Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Taxonomic study of genus Ypsolopha (Lepidoptera: Ypsolophidae) from Korea

Sol-Moon Na,Bo-sun Park,Dong-June Lee,Yang-Seop Bae 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.04

The genus Ypsolopha Latreille 1796, belongs to the family Ypsolophidae, small to medium sized micro-moth, with more than 140 described species around the world. More than 70% of the species are described from the Palearctic and Oriental Regions (Jin et al., 2013). Major taxonomic study of Ypsolopha carried out by following scholars. In the end of 18th to early of 20th century, Fabricius (1798), Hübner (1826), Agassiz (1846), Walshingham (1881, 1889), Busck(1903, 1906) and Meyrick (1914-1937). Furthermore, Moriuti (1964, 1977) studied total 17 Japanese Ypsolopha species and he divided 3 groups which based on fore- and hind- wing venations and shape of labial palpus. The first systematic study of the genus Ypsolopha carried out by K. T. Park (1983), discovered with four species, Ypsolopha blandella (Christoph), Y. yasudai Moriuti, Y. strigosa (Butler), Y. acuminata (Butler) in ‘Illustrated Flora & Fauna of Korea vol. 27 Insecta (Ⅸ)’ and ‘Check List of Insects from Korea’. After than, Ypsolopha longa Moriuti was discovered by Jeong et al.(1995). In 2001, Byun and Park, they described new species, Ypsolopha nigrimaculata Byun and Park. At the same time, Byun and Bae reported 3 newly recorded species; Y. cristata Moriuti, Y. japonica Moriuti, Y. parenthesella (Linnaeus). Up to date, 14 species have been recorded from Korea by Sohn (2010, 2011) with Y. amoenella (Christoph), Y. asperella (Linnaeus), Y. contractella (Caradja) and Y. acerella (Ponomarenko and Sohn). In the present study, we identified 14 species belonging to the genus, with some unidentified species. The materials examined come from the collection of Incheon National University.

한의학(韓醫學)의 좌우리론(左右理論)에 관(關)한 고찰(考察)

박승미 ( Seung Mi Park ),박히준 ( Hi Joon Park ),이향숙 ( Hyang Sook Lee ),손양선 ( Yang Sun Son ),임사비나 ( Sabina Lim ),이혜정 ( Hye Jung Lee ) 대한경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right (男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul: 氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

Overexpression of Zoysia ZjCIGR1 gene confers cold stress resistance to zoysiagrass

Yang‑Ji Kim,Dae‑Hwa Yang,Mi‑Young Park,Hyeon‑Jin Sun,Pill‑Soon Song,Hong‑Gyu Kang,Seok‑Cheol Suh,Yong‑Eok Lee,이효연 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.1

Zoysia japonica Steud. is a warm-season lawn grass popular in Korea and elsewhere. They are cultivated in many places such as river banks, roadside, and play grounds. However, there still is a disadvantage of frequent mowing, and the grass grows poorly under the chilly conditions. To develop a grass variety that circumvents these drawbacks, we cloned the chitininducible gibberellins-responsive1 gene (CIGR1) from zoysiagrass. The full length of the ZjCIGR1 (Zj; Zoysia japonica Steud.) gene was obtained by 5′/3′ RACE PCR and the phylogenetic tree showed that it belonged to the CIGR1-subgroup in the PAT1-group of GRAS protein family. Expression of the ZjCIGR1 in wild-type plants was confirmed in roots, meristems, leaves, and flowers, especially high in the flowers. The transgenic zoysiagrass was confirmed by PCR using gene-specific primers, phosphinothricin-acetyl-transferase (PAT) strip test, and Southern blot analysis. ZjCIGR1-overexpressing plants acquired tolerance to cold stress displaying morphological phenotypes characteristic of stress resistance. In addition, in the transformants, expression of the ZjCIGR1 as well as cold-regulated (COR) gene was increased compared to the wild-type plants under cold stress condition. These results suggest that ZjCIGR1 gene is an important candidate for regulating cold stress resistance.

