of Kwangju in the end of November 1995 was about one million thirty thousand. The average daily water use of the city of Kwangju in 1995 was about four hundred seventy thousand tons a day. The area of high elevation has lack of water because the low pressure prevails in the distribution pipes due to the high elevation. In order to secure the stabilized water supply to those area, the distribution reservoirs are required. Leakage may has been occurred out of pipe junctions, segments of worn pipes, etc. In order to reduce the water leakage, the replacement of worn pipe is strongly recommended.

웹기반의 가축전염병 발생자료 관리시스템(AIMS) 개발

박병호,김석재,황인진,김시동,남향미,위성환 한국농업정보과학회 2003 농업정보과학 Vol.4 No.1

The AIMS(Anima1 Infectious Disease Data Management System) was developed to collect and analyze data on animal infectious disease outbreak (62 diseases). When an animal infectious disease is confirmed at a diagnostic laboratory, the disease outbreak is then reported to the regional government through AIMS. After the regional government confirms the number of animals infected or dead, outbreak date and etc, this information is reported to the Ministry of Agriculture & Forestry and the National Veterinary Research & Quarantine Service through AIMS. The AIMS analyzes the outbreak data and reports the outbreak statistics by region, month and year to them. In addition, the AIMS can identify the farm where there was an outbreak of the animal infectious disease. There are four user roles : 1) Administrator, responsible for the overall operation of the system. 2) Inspector, responsible for confirmation of the animal infectious disease outbreak. 3) Pathologist, responsible for input to an animal infectious disease at first. 4) Gallery, only able to read the outbreak statistics. The AIMS has been implemented using the ASP technology and is operated on the web to allow easy access. The data, middle and presentation tier are based on MS-SQL 2000 server, Microsoft transaction server and Internet Explorer, respectively. The database's stored procedure was used to improve the performance. In addition to above software, the dextupload software is used to upload the files. By using the AIMS, a more accurate statistics for the animal infectious disease outbreak is expected.

단독주택의 용도별 에너지 소비에 관한 연구

김병수,장문석,박효순,송인춘 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

The purpose of this study is to analyze the situation of energy consumption and its characteristics in detached houses. The survey is carried out in detached houses to investigate the energy consumption and energy use trend in according to three different climate zones. Building energy simulation by DOE-2 computer program was undertaken for detailed analysis of the energy use characteristic in detached houses. Also, The room temperature and the energy use of the year were also calculated. Finally, The energy consumption characteristics of heating, cooling, cooking and electric equipments in detached houses depends on life style of resident such as room temperature, occupancy type and equipment operating schedule and etc. And also, the results of this study will be to provide basic data concerned with total energy consumption in detached houses.

링 예약 알고리즘을 이용한 ATM 스위치

주우석,박경희,유승열,최병석 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

We propose a new architecture of multicast ATM switch which has input and output buffers and uses Multicast Ring Reservation Algorithm to resolve output port contention. This new algorithm eliminates internal cell loss due to contention, and reduces the hardware complexity. We can dynamically control the number of cells routed to a specific output port during one cell time with this contention resolution algorithm. The computer simulation is performed under bursty traffic condition to show the performance of this proposed multicast ATM switch.

고위험군의 원발성 전신성 유전분증 1례 보고 및 조혈모세포이식에 대한 문헌고찰

심준,박수정,엄현석,김기영,박은정,강인중,조병식,이안희,한치화 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

저자 등은 클론성 형질세포질환과 동반된 젊은 연령의 원발성 전신성 유전분증 환자를 진단하였기에 다발성 골수종과의 감별 진단, 치료 , 예후 및 고용량 항암화학요법과 조혈모세포이식에 관하여 문헌고찰과 함께 보고하는 바이다. Primary systemic amyloidosis (AL) is a rapidly fatal disorder related to plasma cell dyscrasia. Conventional dose of melphalan, which prolongs the duration of survival by about 10 months, does not improve the functions of impaired organs in most cases. The high dose chemotherapy followed by autologous hematopoietic stem cell rescue for AL, in spite of its high treatment-related mortality, is a new approach to achieve high response rate and better survival. We experienced a 35-year old man with AL(involving heart, liver, stomach, kidneys, peripheral nerve, and rectum) who did not respond to the standard schedule of melphalan plus prednisone and had rapidly fatal course with organ failure. Hence, we evaluate its availability by reviewing the recent reports of high dose chemotherapy in AL.

관상동맥협착 정도 예측을 위한 경동맥 초음파 검사의 유용성

고광일,박병현,오석규,김남호,조정구,정진원 대한노인병학회 2001 대한노인병학회지 Vol.5 No.4

토끼에서 Etofenprox와 Spinosad 합제의 국소자극성 시험

황윤환,김명석,송인배,박병권,양승호,임용현,송치용,안성한,남현수,임정교,정상일,명노일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

This study was performed to evaluation the skin and eye irritation of etofenprox 8% and spinosad 4% combination in male New Zealand White rabbits. In skin irritation test, the combination of etofenprox and spinosad did not showed any change of body weight but caused slight skin irritation with the P.I.I. (primary irritation index) value 0.25. The etofenprox and spinosad combination showed severe eye irritation 1 h, 24 h, 48 h, and 72 h after ocular treatment, having the A.O.I. (acute ocular irritation) value of 37.3. Therefore, these result indicated that the combination of etofenprox and spinosad might be irritant formulation on eye and skin.