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      • SCIEKCI등재

        Nonlinear Regression Analysis to Determine Infection Models of Colletotrichum acutatum Causing Anthracnose of Chili Pepper Using Logistic Equation

        Kang, Wee-Soo,Yun, Sung-Chul,Park, Eun-Woo The Korean Society of Plant Pathology 2010 Plant Pathology Journal Vol.26 No.1

        A logistic model for describing combined effects of both temperature and wetness period on appressorium formation was developed using laboratory data on percent appressorium formation of Colletotrichum acutatum. In addition, the possible use of the logistic model for forecasting infection risks was also evaluated as compared with a first-order linear model. A simplified equilibrium model for enzymatic reactions was applied to obtain a temperature function for asymptote parameter (A) of logistic model. For the position (B) and the rate (k) parameters, a reciprocal model was used to calculate the respective temperature functions. The nonlinear logistic model described successfully the response of appressorium formation to the combined effects of temperature and wetness period. Especially the temperature function for asymptote parameter A reflected the response of upper limit of appressorium formation to temperature, which showed the typical temperature response of enzymatic reactions in the cells. By having both temperature and wetness period as independent variables, the nonlinear logistic model can be used to determine the length of wetness periods required for certain levels of appressorium formation under different temperature conditions. The infection model derived from the nonlinear logistic model can be used to calculate infection risks using hourly temperature and wetness period data monitored by automated weather stations in the fields. Compared with the nonlinear infection model, the linear infection model always predicted a shorter wetness period for appressorium formation, and resulted in significantly under- and over-estimation of response at low and high temperatures, respectively.

      • SCIEKCI등재

        A Web-based Information System for Plant Disease Forecast Based on Weather Data at High Spatial Resolution

        Kang, Wee-Soo,Hong, Soon-Sung,Han, Yong-Kyu,Kim, Kyu-Rang,Kim, Sung-Gi,Park, Eun-Woo The Korean Society of Plant Pathology 2010 Plant Pathology Journal Vol.26 No.1

        This paper describes a web-based information system for plant disease forecast that was developed for crop growers in Gyeonggi-do, Korea. The system generates hourly or daily warnings at the spatial resolution of $240\;m{\times}240\;m$ based on weather data. The system consists of four components including weather data acquisition system, job process system, data storage system, and web service system. The spatial resolution of disease forecast is high enough to estimate daily or hourly infection risks of individual farms, so that farmers can use the forecast information practically in determining if and when fungicides are to be sprayed to control diseases. Currently, forecasting models for blast, sheath blight, and grain rot of rice, and scab and rust of pear are available for the system. As for the spatial interpolation of weather data, the interpolated temperature and relative humidity showed high accuracy as compared with the observed data at the same locations. However, the spatial interpolation of rainfall and leaf wetness events needs to be improved. For rice blast forecasting, 44.5% of infection warnings based on the observed weather data were correctly estimated when the disease forecast was made based on the interpolated weather data. The low accuracy in disease forecast based on the interpolated weather data was mainly due to the failure in estimating leaf wetness events.

      • SCOPUSSCIEKCI등재

        자발성 피막 파열을 일으킨 안상부 기형종 : 증례보고 Case Report

        위성찬,김재휴,김수한,강삼석,이제혁,우정현,정상우 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.11

        A case of spontaneously ruptured suprasellar teratoma, diagnosed preoperatively by computerized tomography(CT) and magnetic resonance image(MRI), is presented. The patient, a 51-year-old man was hospitalized for headache and focal seizure of left upper extremity since 5 days before admission. The CT scan showed an ill-defined hypodense mass in the suprasellar region and multiple small hypodense lesions in the subarachnoid space and cisterns, which were not enhanced by contrast media. The multiple small lesions in the cisterns seemingly derived from the ruptured tumor showed high signal intensity on T₁WI MRI. During operation the ruptured materials were confirmed to be fat globules and the arachnoid membrane was severely thickened and adhesed

