Ho-166 부착풍선도자를 이용한 방사선 조사의 돼지 관상동맥 스텐트 재협착 예방 효과

김원 ( Kim Won ),정명호 ( Jeong Myeong Ho ),박옥영 ( Park Og Yeong ),정우곤 ( Jeong U Gon ),박우석 ( Park U Seog ),김주한 ( Kim Ju Han ),안영근 ( An Yeong Geun ),조정관 ( Jo Jeong Gwan ),박종춘 ( Park Jong Chun ),강정채 ( Kang Je 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1

배경 : 국내에서 개발된 방사선 동위원소 Holmium-166 (166Ho)은 주로 베타선을 방출하며, 166Ho을 부착한 풍선도자를 이용하여 돼지 관상동맥 재협착 모형에서 풍선확장술 후 신생내막 증식을 전신적 부작용 없이 안전하고 효과적으로 억제하였음을 보고한 바 있다. 본 연구에서는 돼지 관상동맥 스텐트 재협착 모형에서 스텐트 시술 후 신생내막 증식에 의한 재협착 병변을 166Ho 부착 풍선도자를 이용하여 치료하여 그 효과를 관찰하고자 하였다. 방법

Antioxidant and hepatoprotective effects of Korean ginseng extract GS-KG9 in a D-galactosamine-induced liver damage animal model

Yun Ho Jo,Hwan Lee,Myeong Hwan Oh,Gyeong Hee Lee,You Jin Lee,Ji Sun Lee,Min Jung Kim,Won Yong Kim,Jin Seong Kim,Dae Seok Yoo,Sang Won Cho,Seon Woo Cha,Mi Kyung Pyo 한국영양학회 2020 Nutrition Research and Practice Vol.14 No.4

BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6 groups. Rats were orally administrated with GS-KG9 (300, 500, or 700 mg/kg) or silymarin (25 mg/kg) for 2 weeks. The rats of the GS-KG9- and silymarin-treated groups and a control group were then intraperitoneally injected Ga1N at a concentration of 650 mg/kg for 4 days. To investigate the protective effect of GS-KG9 against GalN-induced liver injury, blood liver function indicators, anti-oxidative stress indicators, and histopathological features were analyzed. RESULTS: Serum biochemical analysis indicated that GS-KG9 ameliorated the elevation of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in GalN-treated rats. The hepatoprotective effects of GS-KG9 involved enhancing components of the hepatic antioxidant defense system, including glutathione, glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT). In addition, GS-KG9 treatment inhibited reactive oxygen species (ROS) production induced by GalN treatment in hepatocytes and significantly increased the expression levels of nuclear factor erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) proteins, which are antioxidant proteins. In particular, by histological analyses bases on hematoxylin and eosin, Masson"s trichrome, α-smooth muscle actin, and transforming growth factor-β1 staining, we determined that the administration of 500 mg/kg GS-KG9 inhibited hepatic inflammation and fibrosis due to the excessive accumulation of collagen. CONCLUSIONS: These findings demonstrate that GS-KG9 improves GalN-induced liver inflammation, necrosis, and fibrosis by attenuating oxidative stress. Therefore, GS-KG9 may be considered a useful candidate in the development of a natural preventive agent against liver injury.

수중 시체에서 내부 장기 및 대조수에 대한 규조류의 분석

조갑래,서원준,함석훈,이종석,최동호,전병원,김양정,김광훈 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

