정원 작가의 설문조사를 통해 본 코리아가든쇼 운영방안에 관한 연구

최우경(Wookyung Choi),송정화(Jeong Hwa Song),윤정원(Jung Won Yoon),이정희(Chung Hee Lee),김영재(Young Jae Kim),송유진(Yu Jin Song),이현채(Hyun Chae Lee),진혜영(Hye Young Jin) 한국원예학회 2017 한국원예학회 학술발표요지 Vol.2017 No.5

가구 전력 사용량의 평균과 표준편차에 따른 단일과 종합계약 방식의 분석

정우경(Wookyung Jung),정범진(Beom Jin Chung),김동식(Dong Sik Kim) 대한전자공학회 2020 대한전자공학회 학술대회 Vol.2020 No.11

Cooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues.

Yu, Wookyung,Chung, Kwanghoon,Cheon, Mookyung,Heo, Muyoung,Han, Kyou-Hoon,Ham, Sihyun,Chang, Iksoo National Academy of Sciences 2008 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.105 No.7

<P>Recent experiments claiming that Naf-BBL protein follows a global downhill folding raised an important controversy as to the folding mechanism of fast-folding proteins. Under the global downhill folding scenario, not only do proteins undergo a gradual folding, but folding events along the continuous folding pathway also could be mapped out from the equilibrium denaturation experiment. Based on the exact calculation using a free energy landscape, relaxation eigenmodes from a master equation, and Monte Carlo simulation of an extended Muñoz-Eaton model that incorporates multiscale-heterogeneous pairwise interactions between amino acids, here we show that the very nature of a two-state cooperative transition such as a bimodal distribution from an exact free energy landscape and biphasic relaxation kinetics manifest in the thermodynamics and folding-unfolding kinetics of BBL and peripheral subunit-binding domain homologues. Our results provide an unequivocal resolution to the fundamental controversy related to the global downhill folding scheme, whose applicability to other proteins should be critically reexamined.</P>

신부전 치료의 영양학적 접근

안규리,정우경 대한영양의학회 1999 영양의학 Vol.1 No.3

Evaluating the Safety and effectivenesS in adult KorEaN patients treated with Tolvaptan for management of autosomal domInAnt poLycystic kidney disease (ESSENTIAL): short-term outcomes during the titration period

( Hyuk Huh ),( Yong Soo Kim ),( Wookyung Chung ),( Yong Lim Kim ),( Yaerim Kim ),( Seungyeup Han ),( Yeonsoon Jung ),( Ki Young Na ),( Kyu Beck Lee ),( Yun Kyu Oh ),( Hyeong Cheon Park ),( Seung Hyeok 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.2

Background: Tolvaptan reduces height-adjusted total kidney volume (htTKV) and renal function decline in autosomal dominant polycystic kidney disease (ADPKD). This study was aimed at investigating the efficacy and safety of tolvaptan in Korean patients with ADPKD during the titration period. Methods: This study is a multicenter, single-arm, open-label phase 4 study. We enrolled 108 patients with ADPKD (age, 19-50 years) with an estimated glomerular filtration rate (eGFR) of >30 mL/min/1.73 ㎡ and factors defined as indicative of rapid disease progression. After tolvaptan titration, we evaluated efficacy and side effects and assessed factors associated with the effects. Results: After titration for 4 weeks, eGFR and htTKV decreased by 6.4 ± 7.9 mL/min/1.73 ㎡ and 16 ± 45 mL/m, respectively. No serious adverse drug reactions were observed during the titration period. The greatest eGFR decline was observed in the first week, with a starting tolvaptan dose of 45 mg. Multivariate linear regression for htTKV decline showed that the greater the change in urine osmolality (Uosm), the greater the decrease in htTKV (β, 0.436; p = 0.009) in the 1D group stratified by the Mayo Clinic image classification. Higher baseline eGFR was related to a higher htTKV reduction rate in the 1E group (β, -0.642; p = 0.009). Conclusion: We observed short-term effects and safety during the tolvaptan titration period. The decline of htTKV can be predicted as a short-term effect of tolvaptan by observing Uosm changes from baseline to end of titration in 1D and baseline eGFR in 1E groups.