한의학(韓醫學)의 좌우이론(左右理論)에 관(關)한 고찰(考察)

박승미,박히준,이향숙,손양선,임사비나,이혜정,Park Seung-Mi,Park Hi-Joon,Lee Hyang-Sook,Son Yang-Sun,Lim Sa-Bi-Na,Lee Hye-Jung 경락경혈학회 2001 Korean Journal of Acupuncture Vol.18 No.1

We could summerize the concept of the right and left mentioned in Nai-Gyung and some literature of oriental medicine as follow At first the right and left is a directional right and left which implys left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰), secondly it is also the road of eumyang which implys man-left-woman-right(男左女右), left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse. left-liver-right-lung(左肝右肺), left-yang-right-eum(左陽右陰) and man-left-woman-right(男左女右) are expressions of the movement of yang which is a core of chang, at the same time, left-blood-right-ki(左血右氣), left-sinsu-right-myungmon(左腎水右命門), and left-right of pulse are expressions of the eum in response to the movement of yang. (go up and down of water and fire) Finally, both a directional right and left and a road of eumyang mean a road of going up and down of eumyang so, this is very important index in circulation and keeping ballance of eumyang (ki-Hyul:氣血) in the human body therefore, we can treat a disease with acupuncture in the use of this charater, for example when a disease occurs in the left side, we can treat it with acupuncture in the right side, the same applys to right.

측두엽에 발생된 Gliosarcoma

박양화,권익승,홍승관,문명선,신미경 대한신경외과학회 1989 Journal of Korean neurosurgical society Vol.18 No.1

저자들은 근래 좌측 측두엽에 발생된 Gliosarcoma 1예를 수술적 부분적출 및 수술후 방사선 조사로 치료한 후 일시적 증상 호전을 보이다가 수개월 내에 급속한 임상적 악화 및 종양 재증식을 치험하고 희귀한 증례이기에 보고하고저 한다. Gliosarcoma는 악성 뇌교종과 섬유육종이 혼합된 뇌종양으로써, 문헌 고찰 결과 악성 뇌교종 내의 혈관내피세포 과증식이 어떠한 알려지지 않은 기전에 의하여 악성 변화를 일으켜 섬유육종이 발생되는 경우가 대부분으로 사료된다. A case of left temporal gliosarcoma is reported. The patient was a 40-year old man who had headache, behavior change, dysphasia, and mental confusion for about 2 months duration. On brain CT, a large partially cystic mass with homogeneous enhancement was located at left temporal lobe and associated with remarkable pentumoral edema and mass effect. Angiographic tumor vascularity was faintly visualized. Surgical subtotal resection of the tumor and post-operative radiotherapy offered transient symptomatic improvement, being followed within several months by clinical deterioration and regrowth of the tumor on brain CT. Light microscopic studies of the H & E and special stained specimens showed two different components within the tumor in a mixed fashion, i.e. intermingled glioblastoma multiforme and fibrosarcoma. Electron microscopic study of the sarcomatous cells disclosed intracytoplasmic Weibel-Palade-like bodies, a specific marker of endothelial cells. The fibrosarcomatous component of gliosarcoma is believed to be originated from malignant transformation of the hyperplastic endothelial cells within the anaplastic glioma. Literature concerned with gliosarcoma is reviewed.

