건드릴가공의 절삭성에 대한 연구〔Ⅰ〕

李守鍾,鄭英得,朴相福 釜山工業大學校 1990 論文集 Vol.32 No.-

Gundrilling is a key process in deep hole machining which for example, occupye 20~30 percentage on the mild die machining. Recently, according to popularization of NC machine and machining center, Gundrilling's high efficient processing is powerfully required. This paper deal with enperimental research on the machinahility of gundrilling. We obsersed on the cutting power and variety of machined hole diameter in case various materials such as SM20C SM45C SUS304 and gundrill's configurations and cutting oil. The main results are obtained as follows : 1. Machining torque and thrust are well approached MILTON C, SHAW'S theorectical eq. at feed range 0.015~0.02mm/rev. 2. Total machining condition is good at feed range 0.015~0.02mm/rev. 3. Mean hump ratio is founded 1.47~16 in torque 1.03~2.27 in thrust. 4. When gundrill's cutting angle is near 30。-20。removal chip is normally formed.

배추김치 품질에 대한 게껍질 분말의 효과

정영진,이재복 三陟大學校 2003 論文集 Vol.36 No.-

김치의 보존기간에 있어서 김치에 알코올로 처리된 게껍질 분말(CSP) 첨가의 효과를 연구하기 위하여, 10℃에서 관능적인 품질 그리고 중화와 완충작용을 조사하였다. 2% 게껍질 분말을 포함하는 김치의 보관기간은 pH와 산도의 조사에 의하여 30일 이상이었다. 게껍질 분말 김치는 발효하는 동안 강한 중화작용을 보였고, 25일 이후 완충작용을 보였다. 4% 게껍질 분말은 1.5% 젖산용액을 10일간에 걸쳐 98%를 중화시켰다. To study the effect of alcohol treated-crab shell powder(CSP) addition in kimchi on shelf-life, sensory quality, neutralization and buffer action during fermentation at 10℃ were investigated. The edible periods of kimchi containing 2% CSP in kimchi by investigating pH and acidity were after 30 days. CSP in kimchi showed strong neutralization action and buffer action after 25 days during fermentation. The 98% neutralization action of 4% CSP in 1.5% lactic acid solution for 10 days was observed.

Lycopersicum esculentum 'cherry tomato'의 葯培養에 관한 硏究

鄭海駿,李永馥 培材大學校 1984 論文集 Vol.5 No.-

Anthers at the stage of uninucleate microspore of Lycopersicum esculentum 'cherry tomato' were cultured on the Murashige and Skoog's medium suppllemented with NAA and BA. Most of the binucleate microspores were equationally divided whereas the unequational division was relatively rare. The two nuclei formed were again divided into multinuclei, which were further developed into calli. After one month of culture, calli there formed on the MS medium containing BA 2mg/l and NAA 0.25mg/l. Shoot of embryoid-like body was not formed from the calli after subculture on the medium with reduced amounts of auxins.

Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향

장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-

The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....

Dietary Lactose as a Potential Risk Factor for Coronary Heart Disease and Ovarian Cancer

Yeong Ran Jeong, Yoon-Bok Lee 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

Lactose is a disaccharide consisting of a glucose and a galactose. Milk is a sole source of lactose in natural food. Lactase hydrolyzes lactose into glucose and galactose, which are absorbed in the intestine and utilized by the body. After weaning, lactase activity declines. Therefore, the majority of adults have hypolactasia. The prevalence is above 50% in South America, Africa, and Asia. A significant amount of lactose is consumed as cow milk-based food products. However, it has no special nutritional importance for adults, and it is suspected as a dietary risk factor for coronary heart disease (CHD) and ovarian cancer. The aim of this study is to review the evidence and to propose possible mechanisms regarding the relations between lactose intake and CHD and ovarian cancer. Epidemiological studies support the connection of lactose and CHD. Although several mechanisms for elucidation of this connection have been suggested, calcium theory is the most plausible. Galactose is known to be toxic to ovary. Galactose has been suggested to induce ovarian cancer through hypergonadotropic hypogonadism. Some epidemiological data support this but others do not. Consumption of lactose or galactose can induce CHD and ovarian cancer; however, more research will be needed in order to determine the relation between lactose and these diseases.

Production of recombinant human growth hormone conjugated with a transcytotic peptide in Pichia pastoris for effective oral protein delivery.

