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[P339] Actinic keratosis in kidney transplant recipient
( Yo Sup Shin ),( Won Joo Kwon ),( Eun Byul Cho ),( Eun Joo Park ),( Kwang Ho Kim ),( Kwang Joong Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
A 65-year-old female presented with skin lesion on the right eyebrow. She underwent kidney transplantation about 10 years ago, and takes immunosuppressive agents such as methylprednisolone, tacrolimus. Localized single erythematous patch with peripheral scale was observed on the lateral side of the right eyebrow. KOH smear showed negative result. Biopsy performed, and histologic findings revealed hyperkeratosis, parakeratosis, and acanthosis with some dyskeratosis and atypical keratinocytes in epidermis, accompanied by lymphohistiocytic infiltration in uppder dermis. This skin lesion was diagnosed as actinic keratosis and treated with cryosurgery. Despite treated with cryosurgery, skin lesion showed no marked improvement. After patient treated with 2 times of additional cryosurgery, CO<sub>2</sub> laser, and Ingenol mebutate ointment application, skin lesion was improved. Organ transplant recipients are at increased risk of having both systemic and cutaneous cancer development. Especially in renal transplant recipients, they are at increased risk of keratinocyte cancers as a result of their immunosuppressive therapy. If actinic keratoses develop in oragan transplant recipients, they need to be treated aggressively than immunocompetent patients. Therefore, it is essential that clinicians look for skin cancer in organ transplant recipients, and manage prodromal lesion such as actinic keratosis more aggressively.
( Yo Sup Shin ),( Won Joo Kwon ),( Eun Byul Cho ),( Eun Ju Park ),( Kwang Ho Kim ),( Kwang Joong Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Viral warts are common infectious skin disease induced by human papillomavirus (HPV). But treatment of recalcitrant warts is still challenging. Objectives: In this study, we compared the effectiveness of Pulsed dye laser (PDL) and Long pulsed ND:YAG (LPNY) laser in the treatment of recalcitrant viral warts. Methods: We retrospectively analyzed the medical records of patients with recalcitrant warts treated with laser therapy between January, 2013 and February, 2016. Results: 72 patients with recalcitrant warts were evaluated. 39 patients were treated with pulsed dye laser and 33 patients were treated with LPNY laser. The following parameters were used: PDL (spot size, 7mm; pulse duration, 1.5ms; and fluence, 10-14 J/cm2), and LPNY (spot size, 5mm; pulse duration, 20ms; and fluence, 240-300 J/cm2). Complete clearance of 2 patients (5.1%) in PDL group, and 3 patients (9.1%) in LPNY group were observed without significant side effects. The patients who achieved at least 50% improvement from baseline were 20 (51.3%) in PDL, and 22 (66.7%) in LPNY, respectively. Conclusion: This research is meaningful because we compared the effectiveness of the PDL and LPNY in the recalcitrant warts. Both PDL and LPNY laser could be used as a safe and alternative treatment for recalcitrant warts.
여드름 환자의 삶의 질에 대한 고찰: 10년 전과 비교
신요섭 ( Yo Sup Shin ),이민경 ( Min Kyung Lee ),박복원 ( Bok Won Park ),조은별 ( Eun Byul Cho ),박은주 ( Eun Joo Park ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.9
Background: Acne has been found to be associated with psychosocial problems, and the influence of acne may vary according to the era. Objective: We aimed to compare the present quality of life (QOL) of acne patients with that in the past 10 years. Additionally, financial values that patients attach to the treatment of their acne were evaluated. Methods: We analyzed the influences of acne on QOL using self-reported validated questionnaires (WHOQOL-BREF, Skindex-29, APSEA, CADI) between June 2014 and December 2015. Results: 100 acne patients and 70 controls were enrolled in the study. Compared with that in the past 10 years, the quality of life of acne patients decreased in terms of psychological and social relationships, and the difference between males and females was reduced. Clinical characteristics associated with quality of life were identified as age, duration, education, and self-reported severity score, etc. Patient-based financial valuation of treatment costs was associated with the Skindex-29, WHOQOL-BREF, and CADI scores. Conclusion: The impact of acne on QOL, especially psychosocial aspects, is important, and early initiation of the appropriate treatment may help to address the diminished QOL and financial burden of acne patients. (Korean J Dermatol 2017;55(9):572∼579)
단순 절제술로 치료한 기저세포암의 임상적 특징과 재발률에 관한 연구
신요섭 ( Yo Sup Shin ),박복원 ( Bok Won Park ),장예지 ( Ye Ji Jang ),조은별 ( Eun Byul Cho ),박은주 ( Eun Joo Park ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2018 대한피부과학회지 Vol.56 No.3
