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PCN-223 as a drug carrier for potential treatment of colorectal cancer
Nea Young Chun,Se-Na Kim,Youn Seo Choi,Young Bin Choy 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.84 No.-
Colorectal cancer is the second leading cause of cancer-related deaths worldwide. CRC is often treatedwith intravenous 5-fluorouracil (5FU). However, 5FU frequently shows low therapeutic efficacy andserious adverse events. Particulate drug carriers able to enhance intracellular delivery could beadvantageous, since higher 5FU concentrations would be engulfed by cancer cells during a relativelyshort residence within the rectal space to improve local anti-cancer efficacy. Therefore, we propose anovel material based on a zirconium-based metal-organic framework (MOF), PCN-223, as a potentialcarrier of 5FU for rectal delivery of treatment for CRC. PCN-223 nanoparticles, prepared by thesolvothermal method, exhibited a highly porous structure, whereby 79.4 mg/mg 5FU could beencapsulated and released in a sustained manner over 2 h in vitro. PCN-223 was internalized by thehuman colorectal cancer cell line, HCT-116, within 2 h, representing the period that rectally deliveredparticles reside within the rectum. Consequently, 5FU-loaded PCN-223 (5FU@PCN-223) treatmentdecreased the viability of HCT-116 cells compared with treatment with a bolus 5FU solution, suggestingimproved drug efficacy over a short exposure time. Therefore, PCN-223 may be a promising carrier forrectal delivery of 5FU for treatment of colorectal cancer.
( Su Bin Park ),( Kyo Hwa Kang ),( Hyo Jin Park ),( Jong Soon Park ),( Su Hak Heo ),( Hong Kim ),( Young Bin Choy ),( Chan Yeong Heo ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.4
Bioabsorbable plates and screws for bone fixation system have been used owing to many advantages over conventional metallic devices. This study investigated the effects and safety of recently developed modifiable bioabsorbable plate and screw made of 100% poly (L-lactic acid) in the healing process of mandible fracture in arabbit model. In vitro extract test for cytotoxicity and bacterial reverse mutation test for genotoxicity were carried out. Any cytotoxicity caused by extract from experiment sample was not observed. In genotoxicity test, increase in the number of revertants was not observed. As an in vivo test, plates and screws were used for rigid fixation of exper-imental mandible fracture in twenty rabbits. Tissue specimens with plate were taken from the rabbits after 4, 6, 8,10 weeks and histological analysis was studied. After 4 weeks, the plate was covered by connective tissue and severe chronic active inflammation in soft tissue was observed. After 6 weeks, absorbed part in plate and new bone forma-tion around periostium and decrease in inflammation were detected. After 10 weeks, new bone formation was observed in all samples and the thickness of bone increased. The remodeling was not complete yet. This study dem-onstrates that recently developed biodegradable plate and screw system made of poly(L-lactic acid) was effective in mandible fracture regions known as high load-bearing areas. This indicates that bioabsorbable poly (L-lactic acid) plates and screws are available for most of bone fractures, although the adjustment process and long-term follow-up study are necessary for clinical application.
Sepsis diagnosis and treatment using nanomaterials
Jaesung Lim,Yun Young Lee,Young Bin Choy,Wooram Park,Chun Gwon Park 대한의용생체공학회 2021 Biomedical Engineering Letters (BMEL) Vol.11 No.3
Sepsis is a life-threatening reaction that occurs when the body’s severe response to an infection damages the host’s owntissues. Sepsis has been globally recognized as a fatal disease. Rapid treatment of sepsis requires prompt identifi cation,administering antibiotics, careful hemodynamic support, and treating the cause of the infection. Clinical outcomes of sepsisdepend on early diagnosis and appropriate treatment. Unfortunately, current sepsis diagnosis and treatment, such as polymerasechain reaction-based assay, blood culture assay, and antibiotic therapy, are ineff ective; consequently, sepsis-relatedmortality remains high and increases antimicrobial resistance. To overcome this challenge, nanotechnology, which involvesengineering at a nanoscale, is used for diagnosing and treating sepsis. Preclinical models have shown protective eff ects andpotential utility in managing septic shock. Furthermore, nanotechnology treatments based on diverse materials result inthe eff ective treatment of sepsis, improving the survival rate. In this review, we present an overview of the recent researchadvancements in nanotechnology to diagnose and treat sepsis with a brief introduction to sepsis.
( Ji Yea Hwang ),( Young Bin Choy ),( Soon Min Seo ),( Jung Hwan Park ) 한국약제학회 2011 Journal of Pharmaceutical Investigation Vol.41 No.3
This paper demonstrates the development of a method for preparing micropatterned microdiscs in order to increase contact area with cells and to change the release pattern of drugs. The microdiscs were manufactured with hot embossing, where a polyurethane master structure was pressed onto both solid and porous microparticles made of polylacticco- glycolic acid at various temperatures to form a micropattern on the microdiscs. Flat microdiscs were formed by hot embossing of porous microparticles; the porosity allowed space for flattening of the microdiscs. Three types of microgrooves were patterned onto the flat microdiscs using prepared micropatterned molds: (1) 10 μm deep, 5 μm wide, and spaced 2 μm apart; (2) 10 μm deep, 9 μm wide, and spaced 5 μm apart; and (3) 10 μm deep, 50 μm wide, and spaced 50 μm apart. This novel microdisc preparation method using hot embossing to create micropatterns on flattened porous microparticles provides the opportunity for low-cost, rapid manufacture of microdiscs that can be used to control cell adhesion and drug delivery rates.
김수빈(Kim Soo-Bin),조영민(Jo Yeong-Min),김형진(Kim Hyeong-Jin),송승호(Seung-Ho Song),최주엽(Choi Ju-Yeop),최익(Choy Ick),이영권(Lee Young-Kwoun) 한국태양에너지학회 2015 한국태양에너지학회 논문집 Vol.35 No.2
The performance of a photovoltaic array is affected by temperature, solar insolation, partial shading effect, and array configuration. Maximum power point tracking(MPPT) techniques are employed in photovoltaic systems to make full utilization of the PV array output power which depends on solar irradiation and ambient temperature. As much as MPPT is important in photovoltaic systems, many MPPT techniques have been developed. In this paper, several major existing MPPT methods are comparatively analyzed and novel hybrid MPPT algorithm is proposed. The proposed hybrid MPPT algorithm is developed in combination with traditional MPPT methods to complement each other for improving performance and mitigating partial shading effects. The proposed algorithm is implemented and validated using MATLAB/Simulink simulation tool.