Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

Yu, Li-Xiang,Zhou, Nan-Nan,Liu, Li-Yuan,Wang, Fei,Ma, Zhong-Bing,Li, Jie,Yu, Zhi-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95%CI: 1.21-1.70; G carriers vs A carriers, OR: 1.23, 95%CI: 1.11-1.36; dominant model, OR: 1.28, 95%CI: 1.10-1.49 and recessive model, OR: 1.31, 95%CI: 1.12-1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95%CI: 1.26-1.92; G carriers vs. A carriers OR: 1.30, 95%CI: 1.18-1.43; dominant model OR: 1.31, 95%CI: 1.08-1.60 and recessive model OR: 1.44, 95%CI: 1.26-1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.

Lung-Targeting Delivery of Dexamethasone Acetalte Loaded Solid Lipid Nanoparticles

Xiang, Qing-Yu,Wang, Min-Ting,Chen, Fu,Gong, Tao,Jian, Yan-Lin,Zhang, Zhi-Rong,Huang, Yuan 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4

The objective of the present study was to develop a novel solid lipid nanoparticle (SLN) for the lung-targeting delivery of dexamethasone acetate (DXM) by intravenous administration. DXM loaded SLN colloidal suspensions were prepared by the high pressure homogenization method. The mean particle size, drug loading capacity and drug entrapment efficiency (EE %) of SLNs were investigated. In vitro drug release was also determined. The biodistribution and lung-targeting efficiency of DXM-SLNs and DXM-solutions (DXM-sol) in mice after intravenous administration were studied using reversed-phase high-performance liquid chromatography(HPLC). The results (expressed as mean ${\pm}$ SD) showed that the DXM-SLNs had an average diameter of 552 ${\pm}$ 6.5 nm with a drug loading capacity of 8.79 ${\pm}$ 0.04% and an entrapment efficiency of 92.1 ${\pm}$ 0.41%. The in vitro drug release profile showed that the initial burst release of DXM from DXM-SLNs was about 68% during the first 2 h, and then the remaining drug was released gradually over the following 48 hours. The biodistribution of DXM-SLNs in mice was significantly different from that of DXM-sol. The concentration of DXM in the lung reached a maximum level at 0.5 h post DXM-SLNs injection. A 17.8-fold larger area under the curve of DXM-SLNs was achieved compared to that of DXM-sol. These results indicate that SLN may be promising lung-targeting drug carrier for lipophilic drugs such as DXM.

Impact of Low Concentration Fluoride on Toxification and Biological Traits of Silkworm, Bombyx mori

( Yu In Chen ),( Yuan Xiang Jin ),( H. B. Manjunatha ),( S. R. Hosagoudar ) 한국잠사학회 2004 International Journal of Industrial Entomology Vol.9 No.1

Primary survey of avian influenza virus and Newcastle disease virus infection in wild birds in some areas of Heilongjiang Province,China

Yu-Ping Hua,Hong-Liang Chai,Si-Yuan Yang,Xiang-Wei Zeng,Ying Sun 대한수의학회 2005 Journal of Veterinary Science Vol.6 No.4

Two hundred thirty specimens of wild birds were collected from some areas in Heilongjiang Province during the period of 2003~2004, including two batches of specimens collected randomly from a same flock of mallards in Zhalong Natural Reserve in August and December, 2004, respectively. Primary virus isolation and identification for avian influenza virus (AIV) and Newcastle disease virus (NDV) were performed. The results showed that only two specimens of young mallards collected from Zhalong Natural Reserve in August, 2004 were positive to AIV (isolation rate 0.9%), and one strain (D57) of these two virus isolates was identified to be H9 subtype by hemagglutination inhibition test. Meanwhile, the two batches of blood serum samples of mallards from Zhalong were also examined for antibodies against AIV and NDV. Among 38 blood serum samples collected in August, antibodies against the hemagglutinin of H1, H3, H5, H6 and H9 subtypes of AIV were found in 1, 0, 2, 0 and 8 samples, respectively; and 11 samples were found with antibody against NDV. Whereas the NDV isolation in both two batches of specimens of mallard was negative, all of the 32 blood serum samples collected in December were negative for antibodies against AIV and NDV.

Flexural performance of fire damaged and rehabilitated two span reinforced concrete slabs and beams

Yu, Jiang-Tao,Liu, Yuan,Lu, Zhou-Dao,Xiang, Kai Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.42 No.6

Five two-span reinforced concrete (RC) slabs and seven two-span RC beams were tested under the ISO 834 standard fire with different durations. CFRP strengthening was then applied to some of the specimens after the damaged concrete was removed from the specimens and replaced with polymer mortar. All the specimens were loaded to failure to investigate the influence of fire-damage and the effectiveness of strengthening methods. Test results indicated that the flexural capacities of specimens decrease with the fire duration increases. Moreover, fire exposure had more significant effect on the flexural rigidity than on the bearing capacity of the specimens. After rehabilitation, the bearing capacities of specimens reached or even exceeded that of the reference RC specimen, and the strengthening methods seemed to have limited effect on flexural rigidity recovery. From the analysis of moment redistribution of tested beams, elevated temperature is found having different impacts on sagging moment region and hogging moment region. The damage of RC continuous member is definitely a comprehensive response of different regions.