Background: Basal cell carcinoma is the most common form of skin cancer. Surgical excision is commonly used as the therapeutic modality. However, there is insufficient data on the prognosis of Korean patients who have undergone surgical excision for basal cell carcinoma. Objective: We therefore retrospectively analyzed the effectiveness of surgical excision in patients with basal cell carcinoma and compared it with previous studies. Methods: From 2009 to 2015, we enrolled 138 patients with primary basal cell carcinoma who underwent surgical excision and analyzed the recurrence rate, clinical features, surgical procedures, and histopathological subtypes. Results: The case series comprised 138 patients (M:F=1:1.51) with a mean age of 68.7 years. Recurrence after surgical excision was diagnosed in 0 of the 138 patients with a mean follow-up period of 47.5 months (12∼93 months). The mean tumor diameter and surgical margin were 0.9 cm and 3.1 mm, respectively. Most tumors (85.5%) were of the nodular subtype. Primary closure was used most often to repair the surgical defects (44.9%). Conclusion: Surgical excision may be a satisfactory method for the treatment of primary basal cell carcinomas, especially in non-high-risk cases. (Korean J Dermatol 2018;56(3):167∼171)
( Yo Sep Kim ),( Na Young Park ),( Shin Ho Lee ),( Kwang Sup Youn ),( Joon Heon Hong ),( Chang Su Park ),( Hong Kyoon No ) 한국키틴키토산학회 2015 한국키틴키토산학회지 Vol.20 No.1
The effects of milled chitosan solutions on growth and selected quality of soybean sprouts were evaluated.Chitosan solution (1% in 1% acetic acid) was milled for 0, 0.5, 1 and 2 h, and diluted with distilled water to 0.05% to use as soaking solutions. Soybean seeds were soaked in water (control), 0.05% acetic acid and milled chitosan solutions for 8 h, and then cultivated for 3 days at 25 o C. Results indicated that chitosan treatment increased total weight by 7.8-10.0% and hypocotyl length by 6.2-11.1% compared with the control and that the effectiveness of chitosan treatment was not affected by milling times of chitosan solution. Chitosan treatment, irrespective of milling times, did not affect the quality of soybean sprouts. No significant differences in moisture content, hardness and DPPH radical scavenging activity were observed among six treatment groups. The total free amino acid contents of soybean sprouts treated with 0.5 and 1 h-milled chitosan solutions were comparable to that of the control soybean sprouts.
Recurrent hemolytic uremic syndrome caused by DGKE gene mutation: a case report
Shin, Baek Sup,Ahn, Yo Han,Kang, Hee Gyung Korean Society of Pediatric Nephrology 2022 Childhood kidney diseases Vol.26 No.1
Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury without any association with preceding diarrhea. Dysregulation of the complement system is the most common cause of aHUS, and monoclonal humanized anti-C5 antibodies are now recommended as the first-line treatment for aHUS. However, if the complement pathway is not the cause of aHUS, C5 inhibitors are ineffective. In this study, we report the second reported case of aHUS caused by DGKE mutations in Republic of Korea. The patient was an 11-month-old infant who presented with prodromal diarrhea similar to typical HUS, self-remitted with conservative management unlike complement-mediated aHUS but recurred with fever. While infantile aHUS often implies genetic dysregulation of the complement system, other rare genetic causes, such as DGKE mutation, need to be considered before deciding long-term treatment with C5 inhibitors.
몇 가지 식물추출물이 배양 NIH3T3 섬유모세포의 세포생존율과 세포부착률에 미치는 세포독성에 관한 연구
임요섭 ( Yo-sup Rim ),송원섭 ( Won-seob Song ),서영미 ( Young-mi Seo ),박승택 ( Seung-taeck Park ),김신무 ( Shin-moo Kim ) 대한임상검사과학회 2010 대한임상검사과학회지(KJCLS) Vol.42 No.3
This study was aimed to clerify the cytotoxicity of some plant extracts such as Hosta longissima HONDA (HL), Hemerocallis fulva var. Kwanso REGL (HFVK), Hemerocallis fulva L (HF), Macrocapium officinale NAKAI (MO) and Mentha canadensis var. piperascens HARA (MCVP), the cultured NIH3T3 fibroblasts were treated with 25, 50, 100, 150 and 200 μg/mL of five kinds of plant extracts for 48 hours, respectively. The cytotoxicity of plant extracts was measured by MTT and NR assays for the cell viability, and XTT assay for the cell adhesion activity. In this study, HL, MO and FHVK extracts showed the range of midtoxic-non toxic by the criteria of chemical cytotoxicity. While, the HF and MCVP extracts showed midtoxic. In the extract cytotoxicity, HL, MO and FHVK extracts showed non-toxic by the criteria of extract cytotoxicity. While, HF extract was determined as lower-toxic. In the responsive sensitivity of each plant extract on colorimetric assays, HF extract was sensitive to mitochondrial enzyme by MTT assay, lysosomal enzyme by NR assay and mitochondrial nucleus by XTT assay. While, MCVP extract was sensitive to mitochondrial enzyme by MTT assay and lysosomal enzyme by NR assay than other assays. While, HL, HFVK and MO extracts were most sensitive to NR assay. Cell culture is one of useful materials in the screening of cytotoxic and recovary effect on the putative chemical agents or plant extract. And also, colorimetric assay is regarded as very useful tools for quantitative measurement of cytotoxic effect on plant extracts in vitro.