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The Mechanism of Antibacterial Activity of Tetrandrine Against <i>Staphylococcus aureus</i>
Lee, Young-Seob,Han, Sin-Hee,Lee, Su-Hwan,Kim, Young-Guk,Park, Chung-Berm,Kang, Ok-Hwa,Keum, Joon-Ho,Kim, Sung-Bae,Mun, Su-Hyun,Seo, Yun-Soo,Myung, Noh-Yil,Kwon, Dong-Yeul Mary Ann Liebert 2012 Foodborne pathogens and disease Vol.9 No.8
( Young Yil Bahk ),( Hyun Sook Kim ),( Ok-jae Rhee ),( Kyung-a You ),( Kyung Seon Bae ),( Woojoo Lee ),( Tong-soo Kim ),( Sang-seob Lee ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.10
Climate change is expected to affect not only availability and quality of water, the valuable resource of human life on Earth, but also ultimately public health issue. A six-year monitoring (total 20 times) of Escherichia coli O157, Salmonella enterica, Legionella pneumophila, Shigella sonnei, Campylobacter jejuni, and Vibrio cholerae was conducted at five raw water sampling sites including two lakes, Hyundo region (Geum River) and two locations near Water Intake Plants of Han River (Guui region) and Nakdong River (Moolgeum region). A total 100 samples of 40 L water were tested. Most of the targeted bacteria were found in 77% of the samples and at least one of the target bacteria was detected (65%). Among all the detected bacteria, E. coli O157 were the most prevalent with a detection frequency of 22%, while S. sonnei was the least prevalent with a detection frequency of 2%. Nearly all the bacteria (except for S. sonnei) were present in samples from Lake Soyang, Lake Juam, and the Moolgeum region in Nakdong River, while C. jejuni was detected in those from the Guui region in Han River. During the six-year sampling period, individual targeted noxious bacteria in water samples exhibited seasonal patterns in their occurrence that were different from the indicator bacteria levels in the water samples. The fact that they were detected in the five Korea’s representative water environments make it necessary to establish the chemical and biological analysis for noxious bacteria and sophisticated management systems in response to climate change.
( Woosung Hong ),( Yil-seob Lee ),( Chun-wook Park ),( Moon-soo Yoon ),( Young Suck Ro ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.4
Background: With the approval of topical retapamulin ointment in 2011, it was officially required to conduct a post-marketing surveillance (PMS) study to obtain further data of its safety profile and effectiveness, in accordance with the requirement of the Korean Ministry of Food and Drug Safety (MFDS). Objective: This study had prospectively designed to monitor safety and tolerability with the effectiveness of topical retapamulin in clinical practices. Methods: Open label, multi-center, non-interventional observational study was done from May 2011 to October 2015. All subjects had bacterial skin infections of locally approved prescribing information accordingly. The study mainly focused on safety issues in the local target population (3,612 eligible subjects). And, drug effectiveness was also evaluated by physicians. Results: The incidence of adverse events (AEs) and adverse drug reactions (ADRs) were 2.53% and 0.97%, respectively. In terms of the incidence of unexpected AEs and ADRs, 1.45% and 0.33%, and for the incidence of serious AEs, 0.28%, whereas no serious ADRs reported. And, the effectiveness of topical retapamulin rate was 96.1% (1,697 of total 1,765 subjects). Conclusion: Topical retapamulin is to be well-tolerated and effective in patients with bacterial skin infections of locally approved prescribing information. (Ann Dermatol 30(4) 441∼450, 2018)
한국인 제2형 당뇨병 환자에서 로시글리타존/메트포르민의 안전성 및 유효성 평가를 위한 시판 후 조사
이한규,박소현,오신영,이일섭,Lee, HanKyu,Park, So-Hyun,Oh, Shin-Young,Lee, Yil-Seob 대한임상약리학회 2012 臨床藥理學會誌 Vol.20 No.2
Background: To evaluate the safety and effectiveness of rosiglitazone/metformin in patients with type 2 (non-insulin-dependent) diabetes Methods: A total of 982 patients were enrolled by 19 physicians from November 2003 to November 2010. Patients treated with rosiglitazone/metformin at least once, were included in safety assessment. The incidences of adverse events (AEs) and serious adverse events (SAEs) were estimated. The effectiveness of rosiglitazone/metformin was evaluated through change in fasting blood glucose (FBG), 2-hour postprandial glucose (2hr PPG), Hemoglobin A1c (HbA1c). Results: Of the 982 patients, 713 patients with the mean age of $56.4{\pm}11.5$ years were included in the safety assessment. A total of 130 AEs were reported from 110 patients (15.4 %). The most frequent AEs were upper respiratory infection (2.4 %), oedema (2.2 %), gastritis (1.3 %), and weight increase (1.1 %). The incidence of unexpected AEs was 5.9 % (42/713, 47 AEs). Three SAEs such as bacterial pneumonia, hyperglycaemia, chest pain were reported in 2 patients. As it is about effectiveness, patients showed statistically significant reductions after treatment of rosiglitazone/metformin in FBG, 2hr PPG, and HbA1c (P<0.001 by paired t-test, for all). Conclusion: Our data suggest that rosiglitazone/metformin is well tolerated and effective in Korean patients with type 2 (non-insulin-dependent) diabetes.
