석이로부터 분리한 페놀성 화합물의 phospholipase A_2 저해활성

김진우,송경식,유익동,장현욱,유승현,배강규,민태진 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

호알카리성 진균 Cephalosporium sp. RYM-202가 생산하는 alkaline xylanase (CX-III)의 작용에 의해 xylan 기질로부터 생성되는 주요 가수분해 산물은 xylobiose와 중합도가 4 이상인 xylooligosaccharides이었다. 이 효소는 xylobiose에 대한 분해능을 가지고 있지 않지만 xylotriose로부터는 xylobiose를, xylotetraose로부터는 xylobiose와 xylotriose를 주산물로 형성하였다. 이러한 결과들은 CX-III가 transglycosidase 활성을 소유하는 전형적인 endo-type xylanase임을 보여준다. N-bromosuccinimide에 의한 CX-III의 화학적 변화 실험 결과 효소 1분자 당 2개의 tryptophan 잔기가 활성에 관여하는 것으로 나타났다. 그러나 iodoacetamide 및 diethylpyrocarbonate에 의한 효소활성의 저해효과는 나타나지 않음으로써 이 효소의 활성부위에 cysteine과 histidine 잔기가 필수적이지 않음이 확인되었다. The hydrolysis products formed from birchwood xylan by the action of an alkaline xylanase (CX-III) from alkalophilic Cephalosporium sp. RYM-202 were xylobiose and xylooligosaccharides polymerized with more than 4 sugar molecules. This enzyme was not active on xylobiose but readily attacked xylotriose accumulating xylobiose as a major product. The predominant end-products from xylotetraose by CX-III were xylobiose and xylotriose. These results indicate that the enzyme is typically endo-type xylanase possessing transglycosidase activity. Chemaical modification of CX-III with N-bromosuccinimide revealed that two tryptophan residues per molecule of CX-III were essential for its catalytic activity on xylan. On the other hand, iodoacetamide and diethylpyrocarbonate did not influence the activity of the enzyme, suggesting that cysteine and histidine residues are not involved in the active site of this alkaline xylanase.

광주광역시 사회체육 현황과 진흥방안

김현준,장우인 조선대학교 사범대학 부설 교과교육연구소 1998 敎科敎育硏究 Vol.1 No.1

The purpose of the study is to present the present condition of sports and leisure and promotion in Kwangju city. The aims of sports and leisure are to improve living quality, to promote health and to promote social welfare of local residents by spontaneous particioation of local residents themselves. Thus, the government should support executive and financial help local residents to particioate to sports and leisure programs and also local self-government body should poerate sports and leisure facilities and financial programs. thus, we need followings to promote local residents' particioation to sports and leisure programs. 1. sufficient finances for the promotion of sports and leisure. 2. Amplication sporte and leiaure facilities. 3. Developing probrams which present the motive of participation to sports and leisure activities and ways. 4. Training exercise leaders who can maximize the impact of exercise and the efficiency of exercise. 5. Unification of executive organizations of sports and leisure.

