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저농도의 Microcystin-LR를 단기간 처리한 흰쥐에서 투여방법에 따른 독성 지표의 변화
함영국,김성완 한국환경독성학회 2003 환경독성보건학회지 Vol.18 No.3
To investigate the effects of low dosed microcystin-LR(MCLR) on the initial stage of subacute hepatotoxicity in vivo, male Sprague-Dawley rats after weanling were divided in four groups. The orally treated group(OG) was administered orally by 1㎍/kg B.W. at an interval of three days. The free group(FG) has taken the drinking water including 1㎍/L freely and the control group (CG) was only treated with 0.9% saline solution. All groups were treated for a period of 3 weeks. There was a significant correlation in body growth rate between OG and FG and especially, a deterioration of the growth of spleen was observed in the FG after 5 days. The protein levels were also decreased in OG and FG after 9 days. Level of total fat was increased to the 9th day but again decreased up to the initial level. High hemolysis of the isoiated erythrocytes occurred only in OG. Activities of γ-GT of OG and FG were higher twice-fold than CG, but the values of OG were already higher at the first treatment day. No significant change in aspartate aminotransferase(AST) activity was shown in all groups, but the activity of alanine aminotransferase(ALT) was slightly increased at the beginning state. There were much similarities in the results of OG and FG, except the growth inhibition of spleen in FG. It may be concluded that long-term effects of the low doses of mycrocystins in animals including human being can lead to serious health problems, especially to liver and spleen.
직업적 디메틸아세트아미드(Dimethylacetamide) 노출에 의해 집단적으로 발생한 독성간염
최태성,우극현,김진석,박완섭,함정오,정상재,유재영 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2
목적 : DMAC에 노출된 후 집단적으로 발생한 독성 간염 7례보고. 방법 : 2000년 2월 신설된 스판덱스 섬유제조 공장에 근무하는 생산직 근로자 178명중 2000년 2월 부터 8월까지 7명이 간장질환이 발생하였다. 환례들의 나이는 23∼47세였고, 남자 5명, 여자 2명이었다. 이들에 대해 혈액검사, 간 초음파 검사 등의 임상검사와 작업장 조사를 실시하였다. 결과 : 근무 부서는 중합 1명, 방사 1명, 권취 4명, 그리고 포장 1명이며 평균근무기간은 10주였다. 주 호소 증상은 심한 피로감, 어지럼증 및 황달이었고, 검사실 소견상 독성간염의 소견을 보였다. A, B 및 C형 간염 표지자 검사는 모두 음성이었고, 간초음파 소견상 특이 소견이 없었다. 문진 상 알코올 성 간염을 일으킬 정도의 음주력이나 최근 약물 복용력을 가지고 있는 환례는 없었다. 입원 후 보존적인 치료로 모두 급속히 호전되었다. 초기에 발생했던 환례에서 퇴원후 DMAC에 재 노출되어 독성 간염이 재발되었다. 이후 모든 환례들은 퇴원 후 DMAC 비노출 부서로 전환하였고, 퇴원후 지속적인 추적검사에서 간 효소 수치가 완전히 정상화되었고, 정상화되는 기간은 1∼2개월 정도 소요되었다. 결론 : 환례들의 임상증상, 검사결파, 노출력 및 과거력상 DMAC에 의한 독성간염으로 추정된다. Dimethylacetamide is widely used in the production of plasics, resins, synthetic fibers, and gums and in purification and crystallization processes. Inhalation of the vapor or skin absorption of the liquid of dimethylacetamide (DMAC) can cause liver damage. Toxic hepatitis possibly attributable to DMAC exposure occurred in seven works among 178 employees who had worked on a new spandex-fiber production line. A large amount of DMAC is used as a spinning solvent for synthetic fibers in the factory. The patients were aged 23-47 years old and composed of five males and two females. They were involved in the process of polymerization(1 patient), spinning(1), take-up(4) and packaging(1). The mean duration of exposure was 10 weeks. They experienced fatigue, dizziness and jaundice. The patients showed elavated total bilirubln, alanlne aminotransferase (ALT), and aspartate aminotransferase (AST) levels. The serologic test for viral hepatitis A, B and C were negative, as were the abdominal ultrasonographic scans. Based on the presumptive diagnosis of DMAC-induced toxic hepatitis, they were removed from the workplaces. One or two months after removal from the work, the transaminase levels returned to normal. The patients had no history of significant alcohol use, blood transfusion, recent medication, and drug abuse. As a result, authors could not find any attributable cause of toxic hepatitis but the toxicity by DMAC exposure.
