Chlorhexidine varnish 처치 후 고정식 교정장치 장착 환자의 치태내 균주 변화 양상에 대한 장기간 관찰 연구

장영일,양원식,남동석,김태우,백승학 대한치과교정학회 2000 대한치과교정학회지 Vol.30 No.3

본 연구의 목적은 chlorhexidine varnish를 고정식 교정장치 장착 환자의 치면에 도포한 후 나타나는 치태내 균주의 변화 양상을 장기간 관찰하는 것이다. 서울대학교병원 치과진료부 교정과에서 고정식 교정장치로 치료하기로 하였던 환자 100명중에서 32주까지 장기간 추적 (follow-up) 되었던 21명을 최종 연구대상으로 선정 하였다. 실험군(12명)은 chlorhexidine varnish를 1주일 간격으로 4회 도포한 후 고정식 교정장치를 부착하였고, 대조군(9명)은 chlorhexidine varnish처치를 하지 않고 고정식 교정장치를 부착하였다. 그리고 실험군에서는 20주 째에 chlorhexidine varnish를 1회 처치하였다. 두 군에서 고정식 교정장치 부착 직전과 부착 후 4, 8, 20, 32주의 치태내 균주의 변화 양상을 간접면역 형광 현미경법으로 분석하고 SAS 통계프로그램을 사용하여 다음과 같은 결과를 얻었다. 1.Streptococcus mutans는 실험군에서 전 실험기간동안 통계학적으로 유의성 있게 억제되었고 (p〈0.01), 대조군에서 전 실험기간동안 통계학적으로 유의성 있게 증가하였다 (p〈0.05). 2.Streptococcus sanguis, Streptococcus mitis, Actinomyces viscosus, Actinomyces naeslundii는 실험군과 대조군에서 통계학적으로 유의성 있는 변화를 보이지 않았다. 따라서 고정식 교정장치를 사용할 환자에서 chlorhexidine varnish를 처치할 경우 치아 우식의 주 원인균인 Streptococcus mutants를 장기간 선택적으로 억제할 수 있을 것으로 생각된다. The authors observed the long term effects of chlorhexidine vanish treatment on microbial change of dental plaque in orthodontic patients with fixed appliances. The initial sample was 100 patients who were arranged to be treated with fixed orthodontic appliances. The final sample consisted of 21 patients who could be traced for 32 weeks after application of fixed orthodontic appliances. They were classified into the experimental group (12 patients) and the control group (9 patients). The experimental group was treated with chlorhexidine vanish once a week for 4 weeks before application of fixed orthodontic appliance. The control group was not treated with chlorhexidine varnish before application of fixed orthodontic appliance. The experimental group was treated once more after 20 weeks. The microbial changes of dental plaque were analysed by indirect immunofluorescence technique at pre-treatment, post-treatment 4, 8, 20, and 32 weeks. The results were as follows. 1.In the experimental group, streptococus mutans was significantly suppressed during experimental period.(p〈0.01) But, in the control group, streptococcus mutants was significantly increased after placement of fixed orthodontic appliances during experiment period.(p〈0.05) 2.Streptococcus sanglus, Streptococcus mitis, Actinomyces viscosus, and Actinomyces naeslundii did not show significant change between the experimental and the control group during experiment period. So, if we treat the orthodontic patients with chlorhexidine varnish before application of fixed appliances, we may suppress the major cariogenic bacteria, Streptococcus mutans, selectively for long period.

