Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)

전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.

한약에 의해 유발된 급성 간질성 신염 2례

김덕윤,박동건,김응석,강영모,양창헌,이정호,이동철,이영현,김정란 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

간질성 신염은 신장의 간질을 선택적으로 침범하는 염증성 질환으로 여러가지 원인에 의해 유발되며, 이 중 약물에 의한 경우는 각종 항생제, 비스테로이드성 진통제, 항경련제, 이뇨제, 면역억제제등에 의한 증례들이 보고되고 있다. 현재 각종 질환-특히 만성질환-의 치료에서 한약이 차지하는 비중이 적지 않으나, 그 각각의 성분들이 유발할 수 있는 부작용들에 대한 연구는 거의 없는 실정이다. 저자들은 관절염 치료를 위해 중국산 한약을 복용한 후 복통, 피로감 및 육안적 혈뇨를 주소로 내원한 두 환자에서, 단백뇨와 신기능 장애를 보여 시행한 신조직 생검상 급성 간질성 신염에 합당한 병리학적 소견을 보이고, 한약 복용 중지 후 급속한 회복을 보여, 한약에 의해 유발된 것으로 사료되는 급성 간질성 신염 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Acute interstitial nephritis is a disease characterized by renal interstitial inflammatory cell infiltration and acute renal functional deterioration. This is caused mainly by antibiotics, NSAID and diuretics such as thiazide, but cases induced by herb medication are rare. We experienced two cases of acute interstitial nephritis after treatment with herb medication. One 71-year-old female patient and the other 60-year-old female were admitted to the hospital because of general weakness and gross hematuria. Microscopic hematuria, pyuria, and proteinuria were presented. After definitive diagnosis with a renal biopsy, we noted rapid recovery of renal function by drug withdrawal and steroid therapy. We report these cases with a review of the referenced literatures. Key Words : Herb medication, Acute Interstitial nephritis.

