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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
Origin of the radial nerve branch innervating the brachialis muscle
Oh, Chang-Seok,Won, Hyung-Sun,Lee, Kyu-Seok,Chung, In-Hyuk Wiley Subscription Services, Inc., A Wiley Company 2009 Clinical Anatomy Vol.22 No.4
<P>The brachialis muscle is dually innervated by the musculocutaneous nerve running via the anterior division of the brachial plexus and the radial nerve running via the posterior division of the plexus. There have been inconsistent descriptions of the pathway of the radial nerve branch at the brachial plexus. This study investigated the route of the radial nerve branch innervating the brachialis muscle at the brachial plexus. In 20 samples, the radial nerve branch innervating the brachialis muscle was separated and traced up to the cervical nerve under a surgical microscope. All the radial nerve branches innervating the muscle ran via the posterior cord, the posterior division, and the superior or middle trunk at the brachial plexus. The radial nerve branches arose from C5 in 5 cases, C6 in 11 cases, C5 and C6 in 3 cases, and C6 and C7 in 1 case. Clin. Anat. 22:495–499, 2009. © 2009 Wiley-Liss, Inc.</P>
Won, Yong Lim,Ko, Kyung Sun,Park, Jae Oh,Choi, Yoon jung,Lee, Hyeji,Sung, Jung-min,Lee, Mi-young Occupational Safety and Health Research Institute 2019 Safety and health at work Vol.10 No.1
The ultimate goal of the quality control program for special periodic health examination agencies is to diagnose the health condition of a worker correctly, based on accurate examination and analysis skills, leading to protect the worker's health. The quality control program on three areas, chemical analysis for biological monitoring since 1995, and pneumoconiosis, audiometric testing since 1996, has contributed to improve the reliability of occupational health screenings by improving the issues including standardization of testing methods, tools, diagnostic opinions, and reliability of analysis for biological monitoring. It has contributed to improving the reliability of occupational health monitoring by rectifying the following issues associated with previous monitoring: absence of standardized testing methods, testing tools that are not upgraded, mismatching diagnostic opinions, and unreliable results of biological specimen analysis. Nevertheless, there are issues in need of further improvement such as lack of expertise or the use of inappropriate method for health examination, and passive and unwilling participation in the quality control. We suggested solutions to these problems for each area of quality control program. Above all, it is essential to provide active support for health examiners to develop their expertise, while encouraging all the health screening agencies, employers, and workers to develop the desire to improve the system and to maintain the relevance.
( Won-jong Yang ),( Eunhee Park ),( Yu-sun Min ),( Jae-won Huh ),( Ae Ryoung Kim ),( Hyun-min Oh ),( Tae-woo Nam ),( Tae-du Jung ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.1
Background/Aims: This study aimed to evaluate the correlation between clinical risk factors of post-extubation dysphagia (PED) and the severity of impaired pharyngeal swallowing function assessed via videofluoroscopic swallowing studies (VFSSs). Methods: This study was a retrospective review of medical records. Of 116 patients who were admitted to the intensive care unit and underwent VFSS, 32 who had non-neurologic disorders and experienced prolonged intubation (for more than 48 hours) were diagnosed with PED. The severity of PED was evaluated by using a functional dysphagia scale (FDS) and a penetration aspiration scale (PAS), on the basis of VFSS. Results: The Simplified Acute Physiology Score 3 and total FDS score were positively correlated (r = 0.40, p = 0.02). Intubation duration was positively correlated with total PAS and FDS scores (r = 0.62, p < 0.001; r = 0.65, p < 0.001, respectively). The amounts of residue in the valleculae (RV) and pyriform sinuses (RP) were associated with intubation duration (r = 0.58, p < 0.001; r = 0.57, p < 0.001, respectively). Multivariate regression analysis revealed that intubation duration was significantly associated with the total FDS score, RV and RP subscales of the FDS, and total PAS score. Conclusions: The severity of impaired swallowing function, particularly the amount of residue in the pharyngeal recesses assessed via VFSS, was strongly associated with both severity of medical illness and intubation duration. Intubation duration could be a prognostic factor for assessing impaired swallowing function on the basis of VFSS.
