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2차원 및 3차원 초음파를 이용한 태아표면의 해부학적 선별 검사에 관한 연구
윤석범,이해혁,이정재,최경훈,이순곤,이임순,이권해 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2
Objective : Our purpose of this study was to determine the clarity and consuming time of fetal surface screening in thirty-eight fetuses from 24 to 32 weeks of gestation by use of two and three-dimensional ultrasonography. Methods : From May 1998 to July 1998, we performed the fetal surface screening of the fetal face, extremities, and spine. Thirty-eight fetuses of 24-32 weeks of gestation (thirty-seven normal fetuses and one abnormal fetus) were studied by use two-dimensional (AI 5200S, 3.5-5.0MHz; Acoustic Imaging Technologic Cooperation, U.S.A.) and three-dimensional ultrasonography (Volusion 530D, 3.5-5.0 MHz ; Kretz-Medicine, Korea). On the fetal face, we evaluated both orbits, nose, lips and brow. Both hands and feet, five digits and toes should be seen in this study. We evaluated cervical spine and lumbosacral junction of the spine. Results : The maternal average age of 38 patients was 29.9 years and the average gestational age was 29.7 weeks. The results of fetal surface screening were as follows : face (both orbits 89.5%, lips 92.1%, nose 92.1%, and brow 89.5%), extremities (both hands 68.4% and feet 73.7%), and spine (cervical spine 94.7% and lumbosacral junction 97.4%) by use of two-dimensional ultrasonography. By use of three-dimensional ultrasonography, results were as follows : face (both orbits 76.3%, lips 81.6%, nose 81.6%, and brow 78.9%), extremities (both hands 76.3% and feet 78.9%), and spine (cervical spine 71.1% and lumbosacral junction 73.7%). Consuming time for two-dimensional ultrasonography were 4.7 minutes for face, 11.6 minutes for extremities, and 5.7 minutes for spine. Using three-dimensional ultrasonography results were 12.8 minutes for face, 17.9 minutes for extremities, and 11.7 minutes for spine. Average consuming time of all fetal anatomic screening was 22.0 and 42.4 minutes by use of two and three dimensional ultrasonography. In one abnormal fetus had cleft lip and polydactyly of right foot which were detected all by three-dimensional ultrasonography, but we couldn't detect the polydactyly by two-dimensional ultrasonography. Conclusion : Three-dimensional ultrasonography was more time-consuming method, but we suggested that three-dimensional ultrasonography was superior than two-dimensional ultrasonography in fetal surface screening.
이순복,조태순,윤기욱,이종찬,이선미,심성보 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
The dose-response effect of polysaccharide extracts(PS-1) from Artemisia iwayomogi was investigated under various hepatic disease models. Silymarin, DDB and UDCA were used as reference compounds. We found that the maximal effective dose of PS-1 was 100 ㎎/㎏ b.wt. in CCl_4-induced hepatotoxicity, D-galactosamine-induced hepatitis, in ANIT-induced cholestasis and 300 ㎎/㎏ b.wt. in CCl_4-induced chronic liver disease, 30 ㎎/㎏ b.wt. in chronic bile duct ligation and chronic ethanol fatty liver. These findings suggest that PS-1 fraction protects the hepatocyte against various hepatic injuries, and this fracton might be of therapeutic value.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
최근 10년간 원광의대병원에서 시행한 소아 심장혈관 수술의 임상적 고찰
윤향석,정수미,최두영,오광수,오연균,김종덕,양현웅,이삼윤,김형곤,최종범,최순호,노병석 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
We reviewed 10 years experiences of the clinical aspects and early postoperative results in 544 pediatric patients(age less than 16 years old). Among them. 529 cases had the congenital heart diseases, and 15 had the acquired diseases. Open heart surgery was performed in 413 patients. 115 cases were treated with non-open heart surgery. 16 with interventional catheterization. Annual increase of the cardiac patients was not significant in recent 10 years, except slight increase in 1994. The mean age of the study patients had been evidently changed to younger year by year. Total mortality rate of the open heart surgery was 6.4%. The cyanotic congenital heart diseases were high in early postoperative mortality by 25.7%, whereas 4% in acyanotic group. The age group less than one month was most highest in surgical mortality(66.7%). There were no deaths in patients with patent ductus arteriosus(103 cases), atrial septal defect(83 cases) or pulmonary stenosis(17 cases). Among 220 patients with ventricular septal defects(VSD). 10(4.5%) were died early postoperatively. In cyanotic group, the patients with pulmonary atresia with ventricular septal defects(PAVSD), transposition of the great arteries(TGA), interrupted aortic arch(IAA), complex cardiac anomalies with isomerism seemed to be most susceptible to an early death.