악교정 수술후 골격성 Ⅲ급 부정교합 환자의 하악운동 변화에 관한 연구

남동석,양원식,서정훈,장영일 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.2

본 연구는 골격성 III급 부정교합 환자에서 악교정 수술 전후의 하악운동 양상을 관찰하여 수술에 의한 하악운동의 변화를 평가하기 위하여 시행되었다. 서울대학교병원 교정과에서 골격성 III급 부정교합으로 진단받고 수술 전 교정치료를 받은 후, 동 병원 악안면구강외과에서 악교정 수술을 시행한 20명(남;9명, 여;11명)을 대상으로 수술 직전과 수술 2-7개월 후에 Sirognathograph와 BioPak EGN을 이용하여 최대 개폐구 운동과 시상면, 전두면, 수평면에서의 하악한계운동을 기록하고 21개의 항목을 계측하여 다음과 같은 결과를 얻었다. 1. 수술 후에 가장 큰 변화를 보인 항목은 시상면상 전방 운동각도로서, 수술 전 17.4°에서 수술 후 38.8°로 증가하였다. 또한 전치 유도가 형성됨에 따라 전방운동 궤적도 일직선에서 상악 절치의 형태에 따른 곡선으로 변하였다. 2. 수술 전후를 비교할 때 p<0.01 수준에서 유의성을 보인 항목들은 최대 개폐구 운동시 최대 개구량과 최대 전후방 운동량, 시상면상 최대 개구량, 전두면상 좌측방 운동각도의 4항목이었다. 3. 수술 전후를 비교할 때 p<0.05 수준에서 유의성을 보인 항목들은 전두면상 최대 좌우 운동폭, 수평면상 최대 우측방 운동거리, 최대 좌측방 운동각의 3항목이었다. 4. 최대 개폐구 운동시 최대 개구량과 최대 전후방 운동량은 수술 후 측정시간에 따른 차이를 보였다(p<0.05). 즉 2, 3개월군에서보다 5, 6, 7개월군에서 더 많은 운동량 회복을 나타내었다. 5. 수술 전 불규칙하던 개폐구시 운동 궤적은 수술 후 개구로와 폐구로가 일치하며 부드러운 곡선을 이루었는데, 이는 악교정 수술에 의해 교합장애가 제거되었기 때문인 것으로 생각된다. The purpose of this study was to evaluate changes in mandibular movement patterns after orthognathic surgery in skeletal Class III patients. The sample consisted of 20 Class III malocclusion patients(9 males, 11 females). Just before and after(2-7months) surgery, maximum opening & closing movement, mandibular border movement on sagittal, frontal and horizontal planes were recorded using Sirognathograph & BioPak EGN. On each record, 21 items were measured and statistically analyzed. The results were as follows: 1. Angle of protrusive movement on sagittal plane showed greatest change after surgery. Also, as the incisal guidance was established by surgery, straight path of protrusive movement became curved line. 2. Maximum opening distance and maximum antero-posterior distance on maximum opening & closing movement, maximum opening distance on sagittal plane, angle of left lateral excursion on frontal plane were statistically significant after surgery(p<0.01). 3. Maximum width of lateral excursion on frontal plane, distane of right lateral excursion and angle of maximum left lateral excursion on horizontal plane were statistically significant after surgery(p<0.05). 4. Maximum opening distance and maximum antero-posterior distance on maximum opening % closing movement showed significant differences according to post-surgical time(p<0.05). More recovery of range of movement occured in 5-7month group than in 2-3month group. 5. As the occlusal interferences were removed by orthognathic surgery, irregular opening & closing path became smooth curve.

