일산화탄소 및 고압산소의 폭로가 흰쥐의 제2형 폐포세포와 사구체에 미치는 영향에 관한 연구

백두진,정호삼,이계훈,황세진,전영호,전영희 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

The present study was performed to investigate the ultrastructural changes of the type Ⅱ pneumocyte in the lung and that of the glomerulus in the kidney after carbon monoxide(CO) or hyperbaric oxygen (HBO) exposure. The male Sprague-Dawley rats, weighing about 200gm, were used as experimental animals. The animals were divided into CO exposure group, air exposure after CO exposure group, HBO exposure group and HBO exposure after CO exposure group. After single CO and HBO exposure (3790ppm), the specimen of lung and kidney were obtained. According to routine method, EM preparations were made and observed with electron microscope. The results obtained were as follows ; 1. Slight disruption of the mitochondrial membrane was observed in alveolar type Ⅱ pneumocyte, after single CO exposure. 2. In all experimental groups except CO exposure group, decrease in number and atropy of rough endoplasmic reticulum, disruption of double membrane and crista of mitochondria and vacuolar degeneration of lamellar bodies in alveolar type Ⅱ pneumocytes were observed. 3. In all experimental groups, fusion of the pedicles of podocytes, and obliterations of the endothelial fenestrations were observed. These results suggested that CO and HBO exposure may induced the ultrastructural damages in the alveolar type Ⅱ pneumocyte and the glomerulus.

Ethephon 및 Aminoethoxyvinylglycine 처리가 ‘원황’ 배 모의 수출 환경에서의 품질 및 생리장해 발생에 미치는 영향

최진호,이욱용,안영직,황용수,천종필 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

We investigate the effect of preharvest spray of aminoethoxyvinylglycine (AVG), an inhibitor of ACC synthase activity, on fruit quality of ‘Wonhwang’ pear (Pyrus pyrifolia Nakai). And the effects were compared with ethephon which releasing ethylene to elucidate treatment efficacy of ethylene biosynthesis inhibitor on Asian pears. Chemicals were sprayed on 30 days before harvest with AVG (75 and 150 mg/L) and ethephon (100 mg/L), respectively. Highest flesh firmness during 21 days of shelf-life at 25℃ after 30 days of cold storage was attained in the fruit treated with 150 mg/L AVG (26.5N) when compared with untreated control (16.7N), while the fruits treated with 100 mg/L ethephon completely lost their marketability within 14 days of shelf-life by mass drop of firmness down to 11.6N. Low incidence of physiological disorders including pithiness and core browning were attained at the fruits treated with 150 mg/L AVG when we compared with untreated control. No occurrence of mealiness found in the fruits treated with AVG but ethephon treated fruits showed 36.4% during 14 days of shelf-life. Consequently, AVG spray at the concentration of 150mg/L on Asian pear ‘Wonhwang’ fruit regarded as useful preharvest management approach for keeping quality during marketing period after simulated exportation.

광주·전남 지역에서 발생한 스포로트리쿰증 103예에 대한 임상적 고찰(1967-1996)

전인기,김훈희,김성진,이승철,원영호 대한의진균학회 1997 대한의진균학회지 Vol.2 No.2

Background : Sporotrichosis is most common deep cutaneous fungal disease in Korea. It is markedly variable in incidence, distribution, and colinical pattern. The epidemiology have been well known to change over years, and to be influenced by environmental condition and geographic location. Sporotrichosis in Kwangju and Chonnam area is more prevalent compared to other areas in Korea. Objective : Our purpose was to describe the prevalence, epidemiological and clinical features, regional distribution and the change of the incidence according to the climate in different regions. Method : the observation of 103 sporotrichosis patients confirmed by clinical, histopathological and mycological studies had been made in the Department of Dermatology at Chonnam National university Hospital for thirty years from 1967 to 1996. Results and Conclusion : The sporotrichosis patient was 0.09% of 108, 680 outpatients, prevalent at the age of thirties and forties(20%), and 3.2:1 in the ration between male and female. The 58% of total cases visited us within 3 months after the beginning of skin lesion. Almost all initial lesions appeared on the exposed areas, especially upper extremities(68%). The 74% of the total cases was lymphocutaneous type, and the rest was fixed cutaneous type. Most popular occupation of patients was farmer(60%). The 69% of patients visited in spring and winter, especially in february(17%). The incidence of sporotrichosis per average 100,000 population in districts of Kwangju and Chonnam area revealed a difference with the amount of rainfall in winter; average 1.8 person in an area above 125㎜,0.8 person in an area between 100㎜ and 125㎜, and 0.2 person in an area below 100㎜ These rsults suggest that the incidence and clinical features of sporotrichosis are influenced by occupations, leisure and occupational activities, living conditions, and the climate.

