네모나프라이드의 유효성 및 추체외로 부작용 : Haloperidol 및 Risperidone과의 자연관찰적 개방형 비교연구 A Naturalistic Open Comparative Study with Haloperidol and Risperidone

서영수,김용관,신동환,공보금,이정구,박정환,윤성환,정치영,이상경,김영훈 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : This open prospective study was performed in order to evaluate the efficacy and extrapyramidal adverse effects of nemonapride in the schizophrenic patients, and was compared wit one of typical antipshchotics. haloperidol and one of atypical antipsychotics, risperidone. Methods : Thirty male and female schizophrenic patients(DSM-Ⅳ) were treated for 12 weeks with haloperidol(n=10), risperidone(n=10) and nemonapride(n=10). The overall efficacy was assessed at baseline, 1st week, 2nd week, 4th week, 8th week, and 12th week by the Positive and Negative Syndrome Scale for Schizophrenia(PANSS). Also the overall safety was assessed in the same time period by the Extrapyramidal Symptom Rating Scale(ESRS). Results : There were no significant differences in PANSS scores(total, positive, negative, and general psycho­pathology subscale) among haloperidol, risperidone, and nemonapride groups, Treatment responders, defined as at least 20% reduction of baseline total PANSS score, were achieved by 8 patients(80%) in haloperidol group, 10 patients(100%) in risperidone group, and 8 patients(80%) in nemonapride group. And there were no significant differences in ESRS total scores among haloperidol, risperidone, and nemonapride group. Inter-group comparison among haloperidol, risperidone and nemonapride group, as assessed by the ESRS, revealed no significant differences in the shifts to the maximum score, 9.4(±9.4), 6.2(±8.4), and 11.3(±8.1) respectively, and also revealed no significant differences in the mean time reaching the maximum score, 4.5(±4.5) week, 7.8(±4.8) week, and 4.6(±4.4) week, respectivily. Conclusion : There wee no significant differences in the efficacy and extrapyramidal adverse effects among haloperidal, rispecridone and nemonapride groups. These results suggest that nemonapride was as efficacious and safe in he treatment of schizophrenia, as well known and widely used antipsychotics, haloperidol and risperidone.

낮은 상관 특성과 큰 선형 복잡도를 갖는 새로운 p-진 수열군

김영식(Young-Sik Kim),정정수(Jung-Soo Chung),노종선(Jong-Seon No),신동준(Dong-Joon Shin) 한국통신학회 2008 韓國通信學會論文誌 Vol.33 No.7C

최근에 홀수인 소수 p, n=4k, 그리고 d=((p<SUP>2k</SUP>+1)/2²에 대해서 Seo, Kim, No, Shin<SUP>[1]</SUP>이 m-sequence와 d로 decimation한 부분 수열들 사이의 상관 분포를 유도하였다. 하지만 이러한 상관 분포로부터 수열군이 자명하게 결정되지는 않는다. 본 논문에서는 우선 위의 상관 특성을 유지하는 수열군을 선택하는 방법을 제시한다. 더 나아가서 이 수열군과 동일한 상관 특성을 가지면서도 더 큰 선형 복잡도를 갖는 수열군을 새롭게 생성할 것이다. 끝으로 3진 수열의 선형 복잡도를 특정 경우에 대해서 유도하고 이 경우 원래의 수열군보다 더 큰 선형 복잡도를 가짐을 보일 것이다. For an odd prime p, n=4k, and d=((p<SUP>2k</SUP>+1)/2², Seo, Kim, No, and Shin<SUP>[1]</SUP> derived the correlation distribution of p-ary m-sequence of period pⁿ-1 and its decimated sequences by d. In this paper, two new families of p-ary sequences with family size p<SUP>2k</SUP> and maximum correlation magnitude 2√pⁿ-1 are constructed. The linear complexity of new p-ary sequences in the families are derived in the some cases and the upper and lower bounds of their linear complexity for general cases are presented.

