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Li, Qi-Wen,Niu, Shao-Qing,Wang, Han-Yu,Wen, Ge,Li, Yi-Yang,Xia, Yun-Fei,Zhang, Yu-Jing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Background: A moderate dose of radiation is the recommended treatment for solitary plasmacytoma (SP), but there is controversy over the role of surgery. Our study aimed at comparing different treatment modalities in the management of SP. Materials and Methods: Data from 38 consecutive patients with solitary plasmacytoma, including 16 with bone plasmacytoma and 22 with extramedullary plasmacytoma, were retrospectively reviewed. 15 patients received radiotherapy alone; 11 received surgery alone, and 12 received both. The median radiation dose was 50Gy. All operations were performed as radical resections. Local progression-free survival (LPFS), multiple myeloma-free survival (MMFS), progression-free survival (PFS) and overall survival (OS) were calculated and outcomes of different therapies were compared. Results: The median follow-up time was 55 months. 5-year LPFS, MMFS, PFS and OS were 87.0%, 80.9%, 69.8% and 87.4%, respectively. Univariate analysis revealed, compared with surgery alone, radiotherapy alone was associated with significantly higher 5-year LPFS (100% vs 69.3%, p=0.016), MMFS (100% vs 51.4%, p=0.006), PFS (100% vs 33.7%, p=0.0004) and OS (100% vs 70%, p=0.041). Conclusions: Radiotherapy alone can be considered as a more effective treatment for SP over surgery. Whether a combination of radiotherapy and surgery improves outcomes requires further study.
Wen-fang Xia,Qing-shan Zhou,Yu Liu,Qi-zhu Tang,Han-dong Zou 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.2
Purpose: To investigate and compare the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery. Materials and Methods: Thirty-two ASA class I-II children with congenital heart disease undergoing cardiac surgery were randomly divided into two groups: propofol combined with low dose fentanyl (PF group, n = 16) and midazolam combined with low dose fentanyl (MF group, n = 16). Tracheal extubation time and length of Intensive Care Unit (ICU) stay were recorded. Blood samples were taken before operation (T_0), at 2 h after release of the aorta cross-clamp (T_3) and at 24 h after operation (T_4) to measure interleukin 6 (IL-6), IL-8, superoxide dismutase (SOD) and malondialdehyde (MDA) levels. Myocardium samples were collected at 10-20 min after aorta cross-clamp (T_1) and at 10-20 min after the release of the aorta cross-clamp (T_2) to detect heme oxygenase-1 (HO-1) expression. Results: Tracheal extubation time and length of ICU stay in PF group were significantly shorter than those of the MF group (p < 0.05, respectively). After cardiopulmonary bypass, IL-6, IL-8 and MDA levels were significantly increased, and the SOD level was significantly reduced in both two groups, but PF group exhibited lower IL-6, IL-8 and MDA levels and higher SOD levels than the MF group (p < 0.05, respectively). The HO-1 expression in the PF group was significantly higher than that in MF group at the corresponding time points (p < 0.05, respectively). Conclusion: Propofol is superior to midazolam in reducing inflammation and oxidase stress and in improving post-operation recovery in children with congenital heart disease undergoing cardiac surgery.
Synthesis and Viscoelastic Behavior of Non-Stoichiometric Spinel Ferrite Particle Suspension
Han, Jae Kyeong,Han, Wen Jiao,Gao, Chun Yan,Dong, Yu Zhen,Choi, Hyoung Jin IEEE 2018 IEEE transactions on magnetics Vol.54 No.11
<P>Magnetorheological (MR) fluid with tunable and reversible phase transition is one of the most promising smart materials for engineering applications. In this paper, to improve the MR performance of ferrites, non-stoichiometric Zn-doped spinel ferrite (Zn<SUB>0.417</SUB>Fe<SUB>2.583</SUB>O<SUB>4</SUB>) nanoparticles with a high saturation magnetization and a truncated octahedron-like shape were synthesized using a thermal decomposition process. The crystallographic structure was analyzed using X-ray diffraction and field emission transmission electron microscope image. The Zn<SUB>0.417</SUB>Fe<SUB>2.583</SUB>O<SUB>4</SUB> had a high saturation magnetization value of 101 <TEX>$\text {A}\cdot \text {m}^{2}$</TEX>/kg at 933 kA/m, showing higher saturation magnetization than other ferrites. The MR characteristics of the Zn<SUB>0.417</SUB>Fe<SUB>2.583</SUB>O<SUB>4</SUB> particles suspended in silicone oil were studied using a rotation rheometer under various magnetic field strengths. This MR fluid exhibited typical MR characteristics, and its flow curves were fit well with the Herschel–Bulkley model.</P>
Additive effect of rod-like magnetite/sepiolite composite particles on magnetorheology
Yu Zhen Dong,Wen Jiao Han,최형진 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.93 No.-
Rod-like magnetite/sepiolite nanocomposite particles were fabricated using a chemical co-precipitationprocess and introduced as an added ingredient in a carbonyl iron (CI)-based magnetorhologicalfluid(MRF). The morphologies of the composite particles and CI-magnetite/sepiolite mixture were observedby scanning electron microscopy. Two types of MRFs with and without magnetite/sepiolite additive werefabricated, and their MR behaviors and sedimentation stability were investigated using a rotationrheometer and an optical analyzer system of Turbiscan, respectively. The results showed that the additionof rod-like magnetite/sepiolite additives enhanced both the dispersion and MR properties of CI-basedMRF, making its potential application more promising.