유년기 Ⅲ급 부정교합자에서 이모장치의 치료 효과에 관한 연구

남동석,서정훈,양원식,장영일 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.4

본 연구는 유년기의 하악 전돌성 III급 부정교합자에게 이모장치를 착용하여 치료하였을 때 나타나는 변화를, 보다 적절한 대조군을 이용하여 알아보고자 시행하였다. 이모장치를 이용하여 치료한 하악전돌의 골격성 III급 부정교합자중에서 치료 시작 시기가 약 7세경인 29명(남자 14명, 여자 15명)을 실험군으로 하였고, 비슷한 연령으로 골격적 상태가 유사하며 어떤 형태의 교정치료도 받지 않은 III급 부정교합자 21명(남자10명, 여자11명)을 대조군으로 하였다. 2년의 관찰 기간을 거쳐, 초기 및 2년 후의 두부방사선사진을 계측 분석하여 그 변화량을 비교한 결과 (t-test, p<0.05) 다음과 같은 결론을 얻었다. 1. 이모장치를 착용하지 않은 대조군에서는 악골의 부조화가 개선되지 않고, 심화되는 방향으로 성장하였다. 즉, 치료하지 않은 하악 전돌성 III급 부정교합자는 성장에 의해 개선이 일어나지 않음을 나타내었다. 이모장치를 착용한 실험군에서는 전후방 골격 부조화가 감소하였으며, 하악 전돌감이 개선되었다. 2. 두개저와 상악골의 성장은 이모장치에 의해 유의한 변화를 보이지 않았다. 3. 이모장치의 하악골 성장억제 효과를 인정할 수 없었으나, 하악골의 성장 방향의 변화 및 성장 형태의 변화가 관찰되었다. 4. 이모장치 착용시 수직적 성장 경향이 증가하였다. 5. 연구 성적을 종합적으로 검토한 결과, 이모장치의 주된 치료 기전은 하악골의 후하방 회전과 변위이며, 성장 방향과 형태의 변화가 부분적으로 기여한다고 볼 수 있었다. 위의 결과를 종합해 보면 이모장치의 치료효과는 하악 골격 성장의 억제효과라기 보다는 하악골의 후방 회전과 변위에 의한 것이며 성장기 하악 전돌성 III급 부정교합자에서 골격 부조화의 개선 및 전돌감 해소에 유용한 장치라고 생각된다. The purpose of this study was to investigate the changes in the craniofacial skeleton subsequent to chincap therapy in the juvenile skeletal Class III malocclusion with more appropriate control samples. The experimental group consisted of 29 Korean children(14 males, 15 females) who had skeletal Class III malocclusion with prognathic mandible and were undergone chincap therapy from the beginning of treatment. The control group was composed of 21 Korean children(10 males,11 females) who had no orthodontic treatment, but with similar skeletal discrepancies to experimental group. Lateral cephalometric radiographs at the age of 7, and 2 years later were analyized and compared with student`s t-test(p<0.05). The results of this study were as follows; 1. The control group without chincap therapy had not shown any improvement of the skeletal discrepancies, but had grown to be much severe. This means that the untreated Class III patient with prognathic mandible would not be corrected by growth. For the experimental group with chincap therapy, the anterior-posterior skeletal discrepanices and mandibular prognathism were both improved. 2. Neither significant restraint nor acceleration of growth was found in the cranial base and maxilla by chincap treatment. 3. The inhibition of mandibular growth could not be accepted, but the changes of the direction of growth and morphological changes were found. 4. Vertical growth tendency was increased with chincap therapy. 5. When putting together the results of the analyses, it seems to be the rotation and displacement of the mandible that the major treatment effects of chincap are. The changes of the direction of growth and the morphological changes also seems to contibute to the treatment effect partly. In summary, the chincap doesn`t restrain the mandibular growth. But, it is considered as a useful treatment modality for correction of skeletal discrepancies and reduction of mandibular prognathism in growing Class III patients with madibular prognathism.

Cortical Stroke in Parietal Lobe Misdiagnosed as Carpal Tunnel Syndrome

Kim, Seok-Won,Ju, Chang-Il The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.41 No.5

A 56-year-old woman presented with the numbness and pain in the left hand in the 1st, 2nd and 3rd finger area that developed suddenly 7 days prior to admission. In nerve conduction velocity test, the deterioration of nerve conduction velocity as well as the reduction of the potential amplitude were detected. After diagnosis of carpal tunnel syndrome, the open median nerve release was performed. Nonetheless, the preoperative symptoms did not change. The magnetic resonance images [MRI] of brain revealed a cerebral infarction in sensoricortical area of parietal lobe. The patient was referred to the department of neurology, and after conservative treatment, her symptoms were improved.