Kim, Hyun-Sik,Kim, Jong-Ryung,Lee, Hae-Yeon,Kim, Ki-Uk,Huh, Jeong-Seob,Lee, Jun-Hui,Oh, Young-Woo,Byon, Woo-Bong,Gwak, Kwi-Yil,Ju, Seong-Ho The Korean Institute of Electrical and Electronic 2006 전기전자재료학회논문지 Vol.19 No.4
We observed the application possibility of inductive coupler for the underground high-voltage power line communication by means of analysis of signal transmission characteristics and magnetic properties on annealing temperatures for high-permeability Fe-base amorphous alloys. The best electromagnetic and transmission characteristics were shown in nano-crystalline precipitated alloy annealed at temperature $510^{\circ}C$. The transmission characteristics in the low-frequency band depend on permeability of magnetic core materials and its properties of high-frequency band can be improved by impedance matching. Using the high pass filter embedded in the coupler, other noise signal band except for communication signals could be cut off.
Oh, Ki Won,Kim, Deog-Yoon,Lee, Yil-Seob,Kang, Moo Il Japanese Society of Bone and Mineral Metabolism ; 2012 Journal of bone and mineral metabolism Vol.30 No.3
<P>The Osteoporosis Patient Treatment Satisfaction Questionnaire (OPSAT-Q) is a psychometric measure of patient satisfaction with bisphosphonate treatment for osteoporosis. The study was a multicenter, nationwide, cross-sectional, patient-reported outcome study conducted to evaluate treatment satisfaction and quality of life using the OPSAT-Q in patients receiving oral bisphosphonate therapy. This study enrolled postmenopausal women from 43 hospitals and 112 clinics who had intermittently taken oral bisphosphonates for treatment of osteoporosis. 4,220 postmenopausal Korean women with a mean age of 65.3 years and a mean body mass index of 22.9 kg/m(2) participated in the study. All items within each subscale domain were more highly correlated with their hypothesized subscale domain relative to the other subscale domains, and all 16 items were significantly correlated with an overall composite satisfaction score (CSS). All scores showed acceptable internal consistency reliability (Cronbach's alpha >0.70, range 0.88-0.91). Comparisons of OPSAT-Q scores were made between selective subgroups of participants: monthly versus weekly administration, years of taking bisphosphonates, smoking habitus, acid-related medication and comorbid conditions. Mean OPSAT-Q subscale domains and CSS were higher for users of monthly bisphosphonates, with shorter duration, non-smokers, and non-users of acid-related medication. Mean OPSAT-Q subscale domain scores of side-effects were high for absence of comorbid conditions. The OPSAT-Q demonstrated acceptable measurement properties, including validity and reliability of subscale domains and CSS, in oriental women with postmenopausal osteoporosis. Postmenopausal women intermittently using oral bisphosphonate therapy reported increased satisfaction with monthly administration, with shorter duration, non-smokers, non-users of acid-related medication, and an absence of comorbid conditions.</P>
국내 대학병원 환자의 호흡기 검체에서 분리된 세균에 대한 Gatifloxacin의 시험관내 항균력
용동은,김명숙,김신영,이경원,김성규,정윤섭,이일섭 대한감염학회 2004 감염과 화학요법 Vol.36 No.2
목적 : 새로 개발된 8-methoxyquinolone인 gatifloxacin은 호흡기 감염균을 포함한 광범위 세균에 항균력을 보인다. 본 연구에서 저자들은 gatifloxacin과 비교약제의 시험관내 항균력을 최근 우리나라 환자의 호흡기에서 분리된 세균에 대하여 시험하였다. 방법 : 본 저자들은 2000-2001년에 국내 8개 대학병원에서 만성 하부기도 감염증이 급성 악화된 환자의 호흡기 검체에서 분리된 세균 49주와 연세의대 병원 환자의 호흡기 검체에서 분리된 병원균 108균주를 대상으로 하였다. 항균제 최소억제 농도는 NCCLS 한천희석법으로 시험하였다. 결과 : Streptococcus pneumoniae에 대한 gatifloxacin의 MIC_(90)는 1㎍/mL로서 ciprofloxacin과 levofloxacin의 MIC_(90)보다 각각 8배와 2배 낮았다. Haemophilus influenzae와 Moraxella (Branhamella) catarrhalis는 각각 gatifloxacin ≤0.06㎍/mL와 ≤0.25㎍/mL에서 억제되었고 시험한 fluoroquinolones제에 모두 감수성이었다. Klebsiella pneumoniae에 대한 gatifloxacin의 MIC_(90)는 0.06㎍/mL으로 levofloxacin과 moxifloxacin의 MIC_(90)보다 2배 낮았다. 