서방형 Diltiazem제제의 개발을 위한 약동학/약력학적 특성 검토

유경상,배균섭,조주연,장인진,신상구 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

산발성 장형 위선암 환자의 Microsatellite Instability와 병리학적 양상

조창희,홍유찬,안지현,최경현,이상호,신영명,윤기영,정민정,장희경 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : Through many researches, microsatellite is expected to be a good diagnositic and prognostic factor in colorectal cancer, endometrial cancer, gastric cancer, and the others. The prevalence of microsatellite instability (MSI) in gastric carcinoma has reported variously, 13~44%. Purpose : We aimed to determine the prevalence of MSI-high and the relationship between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma of stomach. Material and Methods : We analyzed 106 sporadic intestinal type adenocarcinoma specimens excised from patients who were over thirty-five years old to determine the statue of microsatellite by DNA sequencing. The tissues were formalin-fixed and paraffin embedded. DNA were extracted and amplified by polymerase chain reaction (PCR). MSI was determined using five markers recommended by National Cancer Institute (NCI). Specimens were also studied with five patholical factors-differenciation of tumor cells, depth of invasion, lymph node metastasis, vessel invasion, and perineural invasion- to determine pathological state. Result : The microsatellite statue was determined as MSI-High in 5 cases (4.7%), no MSI-low, and MSS (microsatellite stable) in 101 cases (95.3%). Within the frequency, there was no large gap in the distinction of gender in MSI cases, but in MSS cases, there was three-times more cases in male. MSI cases had moderate-to-poor differenciation and trend to invade toward serosa. All MSI cases showed no perineural invasion. But we could not find any statistical significance between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma. Conclusion : Results suggest that MSI can not make any certain pathological significance in sporadic intestinal type adenocarcinoma. Even though less than 5% of sporadic intestinal type adenocarcinoma patients showed MSI, it can be used as a influential prediagnostic factor of gastric cancer. Further study with large scale of cases will be followed to verify these results.

Nicotine이 계태장기조직의 효소활성에 미치는 영향

조경혜,유은정 서울여자대학교 자연과학연구소 1991 자연과학연구논문집 Vol.2 No.-

임산부 흡연시 담배의 다양한 성분가운데, nicotine이 모체의 대사변동을 통해 간접적으로 또는 태반 융모간 혈류를 따라 직접적으로 태아에게 미치는 영향을 효소학적으로 검증하고자 본 연구를 수행하였다. 인체와의 내성의 차이를 고려하여, 발생중인 계태(8일째)에 0.5ml의 nicotine 용액을 농도별로 (대조군, 제1군:0.206mg/egg, 제2군:0.412mg/egg, 제3군:0.618mg/egg, 제4군:0.824mg/egg) 주입하고, 10일을 더 발육시킨 후 각 장기를 적출하여 마쇄하고 원심분리한 상등액을 시료로 하여 효소활성을 측정한 결과, 대조군에 대한 제2군에서의 specific activity비율이 다음과 같이 증감되었다. Alkaline phosphatase는 폐에서 5.4배, 신장 3.4배, 간과 대퇴부 1.3배, 뇌와 소장에서 1.2배, 심장 1.1배의 증가를 보였고, 위에서는 50% 감소되었다. ATPase는 폐 1.7배, 간 1.6배, 신장에서 1.4배의 증가를 보였고, 심장과 소장에서 1.13배, 위에서 1.07배의 활성을 나타내었으며, 뇌와 대퇴부에서는 오히려 감소하여 각각 90%수준의 specific activity를 보였다. MDH는 152%와 118%로 각각 증가된 폐와 신장을 제외한 모든 장기에서 specific activity가 낮아졌는데, 그 감소비율은 간 29%, 뇌 25%, 위 24% 대퇴부 20%, 심장 17%, 소장 6%로 나타났다. 5'-Nucleotidase는 폐 6.6배, 신장 1.8배, 대퇴부 1.34배, 심장 1.29배, 간 1.1배의 증가를 보인 반면, 뇌와 위, 소장은 대조군에 비해 각각 17%, 22%, 12% 감소를 보였다. Arginase는 폐, 신장에서 각각 1.7배와 1.4배의 두드러진 증가를 보였으며, 뇌와 소장은 1.3배, 간과 대퇴부는 1.1배의 증가가 있었으나, 심장과 위에서는 9%와 19%의 감소를 보여주었다. 소화 및 근육장기에 비해 독성물질을 방어하거나 대사 및 배설하는 장기(간, 폐, 신장)에서 유의적인 증감을 확인할 수 있었는데 특히 폐에서 나타난 큰 변화는 흡연으로 인한 폐조직 손상과는 독립적으로 nicotine이 단독효과를 갖는다는 점을 시사해 준다. 간에서 보다 신장에서의 현저한 효과는 avian species의 대사적 특성으로 말미암아 간기능 일부를 신장이 담당하였기 때문에 나타난 결과로 보며, 이들 enzyme의 활성변화가 사람에게서도 나타나는 가를 확인하기 위해서는 쥐나 원숭이등의 동물실험이 더 부가되어야 하리라 생각된다. In order to study the effect of nicotine on the metabolic activities of the fetal tissues, the changes of enzymatic activities have been investigated in the chick embryonic organs treated with nicotine. Infection concentration which expressed low mortality and ascertained significant change of specific activity is 0.412mg/egg group and each organocellular enzymatic activity is as like follow: 1. Specific activity of alkaline phosphatase is significantly increased in lung, kidney and liver but decreased in stomach. 2. Specific activity of ATPase is increased in lung, liver, and kidney but decreased in brain & thigh muscle. 3. Specific activity of malate dehydrogenase is decreased in liver, brain, stomach, thigh muscle, and heart, but increased in lung and kidney. 4. Specific activity of 5'-nucleotidase is increased in lung, kidney, thigh muscle, and heart but decreased in brain, stomach and intestine. 5. Specific activity of arginase is increased in lung, kidney, brain, and intestine but decreased in heart and stomach. Significant changes of specific activity are ascertained in organs which protect, metabloize or excret toxic materials rather than digestive or muscular organ. In particular, large scale change expressed in lung suggested that the nicotine affccts not only tissue damages by smoking but also the metabolic changes of the fetal tissues at the cellular levels. More remarkable changes in kidney result from metabolic specificity of avian species which kidney is in charge of a part of liver function.

