음주 외상 환자

이성우,문준동,최성혁,문철규,홍윤식 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: We studied the incidence of trauma caused by alcohol related accidents, and the effects that alcohol has on the occurrence, the extent, and the outcome to the patient. Methods: In our study we studied trauma patients excluding pediatric patients(15 years old and under) who came to the Emergency department of Korea University Medical School Anam Hospital from the 1st of January 1996 to 30th of June 1996, looked into their medical records, and studied the records in a retrospective manner. The trauma patients were devided into two groups, a) alcohol-related and b) alcohol-non-related. The two groups were then subdivided according to their sex, age, the time they came in, the anatomical part of the trauma, the mechanism of their injury, the extent of the injury, the length of their hospital stay, the length of their ED stay and were seperately compared and analyzed. Statistically, ANOVA and logistic regression analysis using SAS were used in the study and then was assessed in Chi-square analysis methods. Results: The total of the trauma patients, added up to 832 people, 577:male and 255:female. Among this sum, 163 trauma patients were alcohol related(male:127 & female:36). 115 people were in the age group of 21-40. Compared to the non-alcohol related trauma group, the alcohol-related group had more facial & scalp injuries and tended to come in the hours between 0-6 AM. The cause of the injuries were mostly by fist-fighting and suicide, compared to mostly accidental-slipping injuries in the non alcohol-related group. There were no difference in the degree of the injury(ISS) and the length of hospital stay between the two groups, whereas the length of the stay at the ED was longer to the alcohol-related trauma patients. Conclusion: Alcohol related trauma patients were mostly in their 20s and 30s, came to the hospital at a late time and the reason for their visit were mostly because of fist fighting. In the Emergency department, because prompt and correct diagnosis is quite difficult to make in this group, their ED stay tended to be longer. We can conclude that measuring the blood alcohol level of these patients, continuing the psychological therapy and educating people is needed.

두부외상환자에서의 예후인자

최성혁,문준동,김수진,문철규,이성우,홍윤식 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: Predicting outcome after head trauma is of great interest for clinicians, especially in the early stage. It may provide a basis for therapeutic strategies and may be helpful to select different approaches. But, reliable outcome prediction from head trauma is still unresolved. The purpose of this study is to determine which clinical parameters can be used effectively after an event of head trauma. Methods: In our study we studied head trauma patients who came to the Emergency department of Korea University Medical School Anam Hospital from the 1st of June 1998 to 31th of January 2000, looked into medical records, and studied the records in a retrospective manner. The head trauma patients were divied into two group, a) favourable outcome-related and b) unfavourable outcome-related. The two groups were then subdivided according to their sex, age, the mechanism of their injury, the time they came in, alcohol drinking, loss of consciousness, vomiting, pupil change, previous medical illness, associated injuries and were seperately compared and analyzed. And the factors affecting Glasgow Outcome Scale(GOS) were analyzed in the parameters of Injury Severity Score(ISS), Revised Trauma Score(RTS), Glasgow Coma Scale(GCS), motor score of GCS(mGCS), Marshall Computed Tomographic Classification(MCTC). Statistically, t-test and Mann-Whistney rank sum test using Jandel-sigma were used in the study and then were assessed in Chi-square analysis methods. The statistical significance was determined at a level of p less than 0.05. Results: The total of the head trauma patients, added up to 129 people, 99:males and 30:females. Among this sum, 99 patients showed a favourable outcome and 30 patients showed an unfavourable outcome at discharge. The causes of injury included: automobile accident in 42 cases; fallss in 26; assaults in 6; and accidental-slipping injury etc in 55 cases. 12 patients had bilateral unreactive pupils on admission, 2 had unilateral reactive pupils, and 113 had bilateral reactive pupils. Compared to the favourable outcome-related head trauma group, the unfavourable outcome-relared head trauma group had more history of loss of consciousness, unreactive pupils and tended to have previous medical illness. There were no difference in alcohol related, vomiting and associated injuries between two groups(favourable outcome-related head trauma group: unfavourable outcome-related head trauma group). Substantial difference were observed in GCS, mGCS, ISS, RTS, MCTC between two groups. Patients with unfavourable outcome had a significantly higher ISS, lower RTS, lower mGCS. After MCTC, patients with mass lesion had unfavourable outcome than patients with diffuse injury. Conclusion: Age, history of loss of consciousness, previous medical illness and unreactive pupil change are predictives of outcomes of head trauma patients with respect to Glasgow outcome scale. The lower GCS, lower RTS, lower mGCS, higher ISS, mass lesion based on CT scan provide poorer prognostic outcome in patients with head trauma. Use of prognostic factors thorough complete history taking and physical examination would provide useful prognostic information and facilitate improved therapeutic decision-malting in head-injuried patients.

