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Han Ying-Hao,Mao Ying-Ying,Yu Nan-Nan,Jin Mei-Hua,Jin Ying-Hua,Wang Ai-Guo,Zhang Yong-Qing,Shen Gui-Nan,Cui Yu-Dong,Yu Li-Yun,Lee Dong-Seok,Jo Yu-Jin,Sun Hu-Nan,Kwon Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
Colorimetric and Fluorescent Detecting Phosgene by a Second-Generation Chemosensor
Hu, Ying,Zhou, Xin,Jung, Hyeseung,Nam, Sang-Jip,Kim, Myung Hwa,Yoon, Juyoung American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.5
<P>Because of the current shortage of first-generation phosgene sensors, increased attention has been given to the development of fluorescent and colorimetric based methods for detecting this toxic substance. In an effort focusing on this issue, we designed the new, second-generation phosgene chemosensor <B>1</B> and demonstrated that it undergoes a ring-opening reaction with phosgene in association with color and fluorescent changes with a detection limit of 3.2 ppb. Notably, in comparison with the first-generation sensor RB-OPD, <B>1</B> not only undergoes a much faster response toward phosgene with an overall response time within 2 min, but it also generates no byproducts during the sensing process. Finally, sensor <B>1</B> embedded nanofibers were successfully fabricated and used for accurate and sensitive detection of phosgene.</P> [FIG OMISSION]</BR>
Migration and Energy Aware Network Traffic Prediction Method Based on LSTM in NFV Environment
Ying Hu,Liang Zhu,Jianwei Zhang,Zengyu Cai,Jihui Han 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.3
The network function virtualization (NFV) uses virtualization technology to separate software from hardware. One of the most important challenges of NFV is the resource management of virtual network functions (VNFs). According to the dynamic nature of NFV, the resource allocation of VNFs must be changed to adapt to the variations of incoming network traffic. However, the significant delay may be happened because of the reallocation of resources. In order to balance the performance between delay and quality of service, this paper firstly made a compromise between VNF migration and energy consumption. Then, the long short-term memory (LSTM) was utilized to forecast network traffic. Also, the asymmetric loss function for LSTM (LO-LSTM) was proposed to increase the predicted value to a certain extent. Finally, an experiment was conducted to evaluate the performance of LO-LSTM. The results demonstrated that the proposed LO-LSTM can not only reduce migration times, but also make the energy consumption increment within an acceptable range.
Hu Ying,Liu Rongbo,Gao Fabao 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.7
Objective: To investigate the age-dependent changes in regional cerebral blood flow (CBF) in healthy adults by fitting mathematical models to imaging data. Materials and Methods: In this prospective study, 90 healthy adults underwent pseudo-continuous arterial spin labeling imaging of the brain. Regional CBF values were extracted from the arterial spin labeling images of each subject. Multivariable regression with the Akaike information criterion, link test, and F test (Ramsey’s regression equation specification error test) was performed for 7 models in every brain region to determine the best mathematical model for fitting the relationship between CBF and age. Results: Of all 87 brain regions, 68 brain regions were best fitted by cubic models, 9 brain regions were best fitted by quadratic models, and 10 brain regions were best fitted by linear models. In most brain regions (global gray matter and the other 65 brain regions), CBF decreased nonlinearly with aging, and the rate of CBF reduction decreased with aging, gradually approaching 0 after approximately 60. CBF in some regions of the frontal, parietal, and occipital lobes increased nonlinearly with aging before age 30, approximately, and decreased nonlinearly with aging for the rest of life. Conclusion: In adults, the age-related perfusion patterns in most brain regions were best fitted by the cubic models, and age-dependent CBF changes were nonlinear.
Hu, Ying,Yin, Jun,Yoon, Juyoung Elsevier 2016 Sensors and actuators. B Chemical Vol.230 No.-
<P><B>Abstract</B></P> <P>A cyanine-based chemosensor containing dipicolylamine moieties is reported and its structure is well-defined. Investigation on the optical property shows it is pH-independent. Acidic medium can induce the color change from azure to dark blue while it presents the green in the alkaline condition (pH 10) in comparison to the neutral condition. More, owing to the introduction of dipicolylamine units, this chemosensor can be used as a colorimetric indicator for Zn(II) and Cu(II) ions along with color change from green to bright blue. Especially, its copper complex has a capability of determining the sulfide anion (S<SUP>2−</SUP>) with high selectivity, and as a consequence, the color of solution turns back to the green. This work provides a promising indicator for the analysis of multi species.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Ying Hu,Pengfei Zhao,Bo Yang,Guoxin Dai 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4
High-strength concrete-filled steel tube (CFST) columns offer a number of benefits and are widely used in high-rise building construction. This paper presents a brand new thermal modeling approach in comparison with tremendous test data for the heat transfer analysis. A heat transfer model has been developed to predict the thermal response of high-strength CFST columns under standard fire conditions with consideration of a number of parameters: steel and furnace emissivity, thermal interface conductance and concrete strength. The verified numerical models discussed the variation of emissivity of steel surfaces and thermal interface conductance in fire. It can be concluded that the influence of emissivity and thermal interface conductance is considerable in the numerical analysis. It is also demonstrated that thermal behavior of high-strength CFST columns subjected to fire during heating and cooling stages, and providing the guidance on predicting thermal response of high-strength concrete-filled steel tube columns.