Albumin-to-Fibrinogen Ratio as an Independent Prognostic Parameter in Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of 191 Cases

Yi-Xin Zou,Jia Qiao,Hua-Yuan Zhu,Rui-Nan Lu,Yi Xia,Lei Cao,Wei Wu,Hui Jin,Wen-Jie Liu,Jin-Hua Liang,Jia-Zhu Wu,Li Wang,Lei Fan,Wei Xu,Jian-Yong Li 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2

Purpose Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients. Materials and Methods In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients. Results The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70. Conclusion These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients.

OPTIMAL LAUNCHING-INTENTION-AWARE CONTROL STRATEGY FOR AUTOMATED CLUTCH ENGAGEMENT

Yi-yong Yang,Zao-bei Zhu,Xiang-yu Wang,Zheng Chen,Zi-lin Ma 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.3

Clutch engagement control is critical during launching process in a vehicle equipped with an automated manual transmission (AMT), which is a problem including muti-objective optimization and nonlinear control. In this paper, a optimal launching-intention-aware control strategy is proposed for clutch engagement. Firstly, a launching-intention-aware machine (LIAM) based on artificial neural network (ANN) is designed to identify the driver’s launching intentions. Then the optimal laws of clutch engagement for different launching conditions are obtained based on the dynamic programming (DP), which regard friction loss, vehicle shock, angular acceleration of engine and engine torque as the optimizing indexes. Next, a slidingmode controller (SMC) is designed for the clutch engagement. Finally, the performances of the optimal laws and the SMC are validated by the joint simulation of Simulink-AMESim, and the results show that the requirements of vehicle launching are met. The proposed clutch engagement control strategy would provide a better theoretical support for the practical-extended application of AMT.

Effect of Nd Substitution for Mischmetal on Magnetic Properties in (MM,Nd)-Fe-B Ribbons

Zhu-bai Li,Jing-zhao Li,Zhi-yi Xu,Yong-feng Li,Xue-feng Zhang 한국자기학회 2020 Journal of Magnetics Vol.25 No.1

Mischmetal-based permanent magnets of (MM,Nd)12Fe82B6 were prepared by melt-spinning method via varying the relative content of mischmetal and Nd. The coercivity is low, and the squareness of hysteresis loop is poor in MM12Fe82B6 ribbons. The x-ray diffraction pattern, maximum of δm value as well as the temperature dependence of magnetization indicates that the partial substitution of Nd for MM could improve the crystallinity in the mischmetal-based magnets, and both the coercivity and squareness of hysteresis loop increase with Nd substitution for mischmetal. The increase of squareness should be partially attributed to the improvement in the crystallinity of R₂Fe14B crystal phase. For more than 4 at.% Nd substitution the coercivity is not less than that in corresponding (Ce,Nd)-based magnets, and the coercivity of 7.81 kOe and the maximum energy product of 15.41 MGOe were obtained in MM8Nd₄Fe82B6 ribbons. These investigations show that it is reasonable to use the low cost mischmetal to prepare the resource-saving rare-earth magnets, and that optimizing the addition amount of Nd is necessary to improve the crystallinity and enhance the magnetic properties.

Characterization of Mutations in AlHK1 Gene from Alternaria Longipes: Implication of Limited Function of Two-Component Histidine Kinase on Conferring Dicarboximide Resistance

( Yi Yong Luo ),( Jin Kui Yang ),( Ming Liang Zhu ),( Jin Ping Yan ),( Minghe Mo ),( Ke Qin Zhang ) 한국미생물 · 생명공학회 2008 Journal of microbiology and biotechnology Vol.18 No.1

Four series (S, M, R, and W) of Alternaria longipes isolates were obtained based on consecutive selection with Dimethachlon (Dim) and ultraviolet irradiation. These isolates were then characterized according to their tolerance to Dim, sensitivity to osmotic stress, and phenotypic properties. All the selected Dim-resistant isolates showed a higher osmosensitivity than the parental strains, and the last generation was more resistant than the first generation in the M, R, and W series. In addition, the changes in the Dim resistance and osmotic sensitivity were not found to be directly correlated, and no distinct morphologic characteristics were found among the resistant and sensitive isolates, with the exception of the resistant isolate K-11. Thus, to investigate the molecular basis of the fungicide resistance, a group III two-component histidine kinase (HK) gene, AIHK1, was cloned from nineteen A. longipes isolates. AIHK1p was found to be comprised of a six 92-amino-acid repeat domain (AARD), HK domain, and response regulator domain, similar to the Os-1p from Neurospora crassa. A comparison of the nucleotide sequences of the AIHK1 gene from the Dim-sensitive and -resistant isolates revealed that all the resistant isolates contained a single-point mutation in the AARD of AIHK1p, with the exception of isolate K-11, where the AIHK1p contained a deletion of 107 amino acids. Moreover, the AIHK1p mutations in the isolates of each respective series involved the same amino acid substitution at the same site, although the resistance levels differed significantly in each series. Therefore, these findings suggested that a mutation in the AARD of AIHK1p was not the sole factor responsible for A. longipes resistance to dicarboximide fungicides.