Oh, Jong Kil,Lee, Mi-Sun,Bae, Seung Min,Kim, Eunji,Hwang, Jun-Won,Chang, Hyoung Yoon,Lee, Juhyun,Kim, Jiyoun,Lee, Cheol-Soon,Park, Jangho,Bhang, Soo-Young KOREAN ACADEMY OF MEDICAL SCIENCE 2019 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.34 No.5
<P><B>Background</B></P><P>Two hundred and fifty 11th grade students and teachers from Danwon High School drowned, during a school trip, in the Sewol Ferry Disaster. The goal of this study was to investigate the experiences of the psychiatrists who volunteered and provided psychiatric services to the students at Danwon High School.</P><P><B>Methods</B></P><P>From the second day to the 138th day after the disaster, pro bono psychiatrists provided post-disaster interventions to the 10th and 12th-grade Danwon High School students who did not attend the trip. Officially, 167 psychiatrists conducted outreach in approximately 550 encounters. The study questionnaires were distributed retrospectively to psychiatric volunteers who conducted outreach at Danwon High School. We surveyed the pro bono psychiatrists about their experiences, including the students' chief complaints, psychiatric problems, clinical diagnoses, and psychiatrists' treatment recommendations.</P><P><B>Results</B></P><P>We reached 72 (43.1%) of the 167 volunteers, and they reported on 212 (38.6%) of the 550 encounters. The common chief complaints were mental health problems, companion problems, and family problems. The most frequent psychiatric symptoms were anxiety (76.89%), depressive mood (51.42%), and concentration difficulty (50.94%). The most frequent clinical diagnoses of the students were normal reaction (41.04%), acute stress disorder (24.53%), adjustment disorder (17.92%), anxiety disorders (9.43%), and posttraumatic stress disorder (6.60%). More than half of the students needed “additional counseling/therapy” (41.04%) or “referral to psychiatric treatment” (14.15%).</P><P><B>Conclusion</B></P><P>During the acute aftermath of the Sewol Ferry Disaster, volunteer psychiatrists were able to provide services. These services included psychiatric assessments, crisis counseling, psychological first aid, and referrals for ongoing care. More than half of the students were perceived to have a psychiatric diagnosis, and a substantial proportion of students needed further treatment. Future research should focus on the short- and long-term effects of psychiatric interventions and the characterization of post-disaster mental health needs and service provision patterns.</P>
( Sun Young Ahn ),( Young Oh Kweon ),( Won Young Tak ),( Soo Young Park ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: Development of hepatic adenoma is considered as an important complication of glycogen storage disease type Ia (GSD-Ia) because it can be transformed into hepatocellular carcinoma. Traditionally treatment of choice for a hepatic adenoma is surgical resection. But multiple hepatic adenomas with GSD-Ia present therapeutic dilemmas. Recently, the high frequency of ß-catenin mutations in HCA with GSD-Ia could be related to the increased frequent malignant transformation. The authors present a rare case report that shows multiple hepatic adenomas without ß-catenin mutations occurred in a young male adult with GSD-Ia could be treated with percutaneous radiofrequency ablation (RFA). Case: A 24-year-old male patient was referred to our unit due to multiple liver masses. He was as diagnosed as GSD-Ia about 10 years ago. We performed biopsies on each liver nodules. Biopsy specimens were revealed by standard histopathological examination and immunohistochemistry for ß-catenin, glutamine synthetase and amyloid A. They were all inflammatory type HCA in GSD-Ia. Because nodules were small, multiple and absence of ß-catenin mutation of the adenomas, we performed percutaneous radiofrequency ablation as a less invasive therapeutic option. Follow-up CT studies revealed gradual reduction in the size of RFA zone without new recurrence. Conclusions: Risk stratification of malignant transformation according to immunohistochemistry is important to decide how to manage HCAs in GSD-Ia patients and percutaneous radiofrequency ablation is a good therapeutic modality in low risk HCAs in GSD-Ia patients.
The factors associated with Vitamin D deficiency in community dwelling elderly in Korea
Sun Hea Kim,Jung Eun Oh,Dong Won Song,Choo Yon Cho,Sung Ho Hong,Yong Jin Cho,Byung Wook Yoo,Kyung Suk Shin,Hyun Joe,Hwang Sik Shin,Doo Yong Son 대한지역사회영양학회 2018 Nutrition Research and Practice Vol.12 No.5
BACKGROUND/OBJECTIVE: Recent studies showed vitamin D deficiency is linked to chronic diseases in addition to skeletal metabolism which could threaten the elderly. We analyzed health conditions and socio-demographic factors associated with vitamin D deficiency in community dwelling people aged 65 years and older. SUBJECTS/METHOD: Data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2010 to 2012 were obtained. A total of 2,687 subjects aged 65 years and older were participated. The cutoff value of the Vitamin D deficiency was considered as serum 25-hydroxyvitamin D [25(OH)D] ≤ 20 ng/mL (50 n㏖/L). RESULTS: The overall prevalence rate of vitamin D deficiency in the elderly was 62.1%. The factors such as female, obesity, metabolic syndrome, current smoker, and skipping breakfast were positively associated with vitamin D deficiency, but high intensity of physical activity and more than 9 hours of sleep duration were negatively associated with vitamin D deficiency (all P < 0.05). CONCLUSIONS: It is important that health professions know that the factors proved in this study are connected to vitamin D deficiency thus provide information and intervention strategies of vitamin D deficiency to old aged people.