역행성 심정지 도관 삽입을 위한 술 중 경식도심초음파의 유용성

유미숙;최원주;김정원;박장수;김경태;김지연;어상일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Background: Retrograde cardioplegia catheter (RCC) insertion is one of methods for administration of cardioplegics during cardiopulmonary bypass (CPB). However its success rate depends on only surgeon's experience. We thought the transesophageal echocardiography (TEE) can guide the R CC insertion, because TEE is commonly used for monitoring status of heart during cardiac surgery. This study was designed to evaluate the RC C insertion time by TEE guidance versus conventional method without T EE guidance. Methods: Sixty patients who were scheduled to undergo elective coronary artery bypass graft (CABG) surgery under general anesthesia were divided into groups as follows: group T [RCC insertion into coronary sinus (CS) by TEE guidance, n=30] and group C [RCC insertion into CS by conventional method, n=30]. We recorded the time of insertion of RCC in to CS in two groups. RCC insertion was done by TEE guidance in case that time was over two minutes by conventional methods in group C. Results: The overall time of RCC insertion into CS was 63.8 ± 23.6 seconds in the Group T and 102.3 ±55.7 seconds in the Group C, respectively (p=0.001). There were no complications during RCC into CS by T EE guidance. Conclusions: TEE guidance for RCC insertion into CS is shorten the time of insertion.

폐경 후 여성의 심혈관질환 예방을 위한 식사중재에 대한 준수도(adherence) 평가

정경아,김상연,우정익,장유경 漢陽大學校 韓國生活科學硏究所 2001 韓國 生活 科學 硏究 Vol.- No.19

The purpose of this study is to assess the adherence to dietary intervention for prevention of coronary heart disease (CHD) in postmenopausal women by observing changes of antioxidant vitamins and fatty acid composition in dietary intake and seam level. The subjects with hypercholesterolemia (TC≥240mg/dl) were treated with one of hormone replacement therapy (HRT group), dietary intervention (DIET group) or combination of hormone replacement therapy and dietary intervention (HRT+DIET group) for 12 weeks. The results were as followed. Mean daily nutrient intakes were not significantly changed in the HRT group, but were significantly changed in the DIET group and the HRT+DIET group. Especially, dietary vitamin A and E intakes were increased from less than 75% to more than 90% of RDA for Korean in the two groups. With changes of dietary intakes, serum vitamin A and E levels were also significantly increased in the DIET group and tended to increase in the HRT+DIET group. Dietary fatty acid composition was also not significantly changed in the HRT group, but was significantly chanced in the DIET group and the HRT+DIET group. With changes of dietary fatty acid composition, serum phospholipid fatty acid composition was significantly changed in the DIET group and the HRT+DIET group although there was tendency of returning to initial value after 12 weeks. Judging from changes in serum phospholipid fatty acid composition, subjects' adherence to dietary intervention tended to decrease after 12 weeks. However, the changes of antioxidant vitamins and fatty acid composition in dietary intake were compatible with the changes of those in serum level, and we can conclude that dietary intervention was adhered quite well by subjects.

간호사의 병원감염관리에 대한 인지도, 수행도와 심리적 임파워먼트의 관계

정연욱,이용환,유병철 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Background : High degree of awareness and performance for nosocomial infection control are very significant prevention factor of nosocomial infection which is increasing alarmingly in recent years and one of the common cause of opportunistic infection. The aim of this study was to find out the relation between degree of nurse's awareness and performance for nosocomial infection control and their psychological empowerment as a measurement tool for feeling of achievement in their hospitals. Method : We conducted a questionnaire survey during the period from August 2006 to April 2007. Investigation subjects were 262 nurses in 4 medical centers which is located in Busan. We measured nurse's awareness, performance for nosocomial infection control and psychological empowerment with questionnaire. Data analysis was performed with descriptive analysis, t-test, ANOVA and multiple regression analysis using SPSS Win(ver 12.0k) program. Result : The mean score of nurse's awareness, performance for nosocomial infection control and psychological empowerment were 4.76 ± 0.36, 4.32 ± 0.47 and 3.54 ± 0.58, respectively. The mean scores of nurse's awareness were lower than nurse's performance in total score and all subcategories. The correlation of nurse's awareness, performance for nosocomial infection control and psychological empowerment were statistically significant. The nurse's performance of nosocomial infection control was important influential factor of their psychological empowerment. Conclusion : From the result, we can concluded that nurse's awareness level was lower than nurse's performance level and nurse's performance of nosocomial infection control was important influential factor of their psychological empowerment. Therefore, methods for improving nurse's performance level are required for effective prevention of nosocomial infection and increase their psychological empowerment level.