이규윤,김용배,이영만,양순재,박종섭 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1
Significant soft-tissue defects in the lower extremity including the tibia and the foot are best managed with free skin-muscle of skin-grafted free muscle transfers. While free flap donor sites useful for lower exremity reconstruction include the latissimus dorsi, the rectus abdominis, the gracilis, and the scapular flaps, the latissimus dorsi seems ideal. This muscle has a reliably long vascular pedicle of wide diameter, making microsurgical anastomosis of the thoracodorsal vessels straightforward. Because it is so large, it can cover virtually and size defect. Furthermore, its flat configuration makes it especially easy to fold on itself to that it can be used to closure wounds with complex three-dimensional geometry and dead space. Although the gracilis and rectus abdominis muscles have their roles, in most cases the latissimus dorsi should serve well. We described technical considerations in each case and the advantages of free latissimus dorsi myocutaneous flap on the reconstruction of the soft tissue defect in the lower extremity.
이윤원,이민순,윤상욱,김진수 中部大學校 自然科學硏究所 1999 自然科學硏究論文集 Vol.8 No.1
수락계곡에 있어서 산록시면 하부의 이치림의 군락구조에 대한 속성을 조사한 결과 다음과 같이 요약할 수 있다. 1. 본 군락은 54종의 식생으로 구성되었는데 교목층은 참나무류가 우점하고 있으며, 아교목층 저목층으로 내려갈수록 서어나무 신갈나무의 중요치가 높아지고, 초본층에서도 서어나무 물푸레나무 치묘가 많이 발생하고 있으므로 굴참나무가 우점하는 군락에서 신갈나무, 서어나무 군락으로 천이 cycle이 진행중인 것으로 판단된다. 2. 군락전체의 종다양도는 1.5452로 높았으나, 교목층의 종다양도는 낮았고, 종내경쟁이 심하였으며, 종간경쟁은 초본층이 가장 심하였다. 또한 저목층에서 안정도가 가장 높게 나타났으며, nich breadth는 초본층이 가장 높게 나타나는 것을 볼 때 초본층에서 교목층까지 차례로 생태적 지위가 재편성되는 과정으로 판단된다. 3. 수고 분포도와 흉고직경급 분포도를 토대로 군락동태를 예측해본 결과 천이 초기종인 굴참나무, 갈참나무가 교목층에 우점하는 군락에서, 천이 후기종인 신갈나무, 서어나무가 침입하여 천이가 진행중인 군락으로 판단된다. This research was aimed at figuring out the characteristics of community structre of secondary forest ecotone of deciduous broad leaved trees in foot slope of Wolsobong area, Which valley and foot slope and hill side doing net crossed. It can be expected to provide the fundamental data for tending and natural regeneration of broad leaved forest, in the Mt. Daedun as being known as temperature middle zone. The results are such as follows: The vegetation of the secondary forest ecotone, which foot slpoe and hill side being crossed, was composed of 54 species, the canopy domineted species, Quercus spp., for example. And under story, shurb layer was going lower, dominance species were Carpinus laxiflora, Quercus monglica. So it might be said that the investigated area is doing succession at the present time. Species diversity appeared 1.5452 at high values. Therefore the investigated area is reflecting species composition by environmental factors. On the other hand, at the each layer level, species diversity of the upper layer was lower values and interspecific encounter of herb layer the highest. And it may be concluded that niche breadth does appeared reforming, due to the stability of shurb layer strong of intraspecific encounter. Through analyzing dynamics of the community with using data, height distribution and D.B.H. class distribution range, Quercus variabilis, Quercus aliena species were rapidly growing well adapting. Afterwards it is assessed that the community structure of researched area will be obviously devoloped climax such as dominated Quercus monglica or Carpinus laxiflora community.
