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새로운 Acetylcholinesterase inhibitors의 합성
최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1
노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.
항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고
이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3
In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.
Morphological variations and Fatty acid composition in Soybean (Glycine max) Germplasm
Yu-Mi Choi,Jae Young Song,Gi-An Lee,Do-Yoon Hyun,Myung-Chul Lee,Jeong-Ro Lee,Chang Young Kim,Yeon-Gyu Kim 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Soybean (Glycine max, 2n = 2x = 40) is broadly distributed throughout East and South East Asia, and important crop as a source of protein, oil, food and animal feed. In order to better understand the morphological differentiation of soybean germplasm collected from China, Japan, Korea, Philippines, America, we analyzed the morphological variabilities among 629 soybeans with 11 morphological traits, such as growth type, leaflet, flower color, trichome, seed coat color, color inside seed etc. and measured the fatty acid composition. The result of the principal coordinates analysis (PCoA) based on the 11 morphological traits revealed diversity among all accessions. The PCoA separated the accessions into two main groups, each group with distinctive features. Among tested germplasm, the contents of five fatty acids were as follows: linolenic acid (2.8%-16.23%), linoleic acid (27.4%-56.6%), oleic acid (9.2%-35.0%), stearic acid (2.9%-8.8%), and palmitic acid (8.7%-17.1%). The fatty acid composition has not shown significant variation among all accessions. IT 22268 was the highest linolenic acid composition (16.2%), while IT 154687 was the lowest (2.8%). Forty three of 629 accessions showed the arachidic acid (0.5%-3.6%), which is the saturated fatty acid with a 20 carbon chain and is as a minor constituent of peanut oil (1.1%-1.7%). This result of this characterization served as reliable resources for detailed description and new functional plant breeding of soybean varieties.
Gi-An Lee,Yu-Mi Choi,Jung-Yoon Yi,Jong-Wook Chung,Myung-Chul Lee,Kyung-Ho Ma,Sok-young Lee,Jin-Woong Cho,Jung-Ro Lee 한국작물학회 2014 Korean journal of crop science Vol.59 No.4
Soybean (Glycine max L.) is crucial legume crop as source of high quality vegetable protein and oil, and Korea is regarded as a part of center of soybean origin. To expand the information of conserved genetic diversity, we analyzed the genetic variability of soybean collection mainly introduced Korean accessions using 75 microsatellite markers. A total of 1,503 alleles with an average value of 20.0 alleles were detected among 644 accessions. Korean collection revealed average allele number of 13.4 while Chinese, Japanese and Southeast Asian accessions showed 9.0, 5.4 and 6.5 mean alleles, respectively. Especially, Korean accessions showed more number of private allele per locus as 3.4 contrary to other geographical groups. The mean expected heterozygosity and polymorphic information content was 0.654 and 0.616, respectively, and expected heterozygosity values were not significantly distinguished according to the geographical groups. The phylogenetic dendrogram and deduced population structure based on DNA profiles of 75 SSR loci showed Korean accessions formed distinct gene pool against Chinese accessions, and could be divided into five subpopulations. Korean soybean accessions have specific genetic diversity and might be serve the valuable alleles for bio-industry as a part of the center of soybean origin.
유은미 ( Eun-mi Yu ),이윤미 ( Yun-mi Lee ),권기형 ( Gi-hyung Kwon ) 한국미용예술경영학회 2014 미용예술경영연구 Vol.8 No.1
The rapid development of science and technology in modern society as the high value-added sectors of society to get moving to attention. These areas of high value-added, technology, culture, as well as make it add value to the infinite design, video, performances, affecting various areas. In particular, one of the genre, animated visual field can not be found in the reality of the world of dreams and fantasies which, for the delivery of the story characters and sounds are represented by visual images as visual art, man, woman, and child care and inspiration for many people to leave giving. Take advantage of these animations are being studied in various fields, but in the field of hair and hair style for the animation shown in previous studies, there is only a study, and work in conjunction with a specific animation of hair in one study there was no previous research. Thus, in this study, the Disney animation 'Frozen' hair works the motif was constructed by substituting the works of 4. As a result of the work of making the characters that appear in the image features and hair work properly blended with elements of the real world can be used to determine this was possible, but also by incorporating the Up Style it could produce creative designs. However, the limitations of this study, female characters are made to work only with the hair style was mainly a character study inconvenience this been made, with a follow-up study of the characteristics of various animation research work is done in accordance with the hair.
