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Choi, Yuri,Jeon, Dasom,Choi, Yeongkyu,Ryu, Jungki,Kim, Byeong-Su American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.16
<P>Water splitting is considered the most attractive pursuit in the field of solar energy conversion. In this study, we report the synthesis and application of a supramolecular hybrid of carbon nanodot (CD) and cobalt polyoxometalate (Co-POM) to solar water oxidation. The self-assembly of the alginate-based CD and Co-POM led to the formation of a spherical hybrid of CD/Co-POM. Owing to the facile transfer of photogenerated holes from CD under visible light irradiation, the hybrid donor-acceptor type of CD/Co-POM enabled the rapid scavenging of holes and accumulation of a long-lived oxidation state of Co-POM for efficient solar water oxidation, outperforming conventional [Ru(bpy)<SUB>3</SUB>]<SUP>2+</SUP>-based systems. We believe that this study offers new insights into the development of CD-based nanocomposites with various photocatalytic and optoelectronic applications.</P> [FIG OMISSION]</BR>
Phaeophyta Extracts Exhibit Antiviral Activity against Feline Calicivirus
Choi, Yuri,Kim, Eunjung,Moon, Sunyoung,Choi, Jong-Duck,Lee, Myung-Suk,Kim, Young-Mog The Korean Society of Fisheries and Aquatic Scienc 2014 Fisheries and Aquatic Sciences Vol.17 No.1
The objective of this study was to evaluate the antiviral activity of Phaeophyta extracts against feline calicivirus (FCV), used as a norovirus surrogate. A bioassay-guided cytotoxicity and virus infectivity assay revealed that methanolic extracts of Phaeophyta possessed significant antiviral activity against FCV. Among them, Eisenia bicyclis extract exhibited the highest antiviral activity against FCV. The 50% effective concentration of the extract ($EC_{50}$) inhibiting FCV viral replication by 50% was $80{\mu}g/mL$. The extract also showed the highest selectivity index, calculated from the ratio of the median cellular cytotoxicity concentration ($CC_{50}$) and $EC_{50}$, indicating antiviral efficacy against FCV. In addition, significant interruption of FCV infection was observed by pretreatment of host Crandall-Reese feline kidney cells with the E. bicyclis extract ($200{\mu}g/mL$) prior to virus infection, in a dosedependent manner.
( Yuri Choi ),( Hye Rang On ),( Soo Chan Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Pemphigus is an acquired, rare, chronic, debilitating, and potentially life-threatening autoimmune vesiculobullous disorder that is characterized by mucocutaneous erosions or blisters. Without treatment, such blistering eventually leads to erosions in the skin, resulting in significant mortality. Objectives: This study was conducted to evaluate the efficacy and safety of repeated and prolonged B cell depletion with rituximab for the induction and maintenance of long-term remission in patients with pemphigus vulgaris(PV) or pemphigus foliaceus(PF). Methods: We conducted a single-center observational study of all patients with pemphigus treated with at least 2 courses of Rituximab between January 1, 2006 and July 31, 2013. Results: Fifty-six patients (median age 46 years (22-82 years) with PV (n=47) or PF (n=9) received at least 2 courses of Rituximab to achieve remission or to treat relapses. Overall, 55(98%) of 56 patients achieved remissions at some point during their follow-up. Of 55 patients with complete or partial remission after the initial infusions, 23(42%) patients had one more relapses during a follow-up time of 11 to 56 months. Of 23 patients with relapse, 13 patients received the second infusions of rituximab but 10 patients were treated without rituximab. Conclusion: Rituximab appeared to be effective and safe for the induction and maintenance of remission in patients with pemphigus. Patients treated with additional rituximab may have earlier remission after relapse.
Choi, Yuri,Won, Yeo-Jin,Lee, Sojeong,Kim, Ahrong,Kim, Younggeum,Park, Won-Young,Jo, Hong-Jae,Song, Geun Am,Kwon, Chae Hwa,Park, Do Youn Neoplasia Press 2018 Translational oncology Vol.11 No.3
<P><I>NTRK1</I> gene fusions, the targets of multikinase inhibitors, are promising therapeutic targets for colorectal cancer (CRC). However, screening methods for detecting <I>NTRK1</I> gene fusions in CRC tissues have not been reported. In this study, we investigated the potential use of immunohistochemistry (IHC) for detecting <I>NTRK1</I> gene fusions. We performed and compared IHC with fluorescence in situ hybridization (FISH) in 80 CRC patients. TrkA immunostaining was observed to be both membranous and cytoplasmic and was scored semiquantitatively using staining intensity and proportions. The tumors were observed to be <I>NTRK1</I> gene fusion-positive when ≥20 out of 100 nuclei in FISH. A significant correlation between the IHC and FISH results for determination of the <I>NTRK1</I> gene fusions was observed. We measured the cytoplasmic TrkA expression, which showed an area under the receiver operating characteristic (ROC) curve of 0.926 (range: 0.864-0.987, 95% CI, <I>P</I> = .001). By choosing 4.5 (sum of the intensity and proportion scores of cytoplasmic TrkA expression) as the cut-off value for the positive and negative <I>NTRK1</I> gene fusion groups, the sensitivity and specificity for predicting lymph node metastasis were 100 and 83.8%, respectively (<I>P</I> = .001). Specifically, high cytoplasmic TrkA expression (sum of intensity and proportion scores >4) was associated with the presence of <I>NTRK1</I> gene fusions (<I>P</I> < .0001, r = 0.528). Taken together, our data showed that IHC for TrkA can be used as an efficient screening method for detecting <I>NTRK1</I> gene fusions in CRC.</P>
