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$CCl_4$속에서 Thioamides 와 Dimethyl Sulfoxide (DMSO) 사이의 수소 결합에 대한 연구
도영락,김선진,윤창주,최영상,Young-Lac Do,Seon-Jin Kim,Chang-Ju Yun,Young-Sang Choi 대한화학회 1992 대한화학회지 Vol.36 No.2
사염화탄소 속에서 대단히 묽은 티오아미드 및 티오아미드-DMSO 용액의 $ν_{\alpha}$ + Amide II 조합띠에 대한 근적외선 스펙트럼을 $5^{\circ}C$ 와 $55^{\circ}C$ 사이에서 얻었다. 이 조합띠는 두 개의 Lorentzian-Gaussian product 함수로 분해되며, 각각은 단체 티오아미드 및 1 : 1 티오아미드-DMSO 복합체로 확인되었다. 티오아세트아미드(TA)와 DMSO 사이의 수소결합은 티오프로피온 아미드(TPA)와 DMSO 사이의 수소결합보다 약간 강하며 $CCl_4$ 속에서 TA-DMSO와 TPA-DMSO 1: 1 복합체에 대한 ${\Delta}H^{\circ}$는 각각 -15.3 kJ${\cdot}$$mol^{-1}$ 및 -14.2 kj${\cdot}$$mol^{-1}$이었다. Near-IR spectra for $ν_{\alpha}$+ Amide Ⅱ combination band of thioamides, and very dilute thioamide-DMSO solution in CCl4 were recorded in the temperature range of $5^{\circ}C$ to $55^{\circ}C$. This combination band was resolved by the computer program into two Lorentzian-Gaussian product function which have been identified with monomeric thioamide and thioamide-DMSO 1 : 1 complex. Equilibrium constants and thermodynamic parameters for the thioamide-DMSO hydrogen bonding were elucidated by the analysis of conce ntration and temperature dependent spectra. The hydrogen bonding strength between thioacetamide (TA) and DMSO in $CCl_4$ is stronger than that between thiopropionamide (TPA) and DMSO in CCl4. The ${\Delta}H^{\circ}$ for the TA-DMSO and TPA-DMSO 1 : 1 complex in CCl4 were -15.3 kJ${\cdot}$$mol^{-1}$ and -14.2 kj${\cdot}$$mol^{-1}$, respectively.
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( Jin Sung Park ),( Dong Kyu Kim ),( Hyun Dae Shin ),( Hyun Jae Lee ),( Ho Seung Jo ),( Jin Hoon Jeong ),( Young Lac Choi ),( Choong Jae Lee ),( Sun Chul Hwang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effects of apigenin. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription - polymerase chain reaction (RT-PCR) was used to measure interleukin-1β (IL-1β)-induced expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), and ADAMTS-5. In rabbit articular chondrocytes, the effects of apigenin on IL-1β-induced secretion and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively. The effect of apigenin on MMP-3 protein production was also examined in vivo. In rabbit articular chondrocytes, apigenin inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5. Furthermore, apigenin inhibited the secretion and proteolytic activity of MMP-3 in vitro, and inhibited production of MMP-3 protein in vivo. These results suggest that apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.
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원위 요골 골절 환자의 치료 후 발생 가능한 손목 강직의 위험 인자
이동영(Dong Yeong Lee),황선철(Sun Chul Hwang),남대철(Dae Cheol Nam),정진훈(Jin Hoon Jeong),최영락(Young Lac Choi),박진성(Jin Sung Park) 대한정형외과학회 2015 대한정형외과학회지 Vol.50 No.4
목적: 원위 요골 골절 환자의 치료 후 발생할 수 있는 손목 관절 강직에 영향을 미치는 위험 인자를 알아보고자 한다. 대상 및 방법: 원위 요골 골절로 진단받은 후 수술적 치료를 시행한 환자 55명을 대상으로 하였다. 손목 강직 발생에 영향을 미칠 수 있는 다양한 인자들이 고려되었으며, 로지스틱 회귀 분석을 이용하여 95% 신뢰구간에서의 odds ratio (OR)를 계산하였다. p-value가 0.05 미만에서 유의한 것으로 판단하였다. 결과: 골절의 정복 정도를 반영하는 방사선적 지표 중 수술 직후와 6개월째 척골 변이만이 손목 강직과 관계가 있었다(p<0.05). 단변량 분석에서 환자의 연령(p=0.037; OR, 1.051)과 당뇨의 이환(p=0.016; OR, 8.000)이 손목의 강직과 관계 있는 것으로 나타났다. 강직에 영향을 미칠 수 있는 여러 인자들을 함께 고려한 다변량 분석을 시행한 결과에서는 오직 당뇨의 이환(p=0.034; OR, 6.588)만이 강직의 발생과 관계가 있었다. 결론: 원위 요골 골절 환자의 수술적 치료 후 손목 강직을 예방하기 위해 당뇨병의 이환 여부가 중요하다. 또한 골절의 정복시 척골변이의 정확한 해부학적 복원은 추후 발생 가능한 강직을 예방할 수 있는 중요한 인자로 생각된다. Purpose: The purpose of this study is to evaluate risk factors for wrist stiffness after treatment of distal radius fractures. Materials and Methods: A total of 55 consecutive patients who were diagnosed with distal radius fracture at the current authors’ institution and followed-up for at least 6 months were included in this retrospective study. Data on all factors related to wrist stiffness were considered. The degree of association for each of the factors was determined by calculation of the odds ratio (OR), with a 95% confidence interval. Logistic regression analyses were performed. p-value was set below 0.05. Results: Among radiologic indexes reflecting the degrees of fracture reduction, only ulnar variance showed significant association with wrist stiffness of distal radius fracture (p<0.05). In univariate analysis, age (p=0.037; OR, 1.051) and diabetes mellitus (DM) (p=0.016; OR, 8.000) showed significant association with wrist stiffness. Various factors significant at the p-value less than 0.20 level in univariate analyses were included in the multivariate analyses. In multivariate analyses, only DM (p=0.034; OR, 6.588) showed significant association with wrist stiffness. Conclusion: Contraction of DM is critical to avoid wrist stiffness of distal radius fracture patients. In addition, ulnar variance was considered a significant factor of wrist stiffness in distal radius fracture patients, thus reduction of fracture could be done more in proximity to normal anatomy.
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Park, Jin Sung,Kim, Dong Kyu,Shin, Hyun-Dae,Lee, Hyun Jae,Jo, Ho Seung,Jeong, Jin Hoon,Choi, Young Lac,Lee, Choong Jae,Hwang, Sun-Chul The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the knee joint of rat to evaluate the potential chondroprotective effects of apigenin. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription - polymerase chain reaction (RT-PCR) was used to measure interleukin-$1{\beta}$ (IL-$1{\beta}$)-induced expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), and ADAMTS-5. In rabbit articular chondrocytes, the effects of apigenin on IL-$1{\beta}$-induced secretion and proteolytic activity of MMP-3 were investigated using western blot analysis and casein zymography, respectively. The effect of apigenin on MMP-3 protein production was also examined in vivo. In rabbit articular chondrocytes, apigenin inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5. Furthermore, apigenin inhibited the secretion and proteolytic activity of MMP-3 in vitro, and inhibited production of MMP-3 protein in vivo. These results suggest that apigenin can regulate the gene expression, secretion, and activity of MMP-3, by directly acting on articular chondrocytes.
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