측면 방사선 촬영 자세의 표준화를 위한 정상 척추의 시상면 정렬의 분석

김민석(Min-Seok Kim),정석원(Seok-Won Chung),황창주(Changju Hwang),이춘기(Choon-Ki Lee),장봉순(Bong-Soon Chang) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.7

목적: 양팔의 자세 변화에 따르는 척추의 시상면 정렬의 차이를 분석하고, 환자에게서 가장 기능적인 시상면 정렬을 재현 할 수 있는 측면 기립 방사선 촬영 자세를 제시하고자 하였다. 대상 및 방법: 정상 성인 남자 30명에 대해 제7 경추와 제1 천추의 피부 표면에 표식자를 부착시킨 후 전 척추측면 기립 방사선 촬영을 시행하였다. 팔을 내리고 서있는 자세(자세 A), 견관절을 각각 30°, 90° 굴곡한 자세(자세 B, C), 양팔을 끌어안은 자세(cross-arm position) (자세 D), 견관절을 90° 굴곡시킨 후 팔을 수평봉에 얹은 자세(자세 E)를 취하게 하여, 자세 변화에 따른 시상 수직축(sagittal vertical axis), 흉추 후만각, 요추 전만각, 천추 전경각의 차이에 대해 분석하였다. 결과: 자세 A에서 E의 평균 시상 수직축은 각각 +1.47±2.06 cm, -0.58±2.96 cm, -2.11±2.67 cm, +0.16±2.38 cm, -0.51±2.70 cm으로 일차원 분산분석(one-way ANOVA)을 시행한 결과 그룹간의 유의한 차이를 보였고(p<0.001), Duncan의 사후검증결과 자세 A와 D는 차이가 없는 것으로 판단되어 자세 D가 자세 A에 대해 가장 유사한 자세로 나타났다. 흉추 후만각, 요추 전만각, 천추 전경각은 자세간의 유의한 차이를 보이지 않았다. 결론: 양팔을 끌어안은 자세(crosss-arm position)는 평상시 서있는 자세와 가장 유사한 기능적인 시상면 정렬을 구현할 수 있는 자세로 생각된다. Purpose: To analyze the difference in sagittal balance based on different positions of both arms and to promote the proper lateral spine view which can reconstruct the most functional posture of sagittal balance. Materials and Methods: We applied X-rays to thirty healthy male adults with no spinal diseases after application of marks on the skin surface at the location of the C7 and S1 vertebrae with the following five postures, standing lateral position with both arms neutral (posture A) with both shoulders flexed thirty degrees and ninety degrees (postures B and C) with both arms crossed (posture D) with both shoulders flexed ninety degrees and with both arms on a parallel bar (posture E). We analyzed the differences of the sagittal vertical axis, thoracic kyphotic angle, lumbar lordotic angle, and sacral inclination angle after the postural changes. Results: The average sagittal vertical axis value from posture A to E was 1.47±2.06 cm, -0.58±2.96 cm, -2.11±2.67 cm, 0.16±2.38 cm, and -0.51±2.70 cm. We discovered that five postures were statistically different (one-way ANOVA, p<0.001) and that posture D was the closest to posture A (Duncan's multiple comparison test). However we did not observe any statistical differences among the thoracic kyphotic angle, the lumbar lordotic angle, and sacral inclination angle postures. Conclusion: We can reconstruct the functional sagittal alignment in the cross-arm position, which is the closest to the normal standing position.

A Multicenter Analysis of Clinical Features and Long-Term Outcomes of POEMS Syndrome in Korea

Kook Hye Won,Jang Ji Eun,Min Chang-Ki,Yoon Dok Hyun,Kim Kihyun,Bang Soo-Mee,Park Yong,Lee Jae Hoon,Yoon Sung-Soo,Kim Jin Seok 대한의학회 2024 Journal of Korean medical science Vol.39 No.2

