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구자경(Ja-Kyong Koo),김길조(Gil-Jo Kim),안유환(Yu-Whoan Ahn),김진수(Jin-Soo Kim) 한국정보과학회 1999 한국정보과학회 학술발표논문집 Vol.26 No.2Ⅰ
소프트웨어 제품 품질 측정이란 다양한 소프트웨어의 특성들을 통하여 소프트웨어 제품의 품질을 정확하게 측정하는 것이다. 이를 위해서는 소프트웨어의 종류 및 사용환경에 따라 품질 특성들에 대한 다양한 가중치를 부여하여 평가할 필요가 있다. 본 논문에서는 AHP를 사용하여 품질 특성들에 대한 상대 중요도를 제공하여 특성들에 대한 가중치를 반환하는 가중치 측정시스템을 개발하였다. 본 시스템은 ETRI 소프트웨어 품질보중 연구팀에서 개발하고 있는 소프트웨어 제품 품질 측정도구와 연계되어 사용될 수 있으며 다른 분야에서도 독립적으로 활용될 수 있다.
Yerim Shin,Chaeyeon Yu,Sungmin Jo,Jeong-Sug Kyong,Jinsook Kim 한국청각언어재활학회 2022 Audiology and Speech Research Vol.18 No.3
Purpose: The music rehabilitation program (MRP) promotes auditory, language, cognitive, and motor development of the brain. The significance of MRP was studied through mismatch negativity (MMN) and Music Listening Attitude and Satisfaction Questionnaire for hearing loss (MASQ_H). Methods: Fifteen adult cochlear implant (CI) users (34.5 years; standard deviation, ± 11.6) participated. MMN was tested before and after MRP training at the stimulus intensity level of 70 and 100 dB hearing loss (HL). In addition, MASQ_H was utilized. Results: For the pre- and post-tests of MMN, the average amplitudes of the waveforms were -2.48 ± 1.95 μV and -6.11 ± 4.21 μV and the areas were 208.16 ± 211.59 μV·ms and 527.87 ± 360.42 μV·ms with the significant difference when the stimulus level was presented at 70 dB HL. For MASQ_H, 90.9% of the participants responded that they felt satisfied with listening to music using CI or hearing aid. When asked about the musical factors that were improved in the music listening, the ‘pitch perception’ and ‘timbre perception’ were responded showing increased satisfaction rates. Conclusion: This study confirmed that MRP improved language processing by facilitating auditory processing, cognitive ability, and neural plasticity of the central auditory system through the increased amplitude and area of MMN after MRP application. Furthermore, providing a systematic music training such as MRP could change the music listening attitudes and satisfaction of the CI users’. The active implementation of music rehabilitation is strongly suggested.
Kim Hee-Yeon,Lee Younghay,Yoon Hee-Soo,Kim Yu-Hee,Cho Kyong-A,Woo So-Youn,김한수,박보영,Jung Sung-Chul,Jo Inho,Park Woo-Jae,Park Joo-Won,유경하 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.2
BACKGROUND: The advantages of tonsil-derived mesenchymal stem cells (TMSCs) over other mesenchymal stem cells (MSCs) include higher proliferation rates, various differentiation potentials, efficient immune-modulating capacity, and ease of obtainment. Specifically, TMSCs have been shown to differentiate into the endodermal lineage. Estrogen deficiency is a major cause of postmenopausal osteoporosis and is associated with higher incidences of ischemic heart disease and cerebrovascular attacks during the postmenopausal period. Therefore, stem cell-derived, estrogen-secreting cells might be used for estrogen deficiency. METHODS: Here, we developed a novel method that utilizes retinoic acid, insulin-like growth factor-1, basic fibroblast growth factor, and dexamethasone to evaluate the differentiating potential of TMSCs into estrogen-secreting cells. The efficacy of the novel differentiating method for generation of estrogen-secreting cells was also evaluated with bone marrow- and adipose tissue-derived MSCs. RESULTS: Incubating TMSCs in differentiating media induced the gene expression of cytochrome P450 19A1 (CYP19A1), which plays a key role in estrogen biosynthesis, and increased 17β-estradiol secretion upon testosterone addition. Furthermore, CYP11A1, CYP17A1, and 3β-hydroxysteroid dehydrogenase type-1 gene