실리콘 웨이퍼 공정용 알루미나 정전척의 제작과 특성에 관한 연구

천희곤,조동율,이영섭,박용균,최성호,정광진,Serguei Spoutai 울산대학교 기계부품 및 소재 특성평가연구센터 1999 연구보고서 Vol.1999 No.-

정전척의 유전체 물질로 열전도도와 유전특성 그리고 기계적 특성이 우수한 알루미나에 TiO₂첨가하여 유전체의 비저항을 변화시켜서 정전척(electrostatic chuck)에서 발생하는 정전력인 쿨롱힘(coulomb force)과 존슨-라벡힘(Johnsen-Fahbeck firce_의 영향을 규명하려 하였다. 그리고 비저항, 인가전압, 온도, 습도가 정전력에 어떠한 영향을 주는지 고찰하였으며, 인가전압에 따른 응답 특성에 관하여 고찰하였다. Alumina electrostatic chucks for silicon wafer process with wide range of electrical resistivity were fabricated by controlling the amount of TiO₂ addition (0 wt%, 1.3 wt%, 2 wt%, 2.8 wt%). The dependence of electrostatic force on applied voltage, temperature and humidity was investigated. In addition, response characteristics on applied voltage and relationship between electrical resistivity and electrostatic force characteristics such as Coulomb force and Johnsen-Rahbeck force were discussed

兒童 發達特性에 따른 傳承 民俗놀이 考察

천영일,이진희 중앙대학교 스포츠과학연구소 1999 體育硏究 Vol.- No.12

The purpose of this study is to examine folklore play in complianct with characteristics of children's growth. The results are following like this: First infants developed himself from head to toe, and infant's body developed by playing. The examples of folklore playing in this period were 'dori-dori', 'jjag-ja-gung', 'gonji-gonji', 'jam-jam', 'gone-gone', 'bulmu-bulmu', etc. Second young children develope small muscle movement in this period. And folklore play were singing, story-telling, theatrical play, medical preventing play and playing using arm and leg. Third children's characteristics were very active and strong. In this period play were separated by boys' play and girls'. As a play of children there were a puzzle, prophetic songs, a theatrical play and story-telling. Children developed their association of ideas, rhythm, originality and dictionary by playing. Aso there were preventing play which have grown folklore play. Therefore folklore playing have developed ability, emotion, body and sociality of children.

폴리카본산계 유동화 혼화제 개발

전용진,조석형,홍영호,한종필 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-

폴리카본산계 기능성 고분자를 합성해서 고성능 감수제 원료로 활용하여 고유동화 혼화제를 개발하고자 한다.폴리카본산계 기능성 고분자를 합성한 후, 이를 고유동, 고강도 혼화제 원료로의 제반 물성을 확인하고, 이를 현장에 적용하여 현재의 제품을 획기적으로 개선하고, 혼화제 품질의 우위성을 확보하기 위해 1)시멘트 및 골재 표면에서의 적절한 계면활성을 갖는 분자설계를 하였으며, 2)분자량의 조절 기술의개발를 개발하였다. 합성에 있어서 첫째, 시멘트 및 골재 표면에서의 적절한 계면활성을 갖는 분자설계와 둘째, Mw 5,000정도의 분자량을 갖는 감수제의 합성기술을 개발하였다.이렇게 제조된 고성능 유동화제의 화학구조 해석를 해석하고 분자량 및 분자량 분포를 측정한 다음, 시멘트 페이스트의 유동성, 점도, 슬럼프로스 등을 측정하여 고성능 유동화제의 성능인 시멘트 페이스트의 유동성을 시험하였다.그 결과 고유동성을 갖는 것과 장시간 안정한 유동성을 나타내었으며, 경과 시간에 따른 겉보기 점도변화를 측정한 결과 점도의 상승이 초기에 일어나다가 시간의 경과에 따라 점도가 감소하는 경향을 나타내었다.따라서 경과시간에 따른 유동성손실을 억제할 것으로 기대한다.

