Verticillium Wilt of Okra Caused by Verticillium dahliae Kleb. in China

( Wen-xue Yan ),( Yan-xia Shi ),( A-li Chai ),( Xue-wen Xie ),( Men-yan Guo ),( Bao-ju Li ) 한국균학회 2018 Mycobiology Vol.46 No.3

Okra (Abelmoschus esculentus (L.) Moench) has gained more popularity as an economically significant plant for its nutritional and medicinal value, especially in China. During 2014-2016, the root disease of okra was discovered in four okra commercial fields surveyed in China. A fungul was isolated from the infected tissues, and was identified by Verticillium dahliae based on morphological characteristics. Pathogenicity test demonstrated that the fungus was pathogenic on okra, and fulfilled Koch’s postulates. The analysis of three sequences revealed 99-100% identity with the reported V. dahliae strain in GenBank. Neighbor-joining analysis of the gene sequences revealed that the representative isolates were clustered with V. dahliae. To the best of our knowledge, this is the first report of Verticillium wilt of okra in China.

Thyroid Hormone Reference Intervals among Healthy Individuals In Lanzhou, China

Yan Lu,Wen-Xia Zhang,De-Hong Li,Lian-Hua Wei,Yu-Jun Zhang,Fu-Na Shi,Shen Zhou 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.3

Background: The common reference intervals (RIs) for thyroid hormones currently used in China are provided by equipment manufacturers. This study aimed to establish thyroid hormone RIs in the population of Lanzhou, a city in the subplateau region of northwest China, and compare them with previous reports and manufacturer-provided values. Methods: In total, 3,123 individuals (1,680 men, 1,443 women) from Lanzhou, an iodine-adequate area of China, perceived ashealthy were selected. The Abbott Architect analyzer was used to determine the serum concentration of thyroid hormones. The 95%RI was estimated using the 2.5th and 97.5th percentiles as the lower and upper reference limits, respectively. Results: The serum levels of thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), antithyroglobulin (ATG) antibody,and antithyroid peroxidase (ATPO) antibody levels were significantly correlated with sex (P<0.05). TSH, total thyroxine (TT4), andATPO levels were significantly correlated with age (P<0.05). The serum levels of TSH, ATG, and ATPO in men were significantlylower than in women; in contrast, the serum TT3 level was significantly higher in men than in women (P<0.05). Serum TSH, TT3,TT4, and ATG levels differed across age groups (P<0.05), but no such variation was observed for ATG levels (P>0.05). The established RIs of TSH, ATG, and ATPO in this study differed between sexes (P<0.05). The thyroid hormone RIs established herein wereinconsistent with the manufacturer-provided values. Conclusion: The RIs of thyroid hormones in the healthy population of Lanzhou were inconsistent with those in the manufacturer’smanual. Validated sex-specific values are required for diagnosing thyroid diseases.

Torque Ripple Minimization of PMSM Using Parameter Optimization Based Iterative Learning Control

Changliang Xia,Weitao Deng,Tingna Shi,Yan Yan 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.2

In this paper, a parameter optimization based iterative learning control strategy is presented for permanent magnet synchronous motor control. This paper analyzes the mechanism of iterative learning control suppressing PMSM torque ripple and discusses the impact of controller parameters on steady-state and dynamic performance of the system. Based on the analysis, an optimization problem is constructed, and the expression of the optimal controller parameter is obtained to adjust the controller parameter online. Experimental research is carried out on a 5.2kW PMSM. The results show that the parameter optimization based iterative learning control proposed in this paper achieves lower torque ripple during steady-state operation and short regulating time of dynamic response, thus satisfying the demands for both steady state and dynamic performance of the speed regulating system.

Polymorphic Variation of Inflammation-related Genes and Risk of Non-Hodgkin Lymphoma for Uygur and Han Chinese in Xinjiang

