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Case Reports : Lactic acidosis associated with the usual theophylline dose in a patient with asthma
Youngil I. Koh,Inseon S. Choi 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.2
Metabolic and electrolyte abnormalities, including hypokalemia, hyperglycemia and lactic acidosis, are associated with theophylline overdose. However, we report an unusual case of sinus tachycardia, lactic acidosis, hypokalemia and hyperglycemia associated
Integrated Speed and Steering Control Driver Model for Vehicle–Driver Closed-Loop Simulation
Koh, Youngil,Her, Hyundong,Yi, Kyongsu,Kim, Kilsoo IEEE 2016 IEEE Transactions on Vehicular Technology VT Vol.65 No.6
<P>This paper describes an integrated speed and steering control driver model for vehicle-driver closed-loop simulation at high-speed maneuvering. In numerous research studies, the performance of vehicle control systems is validated via closed-loop computer simulations due to safety, cost, and repeatability issues. A driver model for the analysis of interactions between vehicle systems and drivers is a significant part of the validation. In particular, in developing a chassis control system, limit-driving characteristics of the actual driver, which mainly affects the performance of the system, has to be taken into consideration. Thus, the proposed driver model is developed to realize the actual driver's driving pattern. A speed control part of the proposed driver model consists of two modules, i. e., the real-time velocity planner and the motion stabilizer. The former plans the desired velocity profile from curvature information on a preview desired path in real time. The latter, i. e., the motion stabilizer, is developed to cope with losing maneuverability through deceleration because there is an obvious limitation to securing stability with velocity profile planning only. On the other hand, a steering control part of the proposed driver model utilizes the yaw-rate gain-based selfadaptation algorithm. An actual driver drives a vehicle without an exact understanding of system dynamics, and the self-adaptation algorithm is adequate for this characteristic accordingly. The proposed driver model has been validated by comparison with an expert driver's driving data, collected on the Korea International Circuit in Yeongam, Korea.</P>
( Youngil Koh ),( Hyun Jung Lee ),( Kwang Sung Ahn ),( Young Wook Kim ),( Jong Sun Jung ),( Hyung Lae Kim ),( Jung Whan Yook ),( Hyun Kyung Park ),( Keunchil Park ),( Sung Soo Yoon ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Current cancer research using massive parallel sequencing technologies primarily focuses on somatic changes in the cancer genome. However, it is anticipated that individual germline variations might contribute to tumorigenesis, as exemplified by several well-known examples, such as BRCA2 variations in breast cancer. Thus, it is also important to explore crosstalk between germline variation and somatic mutation in cancer. Methods: We performed whole-exome sequencing (WES) of 80 acute myeloid leukemia (AML) samples and 180 non-small cell lung cancer (NSCLC) samples. First, we searched for cancer hotspots in germline DNA of these samples. Also, we called somatic variants using in-house pipeline Adiscan. Germline hotspot alteration was validated in a separate AML cohort. Results: Non-synonymous changes including MLH1 (Chr3;37067240, T>A), KIT (Chr4;55593464, A>T), and MET (Chr 7;116340262, A>C) were observed in germline of both AML and NSCLC patients. MLH1 germline change was not found in 18 healthy control samples. Frequency of MLH1, KIT, and MET germline changes were similar in AML and NSCLC patients. In contrast to AML, some of NSCLC patients had PTEN, TP53 and STK11 germline changes. When we focused on the crosstalk between germline change and somatic mutation, MET germline alteration seemed to have coupling with IDH2 somatic mutation, while MLH1 germline mutation seemd to have coupling with TTN somatic mutation. When validated in a separate cohort, AML patients with MET germline mutation had good prognosis compred to MET wild-types suggesting prognostic impact of MET germline alteration. Conclusions: Cancer hotspot variations are present in germline of cancer patients, and their frequency might be different across various cancer subtypes. Germline alteration per se may have prognostic impact, and coupling between certain germline alteration and somatic mutation would exist.
Genomics of diffuse large B cell lymphoma
Youngil Koh 대한혈액학회 2021 Blood Research Vol.56 No.-
Next generation sequencing (NGS) technology has revealed the heterogeneity of diffuse large B-cell lymphoma (DLBCL) from a mutation perspective. Accordingly, the conventional cell of origin-based classification of DLBCL has changed to a mutation-based classification. Mutation analysis delineates that B-cell receptor pathway activation, EZH2 mutation, and NOTCH mutations are distinctive drivers of DLBCL. Moreover, the combination of RNA expression data and DNA mutation results suggests similarity between DLBCL subtypes and other non-Hodgkin lymphomas. NGS-based dissection of DLBCL would be the cornerstone for precision treatment in this heterogeneous disease in the near future.