복막투석 환자에서 발생한 진균성 복막염의 임상적 특징

오국환,안규리,오윤규,김현리,정우경,김연수,한진석,김진석,김성권,이정상 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.2

목 적: 진균성 복막염은 지속적 외래 복막투석 환자의 이환율과 사망률을 증가시키는 중요한 질환이다. 저자들은 복막투석 환자에서 발생한 진균성 복막염의 원인 진균과 임상상, 치료 방법 및 결과 등을 살펴보고 동일한 기간에 발생한 세균성 복막염의 임상상과 비교 분석함으로써 진균성 복막염의 예방과 치료에 도움을 얻고자 하였다. 방 법: 1991년 1월부터 1999년 12월까지 서울대학교병원에서 복막투석을 시작한 환자 총376명 중 이 기간 동안에 진균성 복막염으로 진단 받은 환자 14명(총 15예)을 후향적으로 분석하였다. 결 과 : 대상 환자들의 평균 연령은 53.7±11.6세(이하 평균±표준편차)이었으며, 남·녀비는12 : 3이었다. 진균성 복막염을 진단 받은 당시까지의 복막투석 기간은 29.2±27.7개월이었다. 원인균은 Candida species가 10예(62.5%)로 가장 많았으며, Aspergillus 2예, Cryptococcus 1예, Penicillium 1예, Torulopsis 1예, Trichosporon beigelii 1예 등이었다. 5예에서 진균과 아울러 세균의 중복 감염이 확인되었다. 발병 당시의 증상은 일반적으로 알려진 세균성 복막염의증상과 유사하였다. 진균성 복막염 환자에서 복막투석 도관은 모두 제거하였으며, amphotericin B, fluconazole, flucytosine 등을 단독 혹은 병합 투여하였다. 질병의 경과 중에 4예(26.7%)에서 장폐색 또는 복막 유착이 합병되었다. 치료 결과로는, 완치 후 도관 재삽입 후 복막 투석을 지속한 경우가 3예(20%), 혈액투석으로 전환한 경우가 9예(60%)이었고, 3예(20%)는 진균성 복막염으로 인하여 사망하였다. 원인 진균이 Candida species인 환자군과 나머지 군에 있어서 사망률에 차이가 있었으나(33.3% vs 0%) 통계적으로 유의하지는 않았다(p=0.11). 투여한 항진균제의 종류에 따른 사망률의 차이는 없었다. 동일한 기간에 발생한 세균성 복막염과 진균성 복막염 환자들의 특성을 비교해 볼 때 도관 제거율과 기술적 실패율은 진균성 복막염에서 유의하게 더 높았다. 결 론 : 진균성 복막염은 드물게 발생하지만 일반적으로 알려진 세균성 복막염의 사망률보다 더 높은 사망률과 복막투석 중단의 원인이 되는 심각한 질환으로서, Candida species가 가장 흔한 원인균이었다. Purpose : Fungal peritonitis is a fatal disease with a high mortality and morbidity to the peritoneal dialysis(PD) patients. This study was implemented to provide a guideline for the prevention and treatment of fungal peritonitis in PD patients by analyzing the clinical and microbiologic features of fungal peritonitis cases. Methods : We analyzed retrospectively into the 15 cases(14 patients) of fungal peritonitis among 376 end stage renal disease(ESRD) patients who newly started PD in the Seoul National University Hospital from Jan. 1991 to Dec. 1999. Results : The patients' age was 53.6±11.6 years (mean±standard deviation) and their male to female ratio was 12:3. They have been on PD for 29.2±27.7 months before the fungal peritonitis developed. Candida species was the most common etiologic agent, accounting for 10(62.5%) out of the 16 fungal organisms isolated from our patients. Among others were two Aspergillus, one Cryptococcus, one Penicillium, one Torulopsis, and one Trichosporon beigelii cases. Bacterial agents were isolated simultaneously in five fungal peritonitis cases. Peritoneal catheters were all removed no later than 72 hours after the diagnosis was made. Patients were given a single or combined therapy with amphotericin B, fluconazole, or flucytosine on the physician's choice. The outcomes of fungal peritonitis were as follows; 20% continued PD, 60% converted to HD and 20% died of fungal peritonitis. We made a comparative analysis between the fungal and bacterial peritonitis cases which developed in the same 5-year period, which showed significantly higher catheter removal and technique failure rates in the fungal cases. Conclusion : Fungal peritonitis is a rare but a fatal disease with a high mortality and a technique failure rate. Candida species was the most prevalent microorganism in our study. (Korean J Nephrol 2002;21(2):303-311)

