심근경색 모델 흰쥐에서 스트레스가 B-type Natriuretic Peptide 발현 및 심박변이율 변화에 미치는 영향

이삼윤(Sam Youn Lee),이미경(Mi Kyoung Lee),김남호(Nam-ho Kim),주민철(Min Cheol Joo),조항정(Hyang Jeong Jo),강지숙(Ji Sook Kang),김병숙(Byung Sook Kim),윤선식(Sun Sik Yoon),최을식(Eul Sig Choi),이문영(Moon Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

심박변이율의 감소는 심근 경색 환자에서 예후의 악화와 관련되어 있다. 심박변이율 중 very low frequency가 심부전환자의 예후를 판단할 수 있는 독립적 인자로서 사용이 가능하다고 보고된 바 있으며, 심실의 압력 증가에 반응해서 생성되는 B-type natriuretic peptide가 심근 경색의 예후 인자로서 사용할 수 있음 역시 보고된 바 있다. 본 연구에서는 심근경색 모델을 제작하여 일정의 회복 기간을 거친 다음 다시 일정 기간의 스트레스를 겪게 한 후 심박변이율의 변화 및 심실 조직에서의 BNP 발현 정도를 비교하여 스트레스에 의한 영향을 관찰하고자 하였다. Sprague-Dawley계 수컷 흰쥐 15마리를 대상으로 하였다. 실험동물은 인위적 스트레스 및 수술을 받지 않은 대조군(CON, n=5), 심근경색 수술을 받은 후 restraint stress를 받지 않은 군(MI+No Stress, n=5), 심근경색 수술을 받은 후 1주일 동안 restraint stress를 받은 군(MI+Stress, n=5)으로 분류하였다. 심근경색 모델 제작 직후 15분 이상 심전도의 변화를 기록하였으며, 2개월 정도 후 심근경색 수술을 받은 동물을 두 군으로 나누어 그 중 한 군에는 1주일 동안 restraint stress를 가한 후 restraint stress를 가하지 않은 동물과 심박변이율을 비교 분석하였다. 심실 조직은 좌심실 전벽 부위의 위축을 관찰할 수 있었고, 대식세포에 의하여 응고, 괴사된 심근세포의 탐식과 혈관이 풍부한 육아조직 및 섬유 변화를 볼 수 있었다. 심박변이율은 심근경색 수술을 받은 직후 심박수는 유의한 증가를 보였고, standard deviation of the normal to normal intervals (SDNN), very low frequency (VLF) 및 low frequency (LF)의 유의한 감소를 보였다. 심근경색 수술을 받았던 동물에서 두 달 정도의 회복 기간을 거친 후 스트레스를 받지 않은 군은 심박수 및 기타 심박변이율 분석에서 SDNN 값을 제외하고는 정상군과 유의한 차이를 관찰할 수 없었던 반면 1주일 동안 스트레스를 받은 군에서는 심박수가 다시 유의하게 증가했을 뿐만 아니라 SDNN, VLF 및 LF 역시 정상군과 유의한 차이를 보였다. 이상의 결과를 종합하면 심근경색 동물에 대해 1주일 동안 스트레스를 가한 결과 심박변이율이 감소하고 심실에서의 BNP 발현은 더욱 증가하여 악화함을 보여주고 있다. Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI+No Stress), and MI followed by stress group (MI+Stress). MI+Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI+Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI+ Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model. (Korean J Str Res 2010;18:275∼285)

임신부의 인플루엔자 백신 접종률 및 관련요인

김미정,이승연,이광수,김아름,손동욱,정문현,박신구,박지현,이병익,이진수 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Background : During seasonal influenza epidemics and previous pandemics, pregnant women have been at increased risk for complications related to influenza infection. Although influenza vaccination has been widely recommended to pregnant women and immunocompromised hosts, the vaccination rate is presumed to be low in pregnant women. This study was aimed to evaluate the vaccination rate and factors associated with Influenza vaccination among pregnant women, who are at high risk for developing complications from the influenza. Materials and Methods : This study was carried out by telephone survey from April, 2007 to August, 2007. Women who were in their second trimester of pregnancy or above,- during October, 2006 and February, 2007, the recommended vaccination period, and had given birth at Inha University Hospital were selected as the study population. Immunization status, general understanding, and factors associated with vaccination were evaluated. Results : Among a total of 506 eligible pregnant women, 227 (44.8%) responded to the questionnaires. The influenza vaccination rate among the pregnant women was only 4% (9/227). Major reasons for not receiving vaccination were first, not awaring the necessity of immunization during pregnancy (48.5%, 110/227) and second, misunderstanding that it is prohibited during pregnancy (36.1%, 82/227). The major factors that influenced the compliance of vaccination were correct understanding and doctor's recommendation on the influenza immunization during pregnancy. Conclusions : The influenza vaccine coverage on pregnant women was very low and the awareness of influenza vaccination during pregnancy in general was inaccurate. Shift in perception is required and this can be achieved by educating the pregnant women on the safety and efficacy of vaccination. In addition, doctors' active encouragement to vaccination is highly recommended.

