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- 저자 : ( Yoshihiro Muneta ) (검색결과 2 건)
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IFNImmunosuppression of xenograft rejection in porcine kidney PK15 cells by porcine IL-18
최윤실,김영관,심정현,김은미,강형식,윤도영,Yoshihiro Muneta,명평근 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.5
Xenotransplantation, the transplantation of cells, tissues or organs between individuals of different species, would resolve the current shortage of organs, but rejection remains the major hurdle to successful xenotransplantation. In the present study, we analyzed mixed lymphocyte reactions (MLRs) and used 51Cr release assays in order to identify the proliferation and expansion of mouse CD8+cytotoxic T lymphocyte cells against PK15, PK15/pIL-18 or PK15/mIL-18 cells. In addition, we identified T cell populations in mouse splenocytes and lymph node cells using two-color flow cytometry. It was found that the CD8+ T cells of xenograft recipients proliferated extensively and that the survival rates of populations of PK15/mIL-18 or PK15/pIL-18 cells were higher than untransfected controls. Moreover, CD3+T cells were increased in mice injected with PK15 cells or PK15/pIL-18 cells but PK15/pIL-18 cell numbers were lower in lymph nodes than untransfected controls. CD8+ T cells numbers were reduced in the lymph nodes of PK15/pIL-18 injected mice. These results suggest that porcine IL-18 regulates anti-pig cellular rejection in C57BL/6 mice.
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Immunosuppression of xenograft rejection in porcine kidney PK15 cells by porcine IL-18
Choi, Yon Sil,Kim, Young Kwan,Shim, Jung Hyun,Kim, Eun Mi,Kang, Hyung Sik,Yoon, Do Young,Muneta, Yoshihiro,Myung, Pyung Keun 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
Xenotransplantation, the transplantation of cells, tissues or organs between individuals of different species, would resolve the current shortage of organs, but rejection remains the major hurdle to successful xenotransplantation. In the present study, we analyzed mixed lymphocyte reactions (MLRs) and used (51)^Cr release assays in order to identify the proliferation and expansion of mouse CD8^(+) cytotoxic T lymphocyte cells against PK15, PK15/pIL-18 or PK15/mlL-18 cells. In addition, we identified T cell populations in mouse splenocytes and lymph node cells using two-color flow cytometry. It was found that the CD8^(+) T cells of xenograft recipients proliferated extensively and that the survival rates of populations of PK15/mlL-18 or PK15/plL-18 cells were higher than untransfected controls. Moreover, CD3^(+) T cells were Increased in mice injected with PK15 cells or PK15/plL-18 cells but PK15/plL-18 cell numbers were lower In lymph nodes than untransfected controls. CD8^(+) T cells numbers were reduced in the lymph nodes of PK15/plL-18 injected mice. These results suggest that porcine lL-18 regulates anti-pig cellular rejection In C57BL/6 mice.
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