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      • 간경변 환자에서 Oro-cecal Transit Time의 측정

        원경준,이준,변유미,조민근,조주연,서정균,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2

        Background: Neurotransmitter like substances in the gut have been proposed to contribute to the overall portal systemic encephalopathy (PSE). The source of the ammonia in patients with PSE is mainly the small bowel, as a result of the conversion of glutamine in the diet to glutamate and ammonia. PSE is highly responsive to changes in diet, to antibiotic therapy and to ingestion of nondigestible disaccharides such as lactulose. This study was performed to evaluate the relationship between PSE and oro-cecal transit time. In addition, performed to evaluate the effect of severity, cause, complications of liver cirrhosis on oro-cecal transit time. Methods: Between August 2006 and February 2007, 48 cirrhotic patients consecutively was enrolled in study their oro-cecal transit time after informed consent was obtained. A non-invasive hydrogen breath test was used to study oro-cecal transit time (OCTT). Result: The OCTT were delayed in cirrhotic patients with PSE compared without PSE (123.3 ± 42.7 min vs 170.0 ± 58.3 min, p<0.05). OCTT tended to prolongate further as the damage in the liver got worse, nevertheless the result was statistically meaningless (p<0.111). Neither presence of ascites or cause of PSE had any influence on gastrointestinal transit. Conclusions: Cirrhotic patients with PSE have more delayed OCTT than without PSE. Further research is needed to find out the relationship between OCTT and severity of liver cirrhosis.

      • 제 1형 신경섬유종증 환자에서 발생한 위장관 간질종양 1예

        원경준,이준,변유미,조민근,한경택,김원,홍란,임성철,김경종,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

        Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in the gastrointestinal tract, but this tumor is rarely seen in association with type l neurofibromatosis (NFl) Generally, the majority of GISTs are isolated neoplasm and they are sporadically found in the stomach, but the GISTs in NFl patients are usually multiple and usually found in the small intestine. We report a case of multiple GISTs in the jejunum of a 63-year-old woman diagnosed as NFl accompanied by complication of gastrointestinal bleeding, In this case, Patient had multiple cafe-au lait spots and neurofibroma on skin and had freckling on axilla and groin, and then, we made a diagnosis of NFl. Gastrointestinal bleeding is controlled by resection of multiple GISTs. Generally, only 3-5% of all gastrointestinal bleeding comes from the small bowel. Causes of small intestinal bleeding are angiodysplasia, neoplasm, NSAIDs induced ulcer etc. but, If patients have NFl accompanied by complication of gastrointestinal bleeding, GISTs on small bowel must be considered.

      • 시판복분자 딸기 열매의 탄니 화합물

        방근철,김민선,이민원 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

        Rubi Fructus(Korean name : Bog-bun-ja) has been used in oriental traditional medicine as the remedies for impotence, pollution, premature ejaculation and frequency of urination etc. By means of chromatographic methods, three hydrolyzable tannins were isolated from the commercial Rubi Fructus. The structures of these compounds were established as gallic acid, pedunculagin and sanguiin H-6 on the basis of physicochemical and spectroscopic evidences.

      • 미세 골절 진달을 위한 초음파 C-scan의 활용 가능성

        박원근,최민주,이원흠,이윤준,이헌주,강창익,박전홍 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

        The study examines the medical potential of an ultrasonic C-scanning technique and for diagnosis of the fatigue induced micro-fractures of the bone. In general, it is not easy to detect the micro­fracture by a simple radiological technique. In the study, the micro­fractures were made on the tibia taken from pigs using a three point bending. Comparison was made between the ultrasonic C-scan images (25 MHz) and X-ray images of the bones with the micro-fractures, It was found that the micro-fractures invisible on the X-ray images were observed on the ultrasonic images. It is proposed further in-vitro and in-vivo studies making the ultrasonic C-scan technique clinically useful for the diagnosis of the fatigued induced micro-fractures of the bone which are not possible to detect by the conventional radiological method.

      • KCI등재

        한국인 주의력결핍 과잉행동장애 아동에서 도파민 D4 수용체 유전자의 Variable Number of Tandem Repeats (VNTR) 다형성과 Methyphenidate 치료 반응간의 연관성

        천근아,김붕년,조수철,김재원,황준원,신민섭,홍강의 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

