전박부 전골간신경 증후군의 치료

이상열,임병훈,하충건 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

The anterior interosseous nerve syndrome is a compressive neuropathy of a motor branch of the median nerve, caused by tendinous bands (deep head of pronator teres, arcade of flexor superficialis, thickened lacertus fibrosus etc, trauma, enlarged bursae, tumors, anomalous muscles such as Gantser's muscle or palmaris brevis. On clinical examination, there is weakness or paralysis of the flexor pollicis longus, flexor digitorum profundus of the index finger, and the pronator quadratus muscles with a history of pain in the proximal forearm. The patients will assume a weakness of pinch or an unusual posture of pinch without sensory deficit because of loss of function of these muscles, hyperextending the interphalangeal joint of the thumb and the distal interphalangeal joint of the index finger. We experienced two cases of anterior interosseous nerve syndrome with typical clinical manifestations, confirmed by electrodiagnostic studies. In both cases causative anatomical structures were released through surgical exploration. A case was caused by a sharp edge of the flexor superficialis arcade, another case by the tendinous portion of deep head of pronator teres muscle and a thickened lacertus fibrosus. Both cases revealed partial recoveries after postoperative 3 months.

간접면역형광법을 이용한 쭈쭈가무시병의 혈청학적 진단

이증훈,성열훈 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

To determine the antibody titer for the diagnosis of tsutsugamushi disease by indirect immunof-luorescent test n Korea, the antibody titers of 6572 sera of the residents and 296 sera of the 109 patients confirmed as tsutsugamushi disease in the Cungcheung area were analyzed. At cut-off point of 1:40 specificity was 98% and sensitivity, positive predictive value and negative predictive value were 49%, 90%, 86% during the first week after onset, 85%, 94%, 95% during the second week, and 96%, 95%, 99% during the third week. At cut-off point of 1:80 specificity was 99% and sensitivity, positive predictive value and negative predictive value were 47%, 94%, 86% during the first week, 85%, 97%, 95% during the second week, and 96%, 97%, 99% during the third week. At cut-off point of 1:160 specificity was 100% and sensitivity, positive predictive value and negative predictive value were 31%, 995, 82% during the first week, 69%, 100%, 91% during the second week, and 89%, 100%, 97% during the third week.

백반증의 PUVA치료반응에 관한 연구(제1보)

박장규,성열훈,성범진,김영호,이증훈 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

The authors evaluated response to PUVA therapy in 44 vitiligo petients who did'nt show the spontaneous re-pigmentation. In the responded group to PUVA therapy after systemic administration of 8-methoxy psoralen, average MPD of female patients was 3.4 times higher than males, interestingly. Number of irradiation of UVA was similar between male and female, but total doses of female patients group were about 2 times than males till the first re-pigmented spots were noted. The response to PUVA therapy was quite different according to duration of disease and site of lesion. Therefore, we suppose that it is necessary to consider sex of patient, duration of disease, location of vitiligo before making a plan of PUVA therapy.

접촉성 피부염 환자와 정상인의 첩포검사에 관한 연구

박장규,성열훈,성범진 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Numerous studies on epidemiological aspects of contact dermatitis due to various causative antigens have been reported n recent year in Korea. However, degree of sensitization in healthy persons was not reported till now in Korea. We have performed the patch test on patients with contact dermatitis and healthy persons. The study results were as follows; 1. Percent of positive reaction in patients with contact dermatitis was 45.9%. The common allergens of positive reactions were nickel sulfate(21.6%), potassium dichromate (10.8%), neomycin sulfate (8.1%), Balsam of Peru (8.1%), mercuric chloride, ammoniated (5.4%), p-phenylenediamine(5.4%), cinnamic alcohol(5.4%), ethylenediamine dihydrochloride (2.7%), formaldehyde(2.7%), wool wax alcohol(2.7%), thimerosal (2.7%), mercaptobenzothiazole(2.7%), imidazolidinyl urea(2.7%) in order of frequency. 2. Percent of positive reaction in healthy persons was 10.3% and the common allergens were mercuric chloride, ammoniated(5.2%), nickel sulfate(3.1%), cinnamic alcohol(2.1%), ethylenediamine dihydrochloride(1.0%), formaldehyde(1.0%), epoxy resin(1.0%), in order of frequency. We conclude that allergens associated with metals and drugs seem to be the dominant causes of contact dermatitis and healthy persons.