Gu, Xia,Shen, Yan,Fu, Ling,Zuo, Hong-Yun,Yasen, Halida,He, Ping,Guo, Xin-Hong,Shi, Yu-Wei,Yusufu, Muhabaiti Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Polymorphisms of inflammation-related genes have been found to be associated with non-Hodgkin lymphoma (NHL) or some of its subtypes, but only a few relevant data have been reported in China. In this study, the Snapshot method was used to assess genetic variation; a total of 14 single nucleotide polymorphisms (SNPs) for 6 inflammatory factors in 157 NHL cases (64 Uygur ethnic subjects, 93 Han Chinese) and 435 controls (231 Uygur and 204 Han Chinese) were studied from the Xinjiang province of China. Haplotype distribution was estimated using PHASE 2.3 software. Statistical differences in the genotype and haplotype frequencies between case and control groups were also considered and estimated. For the Han population, the geneotype distributions for TNF-${\alpha}rs1800629$, TNF-${\alpha}rs1800630$, IL-6 rs1800795, IL-6 rs1800797, NF-KB1 rs1585215 and TLR-4 rs4986790 showed significant differences between the case and control groups (p<0.05). The TNF-${\alpha}$ gene frequencies of ACG and CCA haplotypes in the cases were higher than in the controls (OR=2.45, 95% CI: 1.55-3.89, p=0.0002, OR=2.53, 95% CI: 1.10-5.80, p=0.029, respectively), and the same findings were detected for TNF-${\beta}$ gene CA haplotype (OR=1.87, 95% CI: 1.21-2.90, p=0.0054). However, for the Uygur population, no such significant differences were detected within the gene-type distribution of the 14 SNPs. The TNF-${\alpha}$ gene frequency of the CCA haplotype between the two groups (OR=1.98, 95% CI: 1.11-3.51, p=0.021) revealed a statistically significant difference. Our results showed that polymorphic variations of inflammation-related genes could be important to the NHL etiology of the Han population, and that these may only have limited influence on the Uygur population.

Predictive control with optimal vector sequence for permanent magnet synchronous motors

Li, Chen,Shi, Ting-Na,Yan, Yan,Zhou, Zhan-Qing,Xia, Chang-Liang The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.2

Conventional model predictive control aims to minimize ripples of the torque, stator flux and current at the end instant of each control period. However, the trajectories of the torque and flux during the entire control period are changed when multiple voltage vectors are applied in different sequences in each period. This indicates that the ripples of the torque and stator flux are influenced by different vector sequences (i.e., the sequence multiple vectors applied in). For that issue, this paper analyzes the RMS values of the stator flux vector ripple when three basic vectors are applied in different five-segment sequences, and proposes a predictive control with optimal vector sequence method. Based on this analysis, the available vector sequences that reduce the stator flux vector ripple are screened out. Moreover, a cost function is constructed to select the optimal vector sequence by evaluating the stator flux ripple during the entire control period and the tracking error of the stator flux vector at the end instant of each control period. Finally, simulation and experimental results verify the effectiveness of the proposed method.

Cytotoxic triterpene glycosides from the roots of Sanguisorba officinalis

Jiang Hu,Yan Song,Hui Li,Benshou Yang,Xia Mao,Yongmao Zhao,Xiaodong Shi 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6

Phytochemical investigation of the ethanolextract of the roots of Sanguisorba officinalis resulted inthe isolation of three new triterpene glycosides, 3b-[(a-Larabinopyranosyl)oxy]-19a,23-dihydroxyolean-12-en-28-oicacid 28-[6-O-acetyl-b-D-glucopyranosyl] ester (1),2a,3b,19a,23-tetrahydroxyurs-12-en-28-oic acid 28-[6-Oacetyl-b-D-glucopyranosyl] ester (2), and 3b-[(a-L-arabinopyranosyl)oxy]-19a-hydroxyurs-12,20(30)-dien-28-oicacid 28-[6-O-acetyl-b-D-glucopyranosyl] ester (3). All thetriterpene glycosides exhibited the significant cytotoxicpotential with low IC50 values (IC50\5.0 lM) against sixtumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCIH460,and BGC-823).

A Predictive Model for Evaluating Responsiveness to Pemetrexed Treatment in Patients with Advanced Colorectal Cancer

Wu, Xue-Yan,Huang, Xin-En,Cao, Jie,Shi, Lin,Xu, Xia,Qian, Zhi-Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Purpose: To highlight the potential factors that could predict the response rate of patients with metastatic colorectal cancer (mCRC) treated with pemetrexed combined chemotherapy after first- or second-line chemotherapy using the FOLFOX regimen. Materials and Methods: Between January 2007 and July 2014, 54 patients diagnosed and pathologically-confirmed with advanced colorectal cancer in Jiangsu Cancer Hospital and Research Institute, were enrolled. They received pemetrexed at a dose of $500mg/m^2$ by 10 minute infusion on day 1, repeated every 3 weeks. Doses were modified depending on nadir counts of blood cells. Combined chemotherapeutic agents included irinotecan, lobaplatin, carboplatin, oxaliplatin, gemcitabine, cis-platinum or bevacizumab. Multiple variables (age, sex, hemoglobin, platinum drugs combined, metastasis sites, LDH, ALP, CEA>40 ug/ml) reported earlier were selected. We used logistic regression analysis to evaluate relationships between these and tumor response. Results: On multivariable analysis, we found that age was significant in predicting the responsiveness to pemetrexed (p<0.05) combined with oxaliplatin. We did not find any other factors which were significantly associated with the response rate to chemotherapy with pemetrexed and irinotecan. Conclusions: By multivariate analysis, we found that age had significant impact on the responsiveness of pemetrexed when combined with oxaliplatin. Additional research based on genomic properties of host and tumors are needed to clarify markers for better selection of patients who could benefit from pemetrexed combined chemotherapy.