expression levels were significantly increased in TMSCs. In bone marrow-derived and adipose tissue-derived MSCs, this differentiation method also induced the gene expression of CYP19A1, but not CYP17A1, suggesting TMSCs are a superior source for estrogen secretion. CONCLUSION: These results imply that TMSCs can differentiate into functional estrogen-secreting cells, thus providing a novel, alternative cell therapy for estrogen deficiency. BACKGROUND: The advantages of tonsil-derived mesenchymal stem cells (TMSCs) over other mesenchymal stem cells (MSCs) include higher proliferation rates, various differentiation potentials, efficient immune-modulating capacity, and ease of obtainment. Specifically, TMSCs have been shown to differentiate into the endodermal lineage. Estrogen deficiency is a major cause of postmenopausal osteoporosis and is associated with higher incidences of ischemic heart disease and cerebrovascular attacks during the postmenopausal period. Therefore, stem cell-derived, estrogen-secreting cells might be used for estrogen deficiency. METHODS: Here, we developed a novel method that utilizes retinoic acid, insulin-like growth factor-1, basic fibroblast growth factor, and dexamethasone to evaluate the differentiating potential of TMSCs into estrogen-secreting cells. The efficacy of the novel differentiating method for generation of estrogen-secreting cells was also evaluated with bone marrow- and adipose tissue-derived MSCs. RESULTS: Incubating TMSCs in differentiating media induced the gene expression of cytochrome P450 19A1 (CYP19A1), which plays a key role in estrogen biosynthesis, and increased 17β-estradiol secretion upon testosterone addition. Furthermore, CYP11A1, CYP17A1, and 3β-hydroxysteroid dehydrogenase type-1 gene expression levels were significantly increased in TMSCs. In bone marrow-derived and adipose tissue-derived MSCs, this differentiation method also induced the gene expression of CYP19A1, but not CYP17A1, suggesting TMSCs are a superior source for estrogen secretion. CONCLUSION: These results imply that TMSCs can differentiate into functional estrogen-secreting cells, thus providing a novel, alternative cell therapy for estrogen deficiency.
Assessment on Antioxidant Properties of Oplopanax elatus Nakai in vitro
Kim, Jun-Heong,Eom, Seok-Hyun,Lee, Han-Shin,Kim, Jae-Kwang,Yu, Chang-Yeon,Kwon, Yong-Soo,Lee, Ju-Kyong,Kim, Myong-Jo The Korean Society of Medicinal Crop Science 2007 韓國藥用作物學會誌 Vol.15 No.2
Effects of Oplopanax elatus have known to various pharmaceutical therapies. However, chemical prosperities in the plant are rarely investigated. In order to detect biological activity, we evaluated the antioxidant activity of five fractions from methanolic extracts in each part of O. elatus. Also, contents of polyphenols and polysaccharides were measured. Five fractions were of sub-fractions using n-hexane, ethyl-acetate, n-butanol, and water from methanolic extracts. Ethylacetate and n-butanol fractions from stem and root exhibited strong antioxidant activity and high total phenolics content. On the HPLC analysis, ten free phenolics, including p-hydroxybenzoic acid, chlorogenic acid, caffeic acid, syringic acid, p-cou maric acid, ferulic acid, naringin, hesperidin, quercetin and trans-cinnamic acid, were identified from the fractions and were shown to different quantitative proportions. Furthermore, ethylacetate and n-butanol fraction had the highest amount of chlorogenic acids, one of the cinnamic acid derivatives possessing pharmacological properties. These results indicated that the fractions of O. elatus, as well as methanolic extracts, could be used as natural antioxidative ingredients.
