The 5th Seoul International Digestive Disease Symposium : Recurrence and Metastasis of Hepatocellular Carcinoma a Synopsis of Recent Studies in Liver Cancer Institute of Shanghai Medical University

(Zhao You Tang) 대한소화기학회 1999 SIDDS Vol.5 No.-

Objective : To outline the progress of studies on recurrence and metastasis of hepatocellular carcinoma (HCC) at author's institution. Methods : Clinical and experimental studies on recurrence and metastasis of HCC in the recent years are highlighted. Results : Surgical resection has played an important role in improving prognosis of HCC, the 5-year survival were 63.4% for small HCC resection (n=806), 39.6% for large HCC resection (n=1061), 64.7% for cytoreduction (using hepatic artery cannulation and ligation) and sequential resection of unresectable HCC (n=93), and 56.0% for cytoreduction using transcatheter arterial chemoembolization (TACE) and followed by resection (n=65). Unfortunately, the 5-year recurrent rate after curative resection of HCC was as high as 61.5%, which was mainly a result of intrahepatic "metastasis" and multicentric origin of HCC. In clinical aspect, re-resection of subclinical recurrence yielded 56% of 5-year survival (n=202); prevention of recurrence by postoperative hepatic regional chemotherapy (n=105) have decreased 3-year recurrent rate from 33% to 18%. In experimental aspect, metastatic human HCC model in nude mice (LCI-D20) and HCC cell line with metastatic potential (MHCC97) have been established. Studies on HCC invasiveness in the molecular level revealed similar results that happened in other solid cancers, and small HCC showed slightly better biological characteristics as compared with large HCC. Studies on prognostic markers revealed that microvessel density (MVD) was negatively correlated with 5-year survival of small HCC, other serum markers are of potential clinical implication. Experimental interventions using antisense H-ras, BB94, heparin, interferon as well as antiangiogenic agents (TNP470, suramin, CAI, gene transfer of dominant-negative flk-1 mutant, antisense VEGF, endostatin, etc.) have been demonstrated to inhibit tumor growth and lung metastasis in LCI-D20 model. Conclusion : Recurrence and metastasis remain the major target to be studied for further improve prognosis of HCC, studies should be conducted both in clinical and experimental aspects. Molecular events of HCC invasiveness deserved to be intensively studied. Antiangiogenesis will be one of the important approach for intervention.

Effect of Minor Sc Addition on the Microstructure Evolution of Al–Cu–Li–Mg Alloy During Homogenization with Different Cooling Modes

Ya Tang,Daihong Xiao,Lanping Huang,Renxuan You,Xinyue Zhao,Nan Lin,Yunzhu Ma,Wensheng Liu 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.10

The microstructure evolution and mechanical properties of Al–3.92Cu–1.10Li–0.68Mg–0.32Ag–0.23Mn–0.35Zn–0.11Zrand Al–3.92Cu–1.12Li–0.76Mg–0.29Ag–0.24Mn–0.24Zn–0.12Zr–0.083Sc (wt%) alloys during homogenization with differentcooling modes were comprehensively studied. It was clearly revealed that the minor Sc addition refined the grainsof as-cast Al–Cu–Li–Mg alloys through the formation of primary Al3(Sc, Zr) phases during the solidification process, andinduced Sc enrichment in the θ (Al2Cu) eutectic. After the homogenization treatment, the majority of coarse nonequilibriumeutectic phases at the grain boundaries dissolved into the α-Al matrix, leading to the relatively uniform distribution ofeach element. Sc-added alloy after homogenization treatments possessed more superior strength and ductility than Sc-freealloy. Compared to the furnace cooling mode, the air cooling mode could inhibit the precipitation of micron-sized coarse T1(Al2CuLi) phase and improve the mechanical properties of the alloys. After homogenization, the continuous Al2Cuphase inthe as-cast Sc-added alloy dissolved and transformed to an array of W-(Al, Cu, Sc) ternary phase, which was identified asAl6Cu6Scwith the body-centered tetragonal structure. The appearance of spherical Al6Cu6Scparticle could not damage themechanical properties of Al–Cu–Li–Mg alloys after the homogenization treatment. The tensile strength, yield strength andelongation of Sc-added alloy after the homogenization by air cooling were 390 MPa, 265 MPa and 10.8%, respectively. Theinvestigation of Al6Cu6Scphase offered a potential avenue to produce high-quality Sc-added 2xxx series alloys.