Research on Temperature Rise Characteristics of Vehicle Motors Under Bench Working Condition

He Liange,Shi Wenjun,Xia Xiaohua,Wu Xinyang,Chen Hongling,Yan Xin 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.6

The specifi c bench test specifi ed by the product design standard is an important basis for judging whether the vehicle motor meets the requirements. To study the temperature rise characteristics of automotive permanent magnet synchronous motors under bench test conditions. Firstly, the bench condition was taken as the target we need to study, and the fi nite element method was used to calculate the loss of each part during the bench test condition. Secondly, use this loss as the heat source for temperature fi eld calculation to simulate the temperature fi eld of the motor under bench test conditions. Finally, a bench test platform was built for testing, and the test results and simulation results were compared and analyzed. Studies have shown that in the entire process of changing conditions, the temperature of each component is not the same as the sensitivity to changes in operating conditions. The maximum relative error between simulation and experiment was 9.4%, which verifi es the eff ectiveness of this research method and process, which has certain guiding signifi cance for the design and optimization of vehicle motors.

Kinetics and computational docking studies on the inhibition of tyrosinase induced by oxymatrine.

Liu, Xiao-Xia,Sun, Shi-Qing,Wang, Yu-Jie,Xu, Wei,Wang, Yi-Fang,Park, Daeui,Zhou, Hai-Meng,Han, Hong-Yan Humana Press 2013 Applied biochemistry and biotechnology Vol.169 No.1

<P>A combination of enzymatic inhibition kinetics and computational prediction was employed to search for an effective inhibitor of tyrosinase. We found that oxymatrine significantly inhibited tyrosinase, and that this reaction was not accompanied by detectable conformational changes. Kinetic analysis showed that oxymatrine reversibly inhibited tyrosinase in a mixed-type manner. Measurements of intrinsic and ANS-binding fluorescences showed that oxymatrine did not induce any conspicuous changes in the tertiary structure. We also conducted a docking simulation between tyrosinase and oxymatrine using two docking programs, Dock6.3 and AutoDock4.2 (binding energy was -118.81 kcal/mol for Dock6 and -8.04 kcal/mol for AutoDock4). The results also suggested that oxymatrine interacts mostly with the residues of CYS83 and HIS263 in the active site of tyrosinase. This strategy of predicting tyrosinase inhibition by simulation of docking coupling with kinetics may prove useful in screening for potential tyrosinase inhibitors. Knowledge of tyrosinase inhibition can provide medical, cosmetic, and agricultural applications. Our study suggests that oxymatrine is an important agent for various applications related to pigment formation.</P>

Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer's Disease: A Diffusion MRI Study with DTI and HARDI Models

Wang, Tao,Shi, Feng,Jin, Yan,Yap, Pew-Thian,Wee, Chong-Yaw,Zhang, Jianye,Yang, Cece,Li, Xia,Xiao, Shifu,Shen, Dinggang Hindawi Publishing Corporation 2016 Neural plasticity Vol.2016 No.-

<P>Alzheimer's disease (AD) is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks. We compared the differences between WM connectivity characteristics at global, regional, and local levels in 26 patients with probable AD and 16 normal control (NC) elderly subjects, using connectivity networks constructed with the diffusion tensor imaging (DTI) model and the high angular resolution diffusion imaging (HARDI) model, respectively. At the global level, we found that the WM structural networks of both AD and NC groups had a small-world topology; however, the AD group showed a significant decrease in both global and local efficiency, but an increase in clustering coefficient and the average shortest path length. We further found that the AD patients had significantly decreased nodal efficiency at the regional level, as well as weaker connections in multiple local cortical and subcortical regions, such as precuneus, temporal lobe, hippocampus, and thalamus. The HARDI model was found to be more advantageous than the DTI model, as it was more sensitive to the deficiencies in AD at all of the three levels.</P>