Background: POEMS syndrome is a rare form of plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins, and skin changes. Owing to its low incidence, there are few reports regarding this syndrome. This multicenter study included 84 patients diagnosed with POEMS syndrome in South Korea. Methods: We retrospectively evaluated 84 patients diagnosed with POEMS syndrome at 8 hospitals in South Korea between January 2000 and October 2022. The clinical characteristics and treatment outcomes were analyzed. Results: The median patient age was 53 years (range, 26–77 years), and 63.1% of the patients were male. All patients had peripheral neuropathy, and 81 (96.4%) had monoclonal plasma cell proliferation. Plasma vascular endothelial growth factor levels were available for 32 patients with a median of 821 pg/mL (range, 26–12,900 pg/mL). Other common features included skin changes (54.2%), volume overload (71.4%), and organomegaly (72.6%). Of the 84 patients, 75 received initial treatment (local radiotherapy, 6 [8.0%]; chemotherapy, 17 [22.7%]; both chemotherapy and local radiotherapy, 9 [12.0%]), upfront autologous stem cell transplantation (ASCT), 43 (57.3%; with induction chemotherapy, n = 12, 16.0%; without induction chemotherapy, n = 31, 41.3%). The median follow-up duration was 40.7 months. The 5-year overall survival (OS) was 78%, and the 5-year progression-free survival (PFS) was 55%. Patients who underwent upfront ASCT and were diagnosed after 2014 had a longer OS and PFS. Conclusion: The demographics of Korean patients with POEMS syndrome were similar to those reported previously. Because of the introduction of new treatment agents and the reduced rate of transplant-related mortality related to ASCT, the treatment outcomes of Korean patients with POEMS syndrome have improved in recent years.

제주물을 이용한 기능성 및 혼합음료의 개발방향 설정에 관한 연구

고성보(Ko, Seong-Bo),현창석(Hyun, Chang-Seok),강경원(Kang, Kyung-Won) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.5

세계적으로 건강기능식품의 주변 환경은 매우 빠르게 변하고 있다. 2012년 세계기능성 음료시장은 269억달 러 규모, 아태지역 시장은 136억달러 규모가 될 것으로 전망하고 있다. 국내 먹는 샘물 시장은 2008년 4,400억원 규 모를 형성하고 있고, 제주삼다수의 매출액은 891억원이다. 그러나 “제주삼다수”라는 브랜드는 한계성을 지니고 있다. 이에 대한 방안으로 제주물의 품질 우수성을 알리는 포괄적인 광고가 필요하며, 제주 물을 이용한 기능성 음료 및 혼 합음료 개발의 성공 가능성을 높이기 위해서 제주워터(Jeju Water)라는 글로벌 통합브랜드 개발이 필요하다. 기능성 및 혼합음료 제품개발시 제주지역의 농산물의 기능성을 적극 활용해 물산업과 제주의 1차산업을 연계해 농산물의 과 잉생산 처리와 고부가가치화를 촉진시킬 필요가 있다. The environment of the health food in the world has been changed very rapidly. The world market volume of functional drinks in 2012 will be estimated at $ 26.9 billion, and Asia-Pacific market is expected to be $ 13.6 billion. The domestic market volume of bottled water in 2008 was 440 billion won, and "Jeju Samdasu" sales was 89.1 billion won. But the brand of "Jeju Samdasu" has the limits. As a solution, the comprehensive advertising of the excellence quality of Jeju water is required. To increase the likelihood of success in development of functional and mixed drinks by the water is necessary to develop a global integrated brand. In developing the functional and mixed drinks by the water, we apply the functionality of the Jeju agricultural products actively, and connect Jeju Water industry with Jeju agricultural industry, which promote the overproduction control and the high value- added agricultural products.