아말감 충전물의 크기와 표면 처리방법에 따른 교정용 브라켓의 전단접착강도에 대한 연구

김현희,차경석,이진우 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.3

상, 하악 구치의 협면은 아말감으로 수복되어 있는 경우가 많으며, 접착 술식과 재료의 발달로 아말감에 교정용 브라켓의 직접 접착 술식이 가능하게 되었다. 그러나 아말감은 치아 협면의 일부분만을 차지하는 경우가 많아 주변의 법랑질에서도 접착력을 얻을 수 있으므로, 임상적으로 통상의 교정용 레진을 사용하여 직접 접착 술식을 시행하고 있다. 그러나 아말감 충전물이 있는 치면에 대한 교정용 레진의 직접 접착 술식의 접착강도에 대한 연구가 없는 실정으로 이에 본 실험을 시행하였다. 상, 하악 소구치를 포매하여 지름1.5mm, 2.0mm, 2.5mm, 3.0mm의 아말감 충전물을 형성한 후sandblasting 시행군과 비시행군으로 나누었다. no-mix type의 교정용 레진인 Ortho-one을 사용하여 브라켓을 접착한 후 전단결합강도를 측정하고 접착 파절 형태를 관찰하여 다음과 같은 결과를 얻었다. 1.아말감 크기에 따른 비교 시 아말감 크기1.5mm군의 전단 강도가 다른 군들에 비해 유의성 있게 높았고, 2.0mm, 2.5mm, 3.0mm군간에는 전단 강도의 차이가 없었다. (p<0.05) 2.Sandblasting 시행여부에 따른 전단결합강도의 차이는 없었다. (p<0.05) 3.각 군간의 비교시 아말감 충전물의 면적이 브라켓 기저부 면적의 약 61%를 차지하는 G군, H군의 전단결합강도는 대조군의 50-60%수준으로 급격히 감소하였다. (p<0.05) 4.브라켓 접착 파절 형태의 관찰 시 sandblasting을 시행하지 않은 군에 비해 sandblasting 시행군의 mARI score가 유의성 있게 높았다. (p<0.05) 이상의 실험결과는 아말감 충전물의 크기가 브라켓 기저부 면적의 약50%이하일 때 sandblasting시행여부에 관계없이 통상적인 교정용 레진을 사용하여 직접 접착 술식을 시행하여도 임상적으로 적절한 전단강도를 얻을 수 있음을 시사하였다. (주요단어 : 아말감 충전물, 전단접착강도) In orthodonitic patients, frequently, amalgam restorations are present on the buccal surface of molars. The ability to successfully bond orthodontic brackets and buccal tubes to amalgam restorations would therefore be of clinical value. But the bond strength to total amalgam surface is probably not critical in most instances. Because there is usually a considerable amount of sound enamel surrounding a buccal amalgam filling. The purpose of this study was to evaluate the bond strengths of orthodontic brackets according to surface treatments and size of amalgam restorations. Eighty tooth specimen were assigned to four groups according to amalgam size-1.5mm, 2.0mm, 2.5mm, 3.0mm diameter-and then divided into two groups : one half was sandblasting group the other half was no sandblasting group. After Bracket bonding, shear bond strength for each specimen was determined and bond failure patterns was evaluated. 1.Shear bond strength of amalgam size 1.5mm group was significantly higher than that of the other groups. (p<0.05) 2.There was no significant difference in the bond strength produced by sandblasting. (p<0.05) 3.Shear bond strength of G and H group of which amalgam restoration ratio to the bracket base sizes were 61% were significantly decreased 50-60% level of that of control group. (p<0.05) 4.There was positive correlation between sandblasting and mARI. (p<0.05) The results of the present study indicate that it may be feasible to bond orthodontic bracket clinically successfully to amalgam restoration with conventional orthodontic resin when its size is less than 50% of that of bracket base. ※ Key words : Bond strength. Amalgam restoration

신발산업용 모바일 포탈 서비스 구현

이양민,이병문,임장수,김창민,강동우,심현숙,이재기 동아대학교 정보기술연구소 2003 情報技術硏究所論文誌 Vol.11 No.1

Cases that apply mobile technology in own company's business processing in various industry area are increasing. In this paper, we propose a Mobile Portal constructin method accepting that flowing these age. Analyze instance that is applying mobile service in another industry to achieve Mobile Portal service and we chose core technology with this result. As focus of research, we implemented interaction interface between web page and database, conversion skill between wire and wireless contents, communicatin method between web page and contents conversion server, and application technology on Mobile service target Business and implemented Mobile service that applicable.

Different Number of Sessions of Intense Pulsed Light and Meibomian Gland Expression Combination Therapy for Meibomian Gland Dysfunction

Seung Hyeun Lee(Seung Hyeun Lee),Minjeong Kim(Minjeong Kim),Won Jun Lee(Won Jun Lee),Yeoun Sook Chun(Yeoun Sook Chun),Kyoung Woo Kim(Kyoung Woo Kim) 대한안과학회 2022 Korean Journal of Ophthalmology Vol.36 No.6