중증 외상환자에서 염기 결핍수치의 유용성

문준동,김수진,문철규,최성혁,전정민,이성우,홍윤식 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3

Background: This study's objective was to determine the prognostic value of the base deficit measured in the emergency department(ED) and to determine whether base deficit can provide information not provided by advanced injury scoring system. Methods: This study was a retrospective analysis of data collected for two years. Thirty-two severe trauma patients who were admitted to the Emergency Department of Korea University Hospital were included in this study. The patients were divided into two groups: the normal base deficit group(-3 mmol/L to 3 mmol/L) and the elevated base deficit group(>3 mmol/L). The base-deficit value, age, sex, head injury, organ failure rate, and survival were considered, and the also Revised Trauma Score(RTS), Acute Physiology And Chronic Health Evaluation(APACHE II), and Injury Severity Score(ISS) were measured. Result: The elevated base-deficit group showed a lower survival rate and a higher organ failure rate compared to the normal base deficit group. Logistic Regression showed a strong association between base deficit and mortality rate. Among the previous injury scoring Systems(RTS, APACHE II, ISS), base deficit had the strongest correlation with RTS. By using base deficit value and the RTS together, we obtained a higher positive predictive value than that obtained by using base deficit or RTS alone. Conclusion: The admission value of the base deficit in the ED is a useful tool in predicting the outcome in severe trauma patients, and it can be an adjunct to previous injury scoring systems. As an advanced injury scoring System is developed in the future, the base deficit may have some significant role.

수간석해 (樹幹析解) 전산프로그램 개발 및 생장량 계산방법의 비교에 관한 연구

변우혁(Woo Hyuk Byun),이우균(Woo Kyun Lee),윤광배(Kwang Bae Yun) 한국산림과학회 1990 한국산림과학회지 Vol.79 No.1

In this study the stem analysis program, which can be operated with personal computer was developed to reduce time and cost of calculation, and to increase accuracy of analysis. The stem analysis method used in this program was compared with other methods. The results obtained were as follows : The value, 1/100mm measured from the latest annual ring measurement machine (Jahrringmeβgeraete Johan Type II) was automatically inputed to the computer and saved into given file name. Turbo Pascal program was written to do this. The measured data was analyzed by stem analysis calculation program written by Fortran-77. Volume and height increments were approximated by spline function, and diameter of the stem disk was calculated by quadratic mean method. The increment values calculated by the programs were printed annually and in every five-year. Stem analysis diagram and several increment graphs were also easily printed. The result compared between those analysis methods showed that quadratic mean could reduce the error caused from eccentric pith. When the stem taper curve method, approximated by spline function, was used in the calculation of tree height and volume, increments would be more exactly calculated.

Establishment of a [¹⁸F]-FDG-PET/MRI Imaging Protocol for Gastric Cancer PDX as a Preclinical Research Tool

Bae, Seong-Woo,Berlth, Felix,Jeong, Kyoung-Yun,Suh, Yun-Suhk,Kong, Seong-Ho,Lee, Hyuk-Joon,Kim, Woo Ho,Chung, June-Key,Yang, Han-Kwang The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol. No.

Purpose: The utility of 18-fluordesoxyglucose positron emission tomography ([<SUP>18</SUP>F]-FDG-PET) combined with computer tomography or magnetic resonance imaging (MRI) in gastric cancer remains controversial and a rationale for patient selection is desired. This study aims to establish a preclinical patient-derived xenograft (PDX) based [<SUP>18</SUP>F]-FDG-PET/MRI protocol for gastric cancer and compare different PDX models regarding tumor growth and FDG uptake. Materials and Methods: Female BALB/c nu/nu mice were implanted orthotopically and subcutaneously with gastric cancer PDX. [<SUP>18</SUP>F]-FDG-PET/MRI scanning protocol evaluation included different tumor sizes, FDG doses, scanning intervals, and organ-specific uptake. FDG avidity of similar PDX cases were compared between ortho- and heterotopic tumor implantation methods. Microscopic and immunohistochemical investigations were performed to confirm tumor growth and correlate the glycolysis markers glucose transporter 1 (GLUT1) and hexokinase 2 (HK2) with FDG uptake. Results: Organ-specific uptake analysis showed specific FDG avidity of the tumor tissue. Standard scanning protocol was determined to include 150 μCi FDG injection dose and scanning after one hour. Comparison of heterotopic and orthotopic implanted mice revealed a long growth interval for orthotopic models with a high uptake in similar PDX tissues. The H-score of GLUT1 and HK2 expression in tumor cells correlated with the measured maximal standardized uptake value values (GLUT1: Pearson r=0.743, P=0.009; HK2: Pearson r=0.605, P=0.049). Conclusions: This preclinical gastric cancer PDX based [<SUP>18</SUP>F]-FDG-PET/MRI protocol reveals tumor specific FDG uptake and shows correlation to glucose metabolic proteins. Our findings provide a PET/MRI PDX model that can be applicable for translational gastric cancer research.