Lee, Jun-Yeong,Kang, Sang-Kee,Li, Hui-Shan,Choi, Chang-Yun,Park, Tae-Eun,Bok, Jin-Duck,Lee, Seung-Ho,Cho, Chong-Su,Choi, Yun-Jaie Humana Press 2015 Molecular biotechnology Vol.57 No.5

<P>Among the possible delivery routes, the oral administration of a protein is simple and achieves high patient compliance without pain. However, the low bioavailability of a protein drug in the intestine due to the physical barriers of the intestinal epithelia is the most critical problem that needs to be solved. To overcome the low bioavailability of a protein drug in the intestine, we aimed to construct a recombinant Pichia pastoris expressing a human growth hormone (hGH) fusion protein conjugated with a transcytotic peptide (TP) that was screened through peroral phage display to target goblet cells in the intestinal epithelia. The TP-conjugated hGH was successfully produced in P. pastoris in a secreted form at concentrations of up to 0.79 g/l. The function of the TP-conjugated hGH was validated by in vitro and in vivo assays. The transcytotic function of the TP through the intestinal epithelia was verified only in the C terminus conjugated hGH, which demonstrated the induction of IGF-1 in a HepG2 cell culture assay, a higher translocation of recombinant hGH into the ileal villi after oral administration in rats and both IGF-1 induction and higher body weight gain in rats after oral administration. The present study introduces the possibility for the development of an effective oral protein delivery system in the pharmaceutical and animal industries through the introduction of an effective TP into hGH.</P>

The Korean Association of lnternal Medicine : Poster Session ; PS 1338 : Nephrology ; Arterial Micro-Calcifi cation is Associated with Coronary Artery Calcium Score in Hemodialysis Patients

( Yeong Bok Lee ),( Su Jin Choi ),( Young Soo Kim ),( Sun Ae Yoon ),( Young Ok Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: We have reported that arterial micro-calcifi cation (AMC) of vascular access has a negative impact on access patency and cardiovascular mortality in hemodialysis (HD) patients. Reasons behind increased cardiovascular mortality in AMC are not fully understood, but it is believed that aortic stiffness is a major contributing factor. Whereas, coronary artery calcifi cation (CAC) is quite common in HD patients and it is known as predictor of future cardiovascular events and all cause mortality in HD patients. The aim of this study was to explore the relationship between AMC and CAC in HD patients. Methods: One hundred HD patients who received vascular access operation were included in this study. The AMC was diagnosed by pathologic examination of arterial specimen by von Kossa stain, which was acquired during the operation. All patients underwent a multi-detector computed tomography (MDCT) imaging procedure and coronary artery calcium score (CACS) was calculated. Patients were classifi ed into two groups, according to the CACS, as low (<100), in 40 patients, and high (≥100), in 60 patients. We compared CACS between the patients with and without AMC. Results: Mean age was 65.1 ± 12.7 years and the male gender was 63 (63.0%). The incidence of AMC was 60.0% (n=60). The mean CACS was 486.8 ± 857.6 (0-5674.1), and the median value was 161.2. Patients with the positive AMC group showed a signifi cantly higher prevalence of diabetes (85.7% vs 45.5%, p=0.000). Positive AMC group showed high incidence of high CACS compared to negative AMC group (76.8% vs 38.6%, p=0.000). By binary logistic regression, high CACS was independently associated with positive AMC (OR 7.566, 95% CI 1.771-32.322, p=0.006). Conclusions: The present study suggests that AMC is closely associated with CACS in HD patients.

신경과 외래를 방문한 두통환자 복약지도

이영필,이순실,박경호,신완균,손인자,이민화,이상복 한국병원약사회 1993 병원약사회지 Vol.10 No.4

Patient counseling and medication teaching was conducted on compliance and orientation to drug therapy for 278 headache patients from Apr. 1993 to Jul. 1993 by co-work of doctors and pharmacists. Counseling was conducted with medication teaching manual and drug sample and then it was recorded to currently medication history, adverse effects and counseling contents. In analysis of counseling contents, headache incidence was higher in female than male (71.6% : 28.4%) and highest on the fifties. The percentage of headache types of tension HA, migraine, mixed type HA was 76.1%, 13.5%, 10.8% respectively. 160 patients(66.1%) had been conducted compliance well. Adverse effects were appeared in the form drowsiness, GI trouble, dry mouth, weight gain, constipation.