( Wan Jung Kim ),( Joo Young Cho ),( Soung Won Jeong ),( Kyoung Min Kim ),( Ik Sung Choi ),( Jeung Ho Ham ),( Bo Young Lee ),( Jin Oh Kim ),( Joon Seong Lee ),( So Young Jin ) 대한소화기학회 2008 Gut and Liver Vol.2 No.3
Background/Aims: All epithelial cells emit autofluoresce, with tumor cells emitting weaker autofluorescence. We categorized patterns of autofluorescence imaging (AFI) and compared their clinical characteristics and pathology findings after endoscopic submucosal dissection. Methods: Twenty patients were enrolled, comprising 4 adenomas and 16 early gastric cancers. AFI findings were classified as follows: G0 (well-defined pink lesion on a green background with a clear interface over ≥50% of its area), G1 (pink-green mottled lesion on a green background with a clear interface over <50% of its area), P1 (pink-green mottled lesion on a purple background with a clear interface over <50% of its area), and P2 (vague lesion on a purple background with a clear interface over ≤10% of its area). Results: Most of the patients (80%) were male, and their median age was 62.4 years (range: 46-78 years). The lesion sizes by white-light mode, AFI mode, and pathology were 20.8±13.1, 22.8±15.4, and 20.0±17.7 mm (mean±SD), respectively. Sixteen cases of adenocarcinoma were classified as follows: G0 (n=10), G1 (n=2), P1 (n=2), and P2 (n=2). The G0 group has no p53 positive lesions, unlike the non-G0 group (p=0.044). All cases with the P1 and P2 patterns were of the gastric and intestinal types, respectively. Conclusions: AFI images of gastric tumors were categorized into four patterns that were useful for defining the resection margin in 87.5% of cases, with G0 being the most common pattern (62.5%). (Gut and Liver 2008;2:186-192)
Capturing Distance Parameters Using a Laser Sensor in a Stereoscopic 3D Camera Rig System
( Wan Young Chung ),( Julian Il Ham ),( Jong Jin Kim ) 한국센서학회 2013 센서학회지 Vol.22 No.6
Camera rigs for shooting 3D video are classified as manual, motorized, or fully automatic. Even in an automatic camera rig, the process of Stereoscopic 3D (S3D) video capture is very complex and time-consuming. One of the key time-consuming operations is capturing the distance parameters, which are near distance, far distance, and convergence distance. Traditionally these distances are measured by tape measure or triangular indirect measurement methods. These two methods consume a long time for every scene in shot. In our study, a compact laser distance sensing system with long range distance sensitivity is developed. The system is small enough to be installed on top of a camera and the measuring accuracy is within 2% even at a range of 50 m. The shooting time of an automatic camera rig equipped with the laser distance sensing system can be reduced significantly to less than a minute.
함인혜,정민영,최용주,이상대,성환길,심상수,황완균 중앙대학교 약학연구소 2000 약학 논총 Vol.14 No.-
Phellinus linteus(polyporaceae) has been used as anti-cancer agent in Korea. We were studied to evaluate the anti-tumor and immunopotentiation effect of Phellinus lintenus(PL) single and mixing administration with three anti-tumor agents in folk medicines(Ulmus davidiana var japonica, Cudrania tricuspiata, and Bupleurun palcatum). Oral administraion to tumor bearing mice significantly prolonged suvival rate compared to control group with the prolongation ratio of 2% to 9%. Nitrite production of Raw 264.7 cell was increase dose-dependently