Highly Efficient and Recyclable g-C3N4/CuO Hybrid Nanocomposite Towards Enhanced Visible-Light Photocatalytic Performance

Shiquan Hong,Yong Yu,Zhijie Yi,Haijun Zhu,Wencheng Wu,Peiyan Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.11

A highly efficient visible-light-driven g-C3N4/CuO hybrid nanocomposite catalyst with different molar contents of CuO are successfully fabricated via a simple liquid phase synthesis process and applied to the degradation of Rhodamine B (RhB) solution. The results reveal that monodisperse CuO nanoparticles with a size of less than 10 nm are uniformly distributed on the surface of gC3N4 nanosheets. Compared with the pure g-C3N4 and CuO, the as-prepared nanocomposite displays significantly enhanced photocatalytic performance under visible-light irradiation. Attractively, the photocatalytic activities of the nanocomposite catalysts can be tuned by adjusting the molar ratio of g-C3N4 and CuO. When the molar ratio reaches 2:1, the nanocomposite exhibits the highest photocatalytic activity, which can decompose RhB completely in 5 min. The improved performance could be ascribed to the formation of heterostructure between g-C3N4 and CuO as well as the decreased particle size of CuO, the presence of H2O2, large surfaceexposure area and the suitable band position of g-C3N4/CuO nanocomposite. Interestingly, the nanocomposite shows excellent stability and recyclable property toward the photodegradation of RhB. Finally, a possible photocatalytic mechanism is proposed.

Evaluation and Utilization of Xinjiang Melon (Cucumis melo ssp. melo) Germplasm Resources

Wu ming zhu,Yi hong ping,Feng jiong xin,Li jin song,Wang deng ming,Aken ya sheng,Zhang yong bing,Zhai wen qiang,Wu hai bo 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

유청단백 함유 체중조절용 식사대체제를 이용한 4주 다이어트 프로그램이 과체중 및 비만 여성의 체중, 체지방 및 체성분에 미치는 영향

석매주(Mei-Zhu Xi),장이림(Yi-Lin Zhang),최영빈(Young-Bin Choi),정기희(Gi-Hee Jeong),김건우(Gun-Woo Kim),박용우(Yong-Woo Park),이복희(Bog-Hieu Lee) 동아시아식생활학회 2016 동아시아식생활학회지 Vol.26 No.1

A Study on the Scenario Transparency of Civil Intelligent Adjudication in China

주복용 ( Fu-yong Zhu ),퉁신위 ( Xin-yu Tong ),가오이헝 ( Yi-heng Gao ) 한중사회과학학회 2024 한중사회과학연구 Vol.22 No.1

과학기술의 발전으로 인하여 민사재판에 있어서도 이른바 ‘스마트 재판’이 등장하였다. 스마트 재판은 과학기술에 재판의 기능을 더한 것으로, 재판절차를 표준화함으로써 재판의 질적 및 효율성을 제고하는데 도움이 된다. 현재 재판과정을 보면, ‘사전회의-공판-판결’을 거치는데, 이때 판결의 편차가 발생하게 된다. 이러한 판결의 편차에 있어 투명성이 보장되지 않기 때문에 스마트 재판에 사용되는 AI의 알고리즘에 대한 분석이 필요하다. 하지만, 알고리즘은 대부분 제조회사의 영업비밀로 보호되고 있다. 이른바 ‘알고리즘 블랙박스’로 인해 민사사건 당사자와 일반대중은 알고리즘의 실제 작동과정과 재판에서의 적용에 관해 알기 어려울 뿐만 아니라, 재판결과에 대한 합리적 의심을 해결할 수 없게 된다. 이로 인해 최근 중국이 스마트 재판을 받아들여 발전시키려는 정책에 걸림돌이 될 수 있다. 이를 위해 스마트 재판의 과정을 시각화함으로써 투명성을 보장할 필요가 있다. 즉, 재판준비과정에서 공판 및 판결에 이르기 까지의 전과정을 AI 알고리즘의 운영이 시각화할 수 있도록 하여야 한다. 기술적으로는 재판과정 간 투명성 보장을 위한 알고리즘을 통해 상호 통합하도록 하여, 실제 재판이라는 물리적 공간과 AI가 제공하는 사이버 공간을 상호 연결하여 융합할 필요가 있다. 또한, 민사재판의 투명성 보장을 통해 ‘기계(프로그램)+인간’이 공생하는 민사재판 모델을 구축하고, 전통적인 ‘현장 정의’ 이론을 ‘디지털 정의’이론으로 전환함으로써 민사사건 해결에 있어 새로운 국면을 열 수 있을 것이다. Technology and civil adjudication of two-way run to write a new chapter of civil intelligent adjudication, intelligent technology for the adjudication of empowerment, help to standardize the adjudication of the operation of the program, enhance the quality of the adjudication of the effectiveness of the adjudication of the realization of the goals of the adjudication of great significance. However, in practice, due to the lack of transparency of pre-trial meetings, court hearings, adjudication and deviation and other scenarios, in particular, the algorithms involved are mostly protected by technology companies as trade secrets. The black box of algorithms makes it difficult for the parties to civil cases and the public to know the actual operation of the algorithms and the logic behind the adjudication actions, and it is impossible to dispel the reasonable doubts of the parties and the public about the adjudication results, which may exacerbate the crisis of the acceptability of civil intelligent adjudication. To this end, we take scene transparency as the perspective, typify the scenes of civil intelligent adjudication, construct intelligent transparency models from different scenes such as pre-trial preparation, trial, adjudication and adjudication deviation, promote the deep integration between technology and adjudication activities, promote the connection, switching and integration of material space and information space through technology, shape the theoretical models of transparency in different scenes, and improve the compatibility between the theoretical models of scene transparency and the development of intelligent adjudication technology. It also improves the adaptability between the theoretical model of scene transparency and the development of intelligent adjudication technology. Based on the justice goal of scene transparency research and development, and in accordance with the principle of human-machine symbiosis, the civil adjudication mode of human-machine symbiosis is constructed to promote the traditional theory of “field justice” to the theory of “digital justice”, improve the digital system of civil case resolution, and promote the realization of the fusion of technology and law. It also promotes the digitalization system of civil case resolution, promotes the integration of technology and law, and promotes the integration of emotion, reason and law in the adjudication results while enhancing the transparency of the intelligent adjudication scenario, so as to continuously improve the acceptability of the civil adjudication results, and to build up an ecological system of trust for civil intelligent adjudication.