전신마취중 에피네프린사용으로 발생되는 부정맥

박선규,진홍용,양홍석 중앙대부설한국의과학연구소 1985 한국의과학 Vol.17 No.3

신이식 환자에서 발생한 Nocardia elegans 폐농양 1예

박기호,고선영,오련,김탁,조오현,김양수,우준희,한덕종,성흥섭,김미나 대한감염학회 2008 감염과 화학요법 Vol.40 No.2

노카르디아는 면역 저하 환자에서 발생하는 기회 감염균으로 배양과 균 동정이 복잡하기 때문에 시기 적절한 진단과 치료가 어려울 때가 흔하다. 그러나 최근 16S 리보좀 RNA 염기서열 분석과 같은 새로운 분자생물학적 방법이 도입되면서 노카르디아 감염의 진단과 치료에 많은 도움이 되고 있다. 저자들은 신이식을 받은 39세 남자에서 발생한 N. eleeans에 의한 폐농양을 경험하였기에 보고하는 바이다. 환자는 항균제 감수성 결과에 따라 적절한 항균제로 치료하였고, 치료 종료 후 1년 동안 재발 없이 외래 경과 관찰 중이다. 본 증례를 통하여 이식 환자와 같은 면역 저하 환자에서 노카르디아 감염의 가능성을 고려하여야 하겠고 분자생물학적 방법에 의한 빠른 균 동정과 적절한 항균제 치료가 중요함을 기억하여야 하겠다. Nocardiosis is well-known opportunistic infection in immunocompromised patients. The timely diagnosis and treatment, however, is stilt a difficult problem. Recently, as newer molecular techniques, particularly 16S rRNA sequencing, are implemented, the diagnosis and management of the infection are improving. We report a case of lung abscess in a 39-year-o1d-man who underwent kidney transplantation. He was diagnosed of Nocardia elegans by 16S rRNA sequencing and was cured of the infection with appropriate antibiotic therapy.

룸바 포워드 워크의 지면반력 분석 : 4 카운트의 워크와 1 카운트의 골반세틀을 중심으로

박양선,임용규 漢陽大學校 體育科學硏究所 2003 體育科學 Vol.23 No.23

This study serves the purpose of understanding ground reaction force analysis of the Rumba forward walk of Latin America Dance through of skilled and unskilled dancers. To accomplish all this, ground reaction force lateral, anteroposterior, vertical factors analysis. The conclusions were as follow; 1.Lateral ground reaction force The differences among Skill(4.05±1.1kg), Unskill(1.7±0.4kg) were meaningful at Pointl (P<.05). The no differences among Skill(-2.5±0.9k9), Unskill(-2.6±1.8k9)were meaningful at proint2. The no differences among Skill(3.3±1.5kg),Unskill(2.0±2.Okg) were meaningful at Point3. 2. Anteroposterior ground reaction force The no differences among Skill(-17.85± 1.11kg), Unskill(-13.35±3.43kg) were meaningful at Pointl The differences among Skill(15.16±0.43kg), Unskill(8.15±3.22kg) were meaningful at Point E(p<.05). The no differences among Skill(23.92±2,06kg), Unskill(16.62±3.55kg) were meaningful at Points(p<05). 3. Vertical ground reaction force The no differences among Skill(65.81±4.46kg), Unskill(59.90±10.72kg) Were meaningful at Pointl. The no differences among Skill(72.84±9,47kg),Unskill(68.23±13.55kg) were meaningful at Point2. The differences among Skill(91.11±7.82kg), Unskill(80.59t14.S4kg) were meaningful at Point3(p<,05).

유비쿼터스 환경에서의 맥진 시스템 설계 연구

양동일,박순희,김진봉,진광윤,최형진 강원대학교 정보통신연구소 2007 정보통신논문지 Vol.11 No.-

This research suggests service-infrastructure for a diagnosis and a prescription of oriental medicine in ubiquitous environment. A pulse is very important as a basic raw material in the field of oriental medicine. So, this research designs service-infrastructure making use of not a position information that is suggested previous but a pulse context information. A processing of a pulse-diagnosis system is proceeding like that is inputted a signal of user's pulse, diagnose and prescript through the analyzing and inferring that signal. A created signal is classified into 6, 'Bu, Chim, Ji, Sak, Heo, Sil', and they are classified into more specific items about each pulse. A classified pulse combines with another pulse and is possible for a diagnosis and inference of new symptoms. This research defines this model as OMPD-CAM(Oriental Medicine Pulse Diagnosis Context Aware Middleware), and designs a pulse context aware middleware.