감마선에 조사된 생쥐에 있어서 방사선방어효과 평가를 위한 생물학적 파라메타

천기정,김봉희,이영근,김진규 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

This study deals with the biological changes in mice after γ-irradiation. Four weeks old BALB/c mice were irradiated with 6.5Gy of γ-ray on the fifth day after oral administration of radioprotectants such as ascorbic acid, tocopherol and cysteine. Control group was irradiated with 6.5Gy without pre-administration of radioprotectors. Blood cells and sperm cells were counted and body, testis and spleen were weighed 3 days after irradiation. And also liver antioxidant activity and range of spleen immune cells were measured. Differences in most biological parameters were not clearly distinguished between experimental groups. However, the relative spleen weight, the relative testis weight and the population size of spleen immune cells such as T helper cells, B cells and macrophages measured by means of FACS showed significant difference between irradiated and radioprotectant administered group. It is concluded that the relative spleen weight, the relative testis weight and the population size of spleen immune cells are easy and useful parameters for assessing the effect of radioprotective substances and for quantifying biological damage of radiation, as well.

쇠비름 수침액이 방사선 조사에 의한 생쥐의 생존율과 뇨중 아미노산 조성에 미치는 영향

천기정,김진규,이영근,김봉희 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

A study has been conducted to investigate the radioprotective effects of purslane extracts (P) when I.p. injected before irradiation (R). For studying the amino acid composition , three groups of ICR mice (7-week-old) were tested. The first group I.p. injected with purslane extract for 5 days were irradiated with 6 Gy of γ-radiation (P+R). The second group was irradiated with 6 Gy without any pretreatment (R). The third group was non-irradiated control (CT). Each group divided into two groups for the survival rate study, one injected with saline (S) and the other injected with purslane extract (P) for five days and then irradiated with 8 Gy. The amino acid composition of urine samples were analyzed with HPLC for 19 days after irradiation. A few kinds of amino acids such as lysine and methionine in urine from P+R group increased in comparison with those from CT or R group. The survival rate of P group maintained much higher than that of S group during experimental period. The results obtained may support that this plant has radioprotective substances by means of life-lengthening, not of urine amino acid components.

"Mandibular Swing 접근법"에 의한 인두후벽암 치험 1례

전영명,고중화,이진석 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1

Traditionally, enbloc resection of the primary tumor with its lymphatics is the surgical procedure of choice for many oral and oropharyngeal malignancies. However, the operative fields reached by conventional approaches are too limited and narrow to remove extensive tumors, especially posterior pharyngeal tumor. The mandibular swing approach has greatly assisted tumor ablation and reconstruction of these areas. The authors essayed a mandibular swing approach for the ablation of a huge posterior pharyngeal wall carcinoma.

일산화탄소 폭로후 고압산소 재폭로시 흰쥐 신장 및 심장의 SOD 활성 변동에 관한 연구

전영희,백두진,황세진,박준숙,정호삼 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.1

Carbon monoxide is generated from the incomplete combustion of carbon-containing materials. Carbon monoxide cause muscle necrosis leading to myoglobinuria and acute renal failure. The hyperbaric oxygen exposure is increased production of active free radicals. Free radicals which promoted peroxidation of unsaturated fatty acids may destroy essential cellular components and itself cytotoxic materials. Superoxide dismutase, one of the protective mechanisms against tissue damage, catalyzed the dismutation of superoxide anion to less toxic product. The author performs the present study to investigate on Mn-SOD and Cu, Zn-SOD immunoreactivities in kidney and heart carbon monoxide (CO) and hyperbaric oxygen (HBO) exposure. The animals were divided CO exposure group, air release after CO exposure group, HBO exposure group and, CO and HBO exposure group. The specimen were sectioned in 16㎛ with cryostate. The Mn-SOD and CuZn-SOD immunohistochemistry was performed in renal corpuscle, proximal and distal convoluted tubules of kidney and, in sarcoplasm and sarcolemma of heart muscle. The results obtained were as follows: 1. The immunoreactivity of Mn-SOD were increased in renal corpuscles and distal convoluted tubules, were similar to control group in proximal convoluted tubules. 2. The immunoreactivity of Cu, Zn-SOD were increased than that of control group in renal corpuscles and distal convoluted tubules, were same that of the control group in proximal convouted tubules. 3. The immunoreactivity of Mn-SOD were increased at all experimental group of sarcoplasms of heart muscle. 4. The immunoreactivity of Cu,Zn-SOD were increased than that of control group in sarcolemma of heart muscle. These results suggest that the immunoreactivity of SOD after CO or HBO exposure is greatly increased in kidney and heart.