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( Do Keun Cho ),( Dong Hun Choi ),( Joon Yong Cho ) 한국운동영양학회 2017 Physical Activity and Nutrition (Phys Act Nutr) Vol.21 No.3
[Purpose] This study aimed to investigate the effects of treadmill exercise on body weight, blood biochemistry, and autophagy. [Methods] Triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, and glucose levels were measured, the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score was calculated, and the soleus muscle was analyzed for autophagy- related factors (Beclin-1, p62, LC3, Lamp- 2) in rats with obesity induced by a high-fat diet. Eight-week-old Sprague Dawley rats were fed a high-fat diet for 35 weeks and then subjected to 10 weeks of treadmill exercise. The experimental group was divided into a Normal Diet-Sedentary (ND-SED, n=8) group, an (High-Fat Diet-Sedentary (HF-SED, n=8) group, and an High-Fat Diet + Treadmill Exercise (HF-TE, n=8) group. The intensity of treadmill exercise was set as 8 m/min for 5 min, 11 m/min for 5 min, 15 m/min for 20 min, and 11 m/min for the last 5 minutes. A glucose tolerance test was performed at the 2nd and 8th week of exercise by sampling of tail blood. [Results] With endurance exercise, the HFTE group showed a significant decrease in body weight, with improved blood biochemical indices and HOMA-IR scores, in comparison with the HF-SED group. However, there was no significant difference in Beclin-1, p62, LC3, and Lamp-2 proteins as measured by autophagic flux in the soleus muscle. [Conclusion] Treadmill exercise induced improvements in body weight, body fat, and biochemical indicators of obesity and Type 2 diabetes, but had no effect on autophagy in soleus muscle.
위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구
노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.
조용근,황진용,박헌식,채성철,전재은,박의현 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.4
목적 : 정량적관상동맥조영술이 최근 널리 보급되고 있지만 국내외를 막론하고 이의 정확도 및 재현도에 관한 연구가 불충분하여 본 연구를 하였다. 대상 및 방법 : 110명의 환자에서 미국 General Electric사의 Advantx L/C/LP 디지탈혈관찰영기와 미국 USCI사의 좌관상동맥용 Judkins형의 Pro-Flo XT^(TM) 6F 도자를 이용하여 좌관상동맥조영술을 같은 각도에서 3회 실시하고 도자의 외경을 일본 Mitutoyo사의 정밀도 0.01㎜의 micrometer로 측정한 후 측정된 도자의 실제 직경과 정량적관상동맥조영술로 측정된 관상동맥의 직경을 비교하였다. 결 과 : USCI® Pro-Flo XT^(TM) 6F 좌관상동맥용 도자의 실제 외경은 1.91±0.03㎜이었고 정량적관상동맥조영술로 측정 한 도자의 외경은 1.94±0.11㎜이었다. 도자를 5.7F로 calibration했을 매 도자의 외경은 1.87±0.12㎜이었다. 세번 다 다른 화상에서 측정한 경우 근위부관상동맥 직경의 차이는 0.02±0.12㎜이었고 같은 화상에서 3회 측정하였던 경우에는 0.11±0.01㎜이었다. 결론 : 정량적관상동맥조영술의 정확도 및 재현도는 사용에 적합한 정도이나 적지 않은 문제점에 대한 보완이 필요하다고 생각된다. During quantitaive coronary angiography(QCA), contrast filled catheter is usually used as a scaling device. However the real diamerer of catheter is almost always smaller than the listed diameter. We measured the real diameter of catheters with precision micrometer(Mitutoyo® Japan). After caliberating the catheter as listed French size and diameter, we did QCA at the same tube position of the diameters of catheter and proximal left coronary artery. All measurements were done 3 times consecutively. The mean real diameter of USCI® Pro-Flo XT^(TM) 6 F left Judkin catheter was 1.91±0.03 ㎜. The mean QCA diamter of the same catheter was 1.94±0.11 ㎜. When we calibrated catheter as 1.91 ㎜. the mean QCA diameter was 1.87±0.12 ㎜. The mean differences of the diameters of the proximal left coronary artery were 0.20±0.12 ㎜ when the measurements were done in three different frames. When the measurements were done in the same frmae, the mean difference decreased to 0.11±0.01 ㎜. We conclude that the precision and reproducibility of QCA are within reasonable range, but more refimement is needed.
전북 평야 수도작 농가의 담수직파 기술개발 방향 및 경제성 분석
조홍기,신용규,박정근 全北大學校 1995 論文集 Vol.39 No.-
New technology plays a role of stimulator in releasing the constraints on growth imposed by resource endowment in any society. In an economy with high population pressures and limited land, increases in output depend on the development of land-saving technology, that can release the constraints imposed by the inelastic supply of land. The development of fertilizer-responsive crop varieties, which is identified as biological technology, can essentially be a new technology designed to facilitate the substitution of fertilizer (or pesticides) for scare land and to raise yield per Ha. In an economy characterized by a relative scarcity of labour, the improvement of agricultural machinery that can save labour and raise labour productivity may reduce the problem of labour shortage. The constraints imposed by an inelastic supply of labour may be offset by advances in so called mechanical technology. The Technology of Direct-Seeding in paddy rice cultivation (TDS), which has rapidly diffused among individual farmers in recent years, may be the same scale-neutral technology as Tong-il HYVs. It may be said that the TDS has been designed to solve the problem that results from the bottlenecks of labour shortage and high labour cost. It is also assumed that the TDS may be the technical innovation that is induced by changes in factor endowments in market economy while Tong-il HYVs may be the technological development that is leaded by the government's incentives to attain self-sufficiency of staple food. In the area of agricultural policy, the study has a crucial role in establishing a desirable direction for agricultural reconstruction-policy for improving agricultural infrastructure and in providing information for the scientific technology-policy for attaining more efficient resource allocation in agricultural research.
조미현,김동우,박용근,지웅길 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-
For the dermal drug delivery system of local anesthetics (lidocaine HCl, and benzocaine), the drugs were formulated as hydrogel. The experiments of the formulation design were summarized as below, the lipid-water partition coefficients of drugs were evaluated and the vehicles with different concentrations of ethanol, glycerine and various enhancers were prepared for the formulation of hydrogel. After using these vehicles, hydrogel were formulated. The gelling agent was poloxamer 407. The resulting preparations were evaluated using in vitro drug permeation and drug accumulation in hairless mouse skin. The preparations were also evaluated by their viscosity and stability, In addition, using the tail-flick analgesia test, analgesic activity of the gel was compared with that of commercial cream.
조근태,김성조,김성민,김용우,김성재,조용곤 한국경영과학회 2004 經營 科學 Vol.21 No.2
The imports of used medical equipment such as CT, MRI have been rapidly increased every year. How to manage those medical equipment has been one of critical issues in the government sector. In this study, we demonstrate how benefit/cost analysis using the Analytic Hierarchy Process (AHP) can be applied to the comparison of used CT/MRI and new CT/MRI. The final results show that the new CT/MRI is more attractive than the used CT/MRI.
조용철,좌종근 濟州大學校 産業技術硏究所 1998 산업기술연구소논문집 Vol.9 No.1
This paper presents a new method to determine the T-type equivalent circuit parameters for steady state analysis of induction motors. To determine the parameters, four simultaneous equations are obtained from the T-type equivalent circuit conditions. The initial values for these equations are evaluated by the simplified equivalent circuits. and then the parameters are calculated by iterative computation. Test results are compared with the computed results of the conventional method and the proposed method to demonstrate the validity of the proposed method. And it is found that the latter method is more accurate than the former method.