Three Cases of Eosinophilic Pustular Folliculitis Without Eosinophilia

( Yeul Hoon Sung ),( Beom Jin Seong ),( Jeung Hoon Lee ),( Jang Kyu Park ) 대한피부과학회 1991 Annals of Dermatology Vol.3 No.1

Angio - Behcet 증후군

성열훈(Yeul Hoon Sung),이종성(Jong Seung Lee),김향배(Hyang Bae Kim),이증훈(Jeung Hoon Lee),박장규(Jang Kyu Park) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.5

We report herein a. case of angio-Behqets syndrome, arterial occlusion type in a 31 year-old male. He had a history of scrotal ulceration, frequent oral ulceration and ocular pain with decreased visual acuity. About 8 months ago, moderately dull pain developed on the volar aspect of left index finger. Subsequently, a bean sized bluish patch developed on the previous painful area and on the ipsilateral thumb tip. Subungual splinter hemorrhages developed on the distal portions of left thumb and index finger nails at the same time. The result of saline puncture test showed the positive reaction in both intradermal and subeutaneous injections. The hrachial angiography showed an obliteration of digital artery at the second proxirnal phalanx of ulnar side.

정상인에서 발생한 Mycobacterium Intracellulare에 의한 관절염 1예

강경훈 ( Gyung Hoon Kang ),김성훈 ( Sung Hoon Kim ),이홍열 ( Hong Yeul Lee ),서현웅 ( Hyun Woong Seo ),송은희 ( Eun Hee Song ),이기원 ( Ki Won Lee ),김성수 ( Sung Soo Kim ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2

Nontuberculous mycobacteria (NTM) are widely distributed in nature and are usually of low pathogenic potential. NTM rarely has been recognized as a cause of musculoskeletal infections that involve joints, bone and soft tissue in immunocompetent patients. The risk factors of its infection are local traumas caused by surgery, injury, or injection. A fifty five-year-old immunocompetent patient visted to hospital due to right wrist mass and pain. Excisional biopsy was done. Histologically granulomatous inflammation was identified and Mycobacterium intracellulare was cultured. Although very rare, NTM should be suspected at least once as a causative pathogen of chronic arthritis when the cause is uncertain.

Genetic relationships of collected strains using simple sequence repeat (SSR) marker in Flammulina velutipes

Sung-I Woo,Kyoung-In Seo,Kab Yeul Jang,Ji-Hoon Im,Pyung-Gyun Shin,Youn-Lee Oh,Min Ji Oh,Won-Sik Kong 한국버섯학회 2017 버섯 Vol.21 No.1

