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( Tong Sun ),( Bulin Du ),( Yao Diao ),( Xuena Li ),( Song Chen ),( Yaming Li ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.7
[18F]Fluorodeoxyglucose (FDG) PET/CT imaging has been widely used in the diagnosis of malignant tumors. ATPase family AAA domain-containing protein 2 (ATAD2) plays important roles in tumor growth, invasion and metastasis. However, the relationship between [18F]FDG accumulation and ATAD2 expression remains largely unknown. This study aimed to investigate the correlation between ATAD2 expression and [18F]FDG uptake in lung adenocarcinoma (LUAD), and elucidate its underlying molecular mechanisms. The results showed that ATAD2 expression was positively correlated with maximum standardized uptake value (SUV<sub>max</sub>), total lesion glycolysis (TLG), glucose transporter type 1 (GLUT1) expression and hexokinase2 (HK2) expression in LUAD tissues. In addition, ATAD2 knockdown significantly inhibited the proliferation, tumorigenicity, migration, [18F]FDG uptake and lactate production of LUAD cells, while, ATAD2 overexpression exhibited the opposite effects. Furthermore, ATAD2 modulated the glycometabolism of LUAD via AKT-GLUT1/HK2 pathway, as assessed using LY294002 (an inhibitor of PI3K/AKT pathway). In summary, to explore the correlation between ATAD2 expression and glycometabolism is expected to bring good news for anti-energy metabolism therapy of cancers. [BMB Reports 2019; 52(7): 457-462]
Xue, Na,Hei, Zhoufei,Zhao, Ze,Wang, Jing,Wang, Ting,Li, Mengxue,Noh, Hyeon Mi,Jeong, Jung Hyun,Yu, Ruijin American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.4
<P>Orange-red-emitting sodium yttrium orthosilicate NaYSiO4:xSm(3+) ( x = 0.005, 0.01, 0.02, 0.05, 0.10, 0.15, and 0.20) were synthesized. The phase structure and photoluminescence properties of these phosphors were investigated. The emission spectrum obtained by excitation into 406 nm contains exclusively the characteristic emissions of Sm3+ at 571 nm, 602 nm, 648 nm, and 710 nm, which correspond to the transitions from (4)G(5/2) to H-6(5/2), H-6(7/2), H-6(9/2), and H-6(11/2) of Sm3+, respectively. The strongest one is located at 602 nm due to the (4)G(5/2). H-6(7/2) transition of Sm3+, generating bright orange-red light. The optimum dopant concentration of Sm3+ ions in NaYSiO4:xSm(3+) is around 2 mol%, and the critical transfer distance of Sm3+ is calculated as 23 angstrom. The thermal quenching temperature is above 500 K. The fluorescence lifetime of Sm3+ in NaYSiO4:0.02Sm(3+) is 1.83 ms. The NaYSiO4:Sm3+ phosphors may be potentially used as red phosphors for white light emitting diodes.</P>