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      • KCI등재

        Black Hole Mass and Accretion Rate of Active Galactic Nuclei

        Xue-Bing Wu,F.K. Liu,J.L. Han,M.Z. Kong,R. Wang 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.4

        The determination of the central black hole mass is crucial to the understanding of active galactic nuclei physics. In this paper, we brie°y review some methods that are currently used to estimate the black hole mass of AGNs. Particularly, we demonstrate the importance of two correlations: one between the black hole mass and the stellar velocity dispersion and the other one between the broad line region (BLR) size and the optical continuum luminosity. Besides applying these relations in deriving the black hole masses of various types of AGNs, we also employ the fundamental plane of elliptical galaxies to estimate the central velocity dispersions of AGN host galaxies, and then the black hole masses of AGNs, including BL Lac objects. In addition, we derive another empirical relation between the BLR size and the H. emission line luminosity from AGNs with the BLR size measured by reverberation mapping studies, and we argue that more accurate black hole masses of extremely radio-loud AGNs can be obtained with it than by using the usual R ¡ L 5100ºA relation because of the jet contribution to the optical continuum. Finally, we point out that black hole mass estimation is very much helpful in determining the accretion rate and in understanding the accretion process in AGNs.

      • miR-27a as an Oncogenic microRNA of Hepatitis B Virus-related Hepatocellular Carcinoma

        Wu, Xin-Jun,Li, Yan,Liu, Dong,Zhao, Lun-De,Bai, Bin,Xue, Ming-Hui Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

        microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through post-transcriptional interactions with mRNA. miRNAs have recently emerged as key regulators of various cancers. Although miR-27a has been implicated in several other cancers, its role in hepatitis B virus-related hepatocellular carcinoma (HCC) is unknown. In this study, we showed miR-27a to be frequently up-regulated in HCC tissues and HCC cell lines (HepG2 and Huh7). Overexpression of miR-27a enhanced cell proliferation, promoted migration and invasion, and activated cell cycling in HepG2 and Huh7 cells. In summary, our results suggest that up-regulation of miR-27a may play an oncogenic role in the development of HCC and might thus be a new therapeutic target in HCC patients.

      • SCIESCOPUSKCI등재

        Effect of cooking methods on bioaccessibility of Zn, Se, Cd, Cu in sea cucumber (Apostichopus japonicus)

        Liu, Chune,Wu, Lele,Xue, Ying,Liu, Feng,Sun, Shan,Wang, Liming 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.3

        In this study, the total concentration and bioaccessibility of four metals (Zn, Se, Cd, Cu) in sea cucumbers (Apostichopus japonicus) before and after cooking were measured. The concentration of Zn, Se, Cd, and Cu were $22.24{\pm}0.75$, $0.75{\pm}0.06$, $0.32{\pm}0.07$, and $1.88{\pm}0.09mg/kg$ in raw cucumber, respectively. The contents of Zn, Se, and Cu in high-pressured samples were significantly higher than that in the raw sea cumber (p < 0.01). The levels of Cd were all decreased after three thermal treatments. The intake of Zn and Cu increased in sea cucumber cooked by all thermal processes. While the bioaccessibility of Se and Cd decreased after cooking. A significant correlation was observed between the concentration and bioaccessibility of minerals. These data provide useful information for dietary risk assessments of minerals in sea cucumbers.

      • KCI등재

        Flatness Measurement of a Mosaic Focal Plane by using a Coaxial Multispectral Laser

        Liu Chang-hua,Guo Ning-Xin,Wang Jian-Li,Chen Tao,Wu Zhi-Yong,Cheng Xue 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.8