편평한 암석절리면의 속도 의존적 전단거동 특성

박병기,이창수,전석원,Park, Byung-Ki,Lee, Chang-Soo,Jeon, Seok-Won 한국터널지하공간학회 2007 한국터널지하공간학회논문집 Vol.9 No.2

최근 암반구조물의 규모가 점차 대형.대단면화됨에 따라 암반 절리면이 자유면에 노출되는 경우가 빈번하게 발생할 수 있으며 지진, 발파와 같은 외부 동적 하중의 영향을 받을 가능성이 커지고 있으므로 다양한 동적 하중조건 하에서 암반 불연속면의 거동 특성 파악을 위한 연구의 필요성이 증대되고 있다. 본 연구에서는 전단속도의 변화에 따른 편평한 화강암 전단면의 마찰특성 변화를 알아보고자 다양한 조건하에서 직접전단시험을 수행하였다. 수행한 직접전단시험은 크게 두 가지로 나눌 수 있는데 첫 번째 시험에서는 시험이 수행되는 동안 각각 7가지의 일정한 전단속도로 전단변위가 발생되도록 하여 전단속도에 따른 마찰계수의 변화를 살펴보았으며, 두 번째 시험에서는 전단변위가 발생되는 중간에3가지 형태의 순간적인 전단속도 변화가 마찰특성에 미치는 영향을 살펴보았다. 수직응력과 전단속도의 변화에 따른 편평한 화강암의 마찰계수 변화는 가해진 수직응력 수준에 영향을 받는 것으로 나타났으며, 전단속도의 변화가 마찰거동에 영향을 미치기 시작하는 전이속도는 수직응력이 증가함에 따라 낮아지는 것으로 나타났다. 또한 전단속도가 느릴수록 stick-slip 거동에서의 응력 저하 폭이 커지는 경향을 보였다. 순간적인 전단속도 변화에 따른 정상 상태에서의 마찰계수 변화를 살펴본 결과 순간적인 속도의 증가에 따라 마찰계수가 감소하는 속도 연화 현상이 나타났으며, 느린 전단속도에서 전단속도의 변화에 따른 마찰계수의 감소폭이 빠른 전단속도에서의 변화에 따른 감소폭보다 더 큰 경향을 보였다. Recently, the probability of rock joints being exposed to free faces is getting higher for the scale of rock mass structures gets larger. Also, the frequency of occurring dynamic events such as earthquakes and blasting has been increasing. Thus, the shear behavior of rock joints under different conditions needs to be investigated. In this study, a series of direct shear tests were carried out under various conditions to examine the velocity-dependent shear behavior of saw-cut rock joints. Two types of direct shear test were carried out. The first was to examine the velocity-dependent shear behavior of saw-cut rock joints at seven different shear velocities, each with three different normal stresses. The second was to examine the shear behavior of saw-cut rock joints when three different instantaneous shear velocities changed. As a result, the coefficient of friction was affected by normal stress. The breakpoint velocity, the point when the change of shear velocity starts to affect the frictional behavior, became lower as normal stress increased. Also, as the shear velocity became lower, the degree of stress-drop on stick-slip behavior became larger. As a result of examining the changes of friction coefficient, velocity weakening (decrease of friction coefficient) was observed. The decrement of friction coefficient due to the changes of shear velocity under slow shear velocity was larger than that under fast shear velocity.

Endoscopy and Imaging Modalities/Basic Science of Gastrointestinal Disorders/Miscellaneous : Changing Pattern Of Digestive And Liver Disease In Korea, 1990-2006 Year; A Single Center Study

