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      • SCIESCOPUSKCI등재

        Obstacles modeling method in cluttered environments using satellite images and its application to path planning for USV

        Shi, Binghua,Su, Yixin,Zhang, Huajun,Liu, Jiawen,Wan, Lili The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.1

        The obstacles modeling is a fundamental and significant issue for path planning and automatic navigation of Unmanned Surface Vehicle (USV). In this study, we propose a novel obstacles modeling method based on high resolution satellite images. It involves two main steps: extraction of obstacle features and construction of convex hulls. To extract the obstacle features, a series of operations such as sea-land segmentation, obstacles details enhancement, and morphological transformations are applied. Furthermore, an efficient algorithm is proposed to mask the obstacles into convex hulls, which mainly includes the cluster analysis of obstacles area and the determination rules of edge points. Experimental results demonstrate that the models achieved by the proposed method and the manual have high similarity. As an application, the model is used to find the optimal path for USV. The study shows that the obstacles modeling method is feasible, and it can be applied to USV path planning.

      • KCI등재

        Secure and Fine-grained Electricity Consumption Aggregation Scheme for Smart Grid

        ( Gang Shen ),( Yixin Su ),( Danhong Zhang ),( Huajun Zhang ),( Binyu Xiong ),( Mingwu Zhang ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.4

        Currently, many of schemes for smart grid data aggregation are based on a one-level gateway (GW) topology. Since the data aggregation granularity in this topology is too single, the control center (CC) is unable to obtain more fine-grained data aggregation results for better monitoring smart grid. To improve this issue, Shen et al. propose an efficient privacy-preserving cube-data aggregation scheme in which the system model consists of two-level GW. However, a risk exists in their scheme that attacker could forge the signature by using leaked signing keys. In this paper, we propose a secure and fine-grained electricity consumption aggregation scheme for smart grid, which employs the homomorphic encryption to implement privacy-preserving aggregation of users’ electricity consumption in the two-level GW smart grid. In our scheme, CC can achieve a flexible electricity regulation by obtaining data aggregation results of various granularities. In addition, our scheme uses the forward-secure signature with backward-secure detection (FSBD) technique to ensure the forward-backward secrecy of the signing keys. Security analysis and experimental results demonstrate that the proposed scheme can achieve forward-backward security of user’s electricity consumption signature. Compared with related schemes, our scheme is more secure and efficient.

      • KCI등재

        Recent Developments in the Use of Intralesional Injections Keloid Treatment

        Aurelia Trisliana Perdanasari,Davide Lazzeri,Weijie Su,Wenjing Xi,Zhang Zheng,Li Ke,Peiru Min,Shaoqing Feng,Yixin Zhang,Paolo Persichetti 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.6

        Keloid scars are often considered aesthetically unattractive and frustrating problems thatoccur following injuries. They cause functional and cosmetic deformities, displeasure, itching,pain, and psychological stress and possibly affect joint movement. The combination of thesefactors ultimately results in a compromised quality of life and diminished functionalperformance. Various methods have been implemented to improve keloid scars using bothsurgical and non-surgical approaches. However, it has proven to be a challenge to identify auniversal treatment that can deliver optimal results for all types of scars. Through a PubMedsearch, we explored most of the literature that is available about the intralesional injectiontreatment of hypertrophic scars and keloids and highlights both current (corticosteroid,5-fluorouracil, bleomycin, interferon, cryotherapy and verapamil) and future treatments(interleukin-10 and botulinum toxin type A). The reference lists of retrieved articles were alsoanalysed. Information was gathered about the mechanism of each injection treatment, itsbenefits and associated adverse reactions, and possible strategies to address adverse reactionsto provide reliable guidelines for determining the optimal treatment for particular types ofkeloid scars. This article will benefit practitioners by outlining evidence-based treatmentstrategies using intralesional injections for patients with hypertrophic scars and keloids.

      • SCOPUSKCI등재

        Recent Developments in the Use of Intralesional Injections Keloid Treatment

        Perdanasari, Aurelia Trisliana,Lazzeri, Davide,Su, Weijie,Xi, Wenjing,Zheng, Zhang,Ke, Li,Min, Peiru,Feng, Shaoqing,Zhang, Yixin,Persichetti, Paolo Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.6

        Keloid scars are often considered aesthetically unattractive and frustrating problems that occur following injuries. They cause functional and cosmetic deformities, displeasure, itching, pain, and psychological stress and possibly affect joint movement. The combination of these factors ultimately results in a compromised quality of life and diminished functional performance. Various methods have been implemented to improve keloid scars using both surgical and non-surgical approaches. However, it has proven to be a challenge to identify a universal treatment that can deliver optimal results for all types of scars. Through a PubMed search, we explored most of the literature that is available about the intralesional injection treatment of hypertrophic scars and keloids and highlights both current (corticosteroid, 5-fluorouracil, bleomycin, interferon, cryotherapy and verapamil) and future treatments (interleukin-10 and botulinum toxin type A). The reference lists of retrieved articles were also analysed. Information was gathered about the mechanism of each injection treatment, its benefits and associated adverse reactions, and possible strategies to address adverse reactions to provide reliable guidelines for determining the optimal treatment for particular types of keloid scars. This article will benefit practitioners by outlining evidence-based treatment strategies using intralesional injections for patients with hypertrophic scars and keloids.

      • KCI등재

        Rational Design and Molecular Engineering of Peptide Aptamers to Target Human Pancreatic Trypsin in Acute Pancreatitis

        Weiyi Shao,Wenxian Zhu,Yanhua Wang,Jingwei Lu,Ge Jin,Yixin Wang,Wenli Su 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.1

        Human pancreatic trypsin (hPT) is an established target for acute pancreatitis (AP) therapeutics. Here, a bioinformatics protocol of protein docking, peptide refinement, dynamics simulation and affinity analysis was described to perform rational design and molecular engineering of hPT peptide aptamers. Protein docking was employed to model the intermolecular interactions between hPT and its cognate inhibitory protein, the human pancreatic trypsin inhibitor (hTI). A number of peptide fragments were cut out from the interaction sites of docked hPT–hTI complexes, from which a decapeptide fragment 13LNGCTLEYRP22 was found to exhibit potent inhibition against hPT (Ki = 5.3 ± 0.8 μM). We also carried out alanine scanning and virtual mutagenesis to systematically examine the independent contribution of peptide residues to binding affinity, and the harvested knowledge were then used to guide modification and optimization of the decapeptide fragment. Subsequently, inhibition studies of nine promising candidates against recombinant hPT were conducted, from which four samples were successfully identified to have high or moderate potency (Ki < 10 μM). In particular, the peptides LQVCTLEYCN and LQICTLEYCT were found to inhibit hPT activity significantly (Ki = 0.23 ± 0.04 and 0.85 ± 0.18 μM, respectively). Structural analysis of hPT– peptide complex systems unraveled diverse chemical interactions such as hydrogen bonds, salt bridges and hydrophobic forces across the complex interfaces.

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