퍼지추론을 이용한 영상의 경계추출에 관한 연구

조철호,최원호 울산대학교 1998 공학연구논문집 Vol.29 No.2

경계의 검출과정은 세 단계로 분류할 수 있는데, 이들은 영상 내의 잡음 등을 제거하기 위한 평활화 과정, 경계를 검출하는 과정, 그리고 추적하는 과정이다. 이들 중 평활화 작업과 경계의 검출과정에 퍼지추론의 방법을 적용하였다. 이는 영상 내에 존재하는 미세한 경계의 특징 등은 보존하면서, 잡음 등의 원하지 않은 오염의 영향을 효과적으로 제거하는데 그 목적이 있다. 우선 국부 지역의 화소들의 특징에 근거한 퍼지 가우시안 평활화 필터를 적용하여 경계 정보는 보호하면서도, 평활화 작업을 수행하여 잡음을 제거하는 방법을 구현하였다. 이는 평활화 작업을 경계의 방향과 가로지르는 방향으로 각각 수행함으로서 가능하였다. 그에 대한 정도는 퍼지 규칙과 퍼지 소속 함수로 정의하였다. 이들에 대한 결과의 검증은 표준 가우시안 평활화 필터 등의 전통적인 영상처리 기술과 비교함으로서 확인하였다. The edge detection is one of the important subjects for image processing and analysis. It consists of three stages: smoothing for reducing noise in image data, detecting edge information, and tracing edges. In this paper, fuzzy reasoning algorithms are applied to edge detection and smoothing processes. It is shown that the fuzzy reasoning algorithms are somewhat effective to reduce contaminants and even to preserve minute edge information. A gaussian smoothing filter, which is based on local image characteristics, is used to reduce noises. To preserve edges, the performance of the filter is prohibited for the perpendicular direction of edges. The edge detection algorithm is enhanced by human's heuristic experience, which is represented in fuzzy rules and fuzzy membership functions. The results are compared with those of standard image processing techniques.

J-R 곡선에 대한 시편크기의 영향에 관한 연구

조연제,석창성,김영진,양원호,최용식 成均館大學校 科學技術硏究所 1995 論文集 Vol.46 No.1

The objective of this paper is to investigate the constraint effect on fracture resistance curves. A series of fracture toughness tests with different specimen sizes taken from nuclear piping materials(SA312 TP347 SA516 Gr. 70) were performed. Test results show that fracture toughness is increased with increase in specimen size, probably due to the relaxation crack tip constraint. Elastic-plastic finite element analyses were also performed to investigate the constraint effect. Numerical results show that the stress triaxiality at the crack tip is the governing factor for fracture toughness.

도피불가능한 전기쇽이후 나타나는 통각억제 체계의 선택적인 활성화와 콜린성 체계의 역할

조소현,조원호 한국심리학회 한국심리학회지 생물 및 생리 Vol.4 No.1

본 연구에서는 도피불가능한 전기쇽 이후 발생하는 통각억제 체계중 어떤 요소가 선택적으로 활성화되는지, 또한 naloxone(Nal)의 사전처치에도 불구하고 통각에 대한 민감성의 감소가 약물의 투여로 인한 신경화학물질의 변화 때문인지를 밝히고자 하였다. 따라서 혐오성의 정도가 심한 도피불가능한 쇽을 가한후 hot-plate를 사용 통각에 대한 민감성을 측정한 결과, 훈련기에서 Nal집단과 Saline(Sal) 집단 모두 퍼센트 통각감소율이 높게 나타났다. 검사기에서는, Sal-Sal 집단과 Nal-Sal집단은 훈련기에서의 통각감소가 유지되는 반면에 Sal-Nal집단과 Nal-Scopolamine(Scop)집단은 각각의 생리식염수 통제집단에 비해 유의미하게 감소하였다. 이러한 사실은 도피불가능한 전기쇽 이후 통각억압 체계의 아편계와 비아편계가 선택적으로 활성화됨을 의미하고, naloxone의 사전투여 이후에 활성화되는 비아편계는 scopolamine을 투여했을때 통각감소가 역전된다는 점에 비추어 볼 때 naloxone으로 역전되지 않은 통각감소(naloxone-nonreversible hypoalgesia)는 ACh의 무스카린(muscarine) 수용기를 매개로 하여 작용했다고 할 수 있다. 이 결과는 콜린성 체계가 비아편계의 활성화에 중요한 역할을 하는 신경화학물질임을 시사해준다. The present experiment was conducted to examine which component of pain inhibition system is selectively active after inescapable electric shock and whether, inspite of naloxone pretreatment, the decrease of pain sensitivity was due to the change of neurochemical substance following drug. In result of assesing the pain sensitivity on using hot-plate apparatus after severe aversiveness of inescapable shock. Nal and Sal group were higher than baseline in the % analgesic rate in training phase. In the testing phase, both Sal-Sal and Nal-Sal group were maintained hypoalgesia but, both Sal-Nal and Nal-Scop group were significantly reduced in compared with each control group. These results indicated that opioid and nonopioid component of pain inhibition system were selectively activated after inescapable shock, and naloxone-nonreversed hypoalgesia was activated by mediation of chlinergic muscarine receptor, in view of that non-opioid hypoalgesia after naloxone pretreatment was reduced by scopolamine treatment. This results suggested that cholinergic drug is an important neurochemical substance in the activation of non-opioid hypoalgesia.

