서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

흰쥐에서 음경발기 평가의 척도로서 음경해면체내압측정술 확립

송윤섭,김용준,이광우,김준모,문기혁,박영호,민영기,유형균,김형건 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: Because studies about the control of penile erection at the entral nervous system was dependent on the animal experiments, establishment of measuring penile erection is important to evaluate the effects changes at the central nervous system on the penile erection. Intracavernous pressure measurement in rats has been introduced as a suitable index for the evaluation of penile erection but this method is invasive and technically difficult. So, we established the intracavernous pressure measurement in rats as the experimental index for penile erection. Materials and Methods: 42 male adult Sprague-Dawley rats (250-300gm) were divided to saline or papaverine treated group. Rats were placed on a heating table to maintain their body temparature and anesthetized with 50mg/kg of pentobarbital sodium by intraperitoneal injection. A cannula was inserted to the left carotid artery to measure systemic blood pressure. Saline (0.05, 0.1ml), papaverine(0.05, 0.1, 0.25, 0.5, 1.0, 2.0mg) were injected intracavernously via 26 guage needle filled with saline or papaverine which connected to pressure transducer and polygraph was inserted into the corpus cavernosum on one side to inject the drug and to measure intracavernous presure. Results: Properly executed insertion and intracavernous administration produced a instantaneous but transient rise in intracavernous pressure that substantially stabilized and maintained at 5.4±0.4mmHg. Intracavernous pressure and duration of penile blood flow following intracavernous injection of papaverine are increased comared to those of saline. Conclusions: Monitoring intracavernous pressure in rats represents a suitable index for the evaluation of penile erection in small laboratory animals.

Real-World National Colonoscopy Volume in Korea: A Nationwide Population-Based Study over 12 Years

Jae Myung Cha,Min Seob Kwak,Hyun-Soo Kim,Su Young Kim,Sohee Park,Geun U Park,Jung Kuk Lee,Soo Jin Kim,Hun Hee Lee,Joo Sung Kim,Won Ho Kim,Big Data Research Group of the Korean Society of Gastroenterol 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.3

Background/Aims: Little is known about the national colonoscopy volume in Asian countries. This study aimed to assess the national colonoscopy volume in Korea over a 12-year period on the basis of a nationwide population-based database. Methods: We conducted a population-based study for colonoscopy claims (14,511,158 colonoscopies performed on 13,219,781 patients) on the basis of the Korean National Health Insurance Service database from 2002 to 2013. The 12-year national colonoscopy burden was analyzed according to patient age, patient sex, and healthcare facility type. Results: The overall volume of colonoscopy increased 8-fold over the 12-year period. The annual colonoscopic polypectomy rate significantly increased in all patient sex and age groups over the 12-years period (all p<0.001). The yearly colonoscopic polypectomy rate for men was significantly increased compared with that for women (2.3% vs 1.7%, p<0.001) and for the screening-age group compared with that for the young-age group (2.0% vs 1.6%, p<0.001). The yearly colonoscopic polypectomy rate relative to the total colonoscopy volume significantly increased in primary, secondary, and tertiary facilities by 2.4%, 1.9%, and 1.4% during the 12-year period (all p<0.001). In addition, the annual colonoscopy volume covered by high-volume facilities significantly increased by 1.8% in primary healthcare facilities over the 12-year period (p<0.001). Conclusions: Healthcare resources should be prioritized to allow adequate colonoscopic capacity, especially for men, individuals in the screening-age group, and at primary healthcare facilities. Cost-effective strategies to improve the quality of colonoscopy may focus on primary healthcare facilities and high-volume facilities in Korea.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

PCR에 의한 뽕나무萎縮病 및 대추나무비자루病 마이코플라스마의 DNA檢出

金榮浩,韓相燮 全北大學校 1994 論文集 Vol.37 No.-

Mulberry dwarf disease and jujube Witches' broom disease are caused by mycoplasma-like organism(MLO), which are transmitted by Hishimonus sellatus. Their disease symptoms are very much similar. To examine the relatedness of mulberry dwarf mycoplasma to the jujube witches' broom mycoplasma, the total DNAs were extracted from four different parts of infected mulberry and jujube. The MLO-DNAs in the total DNAs were amplified by PCR and were identified at 1300bps by agarose gel electrophoresis respectively, But we couldn't find differentiation of Jujube witches' broom MLO to Mulbery dwarf MLO.

