치간 삭제 후 불소 및 수산화인회석 도포 시 법랑질 표면의 함량 및 결정구조 변화에 관한 연구

김상철,홍현실,황영철 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

본 연구의 목적은 치간삭제 후 불소 및 수산화인회석 페이스트의 치면 도포에 대한 법랑질 표면의 결정구조 및 재광화를 평가하고자 하였다. 치간삭제 후 1.23% 인산화 불소 및 10% 수산화인회석 페이스트를 치면에 도포한 후 법랑질 표면의 결정구조 변화를 주사전자현미경으로 관찰하고, 법랑질 표면의 칼슘, 인, 불소 함량 등의 변화를 energy dispersive X-ray spectroscopy (ESD)로 분석하였다. 실험결과 10% 수산화인회석 페이스트 도포한 군에서 칼슘 함량이 증가하였고 (p < 0.01), 치간 삭제 후 거칠었던 법랑질 표면이 매끄럽고 부드러워졌으며 법랑질 결정구조가 작고 치밀해짐을 관찰할 수 있었다. 이상의 결과는 치간삭제 후 불소 및 수산화인회석 도포가 치면 결정구조 및 재광화에 유리하다는 것을 의미한다. The aim of this study was to evaluate the remineralization of interdentally stripped teeth after fluoride gel or hydroxyapatite paste application. Methods: After interdental stripping, 1.23% fluoride gel or 10% hydroxyapatite paste was applied three times a day, with a duration of four minutes, for a week. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) were used to compare the change of surface contents and crystal structures before and after the application of fluoride gel or hydroxyapatite paste. Results: EDS analysis indicated that calcium contents were increased after 10% HAp paste application on stripped enamel (p < 0.01). SEM view showed that enamel surfaces in groups of 1.23% APF gel or 10% HAp paste application were smoother than those of control group, which was regarded as filling of the pore structure. And pores between crystal structures in groups treated with 1.23% APF gel or 10% HAp paste were smaller than those of control group. Conclusions: Application of APF or HAp on stripped enamel could positively influence on the surface contents or crystal structure.

결핵성 늑막삼출과 비결핵성 늑막삼출에서의 가용성 Interleukin-2 수용체의 농도

임현옥 ( Hyun Oak Lim ),함종렬 ( Jong Yeol Ham ),심대석 ( Dae Seok Shim ),황영실 ( Young Sil Hwang ) 대한결핵 및 호흡기학회 1994 Tuberculosis and Respiratory Diseases Vol.41 No.2

용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

브루셀라균에 노출된 미생물 검사실 직원들에 대한 예방적 항생제 요법과 혈청학적 추적검사

이창섭,이혜수,이재현,박진희,최영실,황규잠,이흥범 대한감염학회 2008 감염과 화학요법 Vol.40 No.2

The aerozolization is one of possible Brucella transmission mechanisms, particularly in air-borne exposed laboratory workers. In this study, seven laboratory workers were potentially exposed to B. abortus via aerosols. Two laboratory workers who sniffed an agar plate several times were considered to be at high risk for acquiring the disease, 5 workers who did not work directly with the strain were be considered at low risk of infection. Prophylactic antibiotics of doxycycline 200 mg/day and rifampin 600 mg/day were offered for 6 weeks in high risk workers and 3 weeks for low risk workers respectively. Enrolled workers were advised to check for serological testing of Brucella species every 3 weeks during a total period of 12 weeks. Compliance with taking medicine was 57.1% (4/7) and compliance for completing the serological tests was 85.7% (6/7). None of the laboratory workers developed clinical disease or tested positive serologically during 3 months of seroloaical testing and 1 year of clinical follow-up.