새로운 Polystyrene Ionomer의 합성과 열기계적 성질

조원호,이상철 金烏工科大學校 1990 論文集 Vol.11 No.-

Styrene과 Sodium 2-acrylamido-20methy1 propane sulfonate를 유화중합하여 측쇄에 이온성기를 함유하는 공중합체를 합성하였다. 합성된 공중합체의 공중합 조성에 따른 유리전이온도, 침투거동, 열분해 거동 및 흡승성의 변화를 각각 체계적으로 조사하였다. 실험결과로 부터 합성된 중합체는 블럭성 공중합체인 것으로 밝혀졌다.

초등교사의 과학과 환경 교육에 대한 수업실태 분석 및 인식도

조태호,서승조,백남권,김성규,박강은,박원석 한국환경과학회 2002 한국환경과학회지 Vol.11 No.7

The purpose of this study was to analyze the elementary school teachers' perception toward the environment-related subjects in science education and to investigate their instructional methods in delivering the subjects in the classroom. The participants of this study were 300 elementary school teachers sampled from elementary schools in Kyung Nam Province. The findings of this study were as follows; First, more than half of the teachers surveyed showed that the environment-related units and contents in the science textbook were insufficient to the existing issues. Second, the large portion of teachers responded that the teaching materials in the textbook were insufficient to deliver the contents. Third, the largest portion of respondents replied that their preferred instructional method was a teacher-directed instruction followed by a case study approach. Fourth, in terms of the effectiveness of environmental education, both male and female teachers showed negative responses. Furthermore, male teachers were more negative than female teachers. Fifth, total means of their preference of the environment-related units was 3.13. The unit for sixth graders titled 'Environmental Pollution and Protecting Nature' showed the highest preference, whereas the unit for fifth graders titled 'Structure and Functions of Plants' showed the lowest preference. Sixth, there was no statistically significance in gender and their working areas. Seventh, there was statistically significant differences between male and female teachers in terms of teaching experience. In detail, the teachers with 5 to 9 teaching experience showed the lowest scores, while the teacher with more than 15 years teaching experience showed the highest scores in their perception of the units. Eighth, there was a significant difference between two groups in terms of their educational background. For example, two-year college graduates showed higher preference than four-year college graduates.

사용후 핵연료 처리공정물질의 핵물질 비파괴분석을 위한 중성자 증배 보정인자에 관한 연구

김현조,박재우,고원일,김호동 제주대학교 방사능이용연구소 2002 연구보고 Vol.16 No.-

The quantity of uranium or plutonium present in bulk samples of metal, oxide, mixed-oxide, fuel rods, etc., can often be assayed nondestructively by means of neutron coincidence counting. The self-multiplication phenomenon, which results from the induced fissions existing within the sample, inevitably generates measurement error. In this study, neutron multiplication effects were investigated by the measurement method proposed by Ensslin, and then the correction curves of neutron multiplication were derived. For this, DSNC(DUPIC Safeguards Neutron Counter), a well-type neutron coincidence counter, was use. In addition, the neutron multiplication effects were verified by comparison with the result of MCNP code. The correction curve obtained from this study will be used to increase measurement accuracy of the well-type neutron accounting sysyem in the future.

마이크로파 용융삽입법을 이용한 생분해성 나노복합체의 제조

하원조,신준식,송승욱,김준호,손세모,박성수 한국환경과학회 2004 한국환경과학회지 Vol.13 No.4

The purpose of this study was to investigate the possibility of application of microwave energy for the fabrication of polymer/clay nanocomposite. APES/Clay nanocomposites were prepared at 130℃ for 30min with various content of clay by melt-intercalation method under classical and microwave heating source. APES/Clay samples were characterized by the means of X-ray diffractometry(XRD), thermal gravimetric analysis(TGA), and rheometric dynamic analysis(RDA). It was found that intercalated or exfoliated state was obtained in the samples according to the condition of organic modification, clay content, and heating source.