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김현영,임철홍,정용현,이권섭,이성배,이준연,한정희,전윤석,이용묵 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.4
The purpose of this study was to investigate the acute (4 hours) and repeated-dose (6 hours a day, 5 days a week, 4 weeks) toxic effects of I -hexene on Sprague- Dawley (SD) rats which were treated by inhalation. The results were as follows; I. The median lethal concentration (LC_(50)) was estimated 52,694 ppm (confidence limit 95%; 49,494~55,447 ppm) in acute inhalation. Abnormal clinical signs related to the l-Hexene were not observed with the acute inhalation dose. Gross findings of necropsy revealed on evidence of specific toxicity related to the 1-hexene, II. By repeated inhalation exposure the body weight of male were more or less reduced by the dose of 2,500 ppm and 5,000 ppm compared with control group. However there were no significant variation hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-hexene were not shown. In conclusion when we exposed I-hexene to SD rats for 4 weeks, 5 days per week, 6 hours per day, the Lowest observed effect level (LOEL) was over 2,500 ppm and Non observed effect level (NOEL) was below 500 ppm.
김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1
The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.
Lim, Youn Mook,Lee, Jun Ho,Lee, Young Moo,Nho, Young Chang 한국공업화학회 2003 응용화학 Vol.7 No.2
pH-sensitive hydrogels were studied as a drug carrier for the protection of insulin from the acidic environment of the stomach before releasing it in the small intestine. In this study, hydrogels based on polyvinylpyrrolidone(PVP) networks grafted with acrylic acid (Ac) was prepared via a two-step process. PVP hydrogels were prepared by γ-ray irradiation (radiation dose: 25kGy, does rate: 5.36kGy/h), and then grafting by AAc monomers onto the PVP hydrogels with subsequent irradiation(radiation dose: 10kGy, dose rate: 3.0kGy/h). These grafted hydrogels showed a pH-sensitive swelling behavior in various pH.
Effect of electron beam irradiation on poly(vinylidene fluoride) films at the melting temperature /
Lim, Youn Mook,Kang, Phil Hyun,Lee, Sang Mann,Kim, Sung Sik,Jeun, Joon Pyo,Jung, Chan Hee,Choi, Jae Hak,Lee, Young Moo,Nho, Young Chang The Korean Society of Industrial and Engineering C 2006 Journal of industrial and engineering chemistry Vol.12 No.4
Preparation and Degradation Study of Poly(L-Lactide-co- -capro- lactone) films by –ray Irradiation
Youn-Mook Lim,Sung-Jun An,Sung-In Jeong,Chang-Hee Jung,Yun-Hye Kim,Jae-Hak Choi,Joon-Pyo Jeun,Dong-Sun Im,Phil-Hyun Kang,Heungsoo Shin,Young-Moo Lee,Young-Chang Nho 한국고분자학회 2006 한국고분자학회 학술대회 연구논문 초록집 Vol.2006 No.10
Lim, Youn-Mook,Kim, Bo Hae,Kim, Hee-Bok,Park, EunJi,Park, Seok-Won,Park, Jong-Seok,Choi, Se In,Kwon, Tack-Kyun,Kwon, Seong Keun Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>This study explored a novel strategy to restore the vocal gap by using cross-linked <I>β</I>-glucan hydrogel by <I>γ</I>-irradiation. An aqueous solution of 5 wt% <I>β</I>-glucan was prepared and cross-linked using <SUP>60</SUP>Co <I>γ</I> irradiation. Ten nude mice were injected with 0.8 mL of irradiated <I>β</I>-glucan on the left back and the same volume of nonirradiated <I>β</I>-glucan on the right back for comparison. The mice were sacrificed at 1 and 2 weeks after injection and histological evaluations were performed. Irradiated <I>β</I>-glucan demonstrated a significantly larger volume than nonirradiated <I>β</I>-glucan in the back of nude mice with less inflammatory reaction. After unilateral recurrent laryngeal nerve section in New Zealand White rabbits, irradiated and nonirradiated <I>β</I>-glucan were injected into paralyzed vocal folds. Irradiated <I>β</I>-glucan remained at the paralyzed vocal fold without definite inflammatory signs on endoscopy. High-speed recordings of vocal fold vibration showed decreased vocal gap in irradiated group compared to nonirradiated group. Histologically, the laryngeal epithelium and lamina propria remained intact, without inflammatory cell infiltration. Our newly developed injection material, irradiated <I>β</I>-glucan, showed excellent biocompatibility and remained longer than nonirradiated <I>β</I>-glucan<I> in vivo</I>, suggesting irradiated hydrogels as a new therapeutic approach that may be useful for the long-term treatment of vocal fold palsy.</P>