Effects of Interleukin-6 T15A Single Nucleotide Polymorphism on Baseline Peritoneal Solute Transport Rate in Incident Peritoneal Dialysis Patients

Hwang, Young-Hwan,Son, Min-Jeong,Yang, Jaeseok,Kim, Kiwon,Chung, Wookyung,Joo, Kwon-Wook,Kim, Yonsu,Ahn, Curie,Oh, Kook-Hwan SAGE Publications 2009 Peritoneal dialysis international Vol.29 No.1

<B>Objective</B><P> To study the genetic effects of various inflammatory cytokines on peritoneal solute transport rate (PSTR) in incident Korean peritoneal dialysis (PD) patients. </P><B>Design</B><P> Case-control association study. </P><B>Methods</B><P> 132 patients with baseline peritoneal equilibration test within 1 - 3 months after starting PD were enrolled. We analyzed the influence of single nucleotide polymorphisms (SNPs) of interleukin-6 (IL-6; -572G/C, T15A), tumor necrosis factor-alpha (TNF-α; -1031C/T, -863C/A, -308G/A), and IL-10 (-1082A/G, -592A/C) on baseline PSTR. Clinical parameters such as age, gender, presence of diabetes mellitus, comorbidity, C-reactive protein, and residual renal function were also included as covariates. </P><B>Results</B><P> The T15A SNP of IL-6 (rs13306435) was associated with PSTR. Patients with TA genotype ( n = 18) had significantly lower D4/P creatinine (0.65 ± 0.087 vs 0.73 ± 0.110, p = 0.0046) and higher D4/D0 glucose (0.39 ± 0.174 vs 0.31 ± 0.119, p = 0.027) than patients with TT genotype ( n = 114). The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine ( r<SUP>2</SUP> = 0.1294, p @@<@@ 0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7 ± 14.42 vs 116.8 ± 88.91 pg/minute, p = 0.0358). By multiple logistic regression, TA genotype was negatively associated with a higher PSTR (high or high average; odds ratio 0.18; 95% confidence interval 0.048 - 0.666). </P><B>Conclusions</B><P> In incident Korean PD patients, T15A polymorphism of IL-6 is associated with dialysate IL-6 concentration and baseline PSTR. </P>

Urinary Potassium Excretion and Progression of CKD

Kim, Hyung Woo,Park, Jung Tak,Yoo, Tae-Hyun,Lee, Joongyub,Chung, Wookyung,Lee, Kyu-Beck,Chae, Dong-Wan,Ahn, Curie,Kang, Shin-Wook,Choi, Kyu Hun,Han, Seung Hyeok AMERICAN SOCIETY OF NEPHROLOGY 2019 CLINICAL JOURNAL- AMERICAN SOCIETY OF NEPHROLOGY Vol.14 No.3