배전 옥외용 중전기기 적용을 위한 DGEBA/ESBO 최적 조성에 따른 HVAC, ±HVDC 전기적 절연파괴 특성연구

윤준성(Jun-Seong Yun),전민혁(Min-Hyuk Jeon),김우진(Woo-Jin Kim),이관우(Gwan-Woo Lee),이우성(Woo-Sung Lee),이태학(Tae-Hak Lee),임우현(Woo-Hyun Lim),홍성원(Sung-Won Hong),ONOROV ALISHER,권태광(Kwon-Tae Kwang),박재준(Jae-Jun Park) 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.7

배전 옥외용 중전기기 적용을 위한 DGEBA/ESBO 최적 조성에 따른 HVAC, ±HVDC 전기적 절연파괴 특성연구

윤준성(Jun-Seong Yun),전민혁(Min-Hyuk Jeon),김우진(Woo-Jin Kim),이관우(Gwan-Woo Lee),이우성(Woo-Sung Lee),이태학(Tae-Hak Lee),임우현(Woo-Hyun Lim),홍성원(Sung-Won Hong),ONOROV ALISHER,권태광(Kwon-Tae Kwang),박재준(Jae-Jun Park) 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.7

Piezoelectric Aging Behavior of Lead-free 1-mol% Li2O-excess 0.9(Na0.52K0.48)NbO3-0.1LiTaO3 Multilayer Ceramic Actuators

Yun, Seok-Woo,Lee, Kyung-Su,Nam, Song-Min,Koh, Jung-Hyuk,Jeong, Soon-Jong,Kim, Min-Soo Korean Physical Society 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.58 No.3

Process Optimization for Preparing High Performance PAN-based Carbon Fibers

Yun, Jeong-Hyeon,Kim, Bo-Hye,Yang, Kap-Seung,Bang, Yun-Hyuk,Kim, Sung-Ryong,Woo, Hee-Gweon Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10

wet spun polyacrylonitrile (PAN) fiber precursors. The process variables chosen were treatment temperature, applied tension in stabilization process. The temperature profile of the stabilization was set on the basis of exothermic peaks of the differential scanning calorimetry (DSC) result. Both tensile strength and modulus increased with holding at onset temperatures of the exothermic peaks for extended duration, and with a higher heating rate up to the onset temperatures at a given applied tension among the experimental conditions. The increase in load monotonously increased the tensile modulus, on the other hand, the tensile strength was maximum at the load of 15 mg/filament (T15). The load 20 mg/ filament (T20) was considered to be exceeded to form oriented crystalline structure, possibly introducing more defects in the fiber than under load of T15. The sample CP3-T15 O5 H30 showed the best tensile properties among the samples experimented whose tensile properties are compatible with the commercialized grade of general purpose carbon fibers even at low carbonization temperature such as $800\;{^{\circ}C}$ (the carbonization temperature in the commercial process. 1300∼$1500\;{^{\circ}C}$).

Bioequivalence and Pharmacokinetics of 70 mg Alendronate Sodium Tablets by Measuring Alendronate in Plasma

Yun Min-Hyuk,Woo Jong-Su,Kwon Kwang-Il The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.4

The bioequivalence and pharmacokinetics of alendronate sodium tablets were examined by determining the plasma concentration of alendronate. Two groups, consisting of 24 healthy volunteers, each received a 70 mg reference alendronate sodium tablet and a test tablet in a $2{\times}2$ crossover study. There was a 6-day washout period between doses. The plasma alendronate concentration was monitored for 7 h after the dose, using HPLC-Fluorescence Detector (FD). The area under the plasma concentration-time curve from time 0 to the last sampling time at 7 h $(AUC_{0-7h})$ was calculated using the linear-log trapezoidal rule. The maximum plasma drug concentration $(C_{max})$ and the time to reach $C_{max}(T_{max})$ were derived from the plasma concentration-time data. Analysis of variance was performed using logarithmically transformed $AUC_{0-7h}\;and\;C_{max}$, and untransformed $T_{max}$. For the test medication versus the reference medication, the $AUC_{0-7h}\;were\;87.63{\pm}29.27\;vs.\;102.44{\pm}69.96ng\;h\;mL^{-1}$ and the $C_{max}$ values were $34.29{\pm}13.77\;vs.\;38.47{\pm}24.39ng\;mL^{-1}$ respectively. The $90\%$ confidence intervals of the mean differences of the logarithmic transformed $AUC_{0-7h}$ and $C_{max}$ values were log 0.8234-log 1.1597 and log 0.8222-log 1.1409, respectively, satisfying the bioequivalence criteria guidelines of both the US Food and Drug Administration and the Korea Food and Drug Administration. The other pharmacokinetic parameters for the test drug versus reference drug, respectively, were: $t_{1/2},\;1.87{\pm}0.62\;vs.\;1.77{\pm}0.54\;h;\;V/F,\;2061.30{\pm}986.49\;vs.\;2576.45{\pm}1826.05\;L;\;CL/F,\;835.32{\pm}357.35\;vs.\;889.48{\pm}485.87\;L\;h^{-1}; K_{el},\;0.42{\pm}0.14\;vs.\;0.40{\pm}0.18\;h^{-1};\;Ka,\;4.46{\pm}3.63\;vs.\;3.80{\pm}3.64\;h^{-1};\;and\;T_{lag},\;0.19{\pm}0.09\;vs.\;0.18{\pm}0.06\;h$. These results indicated that two alendronate formulations(70-mg alendronate sodium) were biologically equivalent and can be prescribed interchangeably.