Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

顎矯正術을 받은 顎顔面 寄形患者의 SKELETAL PATTERN의 變化에 關한 硏究

조원표,조병욱,고백진,이용찬 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

In the treatment of dentofacial deformities, analysis of skeletal pattern, with evaluation of plaster dental case, is essential procedure. This study was based on 20 patients with dentofacial deformity who were admitted to the department of oral and maxillofacial surgery Kngnam sacred heart Hospital during the period of Jan 1989. We studied serial cephalometric radiogarphs of patients (pre-op, postop immediately, postop 6 moth). The obtained results indicates the good resistance of rigid fixation against relapse in orthognathic surgery.

정보통신산업 생산성 변화의 산업간 파급효과 분석

조영상,이정동,박찬수,김태유 한국생산성학회 2002 生産性論集 Vol.16 No.3

The Korean ICT industry is evolving at a dramatic speed, increasing its importance in the overall economy and producing numerous externalities on the other industries. The purpose of this srsearch is to investigate the productivity growth of Korean ICT industry and its effects on the other industries and to derive policy implications. For this purpose we perform inter-industry analysis. Inter-industry analysis is conducted to investigate how close co-relationship exist between ICT industry and other indrstries and to see how much ICT industry affects other industries. Our estimates of the productivity growth in the industry and its contribution to the overall korean Economy suggest the direct contribution of the ICT industry is significant, but its spillovers to the other industries are not so impressive. This implies that the link between ICT industry and other industries is weak and that most of the ICT products are used as final products and not as intermediate goods. We also find the high extent of import penetration in Korean ICT industry to be one of its major problems.

시클러 캡슐(세파클러 250㎎)에 대한 경보세파클러 캡슐의 생물학적동등성

조혜영,강현아,김세미,박찬호,오인준,임동구,문재동,이용복 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was to evaluate the bioequivalence of two cefaclor capsules, Ceclor (Lilly Korea Co., Ltd.) and Kyongbocefaclor (Kyongbo Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of cefaclor from the two cefaclor formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2. 4.0. 6.8 buffer solution and water). Twenty four healthy male subjects. 22.96±1.52 years in age and 67.03±7.90 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After one capsule containing 250 mg of cefaclor was orally administered, blood was taken at pre-determined time intervals and the concentrations of cefaclor in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition. the pharmacokinetic parameters such as AUC_(t), C_(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t). C_(max) and untransformed Tmaa. The results showed that the differences between two formulations based on the reference drug, Ceclor. were -1.90%, 2.68% and -7.60% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91-log 1.06 and log 0.92-log 1.18 for AU', and C_(max), respectively). Thus. the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kyongbocefaclor capsule was bioequivalent to Ceclor capsule.

좌새골하정맥을 통하여 중심정맥도관 삽입 3 일 후에 발생한 상대정맥천공과 우흉수 : 증례 보고 A case report

조형찬,손주태,최준영,신일우,이헌근,정영균 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

A 67-year-old male patient had coronary artery bypass graft. Before the induction of general anesthesia, 16 gauge central venous catheter was inserted via left subclavian vein. Initial chest anteroposterior (AP) radiograph showed adequate position, and the central venous pressure measurement through it was satisfactory. This patient's progress was satisfactory, and he was extubated on the second postoperative day. Daily chest AP radiograph had been unremarkable until the third postoperative day, when a right-sided pleural effusion was seen. A day later, the patient complained severe chest pain and dyspnea. We suspected perforation of superior vena cava wall by tip of central venous catheter on the chest computerized tomograph (CT). The injection of radiopaque dye through the central venous catheter confirmed spillage into the mediastinum on the chest CT. Right chest tube was inserted. The patient's condition dramatically improved after chest tube insertion. (Korean J Anesthesiol 2002; 43: 525~530)

MSGC형 센서를 위한 제어시스템 및 영상 획득 S/W 개발

조진호,진경찬,채승표,박영식,김명남 경북대학교 센서기술연구소 1997 연차보고서 Vol.1997 No.-

열전대(thermocouple)를 이용한 Buchanan Plugger 표면의 온도상승 분석

조진숙,황윤찬,김선호,황인남,최보영,정영진,정우남,오원만 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.4