과호흡증후군 환자에서 이온화칼슘,마그네슘과 산-염기상태의 변화에 대한 고찰
윤천재,정순미,장문준,이한식 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3
Background. Tetanic spasm is often noted in hyperventilating patients coming in to emergency departments. Classical explanation for this phenomenon was decreased ionized calcium levels due to respiratory alkalosis precipitated by the hyperventilation. Clinically these symptoms were observed in hypocalcemia and were thought as such without doubt, But6 clinical investigation on the levels of ionized calcium levels have not been clarified. Recent investigations on hyperventilating volunteers have suggested other pathophysiology for tetanic spasm in hyperventilating patients which is the decrement of ionized magnesium level rather than ionized calcium. We wanted to see if these results applied to our hyperventilating patients and see if ionized magnesium level was a factor producing tetanic symptoms. Method and Material, 35 patients with diagnosis of hyperventilation syndrome by emergency physician were studied retrospectively. Hyperventilating patients arriving at Severance hospital Emergency Center from Jan. 1996 to Feb. 1998 were included. Patients with cardiovascular, pulmonary diseases, history of renal or liver disease were excluded. Ion-selective method was used to detect ionized calcium, magnesium levels and arterial blood gas features. Average levels were compared to reference ranges and Wilkoxon-rank, sum test was used to compare hyperventilating patients with tetanic spasm and those with other symptoms such as dyspnea, chest pain and palpitations. Results. 1) Sodium, potassium and chloride levels were 138mmol/L, 3.6mm/l, 106mm/l each which were within a normal range. 2) Degrees of hyperventilation were similar with average of PH 7.54(7.4-7.71), pCO₂ 23.6mmHg, showing respiratory alkalosis. 3) Ionized calcium and ionized magnesium each showed 0.61mg/dl, 0.16mg/dl lower values than the lowest reference ranges which were 4.5-5.6mg/dL for ionized calcium and 1.19-1.63 for ionized magnesium. 4) No statistical difference points were observed between the tetanic spasm group and group without spasm. Female preponderance were noted in tetanic spasm group. Conclusion. We conclude that other than decrement of ionized calcium, decrement of ionized magnesium could be a factor for inducing tetanic spasm in respiratory alkalosis caused by hyperventilation.
TGF-β가 HPV-16의 인체 세포 발암화에 미치는 영향
이윤순,양재호,박일수 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1
Human epithelial cell line immortalized with Ad12-SV40 hybrid virus was transfected with plasmid containing HPV-16 gene. Among these clones, clone-3 and clone-6 showed neoplastic transformation properties of contact inhibition, anchorage independence and cellular adhesion after 7 subcultures. The results suggest that SV40 gene in the immortalized human cell system be in concert with HPV-16 in the process of neoplastic transformation of human cells. While TGF-β₁( 5ng/㎖) inhibited growth of control cells and clone-1 cells which did not show transformation, there was no significant change on the growth of clone-3 cell with transformation properties. When transcriptional level of fibronectin on control cells and clone-3 cells were higher, as compared with control cells. RNA hybridization techniques were performed to compare trasncriptional levels of TGF-β₁ between control cellls and clone-3 cells. Rna level on clone-3 cells with transformation properties was higher than on control cells. These studies indicate that TGF-β₁ is associated with increases of fibronectin, which may lend to changes of TGF-β receptor and loss of its inhibitory action on the transformed cells. Thus, it seems that loss of inhibitory action of TGF-β which is mediated by changes of fibronectin may account for a possible mechanism of action in the HPV-16 induced transformation of human cells.
Shield Disk 상의 Ag-Cu 공정계 합금 도금기술 개발
윤경도,차동관,심기종,민봉기,최순돈,이상기 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.1
The composition and the microstructure of the Ag-Cu alloy electrodeposits electroplated in Succinimide bath were investigated varying the electrolysis conditions such as bath composition, current density and additive agents etc. The cathode overpotential increased with the increase of Succinimide concentration and current density ratio in the bath. The Ag content of the alloy deposits decreased with the increase of current density and pH and temperature in the bath. The optimum condition for 78wt.%Ag-22wt.%Cu code position alloy is an follows : pH10(adjusted by NH_4OH), 0.03M AgNO_3, 0.27M Cu(NO_3)_2 3H_2O, 0.5M Succinimide in bath and 3.5A/dm^2∼5.5A/dm^2 current density.