Wen-Jing He,Shan-Liang Zhu,Na Li,Yu-Qun Han 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.2
In this article, adaptive tracking control for a class of switched stochastic nonlinear systems subject to unknown dead-zone input using multi-dimensional Taylor network (MTN) is studied. Firstly, the characteristic function is introduced to convert the nonlinearity of the input dead-zone into a linear model. Secondly, a novel adaptive control method based on the backstepping recursive design technique is proposed, which combines MTN and common Lyapunov functions (CLFs). Significantly, a method to reduce the computational complexity of switched stochastic nonlinear systems is proposed for the first time, which introduces characteristic function and MTN technology. The result makes clear that the proposed controller can ensure all signals of the closed-loop system are bounded in probability, and the output of the system can track reference signal well. Finally, the effectiveness of proposed control method is verified by simulation results.
Yu Jian,Li Wen,Hou Guo-jun,Sun Da-peng,Yang Yuan,Yuan Sheng-xian,Dai Zhi-hui,Yin Hao-zan,Sun Shu-han,Huang Gang,Zhou Wei-ping,Yang Fu 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hepatitis B protein x (HBx) has been reported to promote tumorigenesis in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the mechanism awaits further investigation. In this study, we found that cFAM210A (a circular RNA derived from the third exon of transcript NM_001098801 of the FAM210A gene; CircBase ID: hsa_circ_0003979) can be silenced by HBx. cFAM210A expression was downregulated and negatively correlated with tumorigenesis in patients with HBV-related HCC. Furthermore, cFAM210A reduced the proliferation, stemness, and tumorigenicity of HCC cells. Mechanistically, HBx increased the N6-methyladenosine (m6A) level of cFAM210A by promoting the expression of RBM15 (an m6A methyltransferase), thus inducing the degradation of cFAM210A via the YTHDF2-HRSP12-RNase P/MRP pathway. cFAM210A bound to YBX1 and inhibited its phosphorylation, suppressing its transactivation function toward MET. These findings suggest the important role of circular RNAs in HBx-induced hepatocarcinogenesis and identify cFAM210A a potential target in the prevention and treatment of HBV-related HCC.
Han-Chun Hung,Chien-Wei Feng,Yen-You Lin,Chun-Hong Chen,Kuan-Hao Tsui,Wu-Fu Chen,Chieh-Yu Pa,Jyh-Horng Sheu,Chun-Sung Sung,Zhi-Hong Wen 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Atopic dermatitis (AD) is a chronic inflammatory skin disease, and its prevalence is increasing. AD usually elicits skin barrier dysfunction, dry skin and itching. As the mechanisms of AD remain unknown, there is an urgent need to find effective therapies. Because of the diversity and complexity of marine environments, the discovery of drugs from marine organisms as novel therapeutic agents for human diseases has seen renewed interest. Dihydroaustrasulfone alcohol (WA-25), the synthetic precursor of austrasulfone, which is a natural product isolated from a Formosan soft coral, has been shown to possess many therapeutic effects in our previous studies. However, the detailed mechanisms and therapeutic effects of WA-25 on AD are incompletely understood. We performed in vitro and in vivo studies to examine the effects of WA-25 on AD. We showed that WA-25 blocks inflammation and oxidative stress. Simultaneously, we also found that WA-25 reduces the AD scores and AD-induced transepidermal water loss (TEWL), scratching behavior, and alloknesis. WA-25 is more effective in cases of AD than are the drugs that are currently used clinically. Importantly, we also found that when nucleophosmin (NPM) was inhibited or when its expression was reduced, the anti-inflammatory and anti-AD effects of WA-25 were blocked. These data suggest that NPM plays dual roles in inflammation and AD. Overall, these results suggest that WA-25 is a potential anti-inflammatory and AD therapeutic agent that is modulated by NPM.
Yu-Qun Han,Wen-Jing He,Na Li,Shan-Liang Zhu 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.12
This paper concerns on the control problem of a class of nonlinear systems with input delay and dynamic uncertainties using multi-dimensional Taylor Network (MTN) control method. Firstly, a new variable is introduced to eliminate the effect of input delay by combining Padé approximation with Laplace transformation. Secondly, a MTN-backstepping-based control strategy is constructively designed by introducing a new coordinate transformation, and the proposed controller has the advantages of simple structure and good real-time performance. Finally, the effectiveness of the proposed MTN-based control approach is demonstrated by three examples.
Bidirectional Hybrid DWDM-PON for HDTV/Gigabit Ethernet/CATV Applications
Hai-Han Lu,Wen-Shing Tsai,Tzu-Shen Chien,Shih-Hung Chen,Yu-Chieh Chi,Che-Wei Liao 한국전자통신연구원 2007 ETRI Journal Vol.29 No.2
A new scheme for bi-directional HDTV/Gigabit Ethernet/CATV transmission over a hybrid densewavelength- division-multiplexing passive optical network (DWDM-PON) is proposed and demonstrated. It is based on injection-locked vertical-cavity surface-emitting lasers and distributed-feedback laser diodes as transmitters. Services with 129 HDTV channels, a 1.25 Gbps Gigabit Ethernet connection, and 77 CATV channels are successfully demonstrated over 40 km single-mode fiber links. Good performance of bit error rate, carrier-to-noise ratio, composite second order, and composite triple beat is achieved in our proposed bidirectional DWDM-PON.