고등학교 성교육 프로그램 개발에 관한 예비적 연구

이영란 참마음교육학회 2006 未來敎育硏究 Vol.13 No.2

본 연구는 현재 제 7차 교육과정의 국민 공통기본 교육과정과 고등학교의 선택교육과정이 모두 적용되는 시점에서 교육인적자원부가 2001년에 제작·배포한 성교육 교사용 지도 지침서와 성교육 관련 각종 고등학교 교과서에 산재된 성교육 프로그램 중 가장 미흡하다고 평가된 양성 평등 의식과 성적 의사결정 능력 등의 영역을 보완하여 좀 더 일관성 있고 체계적인 성교육 프로그램의 개발이 시급하다는 문제의식에서 오늘의 우리 사회가 안고 있는 청소년의 성적 비행과 탈선의 문제들을 학교교육의 현장에서 예방하고 해결하는 데 기여할 수 있는 성교육 프로그램 개발의 필요성과 중요성에서 출발하고 있다. 이 같은 연구의 주요 연구의 내용은 다음과 같다. 첫째, 2001년 교육인적자원부에서 제작·배포한 성교육 관련 교과서의 교사용 지도 지침서와 각종 관련 연구보고서와 논문을 준거로 한 '성교육 관련 교과서 분석의 틀'을 구안·제작한다. 둘째, 본 연구자가 구안·제작한 '성교육 관련 교과서 분석의 틀'로 현행 고등학교의 성교육 관련 교과서의 성교육 프로그램을 분석한다. 셋째, 새로운 학문적 접근인 '인간교육학'의 개념체계에 기초하여 일선 고등학교의 교수-학습 전개과정에서 실제로 활용할 수 있는 '성교육 프로그램 개발의 개념 모형을 구안한다. 넷째, 본 연구자가 구안한 '성교육 프로그램 개발의 개념 모형'을 바탕으로 고등학교의 교수-학습 전개과정에서 성교육을 위한 단일 교과서용 프로그램을 시안적으로 개발한다. At a time when both the national common basic curriculum of the 7th curriculum and the elective course of high schools are applied, the realm of the awareness of gender equality and sexual decision-making was assessed to be the most insufficient of the teacher's manual for sexual education and various sexual education programs scattered in high school textbooks which were produced and distributed by the Ministry of Education and Human Resources Development(MOE) in 2001. Thus, developing a more consistent and systematic sexual education program by supplementing this realm is urgently required. Having such a critical mind, this study begins by stressing the necessity and importance of developing the sexual education program that will contribute to the prevention and solution of the issue of sexual misdemeanors and deviated behaviors on the field of school education which our society is faced with today. In order to satisfy the needs for the study said above, this study set the 3 basic objectives. Firstly, this study analyzes the sexual education programs in the manual for sexual education which were produced and distributed by MOE based on the 7th curriculum currently in practice. Secondly, this study analyzes programs in various textbooks related to the sexual education currently in practice. Thirdly, the program conceptual model for sexual education that can be used on the field of the high school education is proposed, based on which a tentative sexual program is developed. The main contents of this study selected to achieve the basic purpose of this study are as follows. Firstly, this study proposes and produces 'the framework for analyzing the textbooks related to sexual education' in accordance with the teacher's manual for sexual education and various research reports and theses which were produced and distributed by MOE in 2001. Secondly, the sexual education program in the textbooks related to the high school's sexual education that is currently in practice was analyzed using 'the framework for analyzing the textbooks related to sexual education' proposed and produced by the writer. Thirdly, this study proposes the conceptual model for 'development of sexual program that can be practically utilized in the teaching-learning process at the high school based on the conceptual system of 'the Study of Human Education' , a new scientific approach. Fourthly, this study tentatively develops a program for a single textbook for sexual education in the teaching-learning process at high schools based on 'the conceptual model for 'development of sexual program' proposed by the writer. In order to conduct the contents of this study specifically, literature analysis method that is focused on related literature and data was used. The following conclusion was found based on the process and result of this study conducted so far. Firstly, two frameworks for analyzing the textbooks related to sexual education were proposed and produced: that is, 'the framework for sexual education by grade and by subject〈table I-2〉' and 'the framework for sexual education by subject and by printing firm 〈table I-3〉'. Secondly, as a result of analyzing the teacher's manual for high school sexual education currently in practice, it was found that the programs which were dealt with mostly importantly were 3 categories- 'Development of Body and Psychology' , 'Understanding of Human relations' and 'Sexual Culture and Ethics' , 9 realm, 21 sub-realms and 61 themes. Thirdly, two facts were revealed from the analyses of this study. One of the facts is that there is a lack of education system in the teacher's manual for high school sexual education and various sexual education programs in the textbooks currently being used throughout the nation, one other fact is that there is a lack of consistent connection in the context with elementary and middle schools' sexual programs. Fourthly, 'the model for developing the sexual program' presented in 〈picture V-1〉 was proposed, in a accordance with 'the basic element of education' of 「the Study of Human Education」, a new scientific approach. Fifthly, the tentative program for a single textbook for sexual education to be used in the teaching-learning process at high schools was developed in accordance with 'the conceptual model for developing the program for sexual education' and 'the framework for analyzing the textbooks related to sexual education' proposed by the writer. This program for a single text book for high school sexual education was composed of 3 categories, 9 higher realms, 21 middle realms, 29 sub-realms and 75 themes in accordance with the high school teacher's manual provided by MOE.

日本天孫降臨神話考

李永蘭 대구효성 가톨릭 대학교 1988 연구논문집 Vol.36 No.1

중학생의 건강행위에 영향을 미치는 결정요소

이영란,소희영 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

The study aimed to verify The Interaction Model of Client Health Behavior by Cox in order to extend the understanding for the health behavior of middle school students. The survey was conducted to the second-grade students of two middle schools in Dae Chun Metropolitan City by questionnaire from July 5 to 15, 1995. Total 660 students responded the research tool after the explanation of nurse teacher. A demographic questionaire was developed by researcher. Health Perception was measured by Ware's scale, Health self-determinism index for children was used to measure intrinsic motivation. Self-esteem was measured by the Harter's self perception profile for children. Health beha vior was measured by Ki's health behavior scale. Collected data was processed through the frequency, t-test, ANOVA and regression test of SAS program. The findings obtained were as follows; 1. Statistically meaningful difference was found about the health behavior acccrding to gender(t=4.25, p<.001). Boy students showed more health behavior than girl students. 2. As to boy students, the determinants of the health behavior were father's health, student's health and father's education among client peculiarity elements, which appeared to have influence on the intrinsic motivation, health perception and self-esteem of mediating variables. Among the mediating variables health perception was the determinants of the health behavior. 3. As to girl students, the determinants of the health behavior were father's health, student's health, father's education and mother's education among client peculiarity elements, which appeared to have influence on the intrinsic motivation, health perception and self-esteem of the mediating variables. Among the mediating variables, the intrinsic motivation and health perception were the determinants of the health behavior. 4. In this model, the determinants of boy students explained the health tehavior by 6%, and the ones of girl students by 11.6%. From the above findings, the variables constituting the health behavior appeared to be of very low utility. More study seemed to be needed to verify the validity of the IMCHB. It's not possible for nurse teacher to directly mediate the populational sociological variables in regards of student peculiarity. But continuous health education by nurse teacher would improve student's intrinsic motivation, health recognition and self-esteem and guide the desirable health behavior. Besides, cooperation with community resources would be helpful to develop a program improving parent's health, and finally to improve the health behavior of middle school students.