Molecular Dynamics Simulation on Microstructure Evolution During Solidification of Copper Nanoparticles

Yu-Quan Yuan,Xiang-Guo Zeng,Hua-Yan Chen,An-Lin Yao,Yan-Fei Hu 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.11

The effect of cooling rate on the microstructure evolution of liquid Cu nanoparticles during their solidification process is investigated by using a molecular dynamics simulation based on the embedded atom method (EAM) potential developed by Foiles et al.. The potential energy analysis,the pair distribution function and the common neighbor analysis have been used. The results show that the solidification point increases with decreasing cooling rate and that the solidification of the microstructure of Cu nanoparticles varies with the cooling rate. The microstructure consists of fcc,hcp and bcc crystals or mixtures, though the fcc structure dominates, except in the amorphous state. An amorphous structure was obtained when the cooling rate reached 1.0 × 1013 K/s or higher while crystallization degree increased with decreasing cooling rate, and the total content of crystal structures reached to 95% when the cooling rate dropped to 4.0 × 1011 K/s, which was nearly a perfect crystal structure. The results also indicate that a single-crystal nanoparticle will not be obtained by quenching the liquid metal under various cooling rates.

Removal of nitric oxide and sulfur dioxide from flue gases using a FeII-ethylenediamineteraacetate solution

Xiang-li Long,Hai-Song Zhu,Yan-Peng Mao,Yu Chen,Wei-kang Yuan 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.6

The combined absorption of NO and SO2 into the Fe(II)-ethylenediamineteraacetate(EDTA) solution has been realized. Activated carbon is used to catalyze the reduction of FeIII-EDTA to FeII-EDTA to maintain the ability to remove NO with the Fe-EDTA solution. The reductant is the sulfite/bisulfite ions produced by SO2 dissolved into the aqueous solution. Experiments have been performed to determine the effects of activated carbon of coconut shell,pH value, temperature of absorption and regeneration, O2 partial pressure, sulfite/bisulfite and chloride concentration on the combined elimination of NO and SO2 with FeII-EDTA solution coupled with the FeII-EDTA regeneration catalyzed by activated carbon. The experimental results indicate that NO removal efficiency increases with activated carbon mass. There is an optimum pH of 7.5 for this process. The NO removal efficiency increases with the liquid flow rate but it is not necessary to increase the liquid flow rate beyond 25 ml min−1. The NO removal efficiency decreases with the absorption temperature as the temperature is over 35 oC. The Fe2+ regeneration rate may be speeded up with temperature. The NO removal efficiency decreases with O2 partial pressure in the gas streams. The NO removal efficiency is enhanced with the sulfite/bisulfite concentration. Chloride does not affect the NO removal. Ca(OH)2 and MgO slurries have little influence on NO removal. High NO and SO2 removal efficiencies can be maintained at a high level for a long period of time with this heterogeneous catalytic process.

Microstructure and Magnetic Properties of Fe-doped MnBi Permanent Magnet Alloys

Yuan-Hao Tu,Qiong Wu,Hong-Liang Ge,Zi-Sheng Wang,Min-Xiang Pan,Yu Zhao 한국자기학회 2021 Journal of Magnetics Vol.26 No.2

Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis

Huang, Yu-Jing,Qi, Wei-Xiang,He, Ai-Na,Sun, Yuan-Jue,Shen, Zan,Yao, Yang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Objective: The prognostic role of vascular endothelial growth factor (VEGF) in bladder cancer remains controversial. This meta-analysis aimed to explore any association between overexpression and survival outcomes. Methods: We systematically searched for studies investigating the relationships between VEGF expression and outcome of bladder cancer patients. Study quality was assessed using the Newcastle-Ottawa Scale. After careful review, survival data were extracted from eligible studies. A meta-analysis was performed to generate combined hazard ratios (HRs) for overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS). Results: A total of 1,285 patients from 11 studies were included in the analysis. Our results showed that tissue VEGF overexpression in patients with bladder cancer was associated with poor prognosis in terms of OS (HR, 1.843; 95% CI, 1.231-2.759; P = 0.003), DFS (HR, 1.498; 95% CI, 1.255-1.787; P = 0.000) and DSS (HR, 1.562; 95% CI, 0.996-1.00; P = 0.052), though the difference for DSS was not statistically significant. In addition, there was no evidence of publication bias as suggested by Begg's and Egger's tests except for DFS (Begg's test, P = 0.221; Egger's test, P = 0.018). Conclusion: The present meta-analysis indicated elevated VEGF expression to be associated with a poor prognosis in patients with bladder cancer.

Research on the Characteristic of Diesel Elastic-plate Impingement Spray

( Chang Yuan Wang ),( Yong Shang ),( Xiang Rong Li ),( Fu Shui Liu ),( Cheng Hui Yu ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-

A series of experimental research results on the characteristic of diesel elastic-plate impingement spray using High Speed Photography camera are presented in this paper. The experiments were carried out in a constant volume chamber specially designed, which can hold a high ambiance pressure. The special fixed device was designed so that the elastic-plate can be fixed on the spray path, meanwhile the spray incident angle and height can be changed. The free jet spray and elastic-plate impingement spray was compared under the same experimental condition including different injection pressure and different background pressure. Experimental research showed that impingement spray droplets diffuse more quickly than free jet spray.