결론 : Gatifloxacin은 국내 환자의 호흡기병원에서 분리된 세균인 S. pneumoniae, H. influenzae 및 M. (B.) catarhalis에 대한 시험관내 항균력이 우수하였다. Background : Gatifloxacin, a new 8-methoxyquinolone, has a broad-spectrum activity with expanded potency against respiratory pathogens. In this study, we examined the in vitro activity of gatifloxacin and comparators against recently isolated bacteria from respiratory specimens of patients in Korean hospitals. Methods : Forty-nine isolates were from respiratory specimens of patients with acute exacerbations of chronic lower respiratory infections in eight university hospitals and 108 isolates were from respiratory specimens from patients of Yonsei University Hospital. Minimum inhibitory concentrations (MICs) were determined by NCCLS agar dilution method. Results : MIC_(90) of gatifloxacin for Streptococcus pneumoniae was 1 ㎍/mL, which was 8-fold and 2-fold lower than those of ciprofloxacin and levofloxacin, respectively. All strains of Haemophilus influenzae and Moraxella (Branhamella) catarrhalis were inhibited by ≤0.06 ㎍/mL and ≤0.25 ㎍/mL of gatifloxacin, respectively, and were susceptible to all fluoroquinolones tested. MIC_(90) of gatifloxacin for Klebsiella pneumoniae was 0.06 ㎍/mL, which was 2-fold lower than those of levofloxacin and moxifloxacin. Conclusion : Gatifloxacin is highly active against S. pneumoniae, H. influenzae and M. (B.) catarrhalis isolated from respiratory specimens of patients of university hospitals in Korea.
Protective Effect of a Chrysanthemum indicum containing Formulation in Cadmium-Induced Ototoxicity.
Kim, Su-Jin,Myung, Noh-Yil,Shin, Bong-Gi,Lee, Jeong-Han,So, Hong-Seob,Park, Rae-Kil,Um, Jae-Young,Hong, Seung-Heon Institute for Advanced Research in Asian Science a 2011 The American journal of Chinese medicine Vol.39 No.3
<P>Chungshinchongyitang (CSCYT) is an herbal drug formula containing Chrysanthemum indicum and 13 other herbs used for treating auditory diseases. Irreversible hearing loss is a characteristic effect of a number of heavy metals. Cadmium (Cd(2+)) is an environmental contaminant that causes a variety of adverse effects. In the present study, we investigate the protective effects of CSCYT against Cd(2+) induced ototoxicity in vitro and ex vivo. The findings of this study show that CSCYT prevents the destruction of hair cell arrays induced by Cd(2+) in the rat organ of Corti primary explants. CSCYT inhibited cell death, release of cytochrome c and generation of reactive oxygen species induced by Cd(2+) in HEI-OC1 auditory cell line. In addition, we also demonstrated that CSCYT exerted its effect by modulating of apoptosis via the caspase-3 activation and extracellular signal-regulated kinase activation. These results are expected to improve the understanding of the pharmacological mechanism of CSCYT and aid in the development of potential therapeutic strategies against ototoxicity.</P>
Assessment of risk factors for Korean children with Kawasaki disease.
Kim, Jae-Jung,Hong, Young Mi,Yun, Sin Weon,Han, Myung Ki,Lee, Kyung-Yil,Song, Min Seob,Lee, Hyoung-Doo,Kim, Dong Soo,Sohn, Sejung,Ha, Kee-Soo,Hong, Soo-Jong,Kim, Kwi-Joo,Park, In-Sook,Jang, Gi Young,L Springer International] 2012 Pediatric cardiology Vol.33 No.4
<P>Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10% of KD patients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7??days or longer, and the CC/AC genotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6??g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% confidence interval (CI), 1.34-5.68; P??=??0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serum albumin concentration is an independent risk factor for IVIG nonresponsiveness.</P>