        Objectives : In the present study, we investigate the association between homozygosity of the 4-repeat allele (4/4) at the DRD4 and the response to the treatment with MPH in Korean children with ADHD. Methods : The present study included 71 children with ADHD (8.231.78 years) from two children's psychiatric clinics in South Korea. All drug-naive children with ADHD were treated with MPH for about 8 weeks. The subjects who showed improvement of over 50% compared with the baseline ARS score after 8 weeks of treatment were termed as the 'good response' group. The subjects who showed an improvement of less than 50% were considered as the 'poor response' group. After genotyping for DRD4 were performed, we investigated correlation between homozygosity for 4-repeat allele at DRD4 and the response to MPH treatment. Results : We found that while 79.5% (31/39) of the subjects with homozygosity of 4-repeat allele at DRD4 showed good response to MPH treatment, 68.8% (22/32) of the subjects without homozygosity of 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their parents (χ²= 16.762, df= 1, p<0.01). We also found that while 61.5% (24/39) of the subjects with homozygosity of 4-repeat allele at DRD4 showed good response to MPH treatment, 87.5% (28/32) of the subjects without homozygosity of the 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their teachers (χ²= 17.698, df= 1, P<0.01). Conclusion : Our findings support an association between the homozygosity of 4-repeat allele and a good response to MPH in ADHD of Koreans.

      • 환경인자가 무근콘크리트의 피로특성에 미치는 영향

        변근주,김영진,이상민,원대연 연세대학교 산업기술연구소 1989 논문집 Vol.21 No.1

        In this study, a series of experiments is carried out to investigate the fatigue charateristics of plain concrete in water and seawater which is subjected to cyclic loading with constant amplitude. A total of 200 cylindrical specimens (ø10x20 cm), which were made by readymixed concrete, are prepared for this study. From these series of tests, it is observed that the static and fatigue compressive strength of plain concrete in water and seawater is consideraly lower than that in air. The fatigue strength of the concrete in water is decreased with comparision to that in seawater when stress ratio(??)is less than 0.1, but the concrete in water and seawater has similar fatigue characteristics when the stress ratio is not less than 0.1. And it has been found that the fatigue strength of the concrete in water and seawater is affected by the stress ratio.

      • 골다공증 진단에 피부 두께의 임상적 유용성 평가

        박원근,최민주,김호찬,조성제,박전홍 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

        The study was carried out to examine how much clinically useful was the skin thickness in diagnosis of osteoporosis. The project was to look into not only the presumption that patients with osteoporosis have the skin loss at the similar rate of the reduction in the collagen content of the bone but also the correlation between the collagen content and the skin thickness. The skin thickness was measured on the dorsal hand(right) of the patients using an ultrasonic technique with a 20 MHz focused ultrasonic transducer. Measurements of the bone density of the patients were made on both the lumbar spine (L2-4) and the femoral neck using Dual­Energy X­ray Absorptionmeter(DEXA, Norland). An ultrasonic bone densitometer(Mark 6000, Medison Co. Korea) was taken to measure the speed of sound (SOS) on the calcaneus. It was observed that there were some degrees of correlation between the bone density obtained by the DEXA and the SOS of the calcaneous (P<0.01). There was no evidence that the skin thickness was correlated with the DEXA produced bone density and ultrasonically measured SOS.

      • 성상세포종에서 등급에 따른 p53 단백 발현의 차이

        기근홍,양정원,이승학,이민오,성정희 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

        Background and Objectives: Mutation or inactivation of the p53 is important mechanism in a wide variety of human tumors. The purpose of this study is to investigate the relationship between expression amount of p53 protein and the grade of astrocytic gliomas. Materials and Methods: This study analyzes 40 paraffin-embedded astrocytic glioma, including 10 cases of low grade, 20 cases of high grade, and 10 cases of maligant glioma (glioblastoma multiforme) were used to analyze the status of abnormal accumulation of wild type of p53 protein. The evaluation of the immunostaining result was based on the percentage of positive neoplastic cells. Results: Average positive cell rate of p53 protein were 4.2%, 35.4% and 16.2% in low grade astrocytoma, high grade astrocytoma and glioblastoma multiforme, respectively. Conclusion: p53 gene mutations were correlated with histologic grade of glial tumors. High grade and glioblastoma multiforme showed higher positive cell rate than low grade astrocytoma. These results suggest that the high positive rates of p53 protein is related to the poor prognosis.

      • 농축 계수비를 이용한 해산 식품 중의 허용농도 설정

        이원근,이창민 경희대학교 산학협력기술연구원 1999 산학협력기술연구논문집 Vol.5 No.-

        Concentration limit of radioactive accumulation is not established so, effective public information to the people is limit. furthermore, several data which is not suitable for korean is used. Therefore, in this paper, concentration limit is determined using Korean food intake. Even if there were already-established research data, the current research was helpful to researchers in laboratories by giving them the sense of the current status in determining permissible concentration and understanding the plant habitat characteristics about the power plant. Ministary of science of technology will adopt the new recommendation soon, so at this paper, dose limit of new value is used. Experts in this area worry about over-expure by estimation of simple intake limit, therefore, complex intake limit is determined about all kinds of fishery products to solve the problem.

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