상부요로계감염 환자에서 Gallium-67 Citrate 스캔 및 Tc-99m Dimercaptosuccinic Acid(DMSA)스캔의 임상적 의의

이강욱,강민규,장윤경,양종오,이상주,박기현,소영,신영태 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.2

It is often not certain whether the focal defect of renal cortex of Tc-99m Dimercaptosuccinic acid(DMSA) renal scan in patients with acute pyelonephritis means the cortical scar by previous inflammation or recent active inflammatory lesion. Gallium-67 citrate(Ga-67) also has been known to be accumulated at the active inflammatory lesion. In order to evaluate the usefulness of the Ga67 and Tc-99m DMSA renal scan in patients with acute pyelonephritis, we reviewed the results of both study and clinical findings. Nintecn patients with typical clinical findings of acute pyelonephritis and admitted to our institute from Jan. 1998 to Nov. 1998 were included in this study. Tc-99m DMSA and Ga-67 scan were performed mean 3.3 and 7.3 days after admission. Eleven of 19 patients (57.9%) showed abnormally increased focal renal uptake on the Gallium-67 citrate scan and 14 of 19 patients(73.7%) had a cortical defect on the kidneys in Tc-99m DMSA scan. Seven(36.8%) patients had an abnormality in both study. Seven(36.8%) patients had an abnormality only in Tc-99m DMSA scan and 4 (21.1%) patients had an abnormality only in Ga-67 scan. Of 7 patients who had an abnormality on both scan, 5 patients had. an abnormality at same region in both scan and 2 patients had an abnormality at the different sites on the kidneys. With the above results, we speculate that Ga-67 scan and Tc-99m DMSA scan play a complementary role in the patients with upper urinary tract infection.

이면성 및 도플러 심초음파도를 이용하여 진단한 선천성 거대 좌회선지-좌심실 관동맥루

진승원,박준철,이영중,유병현,박현옥,김용주,윤호중,김재형,홍순조,최규보,권종범,원용순,박건 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

진단이 내려지지 않은 만성기침 환자에서 양자펌프억제제의 치료효과

양주연 ( Joo Youn Yang ),이호연 ( Ho Youn Lee ),김남희 ( Nam Hee Kim ),김윤섭 ( Youn Seup Kim ) 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.2

연구배경: 8주 이상 지속되는 만성 기침의 원인 중 하나인 위식도역류질환는 환자의 약 75%가 증상이 없으며, 진단을 위한 24시간 식도 pH감시가 침습적이고 검사가 어려워 진단 및 치료에 어려움이 있다. 따라서 만성 기침환자 중 후비루증후군 및 기관지 천식이 아닌 환자를 대상으로 양자펌프억제제를 투여하고 치료효과를 관찰하였다. 방법 및 대상: 기침증상이 8주 이상인 만성기침 환자 중 X-ray 소견상 이상이 없고 메타콜린 기관지유발시험상 음성이며, 후비루증후군 치료에 반응이 없었던 40명을 대상으로 하였다. 8주 이상 양자펌프억제제를 투여하였으며 50%이상 기침이 감소한 경우를 부분 반응군, 기침이 거의 소실된 경우를 완전 반응군으로 분류하였다. 결과: 대상자 40명중 29명만이 4주 이상 추적되었으며 이중 26명만이 8주까지 추적 관찰되었다. 29명중 남자가 9명, 여자가 20명이었으며 평균나이는 51세였다. 대상자들에서 기침 이외의 증상은 객담이 12%, 콧물이나 비폐색 등의 코 증상이 있는 환자는 10%, 속쓰림, 소화불량 등의 소화기 증상을 호소하는 환자는 13.4%였다. 29명중 4주간 투여 후 증상의 호전이 없는 환자가 3명(10.3%), 50% 이상의 증상호전을 보이는 환자가 22명(75.9%), 그리고 증상이 거의 소실된 환자가 4명(13.8%)로 약 90%정도의 환자가 기침의 증상호전이 있었다. 8주 투여 후 호전이 없는 환자가 2명(7.4%), 50% 이상 증상호전이 있는 환자가 8명(29.6%), 증상이 거의 소실된 환자가 16명(63.0%)이었다. 결론: 8주이상의 만성기침 환자에서 8주 이상 양자펌프억제제 투여 후 92.6%환자가 증상호전이 있었으며 이중 63%는 거의 소실되었다. 하지만 본 연구는 위약을 통한 대조군이 없는 관계로 그 결과의 해석에 어려움이 있다. 앞으로 좀더 많은 환자를 대상으로 하는 이중맹검시험이 필요할 것으로 생각된다. Background: Recent studies have suggested an association between chronic cough and gastroesophageal reflux. Our study aimed to assess the utility of a proton-pump inhibitor in unexplained chronic cough patients. Methods: Patients with chronic cough of unknown etiology were evaluated using a chest x-ray, methacholine challenge test, and an empirical trial of postnasal drip therapy. After excluding other potential causes of the cough, forty patients were included in the study and treated for 8 weeks with a proton-pump inhibitor. Results: Eleven and three patients in the first and second 4 weeks were lost to follow-up, leaving twenty-six patients finally included in the study. Of these patients, two were unimproved, eight partially responded to the proton-pump inhibitor and sixteen responded completely after the 8 week treatment. Conclusion: We suggest that empirical treatment with a proton pump inhibitor in all patients with persistent cough, which is not secondary to asthma or postnasal drip syndrome, represents a practical and simple approach to this ailment. (Tuberc Respir Dis 2006; 60: 137-142)