FIV response analysis of cylinder with hollow section placed in tandem at the rear of upstream cylinder by numerical simulation

Rongjiang Tang,Yizhu Zhao,YuBin Gu,Zeyu You,Yanhong Wei,Ming Zhao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.10

The flow-induced vibration of a circular cylinder with a hollow section that is mounted at the rear is investigated in this work via numerical simulation. The Reynolds number was limited in the range of 6918-1511 by using reduced velocity that corresponds to Ur = 2-12. Five typical center-to-center distance ratios L/D of 3, 4, 5, 6, and 7 and three hollow section positions of left bias, up bias, and middle of cylinder were selected. The displacement time history curve and short-time Fourier transform diagram show that when L/D = 3 and Ur = 3, the cylinder with the hollow position in the middle initially entered the main frequency vibration for 5.64 s, but when L/D = 4 and Ur = 6, the drag coefficient time history curve of the cylinder biased to the left and up at the hollow position demonstrated a "beating" phenomenon, and multiple frequency peaks appeared on the fast Fourier transform diagram.

A Privacy-preserving and Energy-efficient Offloading Algorithm based on Lyapunov Optimization

Lu Chen,Hongbo Tang,Yu Zhao,Wei You,Kai Wang 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.8

In Mobile Edge Computing (MEC), attackers can speculate and mine sensitive user information by eavesdropping wireless channel status and offloading usage pattern, leading to user privacy leakage. To solve this problem, this paper proposes a Privacy-preserving and Energy-efficient Offloading Algorithm (PEOA) based on Lyapunov optimization. In this method, a continuous Markov process offloading model with a buffer queue strategy is built first. Then the amount of privacy of offloading usage pattern in wireless channel is defined. Finally, by introducing the Lyapunov optimization, the problem of minimum average energy consumption in continuous state transition process with privacy constraints in the infinite time domain is transformed into the minimum value problem of each timeslot, which reduces the complexity of algorithms and helps obtain the optimal solution while maintaining low energy consumption. The experimental results show that, compared with other methods, PEOA can maintain the amount of privacy accumulation in the system near zero, while sustaining low average energy consumption costs. This makes it difficult for attackers to infer sensitive user information through offloading usage patterns, thus effectively protecting user privacy and safety.

Traffic Forecast Assisted Adaptive VNF Dynamic Scaling

Hang Qiu,Hongbo Tang,Yu Zhao,Wei You,Xinsheng Ji 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.11

NFV realizes flexible and rapid software deployment and management of network functions in the cloud network, and provides network services in the form of chained virtual network functions (VNFs). However, using VNFs to provide quality guaranteed services is still a challenge because of the inherent difficulty in intelligently scaling VNFs to handle traffic fluctuations. Most existing works scale VNFs with fixed-capacity instances, that is they take instances of the same size and determine a suitable deployment location without considering the cloud network resource distribution. This paper proposes a traffic forecasted assisted proactive VNF scaling approach, and it adopts the instance capacity adaptive to the node resource. We first model the VNF scaling as integer quadratic programming and then propose a proactive adaptive VNF scaling (PAVS) approach. The approach employs an efficient traffic forecasting method based on LSTM to predict the upcoming traffic demands. With the obtained traffic demands, we design a resource-aware new VNF instance deployment algorithm to scale out under-provisioning VNFs and a redundant VNF instance management mechanism to scale in over-provisioning VNFs. Trace-driven simulation demonstrates that our proposed approach can respond to traffic fluctuation in advance and reduce the total cost significantly.

Free Paper Session : Basic ; Association of TP53 mutations with stem cell-Like gene expression and survival of patients with hepatocellular carcinoma (초)

( Hyun Goo Woo ),( Xin Wei Wang ),( Anuradha Budhu ),( Yun Hee Kim ),( So Mee Kwon ),( Zhao You Tang ),( Zong Tang Sun ),( Curtis C. Harris ),( Snorri S. Thorgeirsson ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3(S)

Identification and Mapping of a Thermo-Sensitive Genic Self-Incompatibility Gene in Maize

Xin Ge Lin,Hui Ling Xie,Zhang Ying Xi,Yan Min Hu,Guang Yuan Zhao,Liu Jing Duan,Zong You Hao,Zong Hua Liu,Ji Hua Tang 한국유전학회 2009 Genes & Genomics Vol.31 No.3

In this study, we describe a novel ecological self-incompatibility (SI) line HE97 in maize. The main environmental factors influencing the inbred line characteristics were identified through field sowing trials during a two-year study period (2001 and 2002). The results showed that daily minimum temperature had the greatest effect on floral morphology and breeding system of the SI line. In staminate floret differentiation, when the daily minimum temperature exceeded 24℃, the line exhibited complete self-compatibility; however SI was observed when the daily minimum temperature was below 20℃. Therefore, we characterized the line as exhibiting thermo-sensitive genic self-incompatibility (TGSI). A set of F2 and F2:3 populations, derived from the inbred lines HE97 and Z58, were evaluated for two years to elucidate the TGSI line patterns of inheritance. Classical genetic analyses and QTL mapping results revealed that HE97 self-incompatibility was governed by a single allele, named here as tgsi1. The tgsi1 gene was mapped to chromosome 2 between SSR markers nc131 and bnlg1633, with a distance of 2.40 cM from nc131 and 2.44 cM from bnlg1633.