Neurite Outgrowth on Nanocomposite Scaffolds Synthesized from PLGA and Carboxylated Carbon Nanotubes

Lee, Hyun Jung,Yoon, Ok Ja,Kim, Do Hee,Jang, Yeong Mi,Kim, Hyun Woo,Lee, Won Bok,Lee, Nae-Eung,Kim, Sung Su WILEY-VCH Verlag 2009 Advanced engineering materials Vol.11 No.12

<P>Carbon nanotubes (CNTs) have been suggested as suitable materials for biomedical applications, especially in the neural area. It is essential not only to investigate the biocompatibility of CNTs with the neural system but also to determine proper methods for applying CNTs to neuronal growth. This work represents the first application of CNTs by electrospun poly(D,L-lactic-co-glycolic acid) (PLGA) scaffolds for a neural system. We synthesized electrospun nanocomposites of PLGA and single-walled carbon nanotubes functionalized by carboxylic acid groups (c-SWNTs), and investigated neurite outgrowth from SH-SY5Y cells on these nanocomposites as compared to that on fibrous PLGA alone. Cells on our PLGA/c-SWNT nanocomposite showed significantly enhanced mitochondrial function and neurite outgrowth compared to cells on PLGA alone. We concluded that c-SWNTs incorporated into fibrous PLGA scaffolds exerted a positive role on the health of neural cells.</P> <B>Graphic Abstract</B> <P>Carbon nanotubes (CNTs) have distinctive characteristics such as high conductivity which could help the promotion of neuronal function. Electrospun nanocomposites of poly(D,L-lactic-co-glycolic acid) (PLGA) and CNTs were synthesized, and neurite outgrowth and mitochondrial function of human neuroblastoma cells were investigated on these nanocomposites and compared with that on fibrous PLGA alone. The results showed that CNTs incorporated into fibrous PLGA scaffolds exerted a positive role on the health of neural cells. <img src='wiley_img_2010/14381656-2009-11-12-ADEM200900144-content.gif' alt='wiley_img_2010/14381656-2009-11-12-ADEM200900144-content'> </P>

Promising Therapeutic Effects of Embryonic Stem Cells-Origin Mesenchymal Stem Cells in Experimental Pulmonary Fibrosis Models: Immunomodulatory and Anti-Apoptotic Mechanisms

Hanna Lee,Ok-Yi Jeong,Hee Jin Park,Sung-Lim Lee,Eun-yeong Bok,Mingyo Kim,Young Sun Suh,Yun-Hong Cheon,Hyun-Ok Kim,Suhee Kim,Sung Hak Chun,Jung Min Park,Young Jin Lee,Sang-Il Lee 대한면역학회 2023 Immune Network Vol.23 No.6

Interstitial lung disease (ILD) involves persistent inflammation and fibrosis, leading to respiratory failure and even death. Adult tissue-derived mesenchymal stem cells (MSCs) show potential in ILD therapeutics but obtaining an adequate quantity of cells for drug application is difficult. Daewoong Pharmaceutical’s MSCs (DW-MSCs) derived from embryonic stem cells sustain a high proliferative capacity following long-term culture and expansion. The aim of this study was to investigate the therapeutic potential of DW-MSCs in experimental mouse models of ILD. DW-MSCs were expanded up to 12 passages for in vivo application in bleomycin-induced pulmonary fibrosis and collagen-induced connective tissue disease- ILD mouse models. We assessed lung inflammation and fibrosis, lung tissue immune cells, fibrosis-related gene/protein expression, apoptosis and mitochondrial function of alveolar epithelial cells, and mitochondrial transfer ability. Intravenous administration of DWMSCs consistently improved lung fibrosis and reduced inflammatory and fibrotic markers expression in both models across various disease stages. The therapeutic effect of DW-MSCs was comparable to that following daily oral administration of nintedanib or pirfenidone. Mechanistically, DW-MSCs exhibited immunomodulatory effects by reducing the number of B cells during the early phase and increasing the ratio of Tregs to Th17 cells during the late phase of bleomycin-induced pulmonary fibrosis. Furthermore, DW-MSCs exhibited antiapoptotic effects, increased cell viability, and improved mitochondrial respiration in alveolar epithelial cells by transferring their mitochondria to alveolar epithelial cells. Our findings indicate the strong potential of DW-MSCs in the treatment of ILD owing to their high efficacy and immunomodulatory and anti-apoptotic effects.