Characterization of a Novel Two-Component Regulatory System, HptRS, the Regulator for the Hexose Phosphate Transport System in <i>Staphylococcus aureus</i>

Park, Joo Youn,Kim, Jong Wan,Moon, Bo Youn,Lee, Juyeun,Fortin, Ye Ji,Austin, Frank W.,Yang, Soo-Jin,Seo, Keun Seok American Society for Microbiology 2015 Infection and immunity Vol.83 No.4

<P>Hexose phosphate is an important carbon source within the cytoplasm of host cells. Bacterial pathogens that invade, survive, and multiply within various host epithelial cells exploit hexose phosphates from the host cytoplasm through the <U>h</U>exose <U>p</U>hosphate <U>t</U>ransport (HPT) system to gain energy and synthesize cellular components. In <I>Escherichia coli</I>, the HPT system consists of a two-component regulatory system (UhpAB) and a phosphate sensor protein (UhpC) that tightly regulate expression of a hexose phosphate transporter (UhpT). Although growing evidence suggests that <I>Staphylococcus aureus</I> also can invade, survive, and multiply within various host epithelial cells, the genetic elements involved in the HPT system in <I>S. aureus</I> have not been characterized yet. In this study, we identified and characterized the HPT system in <I>S. aureus</I> that includes the <I>hptRS</I> (a novel two-component regulatory system), the <I>hptA</I> (a putative phosphate sensor), and the <I>uhpT</I> (a hexose phosphate transporter) genes. The <I>hptA</I>, <I>hptRS</I>, and <I>uhpT</I> markerless deletion mutants were generated by an allelic replacement method using a modified pMAD-CM-GFPuv vector system. We demonstrated that both <I>hptA</I> and <I>hptRS</I> are required to positively regulate transcription of <I>uhpT</I> in response to extracellular phosphates, such as glycerol-3-phosphate (G3P), glucose-6-phosphate (G6P), and fosfomycin. Mutational studies revealed that disruption of the <I>hptA</I>, <I>hptRS</I>, or <I>uhpT</I> gene impaired the growth of bacteria when the available carbon source was limited to G6P, impaired survival/multiplication within various types of host cells, and increased resistance to fosfomycin. The results of this study suggest that the HPT system plays an important role in adaptation of <I>S. aureus</I> within the host cells and could be an important target for developing novel antistaphylococcal therapies.</P>

Analysis of risk factors increasing serum creatinine level in patients with psoriasis treated with cyclosporin A