( Jung Hyun Kwon ),( Sang Woo Kim ),( In Sik Chung ),( Myung Gyu Choi ),( Kwan Woo Nam ),( Jung Pil Suh ),( Jae Hyuck Chang ),( Won Haing Hur ),( Yu Kyung Cho ),( Jae Myung Park ),( In Seok Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: Westernization in many Asian countries have changed lifestyles and diets, so once rare diseases have now become prevalent. The aim of this study is to investigate the changing pattern of digestive and liver disease in Korea, from 1990 to 2006. Methods: We extracted data specific gastrointestina (GI) disease based on the International Classification of Diseases code from the in-patients records at the Kangnam St. Mary`s Hospital in 1990, 1996 and 2006. This hospital is a tertiary-care hospital in Seoul, Korea, which has a capacity of 800 beds. Results: The admission rate for GI disease increased between 1990 and 2006. Overall in-patients were 1,623 persons in 1990, 2,368 persons in 1996 and 4,166 persons in 2006. The mean age of in-patients increased as time went by. A stomach cancer was the most common diagnosis during all periods, but its prevalence has decreased. Colon cancer ranked the 7th in 1990, but markedly increased and now ranks the second. The third was a hepatocellular carcinoma. The bile duct and gallbladder cancer, pancreas and esophageal cancer ranking followed with little interval change. In cases of cancer patients, a regular admission dramatically increased for chemotherapy. The number of patients admitted with pre-malignant neoplasm of stomach and colon increased remarkably with the development of endoscopy. The liver transplant, inflammatory bowel discase, and reflux esophagitis emerged form mid-1990s with greater frequencies, yet much below the levels found in the West. The admission rate for peptic ulcer, especially ulcer bleeding remained relatively stable, despite a decreased rate for ulcer perforation. Liver cirrhosis, hepatitis, cholelithiasis with cholecystitis-cholangitis, appendicitis, hemorrhoid and gastritis all decreased. Conclusions: The stomach cancer is the leading cause of admission, despite a recent decline. Colon cancer showed a marked rise. The liver transplant, inflammatory bowel disease and reflux esophagitis were new diagnosis with an increased tendency.

Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial

Lee Woo-Jin,Shin Yong-Won,Chang Hyeyeon,Shin Hye-Rim,Kim Won-Woo,Jung Seok-Won,Kim Manho,Nah Seung-Yeol 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.1

Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory impairment. Methods: In this 8-week, randomized, assessor and participant blinded, placebo–controlled study, participants with subjective memory impairment but preserved cognitive function (Korean Mini-Mental State Examination [K-MMSE] score ≥23) were assigned to GEF 300mg/day or placebo. K-MMSE, Korean versions of the Alzheimer's disease assessment scale, color-word stroop test (K-CWST), clinical dementia rating, and Beck depression inventory-II were evaluated along with the safety profiles. The primary outcome was set as the change in the K-MMSE. Results: Seventy-six participants complete the study protocol. After 8 weeks, there was no inter-group difference in the primary or secondary outcome score changes. However, GEF group showed an improvement in the K-MMSE scores (P= 0.026), and in the number of correct answers in both word reading (P= 0.008) and color reading (P= 0.005) of K-CWST, although only the improvement in the K-CWST scores were higher than the minimum clinically important difference. The frequency of adverse events was comparable between the groups and all were of mild severity. Conclusion: GEF is safe but might not be effective in treating subjective memory impairment within the current study setting. However, GEF showed a trend of improving the global cognition and the frontal executive function. Further large-sized studies with longer follow-up period are warranted. Clinical trial registration: This clinical trial was registered at Clinical Research Information Service of Korea Centers for Disease Control and Prevention: KCT0004636. Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory impairment. Methods: In this 8-week, randomized, assessor and participant blinded, placebo–controlled study, participants with subjective memory impairment but preserved cognitive function (Korean Mini-Mental State Examination [K-MMSE] score ≥23) were assigned to GEF 300mg/day or placebo. K-MMSE, Korean versions of the Alzheimer's disease assessment scale, color-word stroop test (K-CWST), clinical dementia rating, and Beck depression inventory-II were evaluated along with the safety profiles. The primary outcome was set as the change in the K-MMSE. Results: Seventy-six participants complete the study protocol. After 8 weeks, there was no inter-group difference in the primary or secondary outcome score changes. However, GEF group showed an improvement in the K-MMSE scores (P= 0.026), and in the number of correct answers in both word reading (P= 0.008) and color reading (P= 0.005) of K-CWST, although only the improvement in the K-CWST scores were higher than the minimum clinically important difference. The frequency of adverse events was comparable between the groups and all were of mild severity. Conclusion: GEF is safe but might not be effective in treating subjective memory impairment within the current study setting. However, GEF showed a trend of improving the global cognition and the frontal executive function. Further large-sized studies with longer follow-up period are warranted. Clinical trial registration: This clinical trial was registered at Clinical Research Information Service of Korea Centers for Disease Control and Prevention: KCT0004636.