한국전통생활문화에 관한 고찰

이숙,홍윤호,신윤숙,신효식,한경미,최정미,김은정 全南大學校家政科學硏究所 2002 生活科學硏究 Vol.12 No.-

This study is objected on preliminary research for more scientific and wider studies on the Traditional Living Culture of Korea. For this purpose, studies about clothing, food, home management, Traditional Living Culture were reviewed and analysed. The results were as follows : First, Clothing culture studies concentrated on ritual clothings, Second, Food Culture studies included history of traditional food development and recipes. Third, in the field of home management value system, attitudes and parent-child relations were studied,

디자인 프로세스를 적용한 환자복 개발 사례 연구

이연희;박재옥;서미아;안민영 한양대학교 2004 韓國 生活 科學 硏究 Vol.- No.24

The purpose of this project was to design a patient's uniform which gives functional and psychological satisfaction to the patients. The project was developed to follow the design process. That is, the project was based on the survey which is on dissatisfaction of exiting patient's uniform, evaluation criteria and design preference for patient's uniform. The result of the survey was reflected to the design of new patient's uniform for Hanyang University Hospital. The uniform consists of a shirt and a pair of pants. The style of the garment is comfortable box-silhouette for ease and action. The shirt has a compromised neckline of U-neckline and round-neckline. It has buttons on front for closure, a patch pocketon left side of the garment. It also has three-quarter sleeves to complement dissatisfactions on the length and the distinction of seasons. The button extension was deeply given to avoid becoming open. To give decorative accents, piping was added. The ankle-length pants aredesigned to satisfy the need for shortening the length of existing uniform pants. The waistband of the pants has both closures, a drawstring and an elastic band, to make up for the dissatisfactions on durability and slip-off problems. The colors, white, light blue, pink, and yellow, are used to give a psychological sense of security to the patients. The flower symbol of Hanyang University was used for the textile surface design. Therefore, this project is worthwhile to present more systematic and scientific approach for patient's uniform design which gives functional and psychological satisfaction to the patients.

알코올 의존 환자의 MMPI 특성 : 임상 척도와 내용 척도를 중심으로

이윤경,오상우,류미경,박민철 圓光大學校 醫科大學 神經精神科學敎室 1999 圓光精神醫學 Vol.15 No.2

본 연구는 군집 분석을 이용하여 알코올 의존 환자의 MMPI 임상척도와 내용 척도의 특성을 알아보았다. 연구 결과, 60명의 남자 알코올 의존 환자들은 2개의 하위 유형으로 분류되었다. 첫 번째 집단은 모든 척도가 T 점수 45 ~ 55 범위에 있는 정상 유형이었고(n=40, 66.6%), 두번째 집단은 MMPI 타당도 척도의 L, F, K 가 역전된 V형이며 임상 척도는 6-8 유형을 보였다(n=20, 33.4%). 내용 척도에서도 두 집단간에 통계적으로 유의미한 차이가 있었는데, 첫 번째 집단은 프로파일이 정상범위에 속했으며, 두 번째 집단은 ANX, FRS, OBS, HEA, BIZ, ANG, HYP, LSE, SOD, TRT 척도의 T 점수가 첫 번째 하위 유형에 비해 의미있게 상승하였다. 본 연구는 MMPI 임상 척도와 내용 척도가 알코올 의존 환자의 임상적인 진단과 연구에 도움이 된다는 것을 시사한다. This study was to investigate the characteristics of MMPI clinical and content scales on patients with alcohol dependence by using cluster analysis. As a result, the 60 male patients with alcohol dependence were classified into two subtypes. The MMPI profile of first subtype was within normal range, 45~55 of T score(n=40, 66.6%), second subtype had the inverted V shape validity scales and 6-8 clinical scale profile(n=20, 33.4%). The content scale was statistically significant difference between two groups. First subtype was within normal range, second subtype had more elevated T score of ANX, FRS, OBS, HEA, BIZ, ANG, HYP, LSE, SOD, and TRT scale. This study suggest that the MMPI clinical and content scale can be helpful and applicable to clinical diagnosis and research in patients with alcohol dependence.

알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향

이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-

To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.