( Joo Ran Hong ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Min Jung Kim ),( Hae Jeong Youn ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: Cyclosporin A (CsA) is an immune modulating agent in treating psoriasis. Considering its nephrotoxicity, however, serum creatinine (SCr) levels should be monitored carefully. Objectives: The objective of this study is to evaluate the safety of CsA and risk factors associated with a renal impairment in treatment of psoriasis with CsA. Methods: The 284 patients with psoriasis treated with CsA between January 2011 and December 2016 were analyzed. Results: The median duration of treatment was 10 weeks (interquartile range: 4-21) and the mean dose of CsA was 3.14±0.38 mg/kg/day. Although there was a significant increase of SCr levels after CsA treatment (P = 0.01), the overall change was largely reversible on cessation of the drug. More than 25% increase of SCr above baseline was reported in 17 patients (6.0%). Comparing those with increased SCr to the others, there was no significant difference in sex, body mass index, psoriasis area and severity index, disease duration, mean dose of CsA except the age (P = 0.005). Patients older than 60 years resulted at higher risk for a rise in SCr levels when compared with younger patients (P < 0.001). The treatment duration more than a year and hypertension also found to be significantly related to the SCr elevation. Conclusion: Careful SCr monitoring is needed in patients who have factors that might increase the SCr levels, such as old age, treatment duration more than a year and the hypertension.

Fabrication of photocured anion-exchange membranes using water-soluble siloxane resins as cross-linking agents and their application in reverse electrodialysis

Yang, SeungCheol,Kim, Won-Sik,Choi, Jiyeon,Choi, Young-Woo,Jeong, Namjo,Kim, Hanki,Nam, Joo-Youn,Jeong, Haejun,Kim, Yong Ho Elsevier 2019 Journal of membrane science Vol.573 No.-

<P><B>Abstract</B></P> <P>The utilization of large amounts of volatile organic solvents and the complicated process required for industrial manufacturing of ion-exchange membranes necessitate the development of simple, rapid, and environmentally friendly fabrication methods such as those based on photopolymerization. We employed hydrolytic sol–gel reactions between ammonium- and acrylamide-functionalized silane coupling agents to synthesize water-soluble siloxane resins that exhibit high condensation levels (>80%) and comprise oligomers with molecular weights below 2000 Da. These resins were then mixed with a hydrophilic monomer bearing ammonium and acrylamide groups, and porous polyethylene substrates were impregnated with the resulting mixtures and then irradiated with ultraviolet light. The hydrophilicity, mechanical strength, and other properties of the resulting membranes depended on the resin composition, indicating that the substrate pores were efficiently filled with the prepared resins and further suggesting that the membrane performance could be effectively altered by varying the resin composition. Moreover, the obtained membranes exhibited chemical stability in the pH range between 0 and 11 and in hot water at 60 °C. The reverse electrodialysis stack consisting of these membranes showed higher power density than a stack of commercial membranes. Therefore, it can be concluded that without employing volatile organic solvents for reverse electrodialysis, the developed technique is well-suited for the fabrication of ion-exchange membranes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Photocured anion-exchange membranes were fabricated using water-soluble siloxane resins. </LI> <LI> All resins had a high condensation degree, containing oligomers with <I>M</I> <SUB>w</SUB> < 2000 Da. </LI> <LI> These resins acted as cross-linkers and helped to avoid the use of organic solvents. </LI> <LI> The properties of the prepared anion-exchange membranes depended on resin composition. </LI> <LI> Reverse electrodialysis using the prepared membrane shows higher power density than that of the commercial membrane. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Factors Affecting Lumber Conversion Rate of Sawmill Industry in South Korea

Yang, In,Lee, Seong Youn,Joo, Rin Won,Youn, Yeo-chang Korean Society of Forest Science 2007 한국산림과학회지 Vol.96 No.2

This study is conducted to investigate the factors affecting lumber conversion rate of sawmill industry in South Korea. Data were obtained from the survey of 38 sawmills in all geographic regions of South Korea. The variables examined in this study were region, softwood/hardwood log, domestic/imported/both log, the number of power-driven carriages (PDC) installed, the year when and country where PDCs was manufactured, the horse power of PDC, the number of labors required to operate each PDC, the sawing capacity of mill (mill size), and the types of major product and by-products. The lumber recovery factor (LRF) of sawmills were significantly influenced by the origin of logs, level of PDC automation, sawmill size, and size of logs (measured in diameter and length) while not by the location of the mill, types of major product and by-product, log species, and characteristics of PDC. Although these results provide useful information for understanding the technological characteristics of the Korean sawmill industry, further investigation with larger sample is necessary to reveal the more reliable characteristics of sawmill industry in South Korea.