This study was performed to evaluate the actual temperature rise on the surface of Buchanan plugger using thermocouple. The heat carrier system 'System B Heatsource'(Model 1005, Analytic Technologies, Redmond, WA, USA) and the Buchanan pluggers of F, FM, M and ML sizes are used for this study. The temperature was set to 200℃ on digital display and the power level on it was set to 10. Five thermocouples were placed in direct contact with the surface of each size of Buchanan's pluggers at 1 mm increments from the tip to the 4 mm length of shank. The heat control spring was touched for 5 seconds, and temperature rise on the surface of the pluggers were measured at 1 sec intervals for more than 5 seconds with an accuracy of 0.01 using Data Logger. The data were statistically analyzed by one-way ANOVA. The results were as follows. 1. The position at which the temperature peaked was approximately at 1~2 mm far from the tip of Buchanan plugger (p<0.01). 2. The peak temperature was 215.25±2.28℃ in F plugger, 185.94±2.19℃ in FM plugger, 169.51±9.12℃ in M plugger, and 160.79±1.27℃ in ML plugger and the peak temperature was highest in F plugger and followed by, in descending order, FM plugger, M plugger. ML plugger showed the lowest peak temperature (p<0.01). 3. The temperature on the pluggers was decreased with the increase of touching time. This results suggest that the actual temperature on the surface of the pluggers dose not correlate well with the temperature set on digital display. Heat concentrates around the up. The larger plugger reveals lower temperature rise relatively.

진양호의 어류생산 개발에 관한 연구 : 제1보 진양호내에 서식하고있는 담수어류 분포상태 조사 Effect The investigation about the distribution state of inhabited fishes in Lake Jin-yang

조영래,진찬현 진주산업대학교 1973 論文集 Vol.11 No.-

The distrbution state of inhabited fishes in Lake Jin-yang Iocated in the west of Chinju city was investigated from marchl, 1972 to Octoben 31, 1972, and the resultu are follows. 1. In this investigation, 30 species, 23 Genus, 10 Family, 5 Order, I class, I phylum of fish are inhabited in Lake Jin-yang, order eyprinida of Family cyprinidae is dominant species with 60%. Fram the assumption of oxygen Consumption of the fish, about 5,000 tons per year of the common carp can be Produced in Lake Jin-yang. 2. Concerning the fish production in Lake Jin-yang. Carassius carassias ranked 57.3% and Gobiobotia naktongensis ranked 0.13% The main fishes are carassius carassius and cyprints-carpio if we make the use of the water temperatures in the bottom can be developed, trouts carp can be produced 3. Total lenth of inhabited fishes is 89,238 cm and the average lenth is 16.05 cm

요로감염이 진단되었거나 의심되는 영아에서 방광요관역류를 예측할 수 있는 임상적, 실험실적 지표들에 대한 연구

조승만,홍성완,홍찬의,정철주,노영일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3

Background: Vesicoureteral reflux (VUR) in infants may be the main cause of recurrent urinary tract infection (UTI) and renal scarring. So the early diagnosis of VUR is helpful to prevent recurrence of UTI and to alleviate the grade of VUR. This study is to examine the predictability of clinical and laboratory variables for VUR in infants with confirmed or suspected UTI. Material and Methods: Data of infants younger than 12 months who underwent voiding cystourethrography (VCUG) between 2003 and 2006 were evaluated retrospectively. Among the infants with suspected UTI, infants with VUR (Group 1) vs no VUR (Group 2) were compared. And among the Infants with confirmed UTI, infants with VUR (Group 3) vs no VUR (Group 4) were compared, Variables selected in this study were age at onset, gender, fever, laboratory data and imaging (ultrasonography). Results: Among the variables, the mean of C-reactive protein (CRP) in Group 1 and Group 2 were 5.24±6.82 and 2.46±3.75, respectively, showing that Group 1 had a higher value than Group 2 (P=0.0104). And the number of patients with fever □38.5℃ in Group 1 was higher than in Group 2 (U=0.0004). The mean of C-reactive protein (CRP) in Group 3 and Group 4 were 8.95±6.1 and 5.39±6.0, respectively, showing that Group 3 had a higher value than Group 4 (P=0.0409). Conclusion: Fever≥38.5℃ and CRP≥0.6 ㎎/dL were closely associated with VUR in infants with suspected UTI. And CRP□3.4㎎/dL was closely associated with VUR in infants with confirmed UTI. However, further evaluations and studies for these variables will be needed to use them as predictors for VUR.

적절한 용량 이하의 경구용 향응고제 사용 중 발생한 뇌출혈 환자의 임상 양상

조수진,황흥곤,나찬영,이영탁,최현배,조태구 世宗醫學硏究所 2000 世宗醫學 Vol.17 No.2