Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

Pender의 건강증진모형을 적용한 간호대학생의 건강증진행위 관련요인

한석영(Han, Seok­Young) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.8

본 연구목적은 Pender의 건강증진모형을 적용하여 간호대학생의 건강증진행위의 관련변인과 영향요인들을 확인함으로써 간호대학생의 건강증진을 위한 간호중재 방법의 개발을 위한 기초자료를 파악하는데 있다. K 광역시에 소재한 간호대학교의 간호대학생 399명을 대상으로 자료수집을 하였고, 자료분석은 SPSS/WIN 19.0을 사용 하여 대상자의 일반적 특성은 빈도와 백분율을, 대상자의 일반적 특성에 따른 건강 증진행위의 차이는 t-test와 ANOVA로 분석하여 Scheffé test로 사후검증하였고, 건강증진행위 관련요인들과의 상관관계는 Pearson’s correlation coefficient로, 건강증 진행위에 영향을 미치는 요인은 step­wise multiple regression을 이용하였다. 간호대 학생의 건강증진행위 평균은 2.66점이었고, 건강증진행위와 변수들과의 상관관계는 이전 건강관련행위(r=.300, p=.000), 지각된 장애성(r=.178, p=.000), 행위관련 감정 (r=.106, p=.034), 행동계획수립(r=.195, p=.000)과 유의한 순상관관계를 보였다. 간호 대학생의 건강증진행위에 영향을 미치는 가장 중요한 요인은 학년으로 2학년 이 전체 변이의 21.8%를 설명하였고, 이전 건강관련행위, 행동계획수립, 행위관련 감정, 지각된 장애성, 연령과 함께 전체 변이의 36%를 설명하였다. 따라서 본 연구에서 간호대학생의 건강증진행위를 가장 잘 설명해주는 요인으로는 개인적인 특성에서 학년으로 나타났다. 이상의 연구결과를 바탕으로 간호대학생의 학년 및 연령에 따른 건강증진 프로그램이 요구되고, 이전의 건강관리행위, 행동계획수립, 행위관련 감정, 지각된 장애성을 고려한 건강증진 프로그램으로 효과를 높일 수 있는 전략이 필요하 다. The purpose of this study was to identify the factors influencing health promoting behaviors and the related determinants affecting nursing college student’s health based on the Health Promotion Model by Pender(1996). The data was collected by self-reported questionnaire from 399 participants under the permission of data collection in at K metropolitan city. For data analysis, SPSS/ WIN 19.0 program was utilized for descriptive statistics, t­test, ANOVA, Scheffé test, Pearson’s correlation, and step­wise multiple regression. The average score for the HPBs, consisting of 6 subscales was 2.66. The highest mean score was 2.80 in ‘interpersonal relations’ and the lowest one was 2.54 in ‘Physical activity’. The HPBs were positively associated to ‘prior related behavior’ (r=.300, p=.000), ‘perceived barriers to action’ (r=.178, p=.000), and ‘activity related affect’ (r=.106, p=.034), and ‘commitment to a plan of action’ (r= .195, p=.000). The most important variable in HPBs was ‘2nd grade’. It explained 21.8 % out of the total variance of HPBs. ‘Prior related behavior’, ‘perceived barriers to action’, ‘activity related affect’, ‘commitment to a plan of action’, and ‘age’ explained 36%. According to the results of this study, the suggestions were as follows. It is necessary to develop program considering the grade of nursing college students. To facilitate and maintain HPBs of nursing college students must be mutually planned interactive health prevention programs.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

Ergodic Markov Model에 의한 랭킹방법

한영석 수원대학교 자연과학연구소 2001 자연과학논문집 Vol.4 No.-

인터넷의 급속한 양적 증가에 의해 원하는 정보를 색인어 방식만으로는 찾아내기가 쉽지 않다. 따라서 사이트의 여러 가지 특성에 따라 계층적으로 분류해놓은 웹 디렉토리를 이용하거나 관련 전문가들의 추천 리스트를 이용하여 검색하기도 한다. 이는 기존의 색인어 기반의 검색 방식과 달리 어느 정도의 균등한 질적 보장을 제공하며, 색인어로 나타나지 않는 문서나 사이트의 특징을 이용할 수 있기 때문이다. 본 연구에서는 기존의 색인어 기반의 검색 모델에 웹 디렉토리와 추천 문서 같은 문서간의 링크 정보를 결합하는 정보 검색 모델을 제시한다. 특정 질의어의 검색 결과로 얻어낸 문서와 그 문서와 연결된 문서를 이용하여 네트워크를 구성한다. 이 네트워크에 검색기가 제시하는 순위와 유사도, 그리고 문서 간의 링크 정도를 이용해서 확률값을 정해준다. 그리고 이를 Ergodic Markov Model의 특성을 이용하여 각 문서로 이동할 확률값을 계산한다 이를 통해 여러 문서에 널려있는 링크 정보를 이용하여 색인어로 부족한 정보를 얻을 수 있다.