Choi, Yuri,Kang, Byungkyun,Lee, Jooyong,Kim, Sunghu,Kim, Gyeong Tae,Kang, Hyunju,Lee, Bo Ram,Kim, Hajin,Shim, Sang-Hee,Lee, Geunsik,Kwon, Oh-Hoon,Kim, Byeong-Su American Chemical Society 2016 Chemistry of materials Vol.28 No.19
<P>The pursuit of exceptionally high photoluminescence (PL) and stability is critical in the development of novel fluorophores for use in challenging bioimaging and optoelectronic devices. Carbon nanodots (CDs) doped with heteroatoms provide a particularly attractive means of effectively tailoring their intrinsic properties and exploiting new phenomena. Here, we report a one-step, scalable synthesis of boron-and-nitrogen co-doped CD (BN-CD) with outstanding optical properties unlike those of nitrogen-doped CD (N-CD) in solid state as well as solution. The detailed mechanistic framework was explored using a series of spectroscopic analyses and ultrafast spectroscopy coupled with density functional theory calculations, which all conclusively confirmed that the presence of more graphitic structures in the core and well-distributed surface states are responsible for the enhanced PL in BN-CD. Furthermore, single-molecule spectroscopy analysis demonstrated that a single BN-CD shows higher PL intensity and enhanced photobleaching time. We anticipate that this study will aid in uncovering the full potential of CDs in various fields.</P>
Interface Engineering of Hematite with Nacre-like Catalytic Multilayers for Solar Water Oxidation
Choi, Yeongkyu,Jeon, Dasom,Choi, Yuri,Kim, Dongseok,Kim, Nayeong,Gu, Minsu,Bae, Sanghyun,Lee, Taemin,Lee, Hyun-Wook,Kim, Byeong-Su,Ryu, Jungki American Chemical Society 2019 ACS NANO Vol.13 No.1
<P>An efficient water oxidation photoanode based on hematite has been designed and fabricated by tailored assembly of graphene oxide (GO) nanosheets and cobalt polyoxometalate (Co-POM) water oxidation catalysts into a nacre-like multilayer architecture on a hematite photoanode. The deposition of catalytic multilayers provides a high photocatalytic efficiency and photoelectrochemical stability to underlying hematite photoanodes. Compared to the bare counterpart, the catalytic multilayer electrode exhibits a significantly higher photocurrent density and large cathodic shift in onset potential (∼369 mV) even at neutral pH conditions due to the improved charge transport and catalytic efficiency from the rational and precise assembly of GO and Co-POM. Unexpectedly, the polymeric base layer deposited prior to the catalytic multilayers improves the performance even more by facilitating the transfer of photogenerated holes for water oxidation through modification of the flat band potential of the underlying photoelectrode. This approach utilizing polymeric base and catalytic multilayers provides an insight into the design of highly efficient photoelectrodes and devices for artificial photosynthesis.</P> [FIG OMISSION]</BR>
Choi, Yuri,Lee, Kyubae,Gupta, Kailash C.,Park, Soo-Young,Kang, Inn-Kyu The Royal Society of Chemistry 2015 Journal of Materials Chemistry B Vol.3 No.44
<P>Liquid crystal (LC) microdroplets have been prepared for visual detection of HepG2 cells using 4-cyano-4′-pentyl biphenyl molecules in the presence of sodium dodecyl sulfate as a mediator and β-galactose-conjugated poly(styrene-<I>b</I>-acrylic acid) block copolymer (PS-<I>b</I>-PA-G) as a modifier of LC-water interfaces. To clarify the effect of β-galactose-containing ligands on the orientational transitions of LC microdroplets, maltotriose as a ligand simulant was conjugated to poly(styrene-<I>b</I>-acrylic acid) and used as a LC modifier. The interaction of HepG2 cells with the β-galactose-conjugated block copolymer was effective in causing orientational transitions, from radial to bipolar, in LC microdroplets, whereas interactions of HepG2 cells with maltotriose-conjugated block copolymers were ineffective in inducing orientational transitions in LC microdroplets. To confirm the necessity of the PS segment of the block copolymer for transmitting the ligand-receptor interaction forces from the interface to the core of the LC microdroplets, β-galactose-conjugated block copolymers (PS-<I>b</I>-PA-G) and homopolymers (PVLA) were synthesized and used to prepare LC microdroplets. The LC microdroplets containing a β-galactose-conjugated homopolymer did not show orientational transitions upon contact with HepG2 cells. However, LC microdroplets containing a β-galactose-conjugated block copolymer showed orientational transitions from radial to bipolar, indicating that the polystyrene segment in the amphiphilic block copolymer is essential for the effective transmission of ligand-receptor interactions to the core of LC microdroplets. β-Galactose anchored LC microdroplets were able to detect 1.0 ± 0.1 HepG2 cells per μm<SUP>2</SUP> of the test cell and had shown significantly high reproducibility (<I>p</I> < 0.05, <I>n</I> = 3). The configurational transition in LC microdroplets that was dependent on ligand-receptor interactions was used to develop a LC microdroplet-based biosensor for the detection of HepG2 cells in biological fluids.</P>
Self-assembled Hybrid System Based on Carbon Nanomaterials
Yuri Choi(최유리) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Carbon nanomaterials such as carbon nanodots (CDs) have a tremendous attention due to their photosensitizer property and high abundant functional groups for various energy applications. We report the synthesis and application of a supramolecular hybrid of CD and water oxidation catalyst to solar water oxidation. This hybrid structure exhibited the improved photocatalytic efficiency due to the facile transfer of photogenerated holes from CD under visible light irradiation. We believe that this study offers new insights into the development of self-assembled CD-based system with various energy applications.