비지의 영양학적 품질특성

김군자,류호경,이영근,김동섭 밀양대학교 농업기술개발연구소 2000 農業技術開發硏究所報 Vol.4 No.1

This study was carried out to examine the qualities of soybean curd residue for utilizing as foodstuff. The content of moisture, crude protein, crude fat and ash were 80.98, 3.32, 0.94 and 0.82%, respectively. The major fatty acids were linoleic acid, oleic acid, linolenic acid and stearic acid. The hydrolysate of protein of sobean curd residue was composed chiefly of aspartic acid, glutamic acid, glycine, alanine, arginine and threonine, but the major free amino acids of soybean curd residue were arginine(234.1), ethanolamine (91.6), γ -amino-n-butyric acid(60.2), glutamic acid(55.8), valine(49.8), asparagine(47.3) and Iycine(48.3μ mol/100g). Key words : Soybean curd residue, Fatty acid, Amino acid

야생 등줄쥐 (Apodemus agrarius coreae) 간뇌의 Dopamine성 신경세포

정영길,이남섭,민성기,김무강 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

내포 병행 프로그램의 수행중 자료경쟁 탐지를 위한 수정된 SNR 레이블링 알고리즘

김영철,송태섭 진주여자전문대학 1997 論文集 Vol.20 No.-

Detecting races is important for debugging shared-memory parallel programs, because the races result in unintended nondeterministic executions of the programs. Previous monitoring techinque SNR for on-the-fly race detection show a little fault. So this paper presents enhenced SNR labeling algorithm. The program condered in this paper have nested parallelism and no other inter-task coordination

항정자항체 평가에 있어서 정장액 interleukin-6 측정의 유용성

김민의,박영호,송윤섭 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Breakdown of the blood-testis barrier by infection, trauma, or operation allows sensitization of spermatozoal antigens. Sperm antibodies may be a relative cause of infertility in infertile males. Multiple assay techniques have been developed to detect antisperm antibody. Older tests have been supplanted by the newer immunoglobulin specific assays. Immunobead test was used widely. Interleukin(IL)-6 is necessary for formation of antibody. So, this study was performed to investigate the value of interleukin-6 in the detection of immunologic cause of infertility. The antisperm antibody titers and interleukin-6 was measured in 10 healthy males and 30 patients with chronic prostatitis using immunobead methods and enzyme immunoassay kit. Titers of direct and indirect IgG, IgA and IgM antisperm antibody(% binding) was 0/0.7±0.7, 0/0, 0/0.1±0.1 and 0/1.1±0.5, 0/0.1±0.06, 0/1.1±0.6 in control group and patients with chronic prostatitis. Titers of direct and indirect IgG, IgA and IgM antisperm antibody was 1.8±1.7,0, 0.3±0.3 and 0.3±0.9, 0, 2.8±1.1 in patients with chronic prostatitis whom the antisperm antibody was found in. There was significant difference in indirect IgG and IgM between control group and patients with chronic prostatitis whom the antisperm antibody was found in. The value of seminal IL-6(pg/ml) was 3.2±0.9 and 9.6±2.3 in control group and patients with chronic prostatitis. There was significant difference. The value of seminal IL-6 was 7.0±2.7 and 13.4±5.1 in patients without chronic prostatitis and patients with chronic prostatitis. There was no significant difference. It is suggested that the examination of seminal IL-6 alone can be useful to evaluate the immunologic state of seminal tract but can not take the place of Immunobead test that detect the antisperm antibody formation.

β-mercaptoethanol, hyaluronic acid, EGF가 돼지난포란의 체외수정과 체외발생에 미치는 영향에 관한 연구

김용섭,김민수,김상근 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

The study was carried out to evaluate the effects of β-mercaptoethanol(β-ME), hyaluronic acid(HA) and epidemal growth factor(EGF) supplemented to the TCM-199 culture media on in vitro fertilization and in vitro developmental rates of porcine oocytes. The porcine follicular oocytes and embryos were cultured in TCM-199 media containing hormones, β-ME(10, 50, 100 μM), HA (0.5, 1.0, 1.5 ㎎/㎖), EGF(5,8,10%) and PSA(10%) for 40-48 hrs and 8-9 days in a incubator with 5% CO_2 in air at 38.5℃. In vitro developmental rates were defined as development rate on in vitro culture or FDA-test. The results are summarized as follows ; 1. The in vitro feertilization and in vitro developmental rates of porcine oocytes cultured in TCM-199 media supplemented with 10, 50, 100 μM β-ME were 85/113(75.22%), 89/111(80.18%), 92/108(85.19%) and 28/113(24.78%), 36/111(32.43%), 30/108(27.78%), respectively. 2. The in vitro feertilization and in vitro developmental rates of porcine oocytes cultured in TCM-199 media supplemented with 0.5, 1.0, 1.5 ㎎/㎖ HA were 80/103(77.67%), 84/100(84.00%), 82/105(78.09%) and 27/103(26.21%), 35/100(35.00%), 30/105(28.57%), respectively. 3. The in vitro feertilization and in vitro developmental rates of porcine oocytes cultured in TCM-199 media supplemented with 5, 8, 10% EGF were 79/101(78.22%), 86/105(81.90%), 85/103 (82.52%) and 23/101(22.77%), 30/105(28.57%), 32/103(31.07%), respectively. 4. The in vitro feertilization and in vitro developmental rates of porcine oocytes cultured in TCM-199 media supplemented with 10% PSA and 50 u β-ME, 1.0 ㎎/㎖ HA, 8% EGF were 73/85(85.88), 70/80(87.50%), 71/82(86.59%) and 29/85(34.12%), 30/80(37.50%), 25/82(30.49%), respectively. The in vitro fertilization and developmental rates were significantly higher than those of non-supplemented PSA and β-ME, HA, EGF.