Dietary Fiber in Codulbaegi (Korean Lettuce, Ixeris sonchifolia H.) Kimchi

Hwang, Eun Young,Ryu, Hong Soo,Chun, Soon Sil,Park, Kun Young 부산대학교 김치연구소 1995 김치의 과학과 기술 Vol.1 No.-

고들빼기 김치의 식품학적 특성을 알아보기 위하여 김치 제조과정 주의 식이섬유질 함량과 수성 변화를 실험하였으며, 진공동결건조 김치분말에 대한 보수력과 오일 흡착력을 측정하였다. 어린 고들빼기일수록 중성세제 섬유질(NDF) 및 산성세제 섬유질(ADF)의 함량이 많았으며 뿌리부분에는 잎부분에 비하여 적은량의 식이섬유질(ADF 및 NDF)가 함유되어 있었다. 성숙한 뿌리를 제외하고는 일반적으로 5% 식염수에 침지할 경우에는 식이섬유질 ?량은 높아지나 발효가 진행됨에 따라 이들 섬유질의 함량은 서서히 줄어들고 있었다. 셀롤로오즈가 산성세제 섬유질의 90%를 차지하는 것으로 보아 김치제조과정 중의 식이섬유질 함량 변화는 일부 가용성 식이섬유질의 유출 및 셀롤로오즈의 구조변화에 영향을 받은 것으로 생각되었다. 보수력과 오일 흡착력은 식이섬유질 함량변화와 비슷한 결과를 보였으며 오일 흡착력의 40% 정도였다. The effect of processing conditions on the changes in the contents of dietary fiber fractions and its physical properties of Godulbaegi (Korean lettuce, Ixeris sonchifolia H.) was determined during preparation and fermentation for kimchi. Water holding capacity (WHC) and oil adsorption capacity (OAC) were also checked on the subject of freeze dried powder from different stages of the kimchi processing. Neutral detergent fiber (NDF) content in young samples (leaf and root) decreased with prolonged soaking and fermentation period. Every young samples had a higher level in NDF than in ripe samples. Noticeable decrease in acid detergent fiber (ADF) without a change in ripe roots was showed after fermentation (4℃, 60 days). The water holding capacity of freeze dried young plants ranged from 5.78m) / g for roots to 6.31 ml J g for leaves. Soaking and fermentation resulted in decreasing WHC and about 50% of WHC (raw leaves) was lowered after kimchi fermentation (4℃, 40 days). OAC of all samples were lower than WHC in same samples significantly and those were also decreased after soaking and fermentation as WHC.

Dietary Fiber in Godulbaegi(Korean Lettuce, Ixeris sonchifolia H.) Kimchi

황은영(Eun-Young Hwang),류홍수(Hong-Soo Ryu),전순실(Soon-Sil Chun),박건영(Kun-Young Park) 한국식품영양과학회 1995 한국식품영양과학회지 Vol.24 No.3

고들빼기 김치의 식품학적 특성을 알아보기 위하여 김치 제조과정 중의 식이섬유질 함량과 구성 변화를 실험하였으며, 진공동결건조 김치분말에 대한 보수력과 오일 흡착력을 측정하였다. 어린 고들빼기일수록 중성 세제 섬유질(NDF) 및 산성세제 섬유질(ADF)의 함량이 많았으며 뿌리부분에는 잎부분에 비하여 적은량의 식이성유질(ADF 및 NDF)가 함유되어 있었다. 성숙한 뿌리를 제외하고는 일반적으로 5% 식염수에 침지할 경우에는 식이섬유질 함량은 높아지나 발효가 진행됨에 따라 이들 섬유질의 함량은 서서히 줄어들고 있었다. 셀룰로오즈가 산성세제 섬유질의 90%를 차지하는 것으로 보아 김치제조과정 중의 식이섬유질 함량 변화는 일부 가용성 식이섬유질의 유출 및 셀룰로오즈의 구조변화에 영향을 받은 것으로 생각되었다. 보수력과 오일 흡착력은 식이섬유질 함량변화와 비슷한 결과를 보였으며 오일 흡착력은 보수력의 40% 정도였다. The effect of processing conditions on the changes in the contents of dietary fiber fractions and its physical properties of Godulbaegi (Korean lettuce, Ixeris sonchifolia H.) was determined during preparation and fermentation for kimchi. Water holding capacity (WHC) and oil adsorption capacity (OAC) were also checked on the subject of freeze dried powder from different stages of the kimchi processing. Neutral detergent fiber (NDF) content in young samples (leaf and root) decreased with prolonged soaking and fermentation period. Every young samples had a higher level in NDF than in ripe samples. Noticeable decrease in acid detergent fiber (ADF) without a change in ripe roots was showed after fermentation (4℃, 60 days). The water holding capacity of freeze dried young plants ranged from 5.78ml/g for roots to 6.31ml/g for leaves. Soaking and fermentation resulted in decreasing WHC and about 50% of WHC (raw leaves) was lowered after kimchi fermentation (4℃, 40 days). OAC of all samples were lower than WHC in same samples significantly and those were also decreased after soaking and fermentation as WHC.