철도화물의 기업경영적 영업전략 구축을 위한 기본구도

이미영,김병윤 목원대학교 사회과학연구소 1998 社會科學硏究 Vol.- No.2

우리나라의 철도는 1899년도 개통이래, 간선수송의 대동맥 역할을 해오면서 국가산업발전에 크게 기여해 왔다. 그러나, 1970년대 초의 고속도로개통을 기점으로 자연 독점적 기능 이 쇠퇴하여 수송수요 감소로 인한 수입저하로 철도경영은 악화되기 시작하였으며, 철도경영개선계획 등의 철도발전을 위한 자구노력의 필요성이 절실하게 대두 되었다.

탁구선수들의 자기효능감이 경기 승패에 미치는 영향

이미연,박철용 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

The research was devised to verify possibility of application self-efficacy thesis into real situation ping-pong game and to study factors affecting on ping-pong players' self-efficacy and final consequence based on Bandura's self-efficacy thesis. The analysis was started establishing self-efficacy and the final result as independent variables and dependent variables, subjects(high school and college students) and superior/ inferior athletes(whether or not experience quarter final). The significance was α= .05. The result is this. Firstly, analyzing self-efficacy with subjects(high school and college students), college students get higher points than high school students. And the result of the relation between self-efficacy and the final consequence is that a group which shows high self-efficacy achieves more wins compared with a group showing low self-efficacy in both subjects. In comparison with subjects(high school and college students), high school students get higher degree of factors affecting self-efficacy and the final consequence before a game. Secondly, analyzing self-efficacy with gender, male showed higher degree than female. And the result of the relation between self-efficacy and the final result is that a group which shows high self-efficacy wins more in both of them Compared with male and female, both male and female are the factors of self-efficacy and the victory or defeat before a game. Lastly, analyzing self-efficacy with superior/inferior athletes, superior athletes showed higher self-efficacy than inferior athletes. And the result of the relation between self-efficacy and the final result is that a group which gets high self-efficacy achieves more wins. In comparison with superior and inferior athletes, inferior athletes affect on the self-efficacy and the final consequence more than superior athletes.

신경성 염증질환에서 지질 신호전달물질인 lactosylceramide의 역할

이윤선, 유재명, 최경미, 이용문, 홍진태, 윤여표, 유환수 충북대학교 약품자원개발연구소 2007 약학논문집 Vol.22 No.-

-본문참고-

한국어 분석을 위한 범주 문법의 확장

이미선,윤순호,한성국 圓光大學校 1992 論文集 Vol.26 No.2

자연언어 처리를 위해서는 문법체계의 설정이 선행되어야 한다. 생성문법 체계가 일반화되기 전에 범주문법 논리표현식과 자연언어의 체계를 범주에 의해서 표현할 수 있는 가능성을 제시한 것으로 많은 연구가 있었다. 최근 이와 관련하여 함수합성과 형상승규칙을 기반으로한 결합 범주 문법체계가 제시되기도 하였다. 결합범주문법은 WH-이동이나 등위구문등의 처리에 효과적인 것으로 알려지고 있으며 결합범주에 의해 구문 기능과 의미 해석을 동시에 하는 방법을 제시해 주고 있다. 함수합성은 제약적인 순서를 기반으로 하고 있기 때문에 한국어와 같이 어순이 자유로운 언어에 적용할 경우에는, 불합리한 형상승등의 문제점을 야기시키게 된다. 본 논문에서는 이러한 문제점을 해결하고 한국어 등 어순이 자유로운 언어에 적용하기 위해 가환범주의 설정을 제시한다. 가환범주를 사용하므로써 자유어순 언어의 사전구성과 함수합성 등 규칙적용을 효율적으로 할 수 있게 된다. 본 논문에서는 대표적인 한국어구문의 분석을 통해 가환범주의 언어학적 효용성과 처리방식을 보인다. The complexity of Natural Language Processing system makes the implementation of a system a research problem to find an adequate grammar system. Classical categorial grammar in the decades before generative grammar formalisms become the main stream of syntax theory, is based on the idea that the expressions of logical and natural languages can be described entirely in terms of the defined categories. One recent approach on categorial grammar called Combinatory Categorial Grammar (CCG) proposes the operations of functional composition and type-raising in analysis of noncanonical structures such as WH-dependencies and nonidentical phrase conjunction. On the assumption that syntactic categories directly reflect the semantics of the entity in a type-driven system, CCG can make it possible to combine the syntactic functions and semantic interpretation in one combinatorial category. Since the functional operations have the strict ordering properties, the adaption of the current CCG to free word order languages cannot avoid the unusual type-raising operations and will be hard to extend the domain of categories, In this paper, a commutative productive category is proposed to the current CCG for the syntactic analysis of free word order languages like Korean. The commutative productive category is quite natural for categorial lexicon and functional operations. We present the theoretical basis of productive categories and examine the linguistic implication and the processing algorithms for the typical syntactic structures of free order languages through Korean.