기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

은행나무 幼莖組織培養

高大植,金癸煥,朴永珍 全北大學校 1976 論文集 Vol.18 No.-

The response of callus formation and the growth rates of sectioned Gingko hypocotyl to upper, middle and lower section cultured with several methods on white's basic medium are summarised as follow; 1. Organ culture sectioned hypocotyl to upper, middle and lower sections is most flourished at the lower section and followed middle and upper. 2. Sectioned hypocotyl which had attached same ranks of endosperm in embryo are better developed than isolated one. 3. When the upper section of sectioned hypocotyl transfer to lower endosperm and lower one to upper none accelerated effect are given on the endosperm. 4. Shoot without root have developed on lower hypocotyl section attached endosperm.

活性슬럿지法에 의한 炭化水素 함유 廢水의 淨化

고정삼,김재하,강경수,고영환 濟州大學校工科大學附屬産業技術硏究所 1991 尖端技術硏究所論文集 Vol.2 No.-

Activated sludge process which has been widely applied to the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3%(W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21%(W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A.calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

Supercritical Water Oxidation for Harmful Wastes

고영환,윤창훈,현영진 제주대학교 환경연구소 2000 환경연구논문집 : 제주대 Vol.8 No.-

THis study was carried out to investigate the performance of supercritical water oxidation. Such harmful waste as poly chloro bipenyl, penta chloro phenol, p-chloro phenol, o-cresol, pyridine are easily oxidized to unharmful constituents as CO_92), H_(2)O, Cl_(2), NO, etc. The enhanced breakage of harmful wastes come from the physical-chemical properties of supercritical water, that is to say, diffusitivity, ion mobility, specific heat capacity and static dielectric constant of the water. The oxidation rates is reasonably analyzed by three-lumped madel. The reaction rate was density dependant. So the rate was increased with water density. Considering the great increasement of harmful wastes up to now, supercritical water oxidation is applicable to the effective treatment of them.

산업장 소음에 노출된 근로자들의 활동 중 혈압과 심박동수

김영기,차태준,변주현,고광욱,이용환 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 산업장 근무 근로자들에 있어서 소음 노출이 혈압과 심박동수에 미치는 영향을 조사하고자 하였다. 방법 : 부산시 소재 한 주물공장 근무 근로자로서 소음 작업장에 근무하는 102명에 대하여 1998년 3-6월, 1999년 3-6월에 걸쳐 안정시 혈압과 청력손실정도, 일반적 특성이 조사되었다. 소음노출 정도는 noise dosimeter를 사용하여 오전 8시-오후 4시까지 8시간동안 측정하여 평가하였고, 활동 중 혈압과 심박동수는 ambulatory blood pressure로 오전 8 시-오후 10시까지 30분 단위로 측정하였다. 결과 : 연령과 흡연, 신체비만지수의 영향을 고려하였을 때 저연령층에서 85dBA이상의 고소음에 노출된 군에서 소음과 수축기 혈압간에는 유의한 양의 상관관계가 있었으나, 이완기 혈압과 심박등수에서는 유의한 결과를 얻지 못하였다. 연령의 구분없이 상관관계를 구하였을 때에는 수축기 혈압에서만 소음수준과 유의한 상관성이 있었다. 오전 8시-오후 10시까지 측정한 활동 중 혈압과 심박동수의 일일 변화는 40세미만의 저연령층에서는 심박동수에서만 근무후의 오후시간부터 감소하는 양상이 있었고 수축기 혈압과 이완기 혈압에서는 뚜렷한 변화를 발견할 수 없었다. 40세이상군에서는 수축기혈압과 이완기 혈압, 심박동수 모두 근무 중에는 비교적 높은 값을 유지하다가 오후부터는 감소하는 추세를 보이고 있었다. 각 연령군별 소음노출수준에 따른 활동 중 혈압과 심박동수의 비교에서는 40세미만의 연령층에서만 85dBA이상의 고소음군에서 심박동수가 유의하게 더 높은 결과를 얻었다. 결론 : 저연령층인 40세피만에서 85dBA이상의 고소음에 지속적으로 노출될 경우 수축기 혈압이 증가되어 있을 수 있음을 확인하였다. Objectives : This study was carriel out to evaluate the effects of Industrial noise on blood pressure and heart rate. Methods Resting blood pressure, hearing loss, and general characteristics of the 102 subjects who were engaged In a factory in Pusan were measured from March to June for two years, in 1998 and 1999. With noise dosimeter, noise exposure level was measured from 8 A.M. to 4 P.M. Ambulatory blood pressure and heart rate were also measured every 30 minutes from 8 A. M. to 10 p. M. Results : Controlling for age, smoking, and Quetelet's index, in subjects of under 40 years old exposed to higher than 85dBA, noise exposure and systolic blood pressure had astatistically significant correlation, and the same result was obtained in all subjects. The daily variability of ambulatory blood pressure and heart rate were observed in older than 40 years old group, but only heal·t rate in under 40 years old. Conclusions : The blood pressure and heart 1·ate would be elevated when the workers exposed to noise. And in under 40 years old, the systolic blood pressure was elevated to the workers exposed to higher than 85dBA.