아동 정신건강서비스에 대한 요구도 및 실제 이용에 관한 예비적 연구

김신영,조선미,임기영,정영기,신윤미 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : We aimed to identily the degree of perceived need and use of child mental health services, and to examine the factors associated with the perceived need and use of the child mental health services. Methods : The sample consisted of 3,477 children aged 8 to 13 years. The parents completed the sociodemographic data, the Korean version of the Child Behavior Checklist (K-CBCL), and the Korean version of DuPaul's Attention Deficit Hyperacti-vity Disorder Rating Scale (K-ARS). Results : Overall, 10% of children demonstrated the need for mental health services, and 2.36% utilized the child mental health services. All subcategoiy scores of K-CBCL and K-ARS were significantly low in the no help needed group. Factor sassociated with the actual use ofchild mental health services included social problems and thought problems. Conclusion : The demand for child mental health services is high, but only a small number of children are using mental health services. To increase actual use, it is necessary to educate and campaign for various child mental health.

벌 자상에 의해 발생한 횡문근융해증과 급성신부전

박상곤,김영대,강지은,신정현,신병철,박차영,정춘해 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Rhabdomyolysis is a syndrome characterized by muscle necrosis and release of intracellular muscle constituents into the circulation. The spectrum of causes is quite broad and included disorders of traumatic, metabolic, infectious and toxic origin. However, rhabdomvolvsis and acute renal failure following bee sting is rare and its pathogenesis is not well known. We experienced a case of 63-year-old man with acute renal failure and rhabdomyolysis caused by bee sting. He was stung by bee on scalp and neck. Oliguria was developed within several hours. He has fully recovered after general supportive care including fluid therapy and diuretics. This case demonstrates that rhabdomvolysis with consequent acute renal failure are able to developed by bee sting.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

재발성 류마티즘 환자에서 발작의 유발인자

주유철,이동민,양종태,신병철,임태영,서정균,정기영,최동헌,김원,조영신,고희관 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Palindromic rheumatism (PR) is known to be triggered without any obviously inciting events in most patients, although, in a few cases, attacks have been noted to relate to another events such as weather change, childbirth, ingestion of certain foods, or over-exercise. The aim of this study was to characterize the triggering factors on palindromic attacks. Materials and Methods : We evaluated sixty-four patients with PR for the presence of triggering factors and the relationship between attacks and triggering factors by interview of patients. We considered that there was an probable association between episodes and PR, if episodes within 24 hours prior to PR had triggered at least 50% of all attacks and a definite association between episodes and PR, if episodes within 24 hours prior to PR had triggered 100% of all attacks. Results : In 15 patients (35.9%), there was a possible association between episodes of PR and initiating events. In 8 patients (12.5%), there was a definite association between episodes of PR and initiating events. The triggering factors were physical over-activity including exercise (19/64: 29.7%), foods, such as rawfish, crab, and chicken, including alcohol (19/96: 19.8%). However, there were no difference between the groups with and without the triggering factor in sex ratio, duration and onset of PR, the positive rate of rheumatoid factor and involved sites. Conclusion : Our observations showed that PR was triggered by physical over-activity more than in previous reports and hypersensitivity to foods was a causative factor in some patients with PR. However, patients with triggering factors had a similiar clinical profile to patients without triggering factors.

STS 교육운동의 국내 연구 경향 분석과 적용 방안에 관한 조사 연구

정완호,권용주,김영신 한국교원대학교 과학교육연구소 1993 청람과학교육연구논총 Vol.3 No.1

The purposes of this study are to analyse trend of STS movement in Korea and to collect basic data on application of STS to school science education. It investigated, from 1990 to March 1993, journals of 6 associations, a monthly magazine of science education, and printed materials of seminars or workshops about science education. It also surveied a question to 47 science teachers and 26 researchers who had experienced STS workshop. The results of the study are as follows: (1) The studies of STS increased since 1990, but they are made at a introduction or background of STS. (2) The 98.7% of the respondents want to apply STS in school science education. (3) They responded that a device for the application of STS which is added last part of each chapter or last chapter, will use the STS program that made by subject, still maintain current science curriculum. (4) They responded that the knowledge & compreshion domain and inquiry process domain contain more high than others. (5) The STS subjects for application to the school science education are as follows: Environment pollution, science for living, ethics of science, human health and disease, information communication, an ecosystem destruction, development and storage of natural resources. This study suggested that establishment of a research institute for systematic research of STS, in-service training, a new evaluation process, a balancing of other subjects and increasing learning hour and changing objectives.