재발성 가와사끼병의 임상양상과 검사소견

유승택,최은정,이창우,오연균,박승택,윤향석 圓光大學校 醫科學硏究所 2003 圓光醫科學 Vol.18 No.2

뇌졸중 노인을 돌보는 주간호제공자의 부담감과 예측요인 : 한방병원 입원 노인을 중심으로

유수정,김신미,이윤정,박연환 노인간호학회 2004 노인간호학회지 Vol.6 No.1

Purpose : The purpose of this study was to investigate factors influencing burden in primary caregivers caring for an elderly person who has had a stroke. Method : A convenience sample of 124 primary caregivers of elderly people with a stroke admitted to an oriental medicine hospital participated in this study. Interviews were done with a standardized questionnaire including Caregiver Burden Scale (Chang, 1995). Result: Average burden score was 93.19, indicating a moderate to severe level of burden. Time-dependent burden had the highest score of the sub-domains. For general characteristics, the factors significantly influencing caregiver burden were gender and age of the elderly person, age and educational level of the caregiver, whether living together or not, and the presence of another caregiver. Multiple regression analyses demonstrated that level of ADL of the elderly person, relationship between the elderly person and the caregiver prior to the stroke, caregivers' relation to the elderly person and primary income were significant factors in explaining variance in overall burden. Conclusion : Recognition of high levels of caregiver burden and factors influencing burden will allow us to develop different nursing strategies to decrease caregiver burden in those caring for an elderly person with a stroke.

노년기 여성의 식이 섭취 조사를 위한 반정량 식품섭취빈도조사지 개발에 관한 연구

김상연,정경아,장유경 漢陽大學校 韓國生活科學硏究所 2000 韓國 生活 科學 硏究 Vol.- No.18

A data based semiquantitative flood frequency questionnaire, which can be used in studies investigating relationship between diet and cardiovascular diseases in Korean elderly women, was developed. The questionnaire is a 30-minute, face-to-face administered instrument designed especially for assessing food and mixed dishes. Food items were selected from 3-day flood records. 140 food items were finally selected based on the frequency of consumption and the contribution of specific foods to the total population intake of the following 11 nutrients: energy, carbohydrate, protein, fat, cholesterol, SFA, MUFA, PUFA, β -carotene, vitamin C, and vitamin E. The percentage of total nutrient intake which each food provides is presented for the top 50 contributiors of each of the nutrients listed above, as well as the proportion of the population consuming them. Foods sometimes overlooked as important sources are found in some instances to be quantitatively important to population intake, such as carrot as an independent sources of carotenoids. Portion size of each food item was determined considering the mean and median values of the amounts consumed by subjects in the preliminary survey. Frequency of consumption was asked in nine categories ranging from more than 'three times a day' to 'almost never'. A nutrient database was compiled from many sources, but mostly from Korean nutrition society. This flood frequency questionnaire should be useful to epidemiologists with a substantive interest in dietary etiologies and it can reasonably estimate the usual dietary intakes among postmenopausal women for cardiovascular disease study, but shorter form of questionnaire and validation would be needed.

정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

환자중심적 측면에서 본 여성전문병원 병동부의 실내환경 분석연구

황연숙;장윤정;김유연 한양대학교 2007 韓國 生活 科學 硏究 Vol.27 No.1

The purpose of this study is to analyze the wards of women's hospitals in the perspective of patientfocused design. An evaluation checklist of the patient wards was applied to seven women's hospitals that have constructed or remodeled since 2000. The findings indicate that patients' room was generally patient-focused in terms of social interaction and privacy. However, the lacks of kitchenette, balconies, and dimmers were evaluated negatively. Among the patients' room, corridor, and patients' lounge, the lounge was the most negative in terms of patient-focused design. Privacy and home-likeness were insufficient in patients' lounge while control of ventilation and sunlight was well considered. The future study needs to develop advanced survey and interview methodologies in order to support the relevant results.

Porphyromonas gingivalis 분쇄액으로 유도된 파골세포의 분화에 미치는 Taurine과 Alendronate의 효과

금기연,박주현,유윤정,이정현,이승종 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.4

고콜레스테롤혈증을 지닌 폐경 후 여성의 영양소 섭취 평가

김상연,정경아,장유경 漢陽大學校 韓國生活科學硏究所 2003 韓國 生活 科學 硏究 Vol.- No.21

Women have a greater incidence of coronary heart disease(CHD) after menopause. It relates to hormone imbalance-induced changes in known CHD risk factors, especially hyperlipidemia. Accordingly, once women are diagnosed, the rate of morbidity and mortality is greater than for men. Thus, preventive strategies are critical to improve the quality of life in the later years for women. The purpose of this study was to explore the difference of nutrient intakes and diet quality based on nutrient intake between normocholesterolemia and hypercholesterolemia. The subjects were classified as normocholesterolemia and hypercholesterolemia based on The Guideline for Korean Hyperlipidemia. The semiquantitative food frequency questionnaire was used to measure dietary intakes of the subjects. The results obtained are summarized as follows. Intakes of nutrients such as energy, carbohydrate, protein, fat, minerals and antioxidant vitamins were not significantly different between normocholesterolemia group and hypercholesterolemia group. However, antioxidant vitamins and folate intakes in hypercholesterolemia group tended to be lower than those in normocholesterolmia group. Intakes of vitamin A, vitamin E, and Ca in normocholesterolemia and hypercholesterolemia groups were below RDA. In particular, RDA for those nutrients in hypercholesterolemia was much less than RDA for those nutrients in normocholesterolemia. MAR and INQ in hypercholesterolemia group tended to be lower than those in normocholesterolemia. In particular, INQ of vitamin A was significantly(p<0.05) lower in hypercholesterolemia group than in normocholesterolemia group. These results indicate that it is important to use various diet quality index based on nutrient intake such as % RDA, NAR, MAR, and INQ to explore the relationship between blood cholesterol and nutrient intake. Key words : postmenopausal women, hypercholesterolemia,, % RDA, NAR, MAR, INQ