활성슬럿지법에 의한 탄화수소 함유 폐수의 정화

고영환,강경수,김재하,고정삼 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

Activated sludge process which has been widely applied t o the treatment of waste-water was slightly modified to remove hydrocarbons from wastewater. The process of wastewater treatment consisted of two consecutive reactors. Cells of Acinetobacter calcoaceticus were first cultivated in synthetic wastewater containing 3% (W/V) of hydrocarbons. The resulting culture was then exposed to acclimatized active sludge. Hydrocarbon concentrations of the effluent from the process were 0.19-0.21% (W/V). The contents of suspended solid were reduced to 17-53 ㎎/l. The data imply that A. calcoaceticus can be used for the treatment of wastewater containing hydrocarbons.

SST를 이용한 전기강판의 회전자계 특성 측정

음영환,김홍정,고창섭 충북대학교 컴퓨터정보통신 연구소 2006 컴퓨터정보통신연구 Vol.14 No.1

전기강판으로 제작된 전기기기의 보다 정확한 수치적인 해석을 위해서는 회전자계(Rotating magnetic field)에 따른 전기강판의 자계특성을 정확하게 측정할 필요가 있다. 본 논문에서는 2방향 자계인가 형 SST(single sheet tester)를 이용하여 회전자계 인가에 따른 등방성 및 이방성 전기강판의 자계 특성을 측정하였다. 실험을 통하여 등방성 시료와 이방성 시료에 대하여 각각 회전자계 및 교번/회전 자계의 혼합형 자계를 인가하여 1.6[T]와 1.2[T]까지 측정할 수 있었으며, 교번자계 하에서의 철손(Alternating Iron Loss)외에 회전자계의 인가로 인한 B와 H의 위상 차이를 발생하는 회전자계 손실을 측정하였다. It is necessary to measure precisely the magnetic characteristics of electrical steel sheets under rotating magnetic fields, for the accurate numerical performance analysis of electric machines made of electrical steel sheets. In this paper, the magnetic characteristics of electrical steel sheet is measured under rotating magnetic fields using a double-excitation type single sheet tester. Through experiments, The rotating magnetic properties of a Non-oriented and Grain-oriented electrical steel sheet are measured up to 1.6[T] and 1.2[T] respectively. In addition, the iron losses due to not only the alternating magnetic fields, but also the rotating magnetic fields are measured.

왕우렁이(apple snails)의 생리ㆍ생태적 특성에 관한 연구

이상범,고문환,나영은,김진호 한국환경농학회 2002 한국환경농학회지 Vol.21 No.1

왕우렁이가 자연상태에 전파되어 서식되는 경로는 양식장의 배수시, 홍수로 인한 노지 양식장 붕괴 및 제초용 왕우렁이 입식에 의하여 이루어지고 있다. 왕우렁이의 생리적 특성을 보면 알 크기는 2.47 ㎜, 난괴크기는 1.8×4.3×0.94 ㎝, 알무게 12.78 ㎎, 산란수 157∼784개/1마리(평균 321개/마리) 유체크기 1.69×2.15㎜, 유체 무게 3.32㎎ 최저 산란 왕우렁이 크기 2.40×2.26 ㎝ 이상, 1개알 산란소요시간 22.4초 였다. 알의 색변화는 산란직후 우유빛의 연분홍에서 중기에는 선홍색, 부화직전에는 흐린 연보라색으로 변화하면서 부화된다. 왕우렁이 섭식 대상은 벼, 논잡초, 미나리, 토마토, (양)배추, 무, 호박, 콩잎 등 대부분의 농작물을 포함한 식물체 및 동족의 왕우렁이 등 수중동물이었다. 왕우렁이 월동지역은 장항, 장성 및 해남지역으로 양지녘의 식물체 줄기나 벼 그루터기에 산란된 알과 성체 상태로 저수지나 논의 물웅덩이에서 월동고, 5월 중순이후 수로의 벽이나 식물체 줄기에 산란하며 6월과 9월에 번식이 가장 왕성하였다. 서식지 수질특성은 변이 폭이 컸으나 pH가 7.07∼9.50 범위로 알칼리성에서 주로 번성하였다. 왕우렁이에 의한 벼 가해 양상중 바 발아초기에는 왕우렁이 크기에 관계없이 모두 벼싹을 가해하였고, 벼품종과 생육시기에 따라 차이가 있으며 어린묘 일수록 가해율이 높았으며, 이앙후 45일 벼(초장 약 73 ㎝)도 각고 3.3∼3.5 ㎝ 이상의 중형 왕우렁이는 가해하였다. This experiment was carried out to obtain some information about overwintering, physiological and ecological characteristics of apple snails. Another purpose of this experiment was to characterize an appetite for rice plants by apple snails and to elucidate their choice of fresh green ones (vegetables, some other crops, weeds in rice fields). The freshwater snails were found with higher population at sites abundant organic compounds such as plant debris and at regions with high temperature. They also prefer calcium-rich water. This is a naturally occurring process. Apple snails were exceptionally well-adapted to the south regions of Korea, especially Janghang, Jangseong and Haenam, even if the temperature of winter season is cold below 0℃. Apple snails were not very selective in their food choice and eat almost everything available in their environment. A snail have something called a radula in its mouth for grinding up its food. A apple snail also chews on fruits and young succulent plant barks. In case of reproduction, apple snails deposit about 157~784 (average of 321 eggs) milky white to pale orange colored eggs above the waterline. In approximately every 22.4 seconds a new egg appears. The total time needed to deposit a egg mass varies from 58 minutes~4 hours 13 minutes. Apple snails reproduct actively from May to June and from September to October. An appetite of apple snails for rice plants was the different depending on their size and growing stage for rice plants. Apple snails had a great appetite of rice plants as well as dropwort, tomato, cabbage, radish, aquatic plants etc. They preferred to eat young rice plants and drastically quit eating rice plants of over 40 cm in height. Thus considering the food preference of apple snail for various plants including rice, they were thought to be a potentially strong predator in fields, especially, at regions with warmer winter.