증기발생기 전열관 검사를 위한 차동형 원격장와전류 탐촉자 설계

신영길,신상호,정태언 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

As steam generator (SG) tubes have aged, new and subtle flaws have appeared. Most them start growing from outside the tubes. To find outer diameter defects more easily, the author had shown that the remote field eddy current (RFEC) technique, which had shown equal sensitivity to inner diameter (ID) and outer diameter (OD) defects, is feasible for the inspection of SG tubes. Based on the results obtained in that study, this paper designed a differential RFEC probe and studied the characteristics of differential RFEC signal. Finite element modeling studies show that the differential signal still has the equal sensitivity to ID and OD defects and at the same time it is possible to distinguish one from the other. Also noticed is that there is few degrees of signal rotation but sensitive changes in signal length when the depth of small defect varies. If the volume of defect is large, the changing rate of signal length is higher than that of defect size variation. The characteristics of signal show that the proposed differential RFEC technique can be a good alternative for the initial inspection of SG tubes.

NaCl이 보리(Hordeum vulgare L.) 잎의 엽록소 형광에 미치는 영향

정화숙,임영진,박강은,박신영 한국환경과학회 2004 한국환경과학회지 Vol.13 No.12

This study was conducted to investigate the changes of chlorophyll contents and chlorophyll fluorescence in barley(Hordeum vulgare L.) 7 day old seedling treated with 0.2M, 0.4M, 0.6M, 0.8M, and 1.0M NaCl concentration containing Hepes buffer(pH 7.5). Barley was affected by NaCl treatment. The chlorophyll a, b and carotenoid of barley decreased with an increase in NaCl concentration. However, chlorophyll a, b and carotenoid of barley were not greatly influenced by o.8M and 1.0M NaCl. Fv, Fv/Fm and qP were gradually decreased by higher concentration of NaCl. qP, qNP, qR and qE were gradually decreased by 6hr. During barley chloroplast was development NaCl affected chlorophyll synthesis than photosynthetic activity. Whereas barley seedling leaves were more influenced photosynthetic activity than chlorophyll contents by NaCl.

합병증이 동반된 Meckel씨 게실 2례 보고

정병욱,박동일,이준희,서정욱,원유홍,김웅,신현종,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

합병증이 동반된 Meckel씨 게실을 가진 환자의 치료에 대한 필요성은 과정이 문제이다. 하지만 우연히 만나는 게실의 처치는 논란 중이다. 부수적인 게실 절제술(incidental diverticulectomy)의 제안자는 증상이 있는 게실의 외과적 처치는 중요한 이환 및 사망률은 지적한다. 이를 반대하는 사람들은 전 생애를 통해 합병증의 위험성이 낮게 나타나므로 필요가 없다고한다. 게실의 예방적 제거는 개복술시 우연히 발견 될 때 시행한다. 이는 남아있는 게실이 나중에 합병증을 일으키는 것보다 술후 합병증의 위험성이 매우 적음을 알 수 있다. 저자들은 합병증이 동반된 Meckel씨 게실 2예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다. The necessity for therapy with complicated Meckel's diverticular is a matter of course.However, management of the incidentally encountered diverticulum is controversial. Proponents of incidental diverticulectomy point to the significant morbidity and mortality rates of surgical treatment of symptomatic divenicular. Other authors base their opposition to incidental diveniculectomy on the low risk of complications developing during lifetime. Prophyillctic removal of the diveniculum is indicated when it is found incidentally at laparotomy, because there are few postoperative complications and the risk exists that the remaining diverticulum may be the cause of later complication. The 2 cases of complicated Meckel's diverticulum are reported with a brief review of literature.