天孫降臨と聖婚物語

李永蘭 효성여자대학교 한국전통문화연구소 1995 韓國傳統文化硏究 Vol.10 No.-

始祖神이 山上에 來臨하는 神話의 유형은, 北方아시아 지역에 널리 분포되어 있는 것으로,『古事記』『日本書紀』의 내용을 중심으로 하는 일본신화에서도 예외는 아니다. 天上世界의 이야기가 주로 다루어지는 高天原系神話에서는, 天照大神에 의해 天孫이 「中ツ國」에 내려와 혼돈과 무질서 상태의 지상국을 다스리게 된다는 내용이 주를 이루고 있다. 본고에서는 天上世界에서 地上世界로 下降한 天孫이 즉위의식과 함께 곧이어 혼인의식이 갖추어지고 있는 것으로 전하여지는 부분을 들어서 그 점이 의미하는 바의 중요성을 인식하고자 한다. 日本神話의 구성에서 보이고 있는 天孫과 地上神의 딸 "木花之開耶姬"와의 혼인이 의미하는 바에 대하여, 종래의 민속적인 측면에서 연구한 부분, 그리고 제례의식적인 면에서 분석한 내용 등을 아울러 검토한 후, 본 논문에서는 이러한 시각과는 달리 이 부분을 규명해 보고자 한다. 古代帝王이 天神系 또는 天神을 아버지로 하고, 물의 女神을 어머니 또는 妃로 삼아, 天界水界 양쪽을 支配하는 靈能을 所有하고 있는 것으로 얘기되어지는 神話는 여러민족에게 전하고 있는 것으로, 그 形相에는 여러가지 다소 차이는 보이고 있으나, 근본 이면에 있어서는 공통하고 있는 것이다. 記紀神話 중에는 地方아시아적 요소 뿐 아니라, 南方 해양민 문화 요소도 많이 포함하고 있어, 高天原系 神話인 天孫의 강림을 서술한 부분은 다분히 前者의 내용을 다룬 것이며, 木花之開耶姬와의 혼인이야기 부분은 後者의 요소를 전하고 있는 것이다. 그것이 즉위 후 성혼이 있게 되고 그로서 왕권이 성립됨이 묘사 되어진 후, 점차 왕권의 성장과 더불어 왕권의식이 강화되어져 가게 된다. 더불어 木花之開耶姬와의 결혼부분에서 언급되는 天孫의 모습은 분명히 海上來訪型의 神의 性格을 띈 것으로 묘사되어지던 것이, 그 내용이 변화 되어져서, 天上에서 강림하는 天上神의 성격으로 바뀌어져 간 것으로 유추해 보는 바이다.

중학생의 아토피피부염 유무에 따른 생활양식 비교 연구

이화자,조영란,박지은 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.2

Purpose:This study compared lifestyles of middle school students with and without atopic dermatitis in order to obtain the baseline information for health education. Methods:This study involved 256 students from 20 middle schools in Busan who suffered from atopic dermatitis and 231 students from 2 middle schools in Busan who did not have atopic dermatitis. Results:Students with atopic dermatitis had a lower family income (塔=16.99, p<.001) and were more likely to come from a nuclear family (塔=10.28, p<.001) than control students. 98% of the students with atopic dermatitis had several skin symptoms. 78.5% of students with atopic dermatitis reported experiencing difficulties in their daily because of their condition. Students with atopic dermatitis took shorter baths and used soap less frequently than the students in the control group. The students with atopic dermatitis cleaned their houses and bedclothes more often than normal students in an attempt to remove cockroaches and house-dust mites. Students with atopic dermatitis also ate fast and instant foods more often than normal students. Conclusions:Some lifestyle differences exist between students with and without atopic dermatitis. Therefore, education and guidance may be important to promote good health and improve lifestyle quality.

高天原 神話

李永蘭 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1

康有爲의 敎育改革

이영란 조선대학교 전통문화연구소 1999 전통문화연구 Vol.6 No.-