Impact of prior lamivudine use on the antiviral efficacy and development of resistance to entecavir in chronic hepatitis B patients

Joo An Hwang,Kee Bum Kim,Min Jae Yang,임선교,황재철,Jae Youn Cheong,조성원,Soon Sun Kim 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2

Background/Aims: To determine the efficacies of entecavir (ETV) in nucleos(t)ide analogue (NA)-naïve chronic hepatitis B (CHB) patients and in those with prior lamivudine (LAM) use who did not develop resistance. Methods: We retrospectively enrolled 337 patients with CHB who were treated with ETV (0.5 mg daily) for at least 30 months. The study included 270 (80.1%) NA-naïve patients and 67 (19.9%) LAM-use patients. Ten of the LAM-use patients were refractory to LAM therapy without developing resistance. Results: Genotypic resistance to ETV developed more frequently in the LAM-use group (13.1%) than in the NA-naïve group (2.6%) at 60 months (P=0.009). In subgroup analysis, after excluding the 10 patients who were refractory to LAM therapy, the cumulative probability of ETV resistance did not differ significantly between the two groups (P=0.149). Prior LAM refractoriness and a higher hepatitis B virus DNA level at month 12 were independent predictive factors for the development of ETV resistance. Conclusions: ETV resistance developed more frequently in LAM-use patients with CHB. However, prior LAM use without refractoriness did not affect the development of ETV resistance. The serum hepatitis B virus DNA level at month 12 was a major predictor for the development of ETV resistance. (Clin Mol Hepatol 2015;21:131-140)

Original Articles : Impact of prior lamivudine use on the antiviral efficacy and development of resistance to entecavir in chronic hepatitis B patients

( Joo An Hwang ),( Kee Bum Kim ),( Min Jae Yang ),( Sun Gyo Lim ),( Jae Chul Hwang ),( Jae Youn Cheong ),( Sung Won Cho ),( Soon Sun Kim ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.2

Background/Aims: To determine the effi cacies of entecavir (ETV) in nucleos(t)ide analogue (NA)-naive chronic hepatitis B (CHB) patients and in those with prior lamivudine (LAM) use who did not develop resistance. Methods: We retrospectively enrolled 337 patients with CHB who were treated with ETV (0.5 mg daily) for at least 30 months. The study included 270 (80.1%) NA-naive patients and 67 (19.9%) LAM-use patients. Ten of the LAM-use patients were refractory to LAM therapy without developing resistance. Results: Genotypic resistance to ETV developed more frequently in the LAM-use group (13.1%) than in the NA-naive group (2.6%) at 60 months ( P=0.009). In subgroup analysis, after excluding the 10 patients who were refractory to LAM therapy, the cumulative probability of ETV resistance did not differ significantly between the two groups ( P=0.149). Prior LAM refractoriness and a higher hepatitis B virus DNA level at month 12 were independent predictive factors for the development of ETV resistance. Conclusions: ETV resistance developed more frequently in LAM-use patients with CHB. However, prior LAM use without refractoriness did not affect the development of ETV resistance. The serum hepatitis B virus DNA level at month 12 was a major predictor for the development of ETV resistance. (Clin Mol Hepatol 2015;21:131-140)

The synergistic effect of antihistamines and topical corticosteroids on the treatment of atopic dermatitis: a meta-analysis

( Joo Ran Hong ),( Ji Youn Hong ),( Jin Hee Kim ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Song Hee Han ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: H1-antihistamines have been used widely to treat pruritus in atopic dermatitis (AD). Although the evidence for H1-antihistamine monotherapy for pruritus in AD is inconclusive, combination therapy with topical glucocorticoids are particularly considered as to be effective as both short-term intensive therapy and maintenance treatment in patients with frequent relapse. Objectives: We conducted a meta-analysis for confirming the efficacy of antihistamine as an adjunct to topical corticosteroid application in the treatment of AD. Methods: We identified 1,206 studies through systematically searching Medline, Embase, and CENTRAL databases for articles published from 1967 to 2015. Random effects meta-analysis was used to calculate mean differences (MD) with 95% confidence intervals (CI). Results: Two studies satisfying the inclusion criteria of antihistamine therapy with mandatory topical steroid use were selected. Comparing antihistamine monotherapy with combination therapy, patients treated with the addition of antihistamine to topical corticosteroids showed a statistically significant clinical improvement (standard MD, -0.24; 95% CI, -0.42 to -0.05; p = 0.01). Conclusion: This meta-analysis based on two studies suggests that antihistamine therapy as an adjunctive therapy for pruritus in AD may have beneficial effects in combination with topical corticosteroid treatment.