        The wide-field telescope will be an important tool in the discovery and birth of new theories of astronomy in future. The detectors in this kind of telescope mostly adopt a mosaic focal plane array. The focal depth of a large-F-number optical system is very small, and the flatness of the mosaic detector should be less than half the focal depth. In this paper, a new flatness measurement and data processing method is developed. A flatness measurement platform composed of a high-precision gantry platform and a coaxial multispectral displacement meter was built. The flatness of a single detector was measured under uncooled and cooled working conditions, and data processing was conducted, in which the root mean square (RMS) and the peak–valley (PV) values of the cooled detector were 0.0017 mm and 0.0112 mm, respectively. Next, a 2 × 6 mosaic model of the focal plane with a dimension of 148.5 mm × 168.5 mm was built using a metal detector model. The measurement platform was used to measure the flatness of the mosaic focal plane. According to the measurement results, the preliminary installation and mosaic adjustment were completed. The final RMS and PV values of the mosaic focal plane are 0.009 mm and 0.0808 mm, respectively. The experimental results show that the measurement and the data processing method can accurately reflect surface information on the detectors. This suggests that the method has great potential for use in ensuring the accuracy of wide-field telescope equipment in all applicable research areas.

      • KCI등재

        MnO2/graphene supported on Ni foam: an advanced electrode for electrochemical detection of Pb(II)

        Liu Rui,Zhang Chao-Jun,Han Xue,Wu Tian-Heng,Liu Ri-Jia,Sun Yuan,Jin Shuang 한국탄소학회 2023 Carbon Letters Vol.33 No.3

        Graphene-derived materials are an excellent electrode for electrochemical detection of heavy metals. In this study, a MnO2/graphene supported on Ni foam electrode was prepared via ultrasonic impregnation and electrochemical deposition. The resulting electrode was used to detect Pb(II) in the aquatic environment. The graphene and MnO2 deposited on the Ni foam not only improved active surface area, but also promoted the electron transfer. The electrochemical performance towards Pb(II) was evaluated by cyclic voltammetry (CV) and square wave anodic stripping voltammetry (SWASV). The prepared electrode exhibited lower limit of detection (LOD, 0.2 μM (S/N = 3)) and good sensitivity (59.9 μAμM−1) for Pb(II) detection. Moreover, the prepared electrodes showed good stability and reproducibility. This excellent performance can be attributed to the strong adhesion force between graphene and MnO2, which provides compact structures for the enhancement of the mechanical stability. Thus, these combined results provide some technical considerations and scientific insights for the detection of heavy metal ions using composite electrodes.

      • KCI등재

        Evaluation of the volatile profile of wax apple (Syzygium samarangense) wines fermented with different commercial Saccharomyces cerevisiae strains

        Xue Lin,Xiaoping Hu,Wuyang Wu,Sixin Liu,Congfa Li 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.3

        The effect of four commercial Saccharomycescerevisiae strains (D254, VIC, BV818, and RV100) on thevolatile profile of wax apple (Syzygium samarangense)wine was investigated in this study. Alcohols and esterswere the most two abundant groups of identified volatilesin wax apple wines. However, different S. cerevisiaestrains possess various capacities in releasing/synthesizingvolatiles with varied mRNA levels of genes involved involatiles metabolism during wax apple wine fermentation. VIC, which yielded the highest total concentration ofvolatiles and largest number of volatiles with odor activityvalue (OAV)[1, could be used as a starter culture toproduce wax apple wine characterized with intense aroma. D254 and RV100, which produced the greatest variety ofvolatiles and scored the highest in global aroma,respectively, could be used to enhance the wine complexity. Four wax apple wines could be differentiated by theirmain volatile compounds.

      • Phase II Study of Pemetrexed as Second or Third Line Combined Chemotherapy in Patients with Colorectal Cancer

        Wu, Xue-Yan,Huang, Xin-En,You, Shan-Xi,Lu, Yan-Yan,Cao, Jie,Liu, Jin,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

        Purpose: To investigate the safety and efficacy of pemetrexed combined with chemotherapy as second or third line in patients with stage IV colorectal cancer (CRC). Patients and Methods: This trial was conducted to evaluate the effectiveness and safety of pemetrexed given to patients with recurrent or metastatic colorectal carcinoma who previously received 5-FU-based chemotherapy. All patients were required to have a histological diagnosis of colorectal adenocarcinoma with measurable metastatic disease and prior chemotherapy. Patients received pemetrexed at a dose of 500 $mg/m^2$ by 10 minute infusion on day 1, repeated every 21 days. Doses were modified depending on nadir counts. Combined chemotherapy included Oxaliplatin, Irinotecan and cis-platinum. Results: Thirty patients were enrolled and twenty-nine were evaluable for response. One patient did not have repeat radiological testing to determine response because he went off study after only one cycle of treatment for economic reasons. For 29 evaluable patients, 1 partial response, 6 stable disease and 22 progressive disease were recorded. Response rate was 3.45% (1/29). All responses occurred in patients receiving a starting dose of pemetrexed 500 $mg/m^2$. Median time to progression for all eligible patients was 2.5 months. The most common toxicities experienced were mild to moderate fever, hepatic damage, myelosuppression, nausea, vomiting, constipation, abdominal pain, diarrhea, and skin rash. Conclusion: Pemetrexed at 500 $mg/m^2$ given every three weeks combined with chemotherapy is associated with moderate response and good tolerability in patients with stage IV CRC.

      • KCI등재

        Enhanced carrier transport and visible light response in CA-β-CD/g-C3N4/Ag2O 2D/0D heterostructures functionalized with cyclodextrin for effective organic degradation

        Xue Li,Tingting Liu,Fei Tian,Xiyang Tao,Zhansheng Wu 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.11

        The high cost and low carrier separation efficiency of g-C3N4/Ag2O photocatalysts affect its application in the degradation of organic pollutants. In this study, the CA-βCD/g-C3N4/Ag2O 2D/0D heterojunction photocatalysts were successfully prepared to enhance the visible light response and inhibit the electron-hole recombination simultaneously during pollutant degradation. The 10:1:1 CA-βCD/g-C3N4/Ag2O showed the outstanding photochemical catalysis performance for the degradation of organic pollutants. The degradation efficiency of methyl orange, reactive black and norfloxacin was 2.53, 1.92 and 1.14 times than that of 1:1 g-C3N4/Ag2O. In addition, 10:1:1 CA-β-CD/g-C3N4/Ag2O also showed excellent photocatalytic stability. The free radical scavenging experiment and electron spin resonance proved that ·O − 2 was the chief active specie in the degradation process. The mechanism research results showed that the formation of heterojunction improved the utilization rate of sunlight and promoted the separation efficiency of photo-generated electrons and holes, which significantly advanced the photocatalytic activity of the composite catalyst. The preparation of CA-βCD/g-C3N4/Ag2O provided ideas for modification of photocatalyst by macromolecular organic matter.

      • Phase II Study on Safety and Efficacy of Yadanzi<sup>®</sup> (Javanica oil emulsion injection) Combined with Chemotherapy for Patients with Gastric Cancer

        Liu, Jin,Huang, Xin-En,Tian, Guang-Yu,Cao, Jie,Lu, Yan-Yan,Wu, Xue-Yan,Xiang, Jin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

        Objective: To investigate the efficacy and safety of Yadanzi$^{(R)}$ (Javanica oil emulsion injection) combined with chemotherapy for treatment of patients with advanced gastric cancer. Methods: From January 2011 to December 2012, we recruited 75 patients with advanced gastric cancer, who received javanica oil emulsion injection together with chemotherapy. After two cycles of treatment, efficacy and safety of the combined therapies were evaluated. Results: Overall response rate of 75 patients after treatment was 85.3% (CR+PR+SD). Treatment related side effects were recorded. No treatment related death occurred. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced gastric cancer. Further randomized clinical trials should be conducted to confirm whether the addition of Yadanzi$^{(R)}$ to chemotheraphy could be associated with reduced toxicity, enhanced tolerability and improved quality of life for patients with advanced gastric cancer.

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