Susceptibility Loci Associations with Prostate Cancer Risk in Northern Chinese Men

Wang, Na-Na,Xu, Yong,Yang, Kuo,Wei, Dong,Zhang, Yao-Guang,Liu, Ming,Shi, Xiao-Hong,Liang, Si-Ying,Sun, Liang,Zhu, Xiao-Quan,Yang, Yi-Ge,Tang, Lei,Zhao, Cheng-Xiao,Wang, Xin,Chen, Xin,Hui, Juan,Zhang, Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: KLK3 gene products, like human prostate-specific antigen (PSA), are important biomarkers in the clinical diagnosis of prostate cancer (PCa). G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays important roles in the development of PCa. However, associations of these genes with PCa in northern Chinese men remain to be detailed. This study aimed to investigate their impact on occurrence and level of malignancy. Methods: All subjects were from Beijing and Tianjin, including 266 cases with prostate cancer and 288 normal individuals as controls. We evaluated associations between clinical covariates (age at diagnosis, prostate specific antigen, Gleason score, tumor stage and aggressive) and 6 candidate PCa risk loci, genotyped by PCR- high resolution melting curve and sequencing methods. Results: Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men. In addition, subjects with CX (CC+TC) genotypes had a decreased risk for prostrate cancer compared to those carrying the TT homozygote (OR =0.64, 95% CI = 0.45- 0.90, P = 0.008). The TT genotype of 13q22 (rs9600079, T) was associated with tumor stage (P=0.044, OR=2.34, 95% CI=0.94-5.87). Other SNPs were not significantly associated with clinical covariates in prostate cancer (P > 0.05). Conclusions. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus in northern Chinese men.

The Homologous Region 3 from Bombyx mori Nucleopolyhedrovirus Enhancing the Transcriptional Activity of Drosophila hsp70 Promoter

Tang, Shun-Ming,Yi, Yong-Zhu,Zhou, Ya-Jing,Zhang, Zhi-Fang,Li, Yi-Ren,He, Jia-Lu Korean Society of Sericultural Science 2004 International Journal of Industrial Entomology Vol.9 No.2

Drosophila melanogaster heat shock protein 70 gene promoter (Dhsp70p) is widely used in transgenic insect to drive exogenous gene, and the homologous region 3 from Bombyx mori nucleopolyhedrovirus (BmNPVhr3) functions as an enhancer for several promoters. To test whether BmNPVhr3 can enhance the Dhsp70ps transcriptional activity, the reporter plasmids, which contain the Dhsp70p, the reporter $\beta$-galactosidase gene with SV40 terminator and BmNPVhr3 fragment, are constructed and transfected into the insect cell lines (Bm-N cells and Sf-21 cells) by lipofectin-mediated method. The results from the transient expression assay show that BmNPVhr3 significantly increases transcriptional activity of Dhsp70p both under the normal condition and under the heat-shock treatment, although the effects are significantly different between in Bm-N cells and in sf-21 cells. The enhancing behavior of BmNPVhr3 on the Dhsp70p is in an orientation-independent manner. Meanwhile, the effects of heat-shock treatment on Dhsp70p alone or Dhsp70p/BmNPVhr3 combination present no significant difference, indicating that BmNPVhr3 only enhances the transcriptional activity of Dhsp70p, but cant alter its characteristic of the response to the heat-shock stress. The above results suggest that the Dhsp70p/BmNPVhr3 combination is more effective one to drive exogenous gene for transgene or stable cell expression system in insects.