Catalytic green energy production based on engineered active water innovatively prepared using sunlight-illuminated gold nanoparticles

Shih-Hao Yu,Fu-Der Mai,Wei-Yu Kao,Hui-Yen Tsai,Yu-Chuan Liu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-

Water is the most common solvent in our daily lives. This solvent has advantages of green environmentalprotection and low cost. Water is conventionally considered to be an inert solvent, yet it is relatively polarand can form a large number of hydrogen bonds (HBs). But this property also inhibits the dissolution ofmany non-polar gases, causing many important electrocatalytic reactions performed in it to have lowefficiencies. In this work, we propose an innovative application of solar energy-generated active purewater (APW) with reduced HBs to enhance chemical reactions and physical procedures. Compared toconventional deionized water (DIW), the generated APW possessed a lower specific heat of ca. 0.96. The swelling degree of artificial skin in APW significantly increased by ca. 29%. Moreover, the densityof an ethanol/APW solution significantly increased by 0.21% due to more free water molecules beingavailable in APW to form stronger HBs with ethanol. Encouragingly, efficiencies of hydrogen evolutionreactions performed in an APW-based acidic solution and oxygen evolution reactions performed in anAPW-based basic solution significantly increased by 42% and 17%, respectively, compared to DIWbasedsolutions. The developed APW based on utilizing solar energy can create a more-effective greenprocess.

RNA sequencing reveals that Prx II gene knockout can down-regulate the allograft rejection of dermal mesenchymal stem cells

Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3

In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.

Studies on China s Emergency Management Evaluation Based on Meta-analysis Method : Review and Prospect

Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2

Emergency assessment is an important field of the current emergency management research. Foreign related research started earlier and progress rapidly, has a wealth of practical experience, the domestic research is in the stage of exploration. This paper will be introduced to the Meta - analysis method for evaluation of emergency management research, from the perspective of the overall comprehensive analysis of emergency management evaluation and the research itself, the emergency management at home and abroad in the evaluation of excavated in a large number of research literature in the field of general trends and characteristics, by summing up experience and the existing research results, the theoretical research and practice of emergency management evaluation by weak links that exist in the analysis, in order to find the deficiencies in the study of emergency management assessment, for the future development strategy and establish and improve the basis for policy.

Chiral Pool Synthesis of N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine from L-Malic acid

Hao, Bao-Yu,Liu, Jin-Qiang,Zhang, Wei-Han,Chen, Xin-Zhi Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.5

A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and more than 98% ee.

Low-dose Radiation Induces Antitumor Effects and Erythrocyte System Hormesis

Yu, Hong-Sheng,Liu, Zi-Min,Yu, Xiao-Yun,Song, Ai-Qin,Liu, Ning,Wang, Hao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

Objective: Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. Methods: Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the right inguen as an experimental in situ animal model. Six hours before implantation, the mice were given 75mGy whole body X-ray radiation. Tumor growth was observed 5 days later, and the tumor volume was calculated every other day. Fifteen days later, all mice were killed to measure the tumor weight, and to observe necrotic areas and tumor-infiltration-lymphoreticular cells (TILs). At the same time, erythrocyte immune function and the level of 2,3-diphosphoglyceric acid (2,3-DPG) were determined. Immunohistochemical staining was used to detect the expression of EPO and VEGFR of tumor tissues. Results: The mice pre-exposed to low dose radiation had a lower tumor formation rate than those without low dose radiation (P < 0.05). The tumor growth slowed down significantly in mice pre-exposed to low dose radiation; the average tumor weight in mice pre-exposed to low dose radiation was lighter too (P < 0.05). The tumor necrosis areas were larger and TILs were more in the radiation group than those of the group without radiation. The erythrocyte immune function, the level of 2,3-DPG in the low dose radiation group were higher than those of the group without radiation (P < 0.05). After irradiation the expression of EPO of tumor tissues in LDR group decreased with time. LDR-24h, LDR-48h and LDR-72h groups were all statistically significantly different from sham-irradiation group. The expression of VEGFR also decreased, and LDR-24h group was the lowest (P < 0.05). Conclusion: Low dose radiation could markedly increase the anti-tumor ability of the organism and improve the erythrocyte immune function and the ability of carrying $O_2$. Low-dose total body irradiation, within a certain period of time, can decrease the expression of hypoxia factor EPO and VEGFR, which may improve the situation of tumor hypoxia and radiosensitivity of tumor itself.