외상성 횡격막 손상

안성국,이상목,이기형,고석환,김용호,박호철,고영관,조규석 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Fifty two cases of traumatic diaphragmatic injuries that we have experienced from Jan. 1973 to Oct. 1994 were evaluated. The following results were obtained. The age of the patient was ranged from 1 to 74 years. Male was 38 and female was 14 in number with a ratio of 2.7 : 1. The traumatic diaphragmatic injuries were due to blunt trauma in 35 cases(motor vehicle accident 25, fall down 8, press 1, kick by fight 1) and penetrating trauma in 17 cases(stab wound 15, shot wound 1, explosion 1). In the blunt trauma, the preoperative diagnosis of the diaphragmatic injury was possible in 25 out of 35 cases(71%) and in the penetrating trauma, 15 out of 17 cases(88%). In the blunt trauma, the repture site was located in the left in 22 cases(63%) and in the right in 13 cases(31%). In the penetrating trauma, the rupture site was located in the left in 9 cases(53%) and in the right in 8 cases(47%). In the blunt trauma, 20 cases(63%) were treated within 24 hours and in the penetrating, 15 cases(88%) within 24 hours. In the blunt trauma, the herniated organs into the thorax were stomach(7), omentum(6), spleen(6), liver(5), colon(4), small bowel(2) and in the penetrating, stomach(7), colon(6), omentum(3), liver(2), and spleen(1) were herniated. Injury severity score(ISS) of 35-blunt trauma ranged from 11 to 66 with mean value of 30.6. Mean ISS of survivors and nonsurvivors was 27.6 and 52.7 respectively. The diaphragmatic repair of 49 cases was performed with thoracic approach in 23 cases, thoracoabdominal approach in 7 cases and abdominal approach in 19 cases, and 3 cases were not operated. The postoperative complication and mortality were developed in 16 out of 49 cases(33%) and in 5 cases(9.6%) respectively, and the causes of death were hypovolemic shock(1), combined head injury(2), asphyxia(1), and pulomnary edema and renal failure(1). In conclusion, the injuries of the diaphragm should be suspected in all patients with severe blunt trauma or penetrating injuries at thorax and upper abdominal area near the diaphragm. All of the cases had associated injury and most of deaths were related to the severity of associated injuries.

저온 저장 감귤에서의 MA포장의 효과

이상백,김은정,고영환,고정삼 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The effects of MA packaging on the low temperature storage of satsuma mandarin, overwintering satsuma and Kiyomi tangor were investigated. Thickness of film, holes in film and incorporation of antimicrobial agent were considered as parameters for MA packaging. Chitosan was applied to surface of fruits to determine the effects of coation during MA storage. Thickness of film and holes in a bag did not affect decay ratios in three fruits. Decay ratio of satsuma mandarin packaged with LDPE film with 2-5% ceramic antimicrobial agent slightly decreased. Chitosan coating lowered decay ratio of fruit during MA storage. MA packaging with LDPE film was effective in lowering weight loss and preventing delamination of fruits. MA packaging did not affect qualities of fruit during storage.