Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

만성 동맥 폐색증 환자에서 Cilostazol(Pletaal^�)투여시 자각증상 및 혈액 동태에 미치는 영향

김영일,노승무,장일성,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

At department of Surgery, Chungnam National University Hospital, from March 1991 to October 1991, a new platelet aggregation inhibitor, cilostazol, with a vasodilating action, was administered orally in daily doses of 200mg for 8 weeks in chronic arterial occlusive diseases. After administration, the clinical effects of cilostazol were observed in 10 patients with thromboangiitis obliterans and arteriosclerosis obliterans. The results were as follows: 1. The overall improvement rate of the diseases was 80 percent. 2. The adverse effects of cilostazol were headache in one patient, indigestion in one patient, and overall safety rate was 80 percent. It can be concluded that cilostazol is useful in the treatment of chronic arterial occlusive disease.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

새로운 TIF 유도체의 합성 및 특성 분석

권선영,노동윤 서울여자대학교 자연과학연구소 2004 자연과학연구논문집 Vol.16 No.-

금속배위 화합물의 리간드로 사용하기 위하여, 시안기, 히드록시기, 포스포네이트기를 갖는 새로운 4가지 TTF 유도체, (4-(cyanoethylthio)-4', 5'-(ethylenedithio) tetrathiafulvalene (CET-EDTTTF), 4-(hydroxyethylthio)-4', 5'-(ethylenedithio) tetrathiafulvalene (HET. EDTTTF), 4-[(3'-diethoxyphosphinyl) propyl] thio-4', 5'-(ethylenedithio) tetrathiafulvalene (EPPT-EDTTTF), 4, 4'-bis(cyanoethylthio) tetrathiafulvalene (BCET-TTF)) 를 포스파이트를 이용한 짝지음 반응으로 합성하여 분석하였다. 4개의 TTF 유도체들은 [TTF] ⇔ [TTF]^(+) ⇔ [TTF]^(2+) 과정에 해당하는 두 쌍의 산화-환원 피이크가 측정되었고, 이들의 첫 번째 산화전위 (Eox¹) 는 작용기들이 전자를 당기는 능력에 따라서 히드록시 (0.704V) <모노시안 (0.777V) <디시안(0.781V) <포스포네이트 (0.792V)의 순으로 증가하였다. X-선 결정구조 분석에 의하면 trans-BCET-TTF는 삼사정계이며 P-1 결정군에 속한다. 단위세포 파라미터는 a=5.050(4) Å, b = 10.605 (4)Å, C = 15.478 (9)Å, alpha = 77.27(4)°, beta=88.63(6)°, gamma=89.63(5)˚ 이다. Four TTF derivatives containing mono- and di-cvano, hydroxyl and diethylphosphonate groups, (4-(cyanoethylthio)-4', 5'-(ethylenedithio)tetrathiafulvalene (CET-EDTTTF), 4-(hvdroxyethvlthio)-4', 5'-(ethvlenedithio) tetrathiafulvalene (HET-EDTTTF), 4-[(3'-diethoxyphosphinyl)propyl] thio-4', 5'-(ethylenedithio) tetrathiafulvalene (EPIT-EDTTTF), 4, 4'-bis(cyanoethylthio) tetrathiafulvalene (BCET-TTF)) have been synthesized, by the phosphite-based coupling method, and spectroscopically characterized. They showed two pairs of redox peaks corresponding to the processes of [TTF] ⇔ [TTF]^(+) ⇔ [TTF]^(2+). The first oxidation potentials (E' ox) are differentiated depending on the electron-withdrawing ability of the functional group such as 0.777 V (CET-EDTTTF), 0.704 V (HET-EDTTTF), 0.792 V (EPIT-EDTTTF) and 0.781 V (BCET-TTF). According to X-ray structure analysis data of trans- BCET-TTF, it crystallized in triclinic system with P~1 space group and cell parameters: a = 5.050 (4) Å, b = 10.605 (4) Å, c = 15.478 (9) Å, alpha = 77.27 (4)˚, beta = 88.63 (6)˚, gamma = 89.63 (5)˚.

풍력용 농형유도발전기 시스템의 최적제어

최선필,김영빈,노태균,김춘삼,우정인 東亞大學校 2002 東亞論叢 Vol.39 No.-

In this study, we proposed high efficiency wind power generator system for induction generator used SVPWM swiching inverter. First, we propose equivalient circuit for induction generator, it's characteristics equation, and power equation of slip. In addition, we suggest pick Power Traction Slip control methods, adapted variable wind power system. We study simulation result for the proposed system and output power by slip effect. and we identify SVPWM of suitable wind power system by comparison between SPWM and SVPWM Consequently, we show tat the system control result form variable wind power is suitable.

보편적 이동전화 서비스를 위한 방안에 관한 연구

김영곤,노순국,박창균 조선대학교 전자정보통신연구소 2000 電子情報通信硏究所論文誌 Vol.3 No.1

Mobile phone service one of services for the realization of high information society of 21C, has made and repeated a rapid development. Now our country, the subscriber number of mobile communication has outrun the one of wire telephone But several problems caused by that has been making appearance on the stage as a new social phenomenon are appeared In this study at time of information and communication in 21C one of the problems caused by mobile phone rapidly developing, to choose universal service of mobile phone, as compare the cases of many advanced countries with present our conutry situation, we propose that the methods for the offer of universal service of mobile phone

종양치료시 항종양제에 의한 조혈기 장애에 대한 Cephalanthin^(R)의 임상적 평가

김영일,노승무,장일성,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

The clinical effect of Cephalathin Tab^(R). was observed in 33 cases with chemotheraphy in the cancer patients. Cephalathin Tab^(R). was administered per oral 3-6mg daily in three divided for an average of 58 days. The overall effectiveness was 87% and there was no side effect of Cephalathin Tab^(R). In conclusion, Cephalatin Tab^(R). was safe and effective drug for management of hematologic disorder by the anticancer agent.

두 가지 CET-EDTTTF 동질이상 화합물의 구조 비교

권선영,노동윤 서울여자대학교 자연과학연구소 2005 자연과학연구논문집 Vol.17 No.-

CET-EDTTTF was synthesized and crystallized (CH_(2)Cl_(2)/CH_(3)CH_(2)OH) in monoclinic system with P2(1) space group and the cell parameters: a = 5.0570(15)Å, b = 20.702(5)Å, c = 14.759(3)Å, beta = 90.30(2)°. CET-EDTTTF molecules arranged in bc-plane are stacking along the a-axis. There is no intermolecular S···S interaction shorter than the sum of the van der Waals radii of sulfur atom(3.70Å). When CET-EDTTTF was reacted with AgCF_(3)SO_(3), black single crystals of (CET-EDTTTF)·(solv) were obtained after crystallization. It crystallized in triclinic system with P-1 space group and the cell parameters: a = 6.5962(14)Å, b = 9.123(2)Å, c = 15.545(3)Å, alpha = 77.491(3)°, beta = 87.646(3)°, gamma = 69.332(3)°. CET-EDTTTF molecules form dimers with head-to-tail fashion, which are stacking along b-axis. The molecular sheets formed in ab-plane are separated by the solvated molecules. The CET-EDTTTF molecules in this sheet are connected by the intermolecular S···S interactions shorter than 3.70Å.