한국인 환자에서 Vancomycin의 집단약동학 (Population Pharmacokinetics)에 관한 연구

유경상,배균섭,이주연,조주연,장인진,신상구,신완균 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

XML 웹 서비스 기반 항공물류 포워딩 포탈 시스템 개발

조현준,사신우,박경환 東亞大學校附設情報技術硏究所 2005 情報技術硏究所論文誌 Vol.12 No.2

Existing Airway Logistics System is not made of standard data and papers. XML Web Services is considered solving these problems. In this paper, we study how to develop Airway Logistics Forwarding Portal System based on XML Web Services. And develop the actually usable system in real business.

상부 조기 위암 환자의 복강경하 상부 위절제술 3례 경험

조규석,김형철,박경규,이문수,송옥평,임철완,신웅진,주종우,유기원 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Background : The reported incidence of early gastric cancer located in the upper portion of the stomach has been increasing with the recent advances in its diagnosis and screening. Recently, we have successfully performed laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without pyloroplasty on three patients with early gastric carcinoma localized to the upper third of the stomach. We describe our modification of this procedure in this report. Method : After creating an surgical pneumoperitoneum, the stomach was mobilized using laparoscopic coagulating shears. Upper half of the greater curvature and three-quarters of the lesser curvature were then dissected along with regoinal D2 lymphadenectomy. This was followed by a 5 cm, longitudinal mini-laparotomy in the upper abdomen, and the construction of the exteriorized stomach with a gastric tube measuring 20 cm long and 4 cm wide. Reconstruction with an esophagogastrostomy was performed using a circular stapler. Result : No post-operative morbidity or mortality was observed in this small series of patients. The average operative time was 250 minutes (range 220-300 minutes), and the average blood loss was 150 ml (range 90-180 ml). The mean number of lymph nodes harvested during these laparoscopic proximal gastrectomies was 24 nodes (range 22-25 lymph nodes). The average postoperative hospital stays was 7.5 days (range 7-8 days). Conclusion : Our technique of laparoscopic assisted proximal gastrectomy and gastric tube reconstruction without phloroplasty offers a minimally invasive technique with the potential of impoving the post-operative quality of life patients with an early-stage proximal gastric cancer.

Silymarin 함유제형, 레가론 캅셀 140^R 및 타 실리마린 제제의 약동학적 특성에 관한 비교 연구

조주연,배균섭,정인숙,유경상,장인진,신상구 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.2

저탁도시 PAC와 Ca-PAX의 입자제거 및 슬러지 탈수성 비교

심유섭,유명진,조희경,이상수,곽종운 대한상하수도학회 2002 상하수도학회지 Vol.16 No.4

This study was accomplished to evaluate the characteristics of particle removal and sludge dewatering and to find out the optimal condition of coagulation depending on the dosage of different coagulants (PAC, Ca-PAX) in low turbidity water. The experiments were carried out at a pilot plant of conventional rapid sand filtration system using artificial raw water. There was no large difference in the removal efficiencies of turbidity and total particle counts for both coagulants. However, Ca-PAX was required less than PAC to obtain the same efficiency of removal, and the initial head loss in a filter increased more fastly in case of PAC. The results on the evaluation of sludge from settling tank indicated that specific resistance of sludge was decreased inversely to the dose of both coagulant and specific resistance of Ca-PAX sludge was lower than that of PAC, therefore dewatering of sludge in case of Ca-PAX was better.

제 1형 신경섬유종증 환자에서 발생한 위장관 간질종양 1예

원경준,이준,변유미,조민근,한경택,김원,홍란,임성철,김경종,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in the gastrointestinal tract, but this tumor is rarely seen in association with type l neurofibromatosis (NFl) Generally, the majority of GISTs are isolated neoplasm and they are sporadically found in the stomach, but the GISTs in NFl patients are usually multiple and usually found in the small intestine. We report a case of multiple GISTs in the jejunum of a 63-year-old woman diagnosed as NFl accompanied by complication of gastrointestinal bleeding, In this case, Patient had multiple cafe-au lait spots and neurofibroma on skin and had freckling on axilla and groin, and then, we made a diagnosis of NFl. Gastrointestinal bleeding is controlled by resection of multiple GISTs. Generally, only 3-5% of all gastrointestinal bleeding comes from the small bowel. Causes of small intestinal bleeding are angiodysplasia, neoplasm, NSAIDs induced ulcer etc. but, If patients have NFl accompanied by complication of gastrointestinal bleeding, GISTs on small bowel must be considered.

엄지발가락에 발생한 건초 섬유종 1예

이경호,조유경,한예원,김진아,김형민,박철종 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4