아리스톨로크산 함유 생약제에 대한 안전성평가연구 : 3개월간 반복투여독성시험을 통한 신장독성평가

황명실,박미선,문지영,이지선,염영나,이효민,신동환,강진석,윤은경,최미나,육미영,장동덕,길광섭,김승희,양기화 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

본 실험에서는 아리스톨로크산을 함운하고 있는 생약제중 하나인 마두령(.4risfoforfioe JTurruf)의 90일 반복투여독성시헌을 실f,」하였다. 마두령에서 아리스톨로크산을 정량분석한 결과 마두령 단일 건조븐말의 경운 2.112mg/g, 잉상에서 처방되고 있는 마든령복방 (마두령외 9가지 생약제 복합처방) 건조분말꼭 경무에는 0.066m9/5으로 각각 검출되었다. 본 실험에서 용량설정은 마두령 처리군 (저용량 군; 21.3m9/k9/day (임상용량), 중용량군; 2t3mgfg/day, 고용량군; 2430mg딘g b.w./day), 마두령복방 처리군 (427mg/kg b.w./da?; 임상용량) 및 positive control (아리스톨로크산) 처리군 (저용량군;0.05mgag/da17, 중용량군; 0.Smg/kg/day, 고용량군; 5mg./kg/dal·1으료 하여 랫드에게 경구투여하였다. 마두령단방 처궈근 및 마두령복방 처리군에서 저용량군과 중응량군에서는 잉상관찰 및 생화학적 분석에서 패조군과 유의적인 차이가 없었다. 그러나 마두령단방 고용량근에서는 간, 신장의 상대적인 무계가 증가되었고, 신장의 유두이행상피증식 및 암종이 관찰되었으며, 위에서는 편평세포암종이 관찰되었다. 하자만 간손상이나 간암은 유발하지는 않는 것으로 판단되었다. 결론끌으로 본 실험의 결과에서는 아리스톨로크산 함유 생약제인 마두령이 임상용량인 저응량 처리군에서는 독성을 나타내지 않았으나, 고용쏭으로 장기 복용시켰을 깅우 설치류의 전위부위 및 신장에서 독성이 있음을 알 수 있었다. Chines herbs nephropathy (CHN) has been described in young women who had taken a slimming pills containing some chines herbs. Aristolochic acid (AA), suspected substance as the causal factor of CHN, is known a carcinogen. The Aristolochiae fructus (fruit of Aristolochia contorta) was used in Korean Traditional Medicine consists of appropriate amounts of mixed natural products. Subchronic toxicity of A. furctus containing aristolochic acid was investigated in SD rats. The body weight and clinical signs were observed after orally administration of A. futctus at doses of 21.2, 213, and 2130 mg/kg/day; mixture (including 9 other herbs) at dose of 427 mg/kg/day; aristolochic aicd (Ⅰ+Ⅱ) at doses of 0.05, 0.5, and 5 mg/kg/day for 3 months. At the end of the treatment, high dose treated animals revealed a deficit in final body weight about 25% compared with that of control. Organ weights of kidney, liver, testis, or ovary were increased with dose dependent manner. No changes considered to be due to the administration of A. furctus, mixture or aristolochic acid were in hematological and clinical study. However, significant changes at histopathological study of kidney and stomach were boserved in high-dose treated groups. In conclusion, for human health safety it needs appropriate regulatory actions regarding the use of natural herbal medicines known or suspected of containing aristolochic acid.

고추의 LISA 模型開發을 위한 技術ㆍ經濟的 要因分析

Hwang Young-Hyun,Choi Jung,Kim Chung-Sil,Kim Byung-Do 한국유기농업학회 1998 韓國有機農業學會誌 Vol.7 No.1

Correlation between Increased Airway Responsiveness and Severity of Pulmonary Edema

Hwang,Young Sil,Jung,Pan Zoon 대한알레르기학회 1995 천식 및 알레르기 Vol.15 No.3

만성 신부전 환자에서 혈액투석 전후의 기관지 과민반응검사

황영실 ( Young Sil Hwang ),심대석 ( Dae Suk Shim ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.4