인체 방광암에서 p33^ING1의 발현 변화

이석영,신관희,한광희,이상철,김용태,김원재 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

Pastry 마가린 함량과 적층 수에 따른 puff pastry 제조 특성

한장호,김석영,윤여창,이시경 한국응용생명화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.4

Puff pastry의 제조 공정에서 pastry 마가린 함량과 적층 수의 변화가 제품의 수분 함량, 굽기 손실, 부피, vapor action 등에 미치는 영향을 조사하였다. Pastry 마가린 함량이 90%로 동일하고 적층 수가 27결일 경우 10.8±0.6%의 수분 함량을 나타냈으며, 1024결일 경우 16.7±0.3%로 적층 수가 증가할수록 제품의 수분함량은 증가 하는 경향을 보였다. 적층 수를 256결로 동일하게 하고, pastry 마가린 함량이 50%일 경우는 17.3±0.5%로 나타났으며, 130%에서는 7.5±0.2%로 pastry 마가린 함량이 증가할수록 제품의 수분 함량은 감소하였다. Pastry 마가린 함량을 70%로 동일하게 했을 때 굽기 손실의 변화는 27결일 경우 25.0±0.7%로 나타났으며, 1024결일경우엔 18.8±0.6^로 나타나 적층 수가 증가할수록 제품의 굽기 손실은 감소하는 경향을 보였다. 적층 수를 27결로 동일하게 한 경우에서는 pastry 마가린 함량이 90%일 때 25.4±0.4%의 굽기 손실이 발생하였으며, 110%에서 26.9±0.4%로 굽기 손실이 가장 높게 나타났다. Pastry 마가린 함량이 130%이고 적층수가 81결일 때에 21.87±0.79㎖/g로 최대의 부피를 나타내었다. 또한 vapor action의 크기는 9.15㎜가 pastry 마가린 함량 110%, 적층 수 256결에서 8.25±0.50개로 가장 많이 나타났다. This study was carried out to investigate the effect of pastry margarine content and number of layers on moisture content, baking loss. specific loaf volume and the vapor action in the manufacturing process of puff pastry. As the number of layers of the puff pastry increased the moisture content of the products slightly increased. And the moisture contents of the products decreased, as the pastry margarine contents of the puff pastry increased in the same number of layers. The baking loss of the products tended to decrease as the number of layers increased. On the other hand, as the pastry margarine contents of the puff pastry increased, the baking loss of the product increased. When the pastry margarine content in puff pastries became 130%, 81 layers provided the maximum specific loaf volumes 21.62±0.79 ㎖/g of puff pastries. When 110% of margarine and 256 layers were applied for preparation of puff pastry, the number of vapor action was 8.25±0.50 with the vapor action size of 9-15 ㎜.

전파조정기를 이용한 마이크로파 소자용 Calibration

석은영,조현광,서영석,한교용 영남대학교 공업기술연구소 2000 工業技術硏究所論文集 Vol.28 No.1

A microwave device measurement tool kit using the TRL method for microwave tuner was developed. Teflon substrate was used for easy manufacturing. An adapter from CDI was used for the junction transition between microstrip and coaxial line. Mask production procedure which have the 3:1 reduction ratio was developed for microstrip transmission line manufacturing. Using these procedure the Cal Kit which can have Thru, Reflect, and Line was manufactured. TRL error correction method can be applied to the Kit. We tested the Cal kit and the error due to the microstrip line could be corrected. It can be applicable to the accurate measurement of microwave transistors.

부상공정에서 금속이온의 기포 표면 전위 특성 및 반응효율

한무영,독고석,김영환 대한상하수도학회 2004 상하수도학회지 Vol.18 No.2

Flotation processes involve the use of very small bubbles(micro-bubbles) to separate particles from water. The process has become a good alternative to sedimentation, especially where the particles are small or of low density. Although the flotation process commences with a collision between particles and bubbles, most research has been focused only on the characteristics of the particles. In this paper, recent theoretical and experimental research on the characteristics of bubbles is summarized. The effect on the collision efficiency of the size and charge of bubbles is calculated through trajectory analysis. The size and charge of bubbles are measured under different conditions and the ramifications of the results are discussed. The results may lead to a better understanding and optimization of the existing process. In particular, we discuss an idea that a new advanced flotation process might be possible by the modification of the characteristics of the bubble alone or of both bubble and particle.

청소년 자살의 원인과 치료적 개입

한기석,정영조 인제대학교 1992 仁濟醫學 Vol.13 No.2

최근 청소년 자살이 증가하고 있으므로 청소년 자살의 원인과 자살의 예측인자에 대한 고찰을 통하여 이들의 자살을 예방하고 치료에 도움이 되고자 하였는데 특히 부모, 교사 및 일반 타과 의사에게 도움이 되도록 기술하였다. Currently, the suicidal rate is rising most rapidly in adolescence. In this article, we review the recent research for causes and therapeutic intervention of adolescent suicide. The risk factors include psychiatric disorders-such as affective, conduct, and subatance abuse disorders-, developmental and personality types, familial and environmental factors, and biologic factors. It is important for us to prevent suicide that is extensive efforts for early identification and intervention. And it is also needed changes in value system, the attitude of repoters, and the way of bringing up children for prevention it,