신문 활용 교육 프로그램이 초등학생의 논리적 사고력에 미치는 효과
이유미(Lee, Yu-mi),이성용(Yi, Seong-yong),김기순(Kim, Gi-sun),오영선(Oh, Yeong-seon),김두희(Kim, Du-hui),최유리(Choi, Yu-ri),김영선(Kim, Yeong-seon),민윤자(Minn, Yun-ja) 성신여자대학교 교육문제연구소 2013 교육연구 Vol.56 No.-
본 연구의 목적은 초등학생의 논리적 사고력을 향상 시키는데 있어 신문 활용 교육 프로그램의 효과를 살펴보는데 있다. 연구대상은 초등학교 3-6학년 40명(실험: 20명, 통제: 20명)이며 연구 설계는 사전-사후 집단 설계를 활용하였다. 본 연구의 신문 활용 교육 프로그램은 교과와 연계하였으며, 한 학기동안 운영하였다. 연구 결과 첫째, 실험집단은 통제집단에 비하여 논리적 사고력이 통계적으로 유의한 수준(p<.05)에서 향상되었다. 둘째, 실험집단 내에서는 5-6학년군 학생들이 3-4학년군 학생들에 비해 더 높은 향상을 보였다. 이러한 연구 결과는 초등학생의 논리적 사고력 지도와 신문 활용 교육 관점에서 논의되었으며, 앞으로 교과와 연계한 신문 활용 교육 프로그램을 구성하는데 기초자료로 활용될 수 있을 것이다. The purpose of this study was to examine effects of the newspaper in education(NIE) program on the logical thinking of elementary school students. The participants of the study were forty elementary school students(experimental group: 20, control group: 20), and the group design was used to investigate the effectiveness of the NIE program. This NIE program was related to subjects. The results of applying the NIE program were as the following : First, it had effects(p<.05) on progress in logical thinking of elementary school students. Second, 5-6th grade students were more effective than 3-4th grade students in the experimental group. The results of the study were discussed in the logical thinking instruction and NIE perspective for elementary school students, and can be used to plan and implement effective NIE program.
유영미 ( Young Mi Yu ),박순길 ( Soon Gi Park ),박미로 ( Mi Ro Park ) 한국초등특수교육학회 2012 초등특수교육연구 Vol.14 No.1
본 연구는 도시와 농촌지역 초등학교 3학년들의 수학성취도와 학습부진선별척도와의 관계를 알아보기 위한 목적이 있으며, t검정, 상관분석, 단계별 회귀분석을 실시하였다. 첫째, 도시지역 아동들은 농촌지역 아동들보다 말하기, 읽기, 쓰기, 철자법, 수학계산에서 능력이 낮았다. 그러나 수학성취도, 주의력, 생각하기 에서는 집단간 차이가 없었다. 둘째, 성별에 따른 차이는 농촌지역 아동의 주의력에서 있었다. 즉 농촌지역 초등학교 3학년 남학생들은 여학생들보다 주의집중이 더 낮았다. 그러나 전체 성별과 도시지역 아동의 성별에서는 차이가 나타나지 않았다. 셋째, 도시지역 아동의 수학성취도와 상관변인은 주의력, 생각하기, 읽기, 수학계산이었고, 농촌지역 아동의 수학성추도 상관변인은 주의력, 생각하기, 말하기, 읽기이었다. 그러나 철자법은 도시와 농촌지역 아동 모두에서 나타나지 않았다. 넷째, 수학성취도에 영향을 미치는 변인은 알아보면 도시지역 아동의 수학성취도 예언변인은 읽기와 수학계산이었고, 농촌지역 아동의 수학성취도 예언변인은 말하기이었다. This study elementary school children`s math achievement for the purpose, G City and G gun A, B Elementary School 3rd, total 50, predictors of the relat ionship and to evaluate the descriptive statistics, t test, correlation analysis, re gression analysis was performed, First, children in rural areas than urban areas, and children, speaking, readin g, writing, spelling, math calculations, lower ability. However, mathematics achi evement, attention, and thought there was no difference between groups. Second, the gender difference was the child`s attention from the rural areas. In other words, was lower in rural areas, the third grade of elementary school boys than girls attention, Entire gender and urban areas, the gender of the chil d, however, the difference was not significant. Third, children`s math achievement in urban areas were correlated with atten tion, thinking, reading, math calculations, and rural areas, children`s math achie vement correlated variables of attention, I think, speaking, reading, respectively, However, the spelling of the children in both rural and urban areas, did not ap pear. Fourth, look to know the factors affecting mathematics achievement, mathem atics achievement of children in urban areas predictors rural areas, children`s mathematics achievement in reading and mathematics, was calculated predictors speaking.
Development of EST SSR-Markers to study genetic diversity in Foxtail Millet (Setaria italica)
Jae Young Song,Yu-Mi Choi,Su Kyeung Lee,Gi-An Lee,Jae-Gyun Gwag,Myung-Chul Lee 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
Foxtail millet (Setaria italica L.) is the second most widely cultivated species of millet, especially in East Asia and is a tractable experimental model crop for studying functional genomics of millets. However, insufficient researches had been conducted about the foxtail millet germplasm and is significantly impeding its genetic improvement. We attempted to develop EST-derived-SSR (eSSR) markers and utilize them in genetic comparison of germplasm and transferability. A total of 66,027 foxtail millet EST sequences and 42,754 genomic sequence were deduced transcriptom. Approximately 42,000 single tone contigs were generated using DNAstar 5.0 software for redundancy minimization. Nearly 33% of the 14,012 unigenes contained SSRs, but primers were designed for a total of 314 microsatellites concentrating with more than 24 bp of repeats. A total of 314 primers were successfully designed with more than 24 bp of repeats. From these microsatellites, 56 primer pairs were showed polymorphism with over than 15 bp differences among 96 accessions collected from different countries. Polymorphic information content (PIC) value ranged from 0.020 to 0.700 with an average of 0.381 indicating moderate level of informativeness within these EST-SSRs markers. The EST-SSR markers developed in this study will serve as a useful source for genetic studies, such as genetic variability, transferability, association mapping, and molecular breeding