Biocompatible Peritoneal Dialysis Solution Preserves Residual Renal Function

Kim, Sejoong,Oh, Kook-Hwan,Oh, Jieun,Kim, Soo Jin,Chung, Wookyung,Song, Young Rim,Na, Ki Young,Oh, Yun Kyu,Ahn, Curie,Kim, Sung Gyun,Tan, Kathryn C.B. S. Karger AG 2012 American journal of nephrology Vol.36 No.4

<P>Abstract</P><P><B><I>Background/Aims:</I></B> The long-term effects of biocompatible peritoneal dialysis (PD) solution on residual renal function (RRF), inflammation, adipokines and metabolic acidosis are controversial. We evaluated the effects of biocompatible PD solution in continuous ambulatory PD (CAPD) patients for an additional 12-month period. <B><I>Method:</I></B> Among 91 incident patients who started CAPD with either biocompatible PD solution (Balance®, Fresenius; LS, n = 48) or conventional PD solution (CAPD/DPCA®, Fresenius; CS, n = 43), 63 patients, who were followed for 12 months, were enrolled and followed for an additional 12 months. <B><I>Results:</I></B> After 24 months of treatment, the glomerular filtration rate (GFR) of the LS group was twofold higher compared to the CS group (33.5 ± 30.7 vs. 16.3 ± 17.9 l/week/1.73 m<SUP>2</SUP>, respectively, p <I>= </I>0.021). In a subgroup of patients with an initial GFR >2 ml/min/1.73 m<SUP>2</SUP>, the GFR of the LS group was significantly higher than the rate of the CS group after 24 months (43.7 ± 30.5 vs. 18.6 ± 19.0 l/week/1.73 m<SUP>2</SUP>, respectively, p = 0.042). Over a 24-month period, effluent cancer antigen-125 levels were significantly increased in the LS group compared to the CS group, while effluent interleukin-6 levels did not differ between the two groups. The serum tCO<SUB>2</SUB> levels were consistently higher in the LS group compared to the CS group. <B><I>Conclusions:</I></B> We found that the effect of LS on preserving RRF may be maintained over a 24-month treatment period in CAPD patients, and LS use may have other benefits, such as the correction of metabolic acidosis.</P><P>Copyright © 2012 S. Karger AG, Basel</P>

Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company

Choi, Won-Jun,Kang, Seong-Kyu,Ham, Seunghon,Chung, Wookyung,Kim, Ae Jin,Kang, Myunghee Occupational Safety and Health Research Institute 2020 Safety and health at work Vol.11 No.2

Background: Cadmium exposure may induce chronic intoxication with renal damage. Silver soldering may be a source of cadmium exposure. Methods: We analyzed working environment measurement data and periodic health screening data from a small-scale silver soldering company with ten workers. Concentrations of cadmium in air from working environment measurement data were obtained. Concentrations of blood and urinary cadmium, urine protein, and urine β2-microglobulin (β2M) were obtained. The generalized linear model was used to identify the association between blood and urine cadmium and urine β2M concentrations. Clinical features of chronic cadmium intoxication focused with toxicological renal effects were described. Results: The mean duration of work was 8.5 years (standard deviation [SD] = 6.9, range = 3-20 years). Cadmium concentrations in air were ranged from 0.006 to 0.015 mg/㎥. Blood cadmium concentration was elevated in all ten workers, with a highest level of 34.6 ㎍/L (mean = 21.288 ㎍/L, SD = 11.304, range = 9.641-34.630 ㎍/L). Urinary cadmium concentration was elevated in nine workers, with a highest level of 62.9 ㎍/g Cr (mean = 22.151 ㎍/g creatinine, SD = 19.889, range = 3.228-62.971 ㎍/g creatinine). Urine β2M concentration was elevated in three workers. Urinary cadmium concentration was positively associated with urine protein concentration (beta coefficient = 10.27, 95% confidence interval = [4.36, 16.18]). Other clinical parameters were compatible with renal tubular damage. Conclusion: Cadmium intoxication may occur at quite low air concentrations. Exposure limit may be needed to be lowered.