      • 유기물질-물-설탕의 3성분계 확산계수

        강안수,김위경 명지대학교 1986 明大論文集 Vol.17 No.-

        유기물질-물-설탕의 3성분계 확산 flux에 필요한 3성분계 확산계수를 격막cell 방법으로 측정하였다. 설탕수용액의 농도범위, 0∼60 wt%에서 1000ppm의 유기물질(benzaldehyde)을 용해하여 25℃의 일정한 온도에서 격막cell을 이용, 확산시킨 후 자외선 분광기 및 굴절계로 비이상성(nonideality)을 나타내는 설탕농도의 변화에 따른 benzaldehyde의 활동계수를 gas-chromatography를 이용 기상분석법으로 측정하였다. 3성분계의 확산 flux에 필요한 4개의 확산계수중 물의 주확산계수는 2성분계 확산계수를 이용하였고 benzaldehyde의 주확산계수 및 상호확산계수는 격막 cell 방법에서 유도한 식 및 본 실험에서 측정한 농도차를 이용하여 계산하였으며 나머지 benzaldehyde의 상호확산계수는 Onsager의 reciprocity관계를 이용하여 계산하였다. 실험결과 benzaldehyde의 주확산계수 및 상호작용계수는 물의 농도변화에 따라 큰 영향을 받으며 benzaldehyde의 주확산계수와 의사2성분계 확산계수는 물의 농도 차가 적을 경우 거의 비슷하다는 결론을 얻었다. 그리고 benzaldehyde의 활동도계수는 설탕의 농도가 커질수록 작아졌다. The ternary diffusion coefficients of organic component(benzaldehyde)-water-sucrose were measured with the diaphragm cell at 25℃. Solutions of sucrose ranging from 0 to 60 weight percent were prepared with the distilled water, and benzaldehyde of 1,000 ppm was then added as the dilute organic species. The difference in sucrose concentration and benzaldehyde between the solutions on either side of diaphragm cells were analyzed respectively by refractometer and ultra-violet spectrophotometer at 249.5 nm. And gas chromatographic analysis by direct head space injection was used in order to measure the activity coefficients of benzaldehyde, by which the extent of non-ideality of the system is evaluated, as a function of sucrose concentration. From the equations derived in the diaphragm cell and two independent experimental measurements, together with known binary diffusion data for aqueous sucrose solution, the three independent ternary diffusion coefficcients were determined. The fourth diffusion coefficients was then obtained from these three ternary diffusion coefficients by the use of the Onsager's reciprocity relationship. The experimental results showed that the main and cross diffusion coefficients of benzaldhyde were influenced greatly with the variation of water concentration and the main diffusion coefficients of benzaldehyde was similar to the pseudo-binary diffusion coefficients of that in the case of small concentration difference of water. And the activity coefficients of benzaldehyde decreased with increasing sucrose concentration.

      • KCI등재

        Psammaplin A-Modified Novel Radiosensitizers for Human Lung Cancer and Glioblastoma Cells

        Wee, Chan Woo,Kim, Jin Ho,Kim, Hak Jae,Kang, Hyun-Cheol,Suh, Soo Youn,Shin, Beom Soo,Ma, Eunsook,Kim, Il Han The Korean Association for Radiation Protection 2019 방사선방어학회지 Vol.44 No.1

        Background: Psammaplin A (PsA) is a radiosensitizer whereas its clinical application is hampered by poor bioavailability. This study aimed to synthesize novel radiosensitizers using PsA as the lead compound. Materials and Methods: Eight homodimeric disulfides were synthesized from corresponding acid and cystamine dihydrochloride in N-hydroxysuccinimide and dicyclohexylcarbodiimide coupling conditions. One monomeric thiol analog was obtained by reduction of homodimeric disulfide with dithiothreitol. Clonogenic assay was used to measure cell survival after irradiation and drug treatment in human lung cancer (A549) and glioblastoma (U373MG) cells. Results and Discussion: Using the PsA backbone, nine compounds were synthesized. Eight compounds showed variable cytotoxicity with 50% inhibitory concentrations ranging $16.14{\mu}M$ to $150.10{\mu}M$ (A549), and $13.25{\mu}M$ to $50.15{\mu}M$ (U373MG). Four and six compounds radiosensitized A549 and U373MG cells, respectively. Two compounds that radiosensitized both cell lines were tested for its inhibitory effects on DNMT1. One of them was shown to significantly inhibit DNMT1 activity. Conclusion: Novel compounds with radiosensitizing activity were synthesized. These compounds have a great potential to serve as a basis for the development of future radiosensitizers. Further investigation is warranted for their clinical application.

      • SCOPUSKCI등재

        이성분계 물질을 함유한 다공성 물질 건조공정의 선택성

        강안수,김위경 한국화학공학회 1995 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.33 No.6

        이성분계 혼합물을 함유하는 다공성 물질의 건조시 잔류하는 혼합물의 농도는 어떤 한 성분이 우선적으로 제거되는 건조공정의 선택성에 의하여 변한다. 건조공정의 선택성은 주어진 건조조건에서의 평형상태, 기상 및 액상측 물질전달 현상에 의존한다. 이로 인하여 공비점을 가지는 혼합물의 건조시 건조공정의 선택성에 의하여 휘발성이 낮은 물질이 우선적으로 제거되기도 한다. 특히, 액상측 물질전달 현상은 정속구간과 감속구간에서 서로 상이하며, 다공성 물질의 특성에도(모세관의 크기 및 길이) 좌우된다. 이러한 특성때문에 액상측 물질전달 현상이 선택성에 미치는 영향은 매우 중요하다. 본 연구에서는 액상측 물질전달 현상이 선택성에 미치는 영향을 조사하기 위하여 건조물체 내의 농도 및 함량분포를 측정하였다. The concentration of the mixture changes during the drying process of porous materials containing binary mixture, when a component is removed preferentially, so called the selectivity, of the drying process. The selectivity depends on the phase equilibria, gas- and liquid-side mass transfer for given drying conditions. For this reason the less volatile component can be removed preferentially during the drying of porous materials containing binary mixture with azeotrope point. The liquid-side mass transfer rate of the constant rate period differs from that of the falling rate period. The liquid-side mass transfer rate depends on the characteristic of the porous materials(size and length of the capillary). The influence of the liquid-side mass transfer on the selectivity is, therefore, very important. In this study, the distribution of the concentration and the content of the binary mixtures in the porous materials were determined to investigate the influence of the liquid-side mass transfer on the selectivity.

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