Purpose: To evaluate the effect of the intense pulsed light (IPL) and meibomian gland (MG) expression (MGX) combination therapy according to the total numbers of sessions in the meibomian gland dysfunction (MGD). Methods: Ninety patients with MGD were included. Patients had maximal five sessions of IPL (Aqua Cel, Jeisys Medical) and MGX combination therapy at 2-week intervals. The ocular surface disease index (OSDI) questionnaire score, MG profile grades, tear matrix metalloproteinase-9 (MMP-9), tear break-up time (BUT), tear osmolarity, tear secretion, and corneal erosions were evaluated. Results: The number of patients who had a total of one to five sessions (1S to 5S) was 10, 25, 17, 20, and 18, respectively. The time-serial decrease of OSDI scores was significant in patients who had three or more sessions (3S, p = 0.002; 4S, p < 0.001; 5S, p < 0.001). The MG expressibility grade decreased with two or more sessions (2S–5S, p < 0.001), but the meibum quality significantly improved with all sessions (1S, p = 0.012; 2S, p = 0.024; 3S, p = 0.015; 4S, p < 0.001; 5S, p < 0.001). Although tear BUT increased even in patients with one session (1S, p = 0.040; 3S, p = 0.005; 4S, p = 0.006; 5S, p = 0.021), tear MMP-9, osmolarity, Schirmer I, and corneal erosions were not improved in every number of sessions. The female sex was the sole contributor to the final symptomatic improvement (p = 0.042), and the MGD stages were not related to the final OSDI decrease. Conclusions: The OSDI score, MGD grades, and BUT were improved after the IPL and MGX combination therapy in MGD patients. Unlike MGD grades and tear film instability might be improved just after a few sessions, the overall subjective relief was accomplished in three or more sessions.

IoT 안전장비의 통신센서 적합성 검증을 위한 신뢰성평가 개선연구

김일태(IL-Tae Kim),김경흠(Kyung-Heum Kim),김상우(Sang-Woo Kim),김이관(Yi-Gwan Kim),김세기(Se-gi Kim),김현철(Hyeon-Cheol Kim),조구현(Ku-Hyeun Cho) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.3

The Usefulness of the Endonasal Incisional Approach for the Treatment of Nasal Bone Fracture

Kim, Hyo-Seong,Suh, Hyeun-Woo,Ha, Ki-Young,Kim, Boo-Yeong,Kim, Tae-Yeon Korean Society of Plastic and Reconstructive Surge 2012 Archives of Plastic Surgery Vol.39 No.3

Background : Among all facial fractures, nasal bone fractures are the most common, and they have been reduced by closed reduction (CR) for a long time. But several authors have reported suboptimal results when using CR, and the best method of nasal bone reduction is still being debated. We have found that indirect open reduction (IOR) through an endonasal incisional approach is a useful method for more accurate reduction of the nasal bone. Methods : A retrospective chart review was performed of 356 patients who underwent reduction of a nasal bone fracture in our department from January, 2006, to July, 2011. We treated 263 patients with IOR. We assessed patients' and doctors' satisfaction with surgical outcomes after IOR or CR. We evaluated the frequency of nasal bleeding owing to mucosal injury, and followed the surgical outcomes of patients who had simultaneous dorsal augmentation rhinoplasty. Results : According to the analysis of the satisfaction scores, both patients and doctors were significantly more satisfied in the IOR group than the CR group (P<0.05). Mucosal injury with nasal bleeding occurred much less in the IOR group (5.3%) than the CR group (12.9%). Dorsal augmentation rhinoplasty with IOR was performed simultaneously in 34 cases. Most of them (31/34) showed satisfaction with the outcomes. Conclusions : IOR enables surgeons to manipulate the bony fragment directly through the endonasal incisional approach. However, we propose that CR is the proper technique for patients under 16 and for those with comminuted nasal bone fractures because submucosal dissection in IOR can damage the growth or circulation of nasal bone.

Relationship of Plasma Potassium and Hydrogen Ion Concentrations in Acidosis-Induced Hyperkalemia and Hyperkalemia-Induced Acidosis

Kim, Kyu Hyeun,Ahn, Cheol Soo,Kim, Woo Gyeum Seoul National University 1993 The seoul journal of medicine Vol.34 No.2

Anti-inflammatory activity of Sargassum hemiphyllum ethanol extract in LPS-induced RAW 264.7 cells

Hyeun-Deok Choi,Min-Ji Kim,Sun-Hee Park,Min-Ju Kim,So-Yeong Park,Koth-Bong-Woo-Ri Kim,Ji-Hyun Kim,Dong-Hyun Ahn 한국수산해양기술학회(구 한국어업기술학회) 2016 한국수산해양기술학회 학술발표대회 Vol.2016 No.10

Pancreatic Lipase Inhibitors Effect from Sargassum coreanum Ethanol Extract

Hyeun-Deok Choi,Koth-Bong-Woo-Ri Kim,Ji-Hyun Kim,Min-Ji Kim,Sun-Hee Park,Min-Ju Kim,So-Yeong Park,Dong-Hyun Ahn 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10