Prognostic Role of C-reactive Protein in Gastric Cancer: A Meta-analysis

Yu, Qing,Yu, Xiong-Fei,Zhang, Shou-De,Wang, Hao-Hao,Wang, Hai-Yong,Teng, Li-Song Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: A number of studies have investigated the association between increased pretreatment serum C-reactive protein (CRP) levels and the prognosis of gastric cancer. However, due to the inconsistent results, whether the serum CRP level can be a prognostic factor in primary gastric cancer remains controversial. Methods: We searched Medline, PubMed, Embase and the Cochrane Central Register of Controlled Trials for relevant high-quality reports. A meta-analysis was carried out using the included studies to assess the association between pretreatment serum CRP level and overall survival (OS) in patients with gastric cancer. Correlation analyses were conducted to evaluate the relationship between serum CRP and tumor characteristics such as tumor node metastasis (TNM) stage and recurrence. Results: Twelve reports involving 2,597 patients with gastric cancer were included. Primary meta-analysis indicated a significant association between elevated CRP level and poor OS (HR 1.77, 95% CI 1.56-2.00). Subgroup analyses showed no single factor could alter the primary results when we divided the included studies by "number of patients", "max follow-up period", "TNM stage", "treatment" and "cut-off value". Correlation analyses showed that serum CRP level was significantly related to TNM stage (OR 2.96, 95% CI 2.22-3.93) and tumor recurrence (OR 1.81, 95% CI 1.21-2.71). Conclusions: We demonstrated that increased pretreatment serum CRP level (${\geq}10mg/L$) was significantly associated with poor prognosis in gastric cancer patients, either in early or advanced stages.

IoT-base Generic Intelligent Wireless Sensing Platform for Real-time Data Collection and Distribution Data Analysis

( Yu-cheng Yang ),( Kai-sheng Tseng ),( Xiang-yu Huang ),( Sheng-hao Chen ),( Joe-air Jiang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

In this study, a generic intelligent wireless sensing platform with the IoT and wireless transmission technology is established for greenhouse monitoring, which is capable of greenhouse data collection and analysis. The data analyzed by a cloud server would provide important information regarding the efficiency of greenhouse management and cultivation methods. To monitor greenhouse related parameters, an embedded board is placed in a greenhouse as the gateway. Monitoring data and images collected by sensors deployed in the greenhouse are transmitted to the embedded board via an Ethernet or wireless transmission module. The data are eventually sent to a database by wireless AP. The AP connects to the internet by using a 4G USB dongle, which can provide sufficient data transmission speed for real-time data transmission. In wireless hotspots and areas with Wi-Fi, not only can images be transmitted to the cloud, but also can the mobile APP be used to perform remote monitoring, so experimental observations are no longer affected by geographical impacts. Moreover, to ensure the preservation of images and numeric data, the gateway carries a high durability secure digital (SD) memory card to store images and data; if the network encounters some problems, such as unable to connect and a lack of network traffic, the data can be stored in the SD card. Thus, the proposed platform is able to perform heavy information transmission duties and support performing all wireless monitoring tasks. In addition, the analyzed data can be used by agricultural personnel to provide critical cultivation suggestions.

Evaluation of Emergency Management Capability in Chinese College Based on CMM Model

Hao Yu 위기관리 이론과 실천 2015 Journal of Safety and Crisis Management Vol.5 No.2

Emergencies occur in colleges from time to time in recent years, which disturbs teaching and campus life seriously and causes pressure to students and teachers’ mind and hurt of their life. With emergencies happening frequently, it is the need of social development and also the need of maintaining the development and stability of higher education to constantly improve emergency management capability and to prevent and deal with the emergencies scientifically and efficiently. Emergency management capability decides the response level of a university when they emergencies happen. The improvement of the capacity is a process step by step with many stages for different stage requires different capability. This paper constructs the maturity model and evaluation index system of emergency management capability according to CMM and examines it with real data of a university in Henan Province. Result shows that the level of emergency management capability of the university is initial. Correspond with the university’s situation, the result is accurate and reliable and is able to provide reference for finding questions in the process of emergency management, reducing the risk of emergency and improving emergency management capability.

Analysis of Dangerous Chemical Accident Cause Based on Apriori Algorithm

Hao Yu 위기관리 이론과 실천 2016 Journal of Safety and Crisis Management Vol.6 No.1

In order to identify the association between causes of accidents due to hazardous chemicals, clear and definite the key points of safety supervision, and improve the efficiency of security supervision, this study researches 150 accident investigation report as data source by data mining technology, A priori algorithm, and finds out the relationship between factors such as time, step, type, severity and cause. By analyzing the 8 valuable rules, it proposes 4 suggestions for improving key safety supervision, thus to promote the optimization of safety supervision strategy of hazardous chemicals.

Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese

Hao, Yu-Xia,Wang, Jun-Ping,Zhao, Long-Feng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Aim: Associations between polymorphisms in miR-146aG>C, miR-196a2C>T and miR-499A>G and risk of HCC, and interaction with HBV infection in a Chinese population, were the target of the present research. Methods: The duplex polymerase-chain-reaction with confronting-two-pair primers (PCR-RFLP) was performed to determine the genotypes of the miR-146aG>C, miR-196a2C>T and miR-499A>G genotypes. Associations of polymorphisms with the risk of HCC were estimated by conditional logistic regression analysis. Results: Drinking, family history of cancer, HBsAg and HCV were risk factors for HCC. Multivariate regression analyses showed that subjects carrying the miR-196a2 CC genotype had significantly increased risk of HCC, with an adjusted OR (95% CI) of 2.18 (1.23-3.80). In addition, cases carrying the miR-196a2 C allele had a 1.64-fold increase in the risk for HCC (95%CI=1.03-2.49). The miR-196a2 CT and TT genotypes greatly significantly increased the risk of HCC in subjects with HBV infection, with adjusted ORs (95% CI) of 2.02 (1.12-3.68) and 2.69 (1.28-5.71), respectively. Conclusion: Our results demonstrate that miR-196a2 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection.