An Electrochemical Sensor Based on Graphene-Polypyrrole Nanocomposite for the Specific Detection of Pb (II)

Rong Rong,Huimin Zhao,Xiao Rong Gan,Shuo Chen,Xie Quan 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.1

An electrochemical sensor for the rapid, selective and sensitive detection of Pb2+ was developed using polypyrrole-graphene (PPY-rGO) nanocomposite by electrochemical synthesis. The PPYrGO-modified electrode possessed a large effective area because of unique 3D porous architectures, and it displayed excellent selectivity for the determination of Pb2+. The response of Pb2+ on the nanocomposite-modified electrode was evaluated, and the relevant parameters were optimized by square wave anodic stripping voltammetry (SWASV). The stripping response was highly linear (R2 = 0.987) over a Pb2+ concentration range of 5 X 10-9 mol/L to 7.5 X 10-7 mol/L, with a detection limit of 4.7 X 10-11 mol/L (3σ method). Furthermore, its applicability was validated for the determination of Pb2+ levels using spiked tap water at different concentrations. The polyporous structure, satisfactory reproducibility, long-term stability and simple synthesis endow the PPY-rGO nanocomposite a promising application in the determination of Pb2+.

A novel method for the synthesis of nano-sized MgAl2O4 spinel ceramic powde

Xiao-ping Liang,Rong-tao Wang,Ying Peng,Xiao-wei Fan,Jian-xin Li 한양대학교 세라믹연구소 2010 Journal of Ceramic Processing Research Vol.11 No.2

This study describes the preparation and characterization of MgAl2O4 spinel ceramic powders by a polyacrylamide gel method with Al(NO3)3·9H2O and Mg(NO3)3·6H2O as the raw materials, acrylamide as the monomer, N,N-mehtylenebisacrylamide as the cross-linking agent, and deionized water as the solvent. The nanopowders were studied by X-ray diffraction (XRD) and a transmission electron microscope (TEM). The results showed that the nanopowders having a typical spinel structure are ultrapure and nano-sized. Due to the hindering effect of the polyacrylamide network, the average grain size of the MgAl2O4spinel is approximately 20 nm. Moreover, it is confirmed that the optimal sintering temperature for synthesizing the MgAl2O4spinel ceramic nanopowders is 900 oC, which is about 600-1000 oC lower than that of the traditional solid-state method.

Some Motifs Were Important for Myostatin Transcriptional Regulation in Sheep (Ovis aries)

( Rong Du ),( Xiao Rong An ),( Yong Fu Chen ),( Jian Qin ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.4

Disciplinary Measurement & Evaluation In P . E . - : Study about the Method of Technical and Tactical Inventions

Xiao Rong Chen 한국체육학회 1995 국제스포츠과학 학술대회 Vol.1995 No.-

Optimal LQG Control for Networked Control Systems with Remote and Local Controllers

Xiao Liang,Juanjuan Xu,Xiao Lu,Qingyuan Qi,Haixia Wang,Rong Gao 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.1

We consider the finite horizon optimal LQG control problem for networked control systems with a remote controller, a local controller and communication channels with packet dropouts and transmission delays. The local controller can directly observe state signals and send them to the remote controller via a packet-dropout channel. Then the remote controller sends the received measurement signals to the local controller. Afterwards, the two controllers operate the plant through a delayed channel. The contributions of this paper are as follows: Firstly, at the side of the remote controller, we develop an optimal estimator to show that the separation principle holds. Secondly, we derive a non- homogeneous relationship between the state and the costate of systems in virtue of the maximum principle. Finally, a necessary and sufficient condition for the optimal control problem is derived in terms of the two coupled Riccati equations. Numerical examples are employed to illustrate the theoretical results.

The effects of paeoniflorin injection on soluble triggering receptor expressed on myeloid-1 (sTREM-1) levels in severe septic rats

Xiao-Rong Liu,Jie Xu,Yi-Min Wang,Ming-Suo Ji,Fu-Shan Liu 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.6

Paeoniflorin (PAE) is the most abundant compound in Xuebijing injection widely used to treat sepsis. We aimed to investigate effect of PAE on expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in a rat model of sepsis. Wistar rats were divided into Normal, Model, and PAE groups (n=20 each). Endotoxin was administrated at 5 mg/ml/kg in Model and PAE rats to establish rat sepsis model. 1 h after endotoxin administration, PAE was administrated at 4 ml/kg in PAE group once per day for 3 days. Routine blood tests and biochemical indexes were assessed, including aspartate aminotransferase (AST) and creatine kinase-MB (CKMB). The plasma sTREM-1 level was measured using quantitative ELISA. At the end of experiment, the small intestine, liver, kidney and lung were subjected to pathological examinations. A rat model of sepsis-induced multiple organ dysfunction syndrome (MODS) was established successfully with endotoxin administration (5 mg/ml/kg), evidenced by histo-pathological examinations, routine blood tests and biochemical indexes: platelet count decreased and white blood cell count increased (p<0.05), CK-MB and AST increased (p<0.05). PAE treatment significantly reduced the plasma levels of AST, CK-MB, and sTREM-1, compared to Model group (p<0.05). Meanwhile, sepsis-induced damages in the liver, lung, stomach and intestinal mucosa were also markedly ameliorated by PAE treatment. PAE demonstrated a significantly protective effect in a rat model of sepsis by decreasing plasma sTREM-1 level, reducing inflammation, preventing MODS and protecting organ functions.

Effects of Acupuncture at the Acupoints of 12 Meridians on Gastrointestinal and Cardiac Electricity in Healthy Adults

Xiao-Rong Chang,Jing Shen,Mi Liu,Xiao-Juan Wang,Jie Yan 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.3

The effect of acupuncture at the acupoints of 12 meridians on gastrointestinal and cardiac electricity in healthy adults was studied. Specific regulation between meridian points and viscera was also investigated. An electrogastrogram (EGG),electrointestinogram (EIG), carotid pulse graph, phonocardiogram and electrocardiogram were obtained in 30 healthy adults before and after acupuncture at various acupoints of 12 meridians. The effects of acupuncture on the amplitude and frequency of the EGG, EIG, pre-ejection period and the left ventricular ejection time were then analyzed. Acupuncture revealed that LR3 decreased the amplitude of the EGG while LI11 (Quchi), SJ5 (Waiguan), ST36 (Zusanli), SP9 (Yinlingquan) and SI6 (Yanglao) increased the amplitude. Multiple comparisons among the latter five acupoints indicated that there were significant differences between SP9, LI11, SJ5and ST36 (p < 0.01, p < 0.01, p < 0.05) and SI6, LI11 and SJ5 (p < 0.01, p < 0.05). SP9effected EGG amplitude the most, followed by SI6, ST36, SJ5 and LI11. Four acupoints increased the amplitude of the EIG (p < 0.05), including HT5 (Tongli), GB34(Yanglingquan), SP9 and SI6. No significant differences were observed between these acupoints, but SI6 showed the most obvious effect on EIG amplitude, followed by GB34, SP9 and HT5. No significant effects on the frequency of the gastrointestinal slow wave or on cardiac function indexes were observed. Effects were observed, however,on pre-ejection period and left ventricular ejection time. Routine acupuncture had no detrimental effects on the stomach, intestine and heart in healthy adults,but instead regulated physiological function within a normal range. These findings demonstrate the existence of specific connections between the meridian points and the viscera. The results suggest that multiple meridians control the same viscus,and the same meridian can regulate the functions of multiple viscera.

Clinical Study on Fluvoxamine Combined with Oxycodone Prolonged-Release Tablets in Treating Patients with Moderate to Severe Cancer Pain

Xiao, Yang,Liu, Jun,Huang, Xin-En,Ca, Li-Hua,Ma, Yi-Min,Wei, Wei,Zhang, Rong-Xia,Huang, Xiao-Hong,Chang, Juan,Wu, Yi-Jia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

Objective: To observe treatment effects and safety of fluvoxamine combined with oxycodone prolonged-release tablets in treating patients with moderate to severe cancer pain. Methods: Patients confirmed pathologically with cancer and complicated with moderate to severe pain, were divided into control and experimental groups. Oxycodone prolonged-release tablets, with or without fluvoxamine, were administrated to all study patients until pain relief. Degree of pain relief, dose of oxycodone prolonged-release tablets, side effects and quality of life were compared before and after treatment. Results: In total, 120 patients were recruited. No statistically significant difference was detected regarding age, gender, types of cancer, KPS between two groups of patients (P>0.05). Baseline pain score of patients with moderate pain in treatment and control group was $4.9{\pm}0.8$ and $5.1{\pm}0.8$, respectively; and decreased to $1.8{\pm}1.1$ and $1.2{\pm}1.1$ after treatment, respectively. Pain intensity was significantly reduced in the treatment group (P=0.028). Average daily consumption of oxycodone prolonged-release tablets was ($54.0{\pm}19.6$) mg and ($44.7{\pm}18.7$) mg respectively, which is lower in treatment grpup than in control group, but the difference was not statistically significant (P=0.065). Baseline pain score of patients with severe pain in treatment and control groups were $8.3{\pm}1.1$ and $8.3{\pm}1.1$, respectively; and pain intensity after treatment decreased to $2.9{\pm}1.0$ and $2.3{\pm}1.0$. Pain intensity was significantly reduced in the treatment group, with statistical significance (P=0.026). Average daily consumption of oxycodone prolonged-release tablets was ($132.0{\pm}42.2$) mg and ($110.7{\pm}33.9$) mg, respectively, which is lower in treatment group than in control group, and the difference was statistically significant (P=0.035). In terms of quality of life, patients in treatment group had better performance status, daily activity, mood, and sleep than that in control group (P < 0.05). Patients in two groups had similar side effects, eg., constipation, nausea/vomiting, lethargy, dizziness, itchy skin, dysuria, and ataxia. Lower incidence of nausea/vomiting, lethargy, was obtained from patients in treatment than in control group, while significant low constipation was observed in treatment than in control group (35.0% vs 49.2%, P=0.026). Conclusion: Fluvoxamine combined with oxycodone prolonged-release tablets could be more effective in treating patients with cancer pain, and could reduce the dosage of oxycodone prolonged-release tablets and thus be associated with lower side effects, and improved quality of life.

Effect of the reaction temperature on nanocrystallites MgAl2O4 spinel ceramic precursor

Rong-tao Wang,Ying Peng,Xiao-wei Fan,Jian-xin Li,Xiao-ping Liang 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.6

Mg-Al hydrotalcite (Mg6Al2(OH)16CO3·4H2O), the precursor of MgAl2O4 spinel, has been synthesized via a coprecipitation method, using AlCl3·6H2O and MgCl2·6H2O as the raw materials, and NaOH and Na2CO3 as the precipitators. The effect of the reaction temperature, from 50℃ to 90℃, on the Mg-Al hydrotalcite nanocrystallites was analyzed. The nanocrystallites were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). It was confirmed that Mg-Al hydrotalcite nanocrystallites are pure and regularly hexagonal, having a typical hydrotalcite structure. The Mg-Al hydrotalcite crystals grow from about 30 nm to 100 nm with an increase in the reaction temperature from 50℃ to 90 ℃, and the crystal form also tends to perfect and regularly hexagonal. Mg-Al hydrotalcite (Mg6Al2(OH)16CO3·4H2O), the precursor of MgAl2O4 spinel, has been synthesized via a coprecipitation method, using AlCl3·6H2O and MgCl2·6H2O as the raw materials, and NaOH and Na2CO3 as the precipitators. The effect of the reaction temperature, from 50℃ to 90℃, on the Mg-Al hydrotalcite nanocrystallites was analyzed. The nanocrystallites were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). It was confirmed that Mg-Al hydrotalcite nanocrystallites are pure and regularly hexagonal, having a typical hydrotalcite structure. The Mg-Al hydrotalcite crystals grow from about 30 nm to 100 nm with an increase in the reaction temperature from 50℃ to 90 ℃, and the crystal form also tends to perfect and regularly hexagonal.

Metabolomic analysis of biochemical changes in the tissue and urine of proteoglycan-induced spondylitis in mice after treatment with moxibustion

Xiao Xu,Ya-Nan Shi,Rong-Yun Wang,Cai-Yan Ding,Xiao Zhou,Yu-Fei Zhang,Zhi-Ling Sun,Zhi-Qin Sun,Qiu-Hua Sun 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.1

Background: Moxibustion is widely used in East Asian countries to manage the symptom of rheumatic diseases. The aim of this study was to identify potential metabolic profiles of moxibustion on relieving ankylosing spondylitis (AS) mice through UHPLC-Q-TOF/MS metabolomic study. Methods: Thirty-two female Balb/c mice were randomized into healthy control (HC), AS model, moxibustion at acupuncture points (MA) in AS model, and moxibustion at non-acupuncture points (MNA) AS model groups. Moxibustion was administered daily at GV4, bilateral BL23 and bilateral ST36 acupuncture points for four weeks in the MA group. The overall health status, the thickness of hind paws and the tissue concentrations of IL-1β, PGE2, IL-6 and TNF-α were assessed. The UHPLC-Q-TOF/MS was used to explore the perturbations of endogenous metabolites in tissue and urine of AS model mice intervened by moxibustion. Results: Compared with the AS group, the overall health status was significantly improved after 4-week moxibustion intervention (p < 0.05). The results also showed that MA significantly reduced the levels of paw thickness and decreased the levels of four cytokines in the tissue (p < 0.01). Thirty-seven endogenous metabolites identified by the OPLS-DA were considered to be contributing to therapeutic effects of moxibustion. Moreover, metabolic pathway analysis further revealed that the identified metabolites were mainly involved in TCA cycle, Lipid metabolism, Amino Acid metabolism, Intestinal flora metabolism and Purine metabolism. Conclusions: UHPLC-Q-TOF/MS based metabolomics approach, as a novel and powerful tool, can help us to gain the insights into potential mechanisms of action of moxibustion for AS.