자기 공명 영상으로 확인한 중추성 시야 결손을 동반한 Thrombotic thrombocytopenic purpura-Hemolytic Uremic Syndrome 1예
이주홍,박용기,김진도,김용은,이태윤,서경덕,구대영,임권조,정유성,신용훈 대한내과학회 1999 대한내과학회지 Vol.56 No.1
Thrombotic thrombocytopenic purpura (TTP) and the related hemolytic uremic syndrome (HUS) are disorders characterized by thrombocytopenia, microangiopathic hemolytic anemia, a variable degree of impairment of renal function and fluctuating neurological symptoms, which are thought to be due to platelet activation and subsequent formation of thrombi in the microcirculation. The fact that there was no clear-cut clinical and laboratory features that differentiate HUS from TTP has lead to view these two syndromes as a clinical continuum. Microvascular thrombosis is the typical lesion and closely related with endothelial injury and platelet activation. Pathologic alterations of the brain parenchyma are mainly manifested by small multiple infarcts. Numerous cases of CNS complications of these syndromes have been evaluated by using CT, but few reports have mentioned the MR findings. We experienced a case of TTP-HUS that had clinical features of cortical blindness and the brain lesion was confirmed by MRI showing cerebral infarct at the occipital area but it was reversible course. So we report this case with a brief review of literature.
Antioxidant and Antimicrobial Activities of Extracts from a Medicinal Plant, Sea Buckthorn
( Jong Hyun Jeong ),( Ji Won Lee ),( Kyoung Su Kim ),( Ju Sung Kim ),( Sang No Han ),( Chang Yeon Yu ),( Ju Kyong Lee ),( Yong Soo Kwon ),( Myong Jo Kim ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
This study was performed to evaluate the antioxidant and antimicrobial activities from the methanol extracts of the root and stem of Hippophae rhamnoides and their further partitioned fractions including hexane, ethyl acetate, butanol, and water. Antioxidant activities of the plant parts were measured by 1,1-dephenyl-2-picryl-hydrazyl (DPPH), superoxide dismutase (SOD)-like activity, and ferric thiocyanate (FTC) assays, and compared to standard antioxidants of butylated hydroxyl anisole, butylated hydroxyl toluene, α-tocopherol, and ascorbic acid. Antimicrobial activity of the plant extracts and fractions were evaluated by determining the minimum inhibitory concentration values. DPPH assay showed that the overall strong antioxidant activities from the methanol extracts and fractions. The values of SOD-like activities in hexane fractions of the root and stem were close to the measurement of a reference, ascorbic acid at 1,000 ppm. The methanol extract of the root in FTC assay showed a remarkable antioxidant and free radical scavenging activity. The extracts and fractions of the root and stem showed better antimicrobial activity than compared antimicrobial agents, (+)-catechin, ketoconazol, and mycostantin. This study indicates that the plant root and stem contain a variety of compounds contributing to antioxidant and antimicrobial activity, which could be used for food additives and the development of useful natural compounds.
Antioxidant and Antimicrobial Activities of Extracts from a Medicinal Plant, Sea Buckthorn
Jeong, Jong-Hyun,Lee, Ji-Won,Kim, Kyoung-Su,Kim, Ju-Sung,Han, Sang-No,Yu, Chang-Yeon,Lee, Ju-Kyong,Kwon, Yong-Soo,Kim, Myong-Jo The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.1
This study was performed to evaluate the antioxidant and antimicrobial activities from the methanol extracts of the root and stem of Hippophae rhamnoides and their further partitioned fractions including hexane, ethyl acetate, butanol, and water. Antioxidant activities of the plant parts were measured by 1,1-dephenyl-2-picryl-hydrazyl (DPPH), superoxide dismutase (SOD)-like activity, and ferric thiocyanate (FTC) assays, and compared to standard antioxidants of butylated hydroxyl anisole, butylated hydroxyl toluene, $\alpha$-tocopherol, and ascorbic acid. Antimicrobial activity of the plant extracts and fractions were evaluated by determining the minimum inhibitory concentration values. DPPH assay showed that the overall strong antioxidant activities from the methanol extracts and fractions. The values of SOD-like activities in hexane fractions of the root and stem were close to the measurement of a reference, ascorbic acid at 1,000 ppm. The methanol extract of the root in FTC assay showed a remarkable antioxidant and free radical scavenging activity. The extracts and fractions of the root and stem showed better antimicrobial activity than compared antimicrobial agents, (+)-catechin, ketoconazol, and mycostantin. This study indicates that the plant root and stem contain a variety of compounds contributing to antioxidant and antimicrobial activity, which could be used for food additives and the development of useful natural compounds.