Microsatellite SSR markers were developed and utilized to reveal the genetic diversity of 32 strains of Flammulina velutipes collected in Korea, China, and Japan. From SSR-enriched library, 490 white colonies were randomly selected and sequenced. In the 490 sequenced clones, 85 clones (17.35%) were redundant. Among the remaining 405 unique clones, 201 clones (49.6%) contained microsatellite sequences. As a result, 12 primer pairs produced reproducible polymorphic bands within diverse 4 strains and these selected markers were further characterized in 32 Flammulina velutipes strains. A total of 34 alleles were detected using the 12 markers, with an average of 3.42 alleles and the number of alleles ranged from two to seven per locus. The major allele frequency ranged from 0.42 (GB-FV-127) to 0.98 (GB-FV-166), and values for observed (HO) and expected (HE) heterozygosity ranged from 0.00 to 0.94 (mean = 0.18) and from 0.03 to 0.67 (mean = 0.32), respectively. SSR loci amplified with GB-FV-127 markers gave the highest polymorphism information content (PIC) of 0.61 and mean allele number of five, while for loci amplified with GB-FV-166 markers these values were the lowest, namely 0.03 and two. The mean PIC value (0.29) observed in the present study with average number of alleles (3.42). The genetic relationships among 32 Flammulina velutipes strains based on SSR data were generated by UPGMA cluster analysis. In conclusion, we succeeded in developing 12 polymorphic SSRs markers from SSR-enriched library of Flammulina velutipes. These SSRs are presently being used for phylogenic analysis and evaluation of genetic variations. In future, these SSR markers will be used in clarifying taxonomic relationships among the Flammulina velutipes.

Molecular Cloning of Genes Responsible for Parthenogenetic Development Failure

Sang Kyun Jeong,Kyung Kwang Lee,Dae Yeul Yu,Jae Hoon Chung 한국동물자원과학회(구 한국축산학회) 1996 한국축산학회 심포지움자료집 Vol.- No.-

Sorafenib Treatment for Advanced Hepatocellular Carcinoma: The First-Line versus Second-Line Treatment Following Transarterial Chemoembolization

( Sung Won Chung ),( Young Youn Cho ),( Jeong-hoon Lee ),( Young Chang ),( Joon Yeul Nam ),( Yun Bin Lee ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-hwan Yoon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: A number of Asian-Pacific centers perform transarterial chemoembolization (TACE) as the first treatment for advanced hepatocellular carcinoma (HCC), although sorafenib is the standard first-line treatment. In this study, we aimed to compare the overall survival (OS) according to initial treatment (TACE vs sorafenib) among patients experiencing sorafenib treatment in advanced HCC. Methods: We included 200 consecutive patients treated with sorafenib for >4 weeks with or without TACE for advanced HCC at a single tertiary hospital in Korea. The primary endpoint was OS and secondary endpoints included time to progression (TTP) and objective response rate (ORR) and disease control rate (DCR). The risk was compared between groups using a Cox proportional hazards model and inverse probability weighting (IPW) analysis. Results: Eighty-seven patients were initially treated with sorafenib (the sorafenib-first group: 54 treated with sorafenib only and 33 treated with sorafenib followed by TACE) and 113 patients were treated with TACE followed by sorafenib therapy (the TACE-first group). Twenty-eight patients (14%) were Child-Turcotte-Pugh class B and there was no significant difference in baseline characteristics between two groups except sorafenib-first group had more ascites (17.2% vs 7.1%, P=0.04) and prolonged prothrombin time (1.2±0.1 vs 1.1±0.1, P=0.02). The TACE-first group showed significantly longer OS than the sorafenib-first group (hazard ratio [HR]=0.62, 95% confidence interval [CI]=0.45-0.85, log-rank P=0.004). Median OS was 11.6 months in the TACE-first group and 6.9 months in the sorafenib-first group. The TACE-first group had significantly longer OS in multivariable analysis (adjusted HR=0.58; 95% CI=0.41-0.80, P=0.001 and IPW analysis (HR=0.63, 95% CI=0.44-0.91, P=0.01). There was no significant difference in TTP between two groups (HR=0.89, 95% CI=0.62-1.28, P=0.53). ORR was 6.9% in the sorafenib-first group and 10.6% in the TACE-first group (P=0.27 by chi-square test). DCR was 56.3% in the sorafenib-first group and 73.5% in the TACE-first group (P=0.01 by chi-square test). Conclusions: For patients with advanced HCC, second-line sorafenib treatment following TACE has significantly longer OS than first-line sorafenib treatment. An initial aggressive intrahepatic tumor control with loco-regional therapies followed by sorafenib treatment may be a potent strategy